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Structure Content

Département: Biologie structurale et chimie

Tous Publications

Debashis Dhara, Laurence A. Mulard, and Marcel Hollenstein*, Natural, modified and conjugated carbohydratesin nucleic acids, Chem. Soc. Rev. 2025, 54, 2948-2983.

Karlsson E, Andén O, Fan C, Fourati Z, Haouz A, Zhuang Y, Howard RJ, Delarue M, Lindahl E, Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel., Br J Pharmacol 2025 March.

Sieskind R, Missoury S, Madru C, Commenge I, Niogret G, Hollenstein M, Rondelez Y, Sauguet L, Haouz A, Legrand P, Delarue M, Crystal structures of monomeric BsmI restriction endonuclease reveal coordinated sequential cleavage of two DNA strands., Commun Biol 2025 Mar; 8(1): 387.

Olivia Anden, Urska Rovsnik, Marie Lycksell, Marc Delarue, Rebecca J Howard, Erik Lindahl, Structure and dynamics of a multidomain ligand-gated ion channelrevealed under acidic conditions, Biorxiv 2025.

Dejoux A, Zhu Q, Woolfe A, Godon O, Ellouze S, Mottet G, Castrillon C, Gillis C, Pecalvel C, Ganneau C, Iannascoli B, Lemoine F, Saul F, England P, Reber LL, Gouel-Chéron A, de Chaisemartin L, Haouz A, Millot GA, Bay S, Gérard A, Jönsson F, Chollet-Martin S, Bruhns P, Antibody-secreting cell repertoires hold high-affinity anti-rocuronium specificities that can induce anaphylaxis in vivo., J Allergy Clin Immunol 2025 Jan; (): .

Pierre Nicolas Bizat, Nazarii Sabat*, Marcel Hollenstein*, Recent Advances in Biocatalytic and Chemoenzymatic Synthesis of Oligonucleotides, ChemBioChem. 2025, 26, e202400987.

Puszko AK, Batista FA, Ejjoummany A, Bouillon A, Maurel M, Adler P, Legru A, Martinez M, Ortega Varga L, Hadjadj M, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF, Towards Improved Peptidic α-Ketoamide Inhibitors of the Plasmodial Subtilisin-Like SUB1: Exploration of N-Terminal Extensions and Cyclic Constraints., ChemMedChem 2025 Jan; (): e202400924.

Megrian D, Martinez M, Alzari PM, Wehenkel AM, Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA., Commun Biol 2025 Jan; 8(1): 49.

Fruchard L, Babosan A, Carvalho A, Lang M, Li B, Duchateau M, Giai Gianetto Q, Matondo M, Bonhomme F, Hatin I, Arbes H, Fabret C, Corler E, Sanchez G, Marchand V, Motorin Y, Namy O, de Crécy-Lagard V, Mazel D, Baharoglu Z, Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification., Elife 2025 Jan; 13(): .

Grossi V, Cuny P, Militon C, Witwinowski J, Eddhif B, Sylvi L, Nowakowski M, Kosta A, Antheaume I, Cornil J, Dubrac S, Kende J, Gribaldo S, Borrel G, Halophilic archaea produce wax esters and use an alternative fatty acyl-coenzyme A reductase for precursor synthesis., ISME J 2025 Jan; 19(1): .

Riccardo Vernuccio, Alejandro Martínez León, Chetan Poojari, Julian Buchrieser, Christopher Selverian, Yakin Jaleta, Annalisa Meola, Florence Guivel-Benhassine, Françoise Porrot, Ahmed Haouz, Maelenn Chevreuil, Bertrand Raynal, Jason Mercer, Etienne Simon-Loriere, Kartik Chandran, Olivier Schwartz, Jochen Hub, Pablo Guardado-Calvo, Structural insights into tecovirimat antiviral activity and poxvirus resistance, Nature Microbiology, In press, ⟨10.1038/s41564-025-01936-6⟩.

Martínez-Carranza M, Vialle L, Madru C, Cordier F, Tekpinar AD, Haouz A, Legrand P, Le Meur RA, England P, Dulermo R, Guijarro JI, Henneke G, Sauguet L, Communication between DNA polymerases and Replication Protein A within the archaeal replisome., Nat Commun 2024 Dec; 15(1): 10926.

Nandan Haloi, Emelia Karlsson, Marc Delarue, Rebecca J Howard, Erik Lindahl, Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT3A receptor, 2024.

Rémi Sieskind, Sophia Missoury, Clément Madru, Isciane Commenge, Germain Niogret, Marcel Hollenstein, Yannick Rondelez, Ludovic Sauguet, Ahmed Haouz, Pierre Legrand, Marc Delarue*, Crystal structures of monomeric BsmI restriction endonuclease reveal a coordinated action of its two distinct active sites to sequentially cleave the two DNA strands, Communications Biology.

Bekirian C, Valsecchi I, Bachellier-Bassi S, Scandola C, Guijarro JI, Chauvel M, Mourer T, Gow NAR, Aimanianda VK, d'Enfert C, Fontaine T, β-1,6-Glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall., Elife 2024 Dec; 13(): .

Barbachowska M, Harivel T, Nicchi S, Danckaert A, Ghazarian M, Chiaravalli J, Buchrieser C, Rolando M, Arimondo PB, High Content Screening Assay of Inhibitors of the Legionella Pneumophila Histone Methyltransferase RomA in Infected Cells., Chembiochem 2024 Dec; 25(23): e202400293.

Saul FA, Vulliez-Le Normand B, Boes A, Spiegel H, Kocken CHM, Faber BW, Bentley GA, Conformational variability in the D2 loop of Plasmodium Apical Membrane antigen 1., J Struct Biol X 2024 Dec; 10(): 100110.

Lara Johanna Friedrich, Axel Guthart, Min Zhou, Paola B. Arimondo, Thomas Efferth and Mona Dawood, Supercomputer-based virtual screening for DNMT1 inhibitors as novel anticancer agents, Int. J. Mol. Sci..

Nou NO, Covington JK, Lai D, Mayali X, Seymour CO, Johnston J, Jiao JY, Buessecker S, Mosier D, Muok AR, Torosian N, Cook AM, Briegel A, Woyke T, Eloe-Fadrosh E, Shapiro N, Bryan SG, Sleezer S, Dimapilis J, Gonzalez C, Gonzalez L, Noriega M, Hess M, Carlson RP, Liu L, Li MM, Lian ZH, Zhu S, Liu F, Sun X, Gao B, Mewalal R, Harmon-Smith M, Blaby IK, Cheng JF, Weber PK, Grigorean G, Li WJ, Dekas AE, Pett-Ridge J, Dodsworth JA, Palmer M, Hedlund BP, Genome-guided isolation of the hyperthermophilic aerobe Fervidibacter sacchari reveals conserved polysaccharide metabolism in the Armatimonadota., Nat Commun 2024 Nov; 15(1): 9534.

Muok AR, Olsthoorn FA, Briegel A, Unpacking Alternative Features of the Bacterial Chemotaxis System., Annu Rev Microbiol 2024 Nov; 78(1): 169-189.

Kamolrat Somboon, Oliver Melling, Maylis Lejeune, Glaucia M S Pinheiro, Annick Paquelin, Benjamin Bardiaux, Michael Nilges, Phillippe Delepelaire, Syma Khalid, Nadia Izadi-Pruneyre, Dynamic interplay between a TonB-dependent heme transporter and a TonB protein in a membrane environment, mBio, In press, pp.e0178124. ⟨10.1128/mbio.01781-24⟩.

Vernel-Pauillac F, Laurent-Winter C, Fiette L, Janbon G, Aimanianda V, Dromer F, Cryptococcus neoformans infections: aspartyl protease potential to improve outcome in susceptible hosts., mBio 2024 Oct; (): e0273324.

Boullé M, Leleu A, Schacre S, Banal C, Boucharlat A, Renault S, Hollenstein M, Frosk P, Yates F, Lefort N, Agou F, Generation of IPi002-A/B/C human induced pluripotent stem cell lines from MARCH amniotic fluid cells., Stem Cell Res 2024 Oct; 81(): 103589.

Gedeon A, Yab E, Dinut A, Sadowski E, Capton E, Dreneau A, Petit J, Gioia B, Piveteau C, Djaout K, Lecat E, Wehenkel AM, Gubellini F, Mechaly A, Alzari PM, Deprez B, Baulard A, Aubry A, Willand N, Petrella S, Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase., iScience 2024 Oct; 27(10): 110967.

Nilesh B Karalkar, Tatiana Kent, Taylor Tredinnick, Leonardo Betancurt-Anzola, Marc Delarue, Richard Pomerantz, Steven A Benner, Template-Independent Enzymatic RNA Synthesis, 2024.

Dugied G, Douche T, Dos Santos M, Giai Gianetto Q Q, Cassonnet C, Vuillier F, Cassonnet P, Jacob Y, van der Werf S, Komarova A, Matondo M, Karim M, Demeret C, Profiling Cullin4-E3 ligases interactomes and their rewiring in influenza A virus infection., Mol Cell Proteomics 2024 Oct; (): 100856.

Carvalho F, Carreaux A, Sartori-Rupp A, Tachon S, Gazi AD, Courtin P, Nicolas P, Dubois-Brissonnet F, Barbotin A, Desgranges E, Bertrand M, Gloux K, Schouler C, Carballido-López R, Chapot-Chartier MP, Milohanic E, Bierne H, Pagliuso A, Aquatic environment drives the emergence of cell wall-deficient dormant forms in Listeria., Nat Commun 2024 Oct; 15(1): 8499.

Dioury F, San C, Gnanalingam G, Henoumont C, Haouz A, Shepard W, Rousselin Y, Vijayakumar K, Hosten B, Laurent S, Port M, Bifunctional Hexadentate Pyclen-based Chelating Agent for Mild Radiofluorination in Aqueous Solution at Room Temperature with a Ga-18F Ternary Complex., Chemistry 2024 Sep; (): e202403358.

Chekli Y, Thiriet-Rupert S, Caillet C, Quilès F, Le Cordier H, Deshayes E, Bardiaux B, Pédron T, Titecat M, Debarbieux L, Ghigo JM, Francius G, Duval JFL, Beloin C, Biophysical insights into sugar-dependent medium acidification promoting YfaL protein-mediated Escherichia coli self-aggregation, biofilm formation and acid stress resistance., Nanoscale 2024 Sep 26;16(37): 17567-17584.

Nazarii Sabat, Andreas Stämpfli, Steven Hanlon, Serena Bisagni, Filippo Sladojevich, Kurt Püntener, and Marcel Hollenstein*, Template-dependent DNA ligation for the synthesis of modified oligonucleotides., Nat. Commun. 2024, 15, 8009.

Sabat N, Stämpfli A, Hanlon S, Bisagni S, Sladojevich F, Püntener K, Hollenstein M, Template-dependent DNA ligation for the synthesis of modified oligonucleotides., Nat Commun 2024 Sep; 15(1): 8009.

Dejoux A, Zhu Q, Ganneau C, Goff OR, Godon O, Lemaitre J, Relouzat F, Huetz F, Sokal A, Vandenberghe A, Pecalvel C, Hunault L, Derenne T, Gillis CM, Iannascoli B, Wang Y, Rose T, Mertens C, Nicaise-Roland P, , England P, Mahévas M, de Chaisemartin L, Le Grand R, Letscher H, Saul F, Pissis C, Haouz A, Reber LL, Chappert P, Jönsson F, Ebo DG, Millot GA, Bay S, Chollet-Martin S, Gouel-Chéron A, Bruhns P, Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models., Sci Transl Med 2024 Sep; 16(764): eado4463.

Roberto Notario Manzano, Thibault Chaze, Eric Rubinstein, Esthel Pénard, Mariette Matondo, Chiara Zurzolo, Christel Brou, Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators, eLife, 2024, 13, pp.RP99172. ⟨10.7554/eLife.99172⟩.

Baquero DP, Medvedeva S, Martin-Gallausiaux C, Pende N, Sartori-Rupp A, Tachon S, Pedron T, Debarbieux L, Borrel G, Gribaldo S, Krupovic M, Stable coexistence between an archaeal virus and the dominant methanogen of the human gut., Nat Commun 2024 Sep; 15(1): 7702.

Jill-Léa Ramassamy, Ahidjo Ayouba, Guillaume Thaurignac, Chanceline Bilounga Ndongo, Patrick Nnuka, Edouard Betsem, Richard Njouom, Eitel Mpoudi Ngole, Jessica Vanhomwegen, Damien Hoinard, Patrick England, Alexandra Journeaux, Caroline Picard, Damien Thomas, Delphine Pannetier, Sylvain Baize, Eric Delaporte, Martine Peeters, Antoine Gessain, High seroreactivities to orthoebolaviruses in rural Cameroon: a case-control study on non-human primate bites and a cross-sectional survey in rural population, Journal of Infectious Diseases, 2024, pp.jiae399. ⟨10.1093/infdis/jiae399⟩.

Cristiano da Silva Lameira, Sini Münßinger, Lu Yang, Bernhard Eikmanns, Marco Bellinzoni, Corynebacterium glutamicum pyruvate:quinone oxidoreductase: an enigmatic metabolic enzyme with unusual structural features, FEBS Journal, In press, ⟨10.1111/febs.17232⟩.

Planchais C, Fernández I, Chalopin B, Bruel T, Rosenbaum P, Beretta M, Dimitrov JD, Conquet L, Donati F, Prot M, Porrot F, Planas D, Staropoli I, Guivel-Benhassine F, Baquero E, van der Werf S, Haouz A, Simon-Lorière E, Montagutelli X, Maillère B, Rey FA, Guardado-Calvo P, Nozach H, Schwartz O, Mouquet H, Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2., iScience 2024 Jul; 27(7): 110354.

Munar-Palmer M, Santamaría-Hernando S, Liedtke J, Ortega DR, López-Torrejón G, Rodríguez-Herva JJ, Briegel A, López-Solanilla E, Chemosensory systems interact to shape relevant traits for bacterial plant pathogenesis., mBio 2024 Jul; 15(7): e0087124.

Panei FP, Gkeka P, Bonomi M, Identifying small-molecules binding sites in RNA conformational ensembles with SHAMAN., Nat Commun 2024 Jul; 15(1): 5725.

Germain Niogret, Camille Chériaux, Frédéric Bonhomme, Fabienne Levi-Acobas, Carlotta Figliola, Gilles Ulrich, Gilles Gasser* and Marcel Hollenstein*, A toolbox for enzymatic modification of nucleic acids with photosensitizers for photodynamic therapy, RSC Chem. Biol. 2024, 5, 841-852.

Van Blerkom P, Bezault A, Sauvanet C, Hanein D, Volkmann N, The GoldX Fiducial Eraser., Int J Mol Sci 2024 Jul; 25(13): .

Izadi-Pruneyre, N., Karami, Y., Nilges, M., Structure and Dynamics of Type 4a Pili and Type 2 Secretion System Endopili, In: Macromolecular Protein Complexes V, vol 104. Chapter 21. p549-563.

Wuo MG, Dulberger CL, Warner TC, Brown RA, Sturm A, Ultee E, Bloom-Ackermann Z, Choi C, Zhu J, Garner EC, Briegel A, Hung DT, Rubin EJ, Kiessling LL, Fluorogenic Probes of the Mycobacterial Membrane as Reporters of Antibiotic Action., J Am Chem Soc 2024 Jul; 146(26): 17669-17678.

Mareuil F, Moine-Franel A, Kar A, Nilges M, Ciambur CB, Sperandio O, Protein interaction explorer (PIE): a comprehensive platform for navigating protein-protein interactions and ligand binding pockets., Bioinformatics 2024 Jul; 40(7): .

Delcourte L, Sanchez C, Morvan E, Berbon M, Grélard A, Saragaglia C, Dakhli T, Thore S, Bardiaux B, Habenstein B, Kauffmann B, Saupe SJ, Loquet A, NMR resonance assignment of the cell death execution domain BELL2 from multicellular bacterial signalosomes., Biomol NMR Assign 2024 Jun; (): .

Fernández I, Saunders N, Duquerroy S, Bolland WH, Arbabian A, Baquero E, Blanc C, Lafaye P, Haouz A, Buchrieser J, Schwartz O, Rey FA, Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus., Cell 2024 Jun; (): .

Khan S, Partuk EO, Chiaravalli J, Kozer N, Shurrush KA, Elbaz-Alon Y, Scher N, Giraud E, Tran-Rajau J, Agou F, Barr HM, Avinoam O, High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors., iScience 2024 Jun; 27(6): 110019.

Maëva Pichon and Marcel Hollenstein*, Controlled enzymatic synthesis of oligonucleotides, Commun. Chem. 2024, 7, 138.

Fruchard Louna, Babosan Anamaria, Carvalho Andre, Lang Manon, Li Blaise, Duchateau Magalie, Giai-Gianetto Quentin, Matondo Mariette, Bonhomme Frédéric, Hatin Isabelle, Arbes Hugo, Fabret Céline, Sanchez Guillaume, Marchand Virginie, Motorin Yuri, Namy Olivier, de Crécy-Lagard Valérie, Mazel Didier, Baharoglu Zeynep, Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated to queuosine tRNA modification, Elife.

Suladze S, Sarkar R, Rodina N, Bokvist K, Krewinkel M, Scheps D, Nagel N, Bardiaux B, Reif B, Atomic resolution structure of full-length human insulin fibrils., Proc Natl Acad Sci U S A 2024 Jun; 121(23): e2401458121.

Patrice Koehl, Rafael Navaza, Mustafa Tekpinar, Marc Delarue, MinActionPath2: path generation between different conformations of large macromolecular assemblies by action minimization, Nucleic Acids Research, 2024, pp.gkae421. ⟨10.1093/nar/gkae421⟩.

Mistretta M, Cimino M, Campagne P, Volant S, Kornobis E, Hebert O, Rochais C, Dallemagne P, Lecoutey C, Tisnerat C, Lepailleur A, Ayotte Y, LaPlante SR, Gangneux N, Záhorszká M, Korduláková J, Vichier-Guerre S, Bonhomme F, Pokorny L, Albert M, Tinevez JY, Manina G, Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy., Nat Commun 2024 May; 15(1): 4175.

, Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy, Nature Communications.

Dupont M, Krischuns T, Gianetto QG, Paisant S, Bonazza S, Brault JB, Douché T, Arragain B, Florez-Prada A, Perez-Perri JI, Hentze MW, Cusack S, Matondo M, Isel C, Courtney DG, Naffakh N, The RBPome of influenza A virus NP-mRNA reveals a role for TDP-43 in viral replication., Nucleic Acids Res 2024 Apr; (): .

Alexandra Moine-Franel, Fabien Mareuil, Michael Nilges, Constantin Bogdan Ciambur, Olivier Sperandio, A comprehensive dataset of protein-protein interactions and ligand binding pockets for advancing drug discovery, Scientific Data , 2024, 11 (1), pp.402. ⟨10.1038/s41597-024-03233-z⟩.

Alexandra Fillion , Sophie Vichier-Guerre, Paola Barbara Arimondo, Adenine, a key player in biology and medicinal chemistry , Comptes Rendus Chimie, Académie des Sciences .

Zhong X, Nicolardi S, Ouyang R, Wuhrer M, Du C, van Wezel G, Vijgenboom E, Briegel A, Claessen D, CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex., Appl Environ Microbiol 2024 Apr; 90(4): e0208723.

Legru A, Batista FA, Puszko AK, Bouillon A, Maurel M, Martinez M, Ejjoummany A, Ortega Varga L, Adler P, Méchaly A, Hadjadj M, Sosnowski P, Hopfgartner G, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF, Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1., Eur J Med Chem 2024 Apr; 269(): 116308.

Yamaguchi K, Chen X, Rodgers B, Miura F, Bashtrykov P, Bonhomme F, Salinas-Luypaert C, Haxholli D, Gutekunst N, Aygenli BÖ, Ferry L, Kirsh O, Laisné M, Scelfo A, Ugur E, Arimondo PB, Leonhardt H, Kanemaki MT, Bartke T, Fachinetti D, Jeltsch A, Ito T, Defossez , Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells, Nature communication.

Yamaguchi K, Chen X, Rodgers B, Miura F, Bashtrykov P, Bonhomme F, Salinas-Luypaert C, Haxholli D, Gutekunst N, Aygenli BÖ, Ferry L, Kirsh O, Laisné M, Scelfo A, Ugur E, Arimondo PB, Leonhardt H, Kanemaki MT, Bartke T, Fachinetti D, Jeltsch A, Ito T, Defossez PA. , Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells, Nature Communications.

Brunet J, Choucha Z, Gransagne M, Tabbal H, Ku M-W, Buchrieser J, Fernandes P, Batalie D, Lopez J, Ma L, Dufour E, Simon E, Hardy D, Petres S, Guinet F, Strick-Marchand H, Monot M, Charneau P, Majlessi L, Duprex WP, Gerke C, Martin A, Escriou N, A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model., J Virol 2024 Apr; (): e0169323.

Scelfo A, Barra V, Abdennur N, Spracklin G, Busato F, Salinas-Luypaert C, Bonaiti E, Velasco G, Bonhomme F, Chipont A, Tijhuis AE, Spierings DCJ, Guérin C, Arimondo P, Francastel C, Foijer F, Tost J, Mirny L, Fachinetti D, Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization., J Cell Biol 2024 Apr; 223(4): .

Perraud V, Vanderhoydonck B, Bouvier G, Dias de Melo G, Kilonda A, Koukni M, Jochmans D, Rogée S, Ben Khalifa Y, Kergoat L, Lannoy J, Van Buyten T, Izadi-Pruneyre N, Chaltin P, Neyts J, Marchand A, Larrous F, Bourhy H, Mechanism of action of phthalazinone derivatives against rabies virus., Antiviral Res 2024 Apr; 224(): 105838.

Boullé M, Boucharlat A, Leleu A, Banal C, Coussement A, Hollenstein M, Yates F, Lefort N, Agou F, Generation of IPi001-A/B/C human induced pluripotent stem cell lines from healthy amniotic fluid cells., Stem Cell Res 2024 Apr; 76(): 103350.

David Fernandez-Martinez, Youxin Kong, Sylvie Goussard, Agustin Zavala, Pauline Gastineau, Martial Jean-Pierre Rey, Gabriel Ayme, Julia Chamot‐rooke, Pierre Lafaye, Matthijn Vos, Ariel Mechaly, Guillaume Duménil, Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms, Nature Communications, 2024, 15 (1), pp.2414. ⟨10.1038/s41467-024-46677-y⟩.

Germain Niogret, Pascal Röthlisberger, Fabienne Levi-Acobas, Frédéric Bonhomme, Gilles Gasser, Marcel Hollenstein∗, Facilitated Synthetic Access to Boronic Acid-Modified Nucleoside Triphosphates and Compatibility with Enzymatic DNA Synthesis, Synlett 2024, 35, 677-683.

Martinez M, Bouillon A, Brûlé S, Raynal B, Haouz A, Alzari PM, Barale J-C, Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress., mBio 2024 Mar; 15(3): e0019824.

Baskaran K, Ploskon E, Tejero R, Yokochi M, Harrus D, Liang Y, Peisach E, Persikova I, Ramelot TA, Sekharan M, Tolchard J, Westbrook JD, Bardiaux B, Schwieters CD, Patwardhan A, Velankar S, Burley SK, Kurisu G, Hoch JC, Montelione GT, Vuister GW, Young JY, Restraint validation of biomolecular structures determined by NMR in the Protein Data Bank., Structure 2024 Mar; (): .

Andrea Scelfo, Viviana Barra, Nezar Abdennur, George Spracklin, Florence Busato, Catalina Salinas Luypaert, Elena Bonaiti, Guillaume Velasco, Frédéric Bonhomme, Anna Chipont, Andréa Tijhuis, Diana Spierings, Coralie Guerin, Paola B Arimondo, Claire Francastel, Floris Foijer, Jörg Tost, Leonid Mirny, and Daniele Fachinetti. , Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization, J Cell Biol.

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Malki I, Cardoso de Amorim G, Simenel C, Prochnicka-Chalufour A, Delepierre M, Izadi-Pruneyre N, (1)H, (13)C and (15)N resonance assignments of the periplasmic signalling domain of HasR, a TonB-dependent outer membrane heme transporter, Biomol NMR Assign 2013 Apr;7(1):43-6.

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Segala E, Sougakoff W, Nevejans-Chauffour A, Jarlier V, Petrella S, New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure, Antimicrob. Agents Chemother. 2012 May;56(5):2326-34.

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Connell BJ, Baleux F, Coic YM, Clayette P, Bonnaffé D, Lortat-Jacob H, A synthetic heparan sulfate-mimetic peptide conjugated to a mini CD4 displays very high anti- HIV-1 activity independently of coreceptor usage, Chem. Biol. 2012 Jan;19(1):131-9.

Kubiak X, Pluvinage B, Li de la Sierra-Gallay I, Weber P, Haouz A, Dupret JM, Rodrigues-Lima F, Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3], Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012 Feb;68(Pt 2):196-8.

Darmon A, Piton J, Roué M, Petrella S, Aubry A, Mayer C, Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase CTD, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012 Feb;68(Pt 2):178-80.

Liu MF, Cescau S, Mechold U, Wang J, Cohen D, Danchin A, Boulouis HJ, Biville F, Identification of a novel nanoRNase in Bartonella, Microbiology (Reading, Engl.) 2012 Apr;158(Pt 4):886-95.

Karst JC, Barker R, Devi U, Swann MJ, Davi M, Roser SJ, Ladant D, Chenal A, Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin, J. Biol. Chem. 2012 Mar;287(12):9200-12.

Selwa E, Laine E, Malliavin TE, Differential role of calmodulin and calcium ions in the stabilization of the catalytic domain of adenyl cyclase CyaA from Bordetella pertussis, Proteins 2012 Apr;80(4):1028-40.

Xu XP, Rouiller I, Slaughter BD, Egile C, Kim E, Unruh JR, Fan X, Pollard TD, Li R, Hanein D, Volkmann N, , Three-dimensional reconstructions of Arp2/3 complex with bound nucleation promoting factors., EMBO J 2012 Jan; 31(1): 236-47.

Bardiaux B, Malliavin T, Nilges M, ARIA for solution and solid-state NMR, Methods Mol. Biol. 2012;831:453-83.

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Carette X, Blondiaux N, Willery E, Hoos S, Lecat-Guillet N, Lens Z, Wohlkönig A, Wintjens R, Soror SH, Frénois F, Dirié B, Villeret V, England P, Lippens G, Deprez B, Locht C, Willand N, Baulard AR, Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands, Nucleic Acids Res. 2012 Apr;40(7):3018-30.

Cisneros DA, Bond PJ, Pugsley AP, Campos M, Francetic O, Minor pseudopilin self-assembly primes type II secretion pseudopilus elongation, EMBO J. 2012 Feb;31(4):1041-53.

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Matot B, Le Bihan YV, Lescasse R, Pérez J, Miron S, David G, Castaing B, Weber P, Raynal B, Zinn-Justin S, Gasparini S, Le Du MH, The orientation of the C-terminal domain of the Saccharomyces cerevisiae Rap1 protein is determined by its binding to DNA, Nucleic Acids Res. 2012 Apr;40(7):3197-207.

Faure G, Saul F, Structural and Functional Characterization of Anticoagulant, FXa-binding Viperidae Snake Venom Phospholipases A2, Acta Chim Slov 2011 Dec;58(4):671-7.

Falord M, Karimova G, Hiron A, Msadek T, GraXSR proteins interact with the VraFG ABC transporter to form a five-component system required for cationic antimicrobial peptide sensing and resistance in Staphylococcus aureus, Antimicrob. Agents Chemother. 2012 Feb;56(2):1047-58.

Duclert-Savatier N, Martínez L, Nilges M, Malliavin TE, The redundancy of NMR restraints can be used to accelerate the unfolding behavior of an SH3 domain during molecular dynamics simulations, BMC Struct. Biol. 2011;11:46.

Postic G, Danchin A, Mechold U, Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae, RNA 2012 Jan;18(1):155-65.

Lopez-Garcia LA, Schulze JO, Fröhner W, Zhang H, Süss E, Weber N, Navratil J, Amon S, Hindie V, Zeuzem S, Jørgensen TJ, Alzari PM, Neimanis S, Engel M, Biondi RM, Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket, Chem. Biol. 2011 Nov;18(11):1463-73.

Tosi T, Nickerson NN, Mollica L, Jensen MR, Blackledge M, Baron B, England P, Pugsley AP, Dessen A, Pilotin-secretin recognition in the type II secretion system of Klebsiella oxytoca, Mol. Microbiol. 2011 Dec;82(6):1422-32.

Chenal A, Vendrely C, Vitrac H, Karst JC, Gonneaud A, Blanchet CE, Pichard S, Garcia E, Salin B, Catty P, Gillet D, Hussy N, Marquette C, Almunia C, Forge V, Amyloid fibrils formed by the programmed cell death regulator Bcl-xL, J. Mol. Biol. 2012 Jan;415(3):584-99.

Zhang Q, Huang Y, Zhang Y, Fang X, Claes A, Duchateau M, Namane A, Lopez-Rubio JJ, Pan W, Scherf A, A critical role of perinuclear filamentous actin in spatial repositioning and mutually exclusive expression of virulence genes in malaria parasites, Cell Host Microbe 2011 Nov;10(5):451-63.

Briegel A, Beeby M, Thanbichler M, Jensen GJ, Activated chemoreceptor arrays remain intact and hexagonally packed., Mol Microbiol 2011 Nov; 82(3): 748-57.

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Babault N, Cordier F, Lafage M, Cockburn J, Haouz A, Prehaud C, Rey FA, Delepierre M, Buc H, Lafon M, Wolff N, Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death, Structure 2011 Oct;19(10):1518-24.

Frydman-Marom A, Convertino M, Pellarin R, Lampel A, Shaltiel-Karyo R, Segal D, Caflisch A, Shalev DE, Gazit E, Structural basis for inhibiting β-amyloid oligomerization by a non-coded β-breaker-substituted endomorphin analogue, ACS Chem. Biol. 2011 Nov;6(11):1265-76.

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Nickerson NN, Tosi T, Dessen A, Baron B, Raynal B, England P, Pugsley AP, Outer membrane targeting of secretin PulD protein relies on disordered domain recognition by a dedicated chaperone, J. Biol. Chem. 2011 Nov;286(45):38833-43.

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Wagner T, Bellinzoni M, Wehenkel A, O'Hare HM, Alzari PM, , Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism., Chem Biol 2011 Aug; 18(8): 1011-20.

Lacroix C, Giovannini D, Combe A, Bargieri DY, Späth S, Panchal D, Tawk L, Thiberge S, Carvalho TG, Barale JC, Bhanot P, Ménard R, FLP/FRT-mediated conditional mutagenesis in pre-erythrocytic stages of Plasmodium berghei, Nat Protoc 2011 Sep;6(9):1412-28.

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Bastianelli G, Bouillon A, Nguyen C, Crublet E, Pêtres S, Gorgette O, Le-Nguyen D, Barale JC, Nilges M, Computational reverse-engineering of a spider-venom derived peptide active against Plasmodium falciparum SUB1, PLoS ONE 2011;6(7):e21812.

Chiaravalli J, Fontan E, Fsihi H, Coic YM, Baleux F, Véron M, Agou F, Direct inhibition of NF-κB activation by peptide targeting the NOA ubiquitin binding domain of NEMO, Biochem. Pharmacol. 2011 Nov;82(9):1163-74.

Faure G, Xu H, Saul FA, Crystal structure of crotoxin reveals key residues involved in the stability and toxicity of this potent heterodimeric β-neurotoxin, J. Mol. Biol. 2011 Sep;412(2):176-91.

Robichon C, Karimova G, Beckwith J, Ladant D, Role of leucine zipper motifs in association of the Escherichia coli cell division proteins FtsL and FtsB, J. Bacteriol. 2011 Sep;193(18):4988-92.

Pantel A, Petrella S, Matrat S, Brossier F, Bastian S, Reitter D, Jarlier V, Mayer C, Aubry A, DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis, Antimicrob. Agents Chemother. 2011 Oct;55(10):4524-9.

Polge C, Heng AE, Jarzaguet M, Ventadour S, Claustre A, Combaret L, Béchet D, Matondo M, Uttenweiler-Joseph S, Monsarrat B, Attaix D, Taillandier D, Muscle actin is polyubiquitinylated in vitro and in vivo and targeted for breakdown by the E3 ligase MuRF1, FASEB J. 2011 Nov;25(11):3790-802.

Shepard W, Soutourina O, Courtois E, England P, Haouz A, Martin-Verstraete I, Insights into the Rrf2 repressor family–the structure of CymR, the global cysteine regulator of Bacillus subtilis, FEBS J. 2011 Aug;278(15):2689-701.

Gubellini F, Verdon G, Karpowich NK, Luff JD, Boël G, Gauthier N, Handelman SK, Ades SE, Hunt JF, Physiological response to membrane protein overexpression in E. coli, Mol. Cell Proteomics 2011 Oct;10(10):M111.007930.

Bensasson RV, Zoete V, Jossang A, Bodo B, Arimondo PB, Land EJ, Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters, Free Radic. Biol. Med. 2011 Oct;51(7):1406-10.

Moison C, Arimondo PB, Guieysse-Peugeot AL, Commercial reverse transcriptase as source of false-positive strand-specific RNA detection in human cells, Biochimie 2011 Oct;93(10):1731-7.

Chen S, Beeby M, Murphy GE, Leadbetter JR, Hendrixson DR, Briegel A, Li Z, Shi J, Tocheva EI, Müller A, Dobro MJ, Jensen GJ, Structural diversity of bacterial flagellar motors., EMBO J 2011 Jun; 30(14): 2972-81.

Lam CH, Hipolito CJ, Hollenstein M, Perrin DM, A divalent metal-dependent self-cleaving DNAzyme with a tyrosine side chain, Org. Biomol. Chem. 2011 Oct;9(20):6949-54.

Poitevin F, Orland H, Doniach S, Koehl P, Delarue M, AquaSAXS: a web server for computation and fitting of SAXS profiles with non-uniformally hydrated atomic models, Nucleic Acids Res. 2011 Jul;39(Web Server issue):W184-9.

Pietropaolo A, Branduardi D, Bonomi M, Parrinello M, A chirality-based metrics for free-energy calculations in biomolecular systems, J Comput Chem 2011 Sep;32(12):2627-37.

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Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M, Alzari PM, , 3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation., J Biol Chem 2011 Aug; 286(31): 27399-405.

Ceccaldi A, Rajavelu A, Champion C, Rampon C, Jurkowska R, Jankevicius G, Sénamaud-Beaufort C, Ponger L, Gagey N, Ali HD, Tost J, Vriz S, Ros S, Dauzonne D, Jeltsch A, Guianvarc'h D, Arimondo PB, C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development, Chembiochem 2011 Jun;12(9):1337-45.

Theillet FX, Frank M, Vulliez-Le Normand B, Simenel C, Hoos S, Chaffotte A, Bélot F, Guerreiro C, Nato F, Phalipon A, Mulard LA, Delepierre M, Dynamic aspects of antibody:oligosaccharide complexes characterized by molecular dynamics simulations and saturation transfer difference nuclear magnetic resonance, Glycobiology 2011 Dec;21(12):1570-9.

Barducci A, Bonomi M, Derreumaux P, Assessing the Quality of the OPEP Coarse-Grained Force Field, J Chem Theory Comput 2011 Jun;7(6):1928-34.

Pitts SL, Jablonksy MJ, Duca M, Dauzonne D, Monneret C, Arimondo PB, Anklin C, Graves DE, Osheroff N, Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme–drug–DNA complex, Biochemistry 2011 Jun;50(22):5058-66.

Mareuil F, Blanchet C, Malliavin TE, Nilges M, Grid computing for improving conformational sampling in NMR structure calculation, Bioinformatics 2011 Jun;27(12):1713-4.

Seantier B, Dezi M, Gubellini F, Berquand A, Godefroy C, Dosset P, Lévy D, Milhiet PE, Transfer on hydrophobic substrates and AFM imaging of membrane proteins reconstituted in planar lipid bilayers, J. Mol. Recognit. 2011 May-Jun;24(3):461-6.

Oppezzo P, Obal G, Baraibar MA, Pritsch O, Alzari PM, Buschiazzo A, Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity, Biochim. Biophys. Acta 2011 Sep;1814(9):1154-61.

Swulius MT, Chen S, Jane Ding H, Li Z, Briegel A, Pilhofer M, Tocheva EI, Lybarger SR, Johnson TL, Sandkvist M, Jensen GJ, Long helical filaments are not seen encircling cells in electron cryotomograms of rod-shaped bacteria., Biochem Biophys Res Commun 2011 Apr; 407(4): 650-5.

Le Breton C, Hennion M, Arimondo PB, Hyrien O, Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts, PLoS ONE 2011 Apr;6(4):e18554.

Valle A, López-Castilla A, Pedrera L, Martínez D, Tejuca M, Campos J, Fando R, Lissi E, Alvarez C, Lanio ME, Pazos F, Schreier S, Cys mutants in functional regions of Sticholysin I clarify the participation of these residues in pore formation, Toxicon 2011 Jul;58(1):8-17.

Wieninger SA, Serpersu EH, Ullmann GM, ATP binding enables broad antibiotic selectivity of aminoglycoside phosphotransferase(3′)-IIIa: an elastic network analysis, J. Mol. Biol. 2011 Jun;409(3):450-65.

Martínez L, Malliavin TE, Blondel A, Mechanism of reactant and product dissociation from the anthrax edema factor: a locally enhanced sampling and steered molecular dynamics study, Proteins 2011 May;79(5):1649-61.

Sotomayor-Pérez AC, Ladant D, Chenal A, Calcium-induced folding of intrinsically disordered repeat-in-toxin (RTX) motifs via changes of protein charges and oligomerization states, J. Biol. Chem. 2011 May;286(19):16997-7004.

Juillerat A, Lewit-Bentley A, Guillotte M, Gangnard S, Hessel A, Baron B, Vigan-Womas I, England P, Mercereau-Puijalon O, Bentley GA, Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition, Proc. Natl. Acad. Sci. U.S.A. 2011 Mar;108(13):5243-8.

Bernard A, Vranken WF, Bardiaux B, Nilges M, Malliavin TE, Bayesian estimation of NMR restraint potential and weight: a validation on a representative set of protein structures, Proteins 2011 May;79(5):1525-37.

Delaune A, Poupel O, Mallet A, Coic YM, Msadek T, Dubrac S, Peptidoglycan crosslinking relaxation plays an important role in Staphylococcus aureus WalKR-dependent cell viability, PLoS ONE 2011;6(2):e17054.

Selevsek N, Matondo M, Sanchez Carbayo M, Aebersold R, Domon B, Systematic quantification of peptides/proteins in urine using selected reaction monitoring, Proteomics 2011 Mar;11(6):1135-47.

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Hipolito CJ, Hollenstein M, Lam CH, Perrin DM, Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes, Org. Biomol. Chem. 2011 Apr;9(7):2266-73.

Mechaly AE, Bellomio A, Gil-Cartón D, Morante K, Valle M, González-Mañas JM, Guérin DM, Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins, Structure 2011 Feb;19(2):181-91.

Dupré M, Cantel S, Verdié P, Martinez J, Enjalbal C, , Sequencing Lys-N proteolytic peptides by ESI and MALDI tandem mass spectrometry., J Am Soc Mass Spectrom 2011 Feb; 22(2): 265-79.

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Auvynet C, Topalis D, Caillat C, Munier-Lehmann H, Seclaman E, Balzarini J, Agrofoglio LA, Kaminski PA, Meyer P, Deville-Bonne D, El Amri C, Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase, Biochem. Biophys. Res. Commun. 2009 Oct;388(1):6-11.

Mulard LA, Phalipon A, From epitope characterization to the design of semi-synthetic glycoconjugate vaccines against Shigella flexneri 2a infection, ACS Symp Ser No. 989, R. Roy Ed, American Chemical Society, Washington, DC, USA 2009, pp 105-136.

Corzo G, Prochnicka-Chalufour A, García BI, Possani LD, Delepierre M, Solution structure of Cn5, a crustacean toxin found in the venom of the scorpions Centruroides noxius and Centruroides suffusus suffusus, Biochim. Biophys. Acta 2009 Nov;1794(11):1591-8.

Perruchini C, Pecorari F, Bourgeois JP, Duyckaerts C, Rougeon F, Lafaye P, Llama VHH antibody fragments against GFAP: better diffusion in fixed tissues than classical monoclonal antibodies, Acta Neuropathol. 2009 Nov;118(5):685-95.

Boucontet L, Grana M, Alzari PM, Pereira P, Mechanisms determining cell membrane expression of different gammadelta TCR chain pairings, Eur. J. Immunol. 2009 Jul;39(7):1937-46.

Chenal A, Prongidi-Fix L, Perier A, Aisenbrey C, Vernier G, Lambotte S, Haertlein M, Dauvergne MT, Fragneto G, Bechinger B, Gillet D, Forge V, Ferrand M, Deciphering membrane insertion of the diphtheria toxin T domain by specular neutron reflectometry and solid-state NMR spectroscopy, J. Mol. Biol. 2009 Sep;391(5):872-83.

Chaze T, Meunier B, Chambon C, Jurie C, Picard B, Proteome dynamics during contractile and metabolic differentiation of bovine foetal muscle, Animal 2009 Jul;3(7):980-1000.

Chaze T, Meunier B, Chambon C, Jurie C, Picard B, Proteome dynamics during contractile and metabolic differentiation of bovine foetal muscle, Animal 2009 Jul;3(7):980-1000.

Volkmann N, , Confidence intervals for fitting of atomic models into low-resolution densities., Acta Crystallogr D Biol Crystallogr 2009 Jul; 65(Pt 7): 679-89.

Fang M, Zeisberg WM, Condon C, Ogryzko V, Danchin A, Mechold U, Degradation of nanoRNA is performed by multiple redundant RNases in Bacillus subtilis, Nucleic Acids Res. 2009 Aug;37(15):5114-25.

Said Hassane F, Phalipon A, Tanguy M, Guerreiro C, Bélot F, Frisch B, Mulard LA, Schuber F, Rational design and immunogenicity of liposome-based diepitope constructs: application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen, Vaccine 2009 Aug;27(39):5419-26.

Marsolier-Kergoat MC, Yeramian E, GC content and recombination: reassessing the causal effects for the Saccharomyces cerevisiae genome, Genetics 2009 Sep;183(1):31-8.

Guillière F, Peixeiro N, Kessler A, Raynal B, Desnoues N, Keller J, Delepierre M, Prangishvili D, Sezonov G, Guijarro JI, Structure, function, and targets of the transcriptional regulator SvtR from the hyperthermophilic archaeal virus SIRV1, J. Biol. Chem. 2009 Aug;284(33):22222-37.

Guerin ME, Schaeffer F, Chaffotte A, Gest P, Giganti D, Korduláková J, van der Woerd M, Jackson M, Alzari PM, Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis, J. Biol. Chem. 2009 Aug;284(32):21613-25.

Romain F, Barbosa I, Gouge J, Rougeon F, Delarue M, Conferring a template-dependent polymerase activity to terminal deoxynucleotidyltransferase by mutations in the Loop1 region, Nucleic Acids Res. 2009 Aug;37(14):4642-56.

Champion E, André I, Moulis C, Boutet J, Descroix K, Morel S, Monsan P, Mulard LA, Remaud-Siméon M, Design of alpha-transglucosidases of controlled specificity for programmed chemoenzymatic synthesis of antigenic oligosaccharides, J. Am. Chem. Soc. 2009 Jun;131(21):7379-89.

Bardiaux B, Bernard A, Rieping W, Habeck M, Malliavin TE, Nilges M, Influence of different assignment conditions on the determination of symmetric homodimeric structures with ARIA, Proteins 2009 May;75(3):569-85.

Aisenbrey C, Prongidi-Fix L, Chenal A, Gillet D, Bechinger B, Side chain resonances in static oriented proton-decoupled 15N solid-state NMR spectra of membrane proteins, J. Am. Chem. Soc. 2009 May;131(18):6340-1.

Koehl P, Orland H, Delarue M, Computing ion solvation free energies using the dipolar Poisson model, J Phys Chem B 2009 Apr;113(17):5694-7.

Sánchez-Porro C, Mellado E, Pugsley AP, Francetic O, Ventosa A, The haloprotease CPI produced by the moderately halophilic bacterium Pseudoalteromonas ruthenica is secreted by the type II secretion pathway, Appl. Environ. Microbiol. 2009 Jun;75(12):4197-201.

Bellinzoni M, Alzari PM, , Bacterial metabolism under FHA control., Structure 2009 Apr; 17(4): 487-8.

Boutet J, Guerreiro C, Mulard LA, Efficient synthesis of six tri- to hexasaccharide fragments of Shigella flexneri serotypes 3a and/or X O-antigen, including a study on acceptors containing N-trichloroacetylglucosamine versus N-acetylglucosamine, J. Org. Chem. 2009 Apr;74(7):2651-70.

Duclert-Savatier N, Poggi L, Miclet E, Lopes P, Ouazzani J, Chevalier N, Nilges M, Delarue M, Stoven V, Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation, J. Mol. Biol. 2009 May;388(5):1009-21.

Bay S, Fort S, Birikaki L, Ganneau C, Samain E, Coïc YM, Bonhomme F, Dériaud E, Leclerc C, Lo-Man R, Induction of a melanoma-specific antibody response by a monovalent, but not a divalent, synthetic GM2 neoglycopeptide, ChemMedChem 2009 Apr;4(4):582-7.

Convertino M, Pellarin R, Catto M, Carotti A, Caflisch A, 9,10-Anthraquinone hinders beta-aggregation: how does a small molecule interfere with Abeta-peptide amyloid fibrillation?, Protein Sci. 2009 Apr;18(4):792-800.

Vekhoff P, Halby L, Oussedik K, Dallavalle S, Merlini L, Mahieu C, Lansiaux A, Bailly C, Boutorine A, Pisano C, Giannini G, Alloatti D, Arimondo PB, Optimized synthesis and enhanced efficacy of novel triplex-forming camptothecin derivatives based on gimatecan, Bioconjug. Chem. 2009 Apr;20(4):666-72.

Theillet FX, Saul FA, Vulliez-Le Normand B, Hoos S, Felici F, Weintraub A, Mulard LA, Phalipon A, Delepierre M, Bentley GA, Structural mimicry of O-antigen by a peptide revealed in a complex with an antibody raised against Shigella flexneri serotype 2a, J. Mol. Biol. 2009 May;388(4):839-50.

Bourdeau RW, Malito E, Chenal A, Bishop BL, Musch MW, Villereal ML, Chang EB, Mosser EM, Rest RF, Tang WJ, Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis, J. Biol. Chem. 2009 May;284(21):14645-56.

Mechaly AE, Bellomio A, Morante K, González-Mañas JM, Guérin DM, Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009 Apr;65(Pt 4):357-60.

Delfosse V, Girard E, Birck C, Delmarcelle M, Delarue M, Poch O, Schultz P, Mayer C, Structure of the archaeal pab87 peptidase reveals a novel self-compartmentalizing protease family, PLoS One. 2009;4(3):e4712..

Champion C, André I, Mulard LA, Monsan P, Remaud-Siméon M, Morel S, Synthesis of L-rhamnose and N-acetyl-D-glucosamine derivatives with glucansucrases, J. Carbohydr. Chem. 2009; 28: 142-60.

Koehl P, Orland H, Delarue M, Beyond the Poisson-Boltzmann model: modeling biomolecule-water and water-water interactions, Phys. Rev. Lett. 2009 Feb;102(8):087801.

Martín M, Albanesi D, Alzari PM, de Mendoza D, Functional in vitro assembly of the integral membrane bacterial thermosensor DesK, Protein Expr. Purif. 2009 Jul;66(1):39-45.

Laine E, Blondel A, Malliavin TE, Dynamics and energetics: a consensus analysis of the impact of calcium on EF-CaM protein complex, Biophys. J. 2009 Feb;96(4):1249-63.

Phalipon A, Tanguy M, Grandjean C, Guerreiro C, Bélot F, Cohen D, Sansonetti PJ, Mulard LA, A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection, J. Immunol. 2009 Feb;182(4):2241-7.

Caillet-Saguy C, Piccioli M, Turano P, Izadi-Pruneyre N, Delepierre M, Bertini I, Lecroisey A, , Mapping the interaction between the hemophore HasA and its outer membrane receptor HasR using CRINEPT-TROSY NMR spectroscopy., J Am Chem Soc 2009 Feb; 131(5): 1736-44.

Bousquet-Dubouch MP, Baudelet E, Guérin F, Matondo M, Uttenweiler-Joseph S, Burlet-Schiltz O, Monsarrat B, Affinity purification strategy to capture human endogenous proteasome complexes diversity and to identify proteasome-interacting proteins, Mol. Cell Proteomics 2009 May;8(5):1150-64.

Alvey L, Prado S, Saint-Joanis B, Michel S, Koch M, Cole ST, Tillequin F, Janin YL, Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity, Eur J Med Chem 2009 Jun;44(6):2497-505.

Laowanapiban P, Kapustina M, Vonrhein C, Delarue M, Koehl P, Carter CW, Independent saturation of three TrpRS subsites generates a partially assembled state similar to those observed in molecular simulations, Proc. Natl. Acad. Sci. U.S.A. 2009 Feb;106(6):1790-5.

Hollenstein M, Hipolito CJ, Lam CH, Perrin DM, A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+), Nucleic Acids Res. 2009 Apr;37(5):1638-49.

Sala C, Haouz A, Saul FA, Miras I, Rosenkrands I, Alzari PM, Cole ST, Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis, Mol. Microbiol. 2009 Mar;71(5):1102-16.

Krieg S, Huché F, Diederichs K, Izadi-Pruneyre N, Lecroisey A, Wandersman C, Delepelaire P, Welte W, Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex, Proc. Natl. Acad. Sci. U.S.A. 2009 Jan;106(4):1045-50.

Guillou, S.; Nesme, O.; Ermolenko, M. S.; Janin, Y. L., Carbon-4 arylation of 3-alkoxypyrazoles, Tetrahedron 2009, 65, 3529-3535.

Guillou, S.; Bonhomme, F. J.; Janin, Y. L., Nitrogen’s reactivity of various 3-alkoxypyrazoles, Tetrahedron 2009, 65, 2660-2668.

Yoon SH, Chamot-Rooke J, Perkins BR, Hilderbrand AE, Poutsma JC, Wysocki VH, IRMPD spectroscopy shows that AGG forms an oxazolone b2+ ion, J. Am. Chem. Soc. 2008 Dec;130(52):17644-5.

England P, Wehenkel A, Martins S, Hoos S, André-Leroux G, Villarino A, Alzari PM, The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling, FEBS Lett. 2009 Jan;583(2):301-7.

Friedman R, Pellarin R, Caflisch A, Amyloid aggregation on lipid bilayers and its impact on membrane permeability, J. Mol. Biol. 2009 Mar;387(2):407-15.

Neres J, Brewer ML, Ratier L, Botti H, Buschiazzo A, Edwards PN, Mortenson PN, Charlton MH, Alzari PM, Frasch AC, Bryce RA, Douglas KT, Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening, Bioorg. Med. Chem. Lett. 2009 Feb;19(3):589-96.

Rich RL, Papalia GA, Flynn PJ, Furneisen J, Quinn J, Klein JS, Katsamba PS, Waddell MB, Scott M, Thompson J, Berlier J, Corry S, Baltzinger M, Zeder-Lutz G, Schoenemann A, Clabbers A, Wieckowski S, Murphy MM, Page P, Ryan TE, Duffner J, Ganguly T, Corbin J, Gautam S, Anderluh G, Bavdek A, Reichmann D, Yadav SP, Hommema E, Pol E, Drake A, Klakamp S, Chapman T, Kernaghan D, Miller K, Schuman J, Lindquist K, Herlihy K, Murphy MB, Bohnsack R, Andrien B, Brandani P, Terwey D, Millican R, Darling RJ, Wang L, Carter Q, Dotzlaf J, Lopez-Sagaseta J, Campbell I, Torreri P, Hoos S, England P, Liu Y, Abdiche Y, Malashock D, Pinkerton A, Wong M, Lafer E, Hinck C, Thompson K, Primo CD, Joyce A, Brooks J, Torta F, Bagge Hagel AB, Krarup J, Pass J, Ferreira M, Shikov S, Mikolajczyk M, Abe Y, Barbato G, Giannetti AM, Krishnamoorthy G, Beusink B, Satpaev D, Tsang T, Fang E, Partridge J, Brohawn S, Horn J, Pritsch O, Obal G, Nilapwar S, Busby B, Gutierrez-Sanchez G, Gupta RD, Canepa S, Witte K, Nikolovska-Coleska Z, Cho YH, D'Agata R, Schlick K, Calvert R, Munoz EM, Hernaiz MJ, Bravman T, Dines M, Yang MH, Puskas A, Boni E, Li J, Wear M, Grinberg A, Baardsnes J, Dolezal O, Gainey M, Anderson H, Peng J, Lewis M, Spies P, Trinh Q, Bibikov S, Raymond J, Yousef M, Chandrasekaran V, Feng Y, Emerick A, Mundodo S, Guimaraes R, McGirr K, Li YJ, Hughes H, Mantz H, Skrabana R, Witmer M, Ballard J, Martin L, Skladal P, Korza G, Laird-Offringa I, Lee CS, Khadir A, Podlaski F, Neuner P, Rothacker J, Rafique A, Dankbar N, Kainz P, Gedig E, Vuyisich M, Boozer C, Ly N, Toews M, Uren A, Kalyuzhniy O, Lewis K, Chomey E, Pak BJ, Myszka DG, A global benchmark study using affinity-based biosensors, Anal. Biochem. 2009 Mar;386(2):194-216.

Cordier F, Grubisha O, Traincard F, Véron M, Delepierre M, Agou F, The zinc finger of NEMO is a functional ubiquitin-binding domain, J. Biol. Chem. 2009 Jan;284(5):2902-7.

Vekhoff P, Ceccaldi A, Polverari D, Pylouster J, Pisano C, Arimondo PB, Triplex formation on DNA targets: how to choose the oligonucleotide, Biochemistry 2008 Nov;47(47):12277-89.

Bruhns P, Iannascoli B, England P, Mancardi DA, Fernandez N, Jorieux S, Daëron M, Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses, Blood 2009 Apr;113(16):3716-25.

Chenal A, Guijarro JI, Raynal B, Delepierre M, Ladant D, RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion, J. Biol. Chem. 2009 Jan;284(3):1781-9.

Bocquet N, Nury H, Baaden M, Le Poupon C, Changeux JP, Delarue M, Corringer PJ, X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation, Nature 2009 Jan;457(7225):111-4.

Karimova G, Robichon C, Ladant D, Characterization of YmgF, a 72-residue inner membrane protein that associates with the Escherichia coli cell division machinery, J. Bacteriol. 2009 Jan;191(1):333-46.

Tanous C, Soutourina O, Raynal B, Hullo MF, Mervelet P, Gilles AM, Noirot P, Danchin A, England P, Martin-Verstraete I, The CymR regulator in complex with the enzyme CysK controls cysteine metabolism in Bacillus subtilis, J. Biol. Chem. 2008 Dec;283(51):35551-60.

Caillat C, Topalis D, Agrofoglio LA, Pochet S, Balzarini J, Deville-Bonne D, Meyer P, Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy, Proc. Natl. Acad. Sci. U.S.A. 2008 Nov;105(44):16900-5.

Kerff F, Amoroso A, Herman R, Sauvage E, Petrella S, Filée P, Charlier P, Joris B, Tabuchi A, Nikolaidis N, Cosgrove DJ, Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization, Proc. Natl. Acad. Sci. U.S.A. 2008 Nov;105(44):16876-81.

Mancardi DA, Iannascoli B, Hoos S, England P, Daëron M, Bruhns P, FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation, J. Clin. Invest. 2008 Nov;118(11):3738-50.

Frison G, van der Rest G, Turecek F, Besson T, Lemaire J, Maître P, Chamot-Rooke J, Structure of electron-capture dissociation fragments from charge-tagged peptides probed by tunable infrared multiple photon dissociation, J. Am. Chem. Soc. 2008 Nov;130(45):14916-7.

Lafaye P, Achour I, England P, Duyckaerts C, Rougeon F, Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation, Mol. Immunol. 2009 Feb;46(4):695-704.

O'Hare HM, Durán R, Cerveñansky C, Bellinzoni M, Wehenkel AM, Pritsch O, Obal G, Baumgartner J, Vialaret J, Johnsson K, Alzari PM, , Regulation of glutamate metabolism by protein kinases in mycobacteria., Mol Microbiol 2008 Dec; 70(6): 1408-23.

Boutet J, Mulard LA, Synthesis of 2 tetra- and 4 pentasaccharide fragments of Shigella flexneri serotypes 3a and/or X O-antigens from a common tetrasaccharide intermediate, Eur. J. Org. Chem. 2008: 5526–5542.

Binesse J, Delsert C, Saulnier D, Champomier-Vergès MC, Zagorec M, Munier-Lehmann H, Mazel D, Le Roux F, Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus, Appl. Environ. Microbiol. 2008 Dec;74(23):7108-17.

Cain SA, Baldwin AK, Mahalingam Y, Raynal B, Jowitt TA, Shuttleworth CA, Couchman JR, Kielty CM, , Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions., J Biol Chem 2008 Oct; 283(40): 27017-27.

Buschiazzo A, Alzari PM, Structural insights into sialic acid enzymology, Curr Opin Chem Biol 2008 Oct;12(5):565-72.

Chaze T, Meunier B, Chambon C, Jurie C, Picard B, In vivo proteome dynamics during early bovine myogenesis, Proteomics 2008 Oct;8(20):4236-48.

Tivol WF, Briegel A, Jensen GJ, An improved cryogen for plunge freezing., Microsc Microanal 2008 Oct; 14(5): 375-9.

Azuara C, Orland H, Bon M, Koehl P, Delarue M, Incorporating dipolar solvents with variable density in Poisson-Boltzmann electrostatics, Biophys. J. 2008 Dec;95(12):5587-605.

Markwick PR, Malliavin T, Nilges M, Structural biology by NMR: structure, dynamics, and interactions, PLoS Comput. Biol. 2008;4(9):e1000168.

England P, Westblade LF, Karimova G, Robbe-Saule V, Norel F, Kolb A, Binding of the unorthodox transcription activator, Crl, to the components of the transcription machinery, J. Biol. Chem. 2008 Nov;283(48):33455-64.

Bonomi M, Branduardi D, Gervasio FL, Parrinello M, The unfolded ensemble and folding mechanism of the C-terminal GB1 beta-hairpin, J. Am. Chem. Soc. 2008 Oct;130(42):13938-44.

Vigan-Womas I, Guillotte M, Le Scanf C, Igonet S, Petres S, Juillerat A, Badaut C, Nato F, Schneider A, Lavergne A, Contamin H, Tall A, Baril L, Bentley GA, Mercereau-Puijalon O, An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype, Infect. Immun. 2008 Dec;76(12):5565-80.

Ebersbach G, Briegel A, Jensen GJ, Jacobs-Wagner C, A self-associating protein critical for chromosome attachment, division, and polar organization in caulobacter., Cell 2008 Sep; 134(6): 956-68.

Krehenbrink M, Chami M, Guilvout I, Alzari PM, Pécorari F, Pugsley AP, Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD, J. Mol. Biol. 2008 Nov;383(5):1058-68.

Shoaib M, Baconnais S, Mechold U, Le Cam E, Lipinski M, Ogryzko V, Multiple displacement amplification for complex mixtures of DNA fragments, BMC Genomics 2008;9:415.

Balganesh TS, Alzari PM, Cole ST, Rising standards for tuberculosis drug development, Trends Pharmacol. Sci. 2008 Nov;29(11):576-81.

Nilges M, Bernard A, Bardiaux B, Malliavin T, Habeck M, Rieping W, Accurate NMR structures through minimization of an extended hybrid energy, Structure 2008 Sep;16(9):1305-12.

Boutet J, Guerreiro C, Mulard LA, Synthesis of branched tri- to pentasaccharides representative of fragments of Shigella flexneri serotypes 3a and/or X O-antigens, Tetrahedron 2008; 64: 10558-72.

Junglas B, Briegel A, Burghardt T, Walther P, Wirth R, Huber H, Rachel R, Ignicoccus hospitalis and Nanoarchaeum equitans: ultrastructure, cell-cell interaction, and 3D reconstruction from serial sections of freeze-substituted cells and by electron cryotomography., Arch Microbiol 2008 Sep; 190(3): 395-408.

Vestergaard G, Shah SA, Bize A, Reitberger W, Reuter M, Phan H, Briegel A, Rachel R, Garrett RA, Prangishvili D, Stygiolobus rod-shaped virus and the interplay of crenarchaeal rudiviruses with the CRISPR antiviral system., J Bacteriol 2008 Oct; 190(20): 6837-45.

Galloux M, Vitrac H, Montagner C, Raffestin S, Popoff MR, Chenal A, Forge V, Gillet D, Membrane Interaction of botulinum neurotoxin A translocation (T) domain. The belt region is a regulatory loop for membrane interaction, J. Biol. Chem. 2008 Oct;283(41):27668-76.

Alvey L, Prado S, Huteau V, Saint-Joanis B, Michel S, Koch M, Cole ST, Tillequin F, Janin YL, A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial, Bioorg. Med. Chem. 2008 Sep;16(17):8264-72.

Achour I, Cavelier P, Tichit M, Bouchier C, Lafaye P, Rougeon F, Tetrameric and homodimeric camelid IgGs originate from the same IgH locus, J. Immunol. 2008 Aug;181(3):2001-9.

Duca M, Vekhoff P, Oussedik K, Halby L, Arimondo PB, The triple helix: 50 years later, the outcome, Nucleic Acids Res. 2008 Sep;36(16):5123-38.

You C, Sekowska A, Francetic O, Martin-Verstraete I, Wang Y, Danchin A, Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis, BMC Microbiol. 2008 Jul;8:128.

Grandjean C, Boutonnier A, Dassy B, Fournier JM, Mulard LA, Investigation towards bivalent chemically defined glycoconjugate immunogens prepared from acid-detoxified lipopolysaccharide of Vibrio cholerae O1, serotype Inaba, Glycoconj. J. 2009 Jan;26(1):41-55.

Petrella S, Ziental-Gelus N, Mayer C, Renard M, Jarlier V, Sougakoff W, Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France, Antimicrob. Agents Chemother. 2008 Oct;52(10):3725-36.

Phalipon A, Mulard LA, Sansonetti PJ, Vaccination against shigellosis: is it the path that is difficult or is it the difficult that is the path?, Microbes Infect. 2008 Jul;10(9):1057-62.

Vulliez-Le Normand B, Saul FA, Phalipon A, Bélot F, Guerreiro C, Mulard LA, Bentley GA, Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody, Proc. Natl. Acad. Sci. U.S.A. 2008 Jul;105(29):9976-81.

Familiar O, Munier-Lehmann H, Negri A, Gago F, Douguet D, Rigouts L, Hernández AI, Camarasa MJ, Pérez-Pérez MJ, Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, ChemMedChem 2008 Jul;3(7):1083-93.

Briegel A, Ding HJ, Li Z, Werner J, Gitai Z, Dias DP, Jensen RB, Jensen GJ, Location and architecture of the Caulobacter crescentus chemoreceptor array., Mol Microbiol 2008 Jul; 69(1): 30-41.

Boutet, J.; Kim, T. H.; Guerreiro, C.; Mulard, L. A., Efficient route to orthogonally protected precursors of 2-acylamino-2-deoxy-3-O-substituted--D-glucopyranose derivatives and use thereof, Tetrahedron Lett. 2008; 49: 5339-42.

Bardiaux B, Bernard A, Rieping W, Habeck M, Malliavin TE, Nilges M, Graphical analysis of NMR structural quality and interactive contact map of NOE assignments in ARIA, BMC Struct. Biol. 2008;8:30.

Laine E, Yoneda JD, Blondel A, Malliavin TE, The conformational plasticity of calmodulin upon calcium complexation gives a model of its interaction with the oedema factor of Bacillus anthracis, Proteins 2008 Jun;71(4):1813-29.

Garduño E, Wong-Barnum M, Volkmann N, Ellisman MH, , Segmentation of electron tomographic data sets using fuzzy set theory principles., J Struct Biol 2008 Jun; 162(3): 368-79.

Auer M, Koster AJ, Ziese U, Bajaj C, Volkmann N, Wang da N, Hudspeth AJ, , Three-dimensional architecture of hair-bundle linkages revealed by electron-microscopic tomography., J Assoc Res Otolaryngol 2008 Jun; 9(2): 215-24.

Kaminski PA, Dacher P, Dugué L, Pochet S, In vivo reshaping the catalytic site of nucleoside 2′-deoxyribosyltransferase for dideoxy- and didehydronucleosides via a single amino acid substitution, J. Biol. Chem. 2008 Jul;283(29):20053-9.

Cain SA, Raynal B, Hodson N, Shuttleworth A, Kielty CM, , Biomolecular analysis of elastic fibre molecules., Methods 2008 May; 45(1): 42-52.

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Olivera Francetic, Nienke Buddelmeijer, Shawn Lewenza, Carol A Kumamoto, Anthony P Pugsley, Signal recognition particle-dependent inner membrane targeting of the PulG Pseudopilin component of a type II secretion system., Journal of Bacteriology, 2007, 189 (5), pp.1783-1793. ⟨10.1128/JB.01230-06⟩.

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Fernandez P, Saint-Joanis B, Barilone N, Jackson M, Gicquel B, Cole ST, Alzari PM, The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth, J. Bacteriol. 2006 Nov;188(22):7778-84.

Gubellini F, Francia F, Busselez J, Venturoli G, Lévy D, Functional and structural analysis of the photosynthetic apparatus of Rhodobacter veldkampii, Biochemistry 2006 Sep;45(35):10512-20.

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Loth K, Abergel D, Pelupessy P, Delarue M, Lopes P, Ouazzani J, Duclert-Savatier N, Nilges M, Bodenhausen G, Stoven V, Determination of dihedral Psi angles in large proteins by combining NH(N)/C(alpha)H(alpha) dipole/dipole cross-correlation and chemical shifts, Proteins 2006 Sep;64(4):931-9.

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Yang J, Piñol R, Gubellini F, Lévy D, Albouy PA, Keller P, Li MH, Formation of polymer vesicles by liquid crystal amphiphilic block copolymers, Langmuir 2006 Aug;22(18):7907-11.

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Chapgier A, Boisson-Dupuis S, Jouanguy E, Vogt G, Feinberg J, Prochnicka-Chalufour A, Casrouge A, Yang K, Soudais C, Fieschi C, Santos OF, Bustamante J, Picard C, de Beaucoudrey L, Emile JF, Arkwright PD, Schreiber RD, Rolinck-Werninghaus C, Rösen-Wolff A, Magdorf K, Roesler J, Casanova JL, Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease, PLoS Genet. 2006 Aug;2(8):e131.

Pehar M, Vargas MR, Robinson KM, Cassina P, England P, Beckman JS, Alzari PM, Barbeito L, Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons, Free Radic. Biol. Med. 2006 Dec;41(11):1632-44.

Milhiet PE, Gubellini F, Berquand A, Dosset P, Rigaud JL, Le Grimellec C, Lévy D, High-resolution AFM of membrane proteins directly incorporated at high density in planar lipid bilayer, Biophys. J. 2006 Nov;91(9):3268-75.

Neres J, Buschiazzo A, Alzari PM, Walsh L, Douglas KT, Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi, Anal. Biochem. 2006 Oct;357(2):302-4.

Rouis S, Lafaye P, Jaoua-Aydi L, Sghaier Z, Ayadi H, Gargouri-Bouzid R, Cloning and expression of functional single-chain Fv antibodies directed against NIa and coat proteins of potato virus Y, J. Virol. Methods 2006 Oct;137(1):1-6.

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Petrella S, Cambau E, Chauffour A, Andries K, Jarlier V, Sougakoff W, Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria, Antimicrob. Agents Chemother. 2006 Aug;50(8):2853-6.

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Lindahl E, Azuara C, Koehl P, Delarue M, NOMAD-Ref: visualization, deformation and refinement of macromolecular structures based on all-atom normal mode analysis, Nucleic Acids Res. 2006 Jul;34(Web Server issue):W52-6.

Azuara C, Lindahl E, Koehl P, Orland H, Delarue M, PDB_Hydro: incorporating dipolar solvents with variable density in the Poisson-Boltzmann treatment of macromolecule electrostatics, Nucleic Acids Res. 2006 Jul;34(Web Server issue):W38-42.

Viens A, Mechold U, Brouillard F, Gilbert C, Leclerc P, Ogryzko V, Analysis of human histone H2AZ deposition in vivo argues against its direct role in epigenetic templating mechanisms, Mol. Cell. Biol. 2006 Jul;26(14):5325-35.

Belotserkovskii BP, Arimondo PB, Cozzarelli NR, Topoisomerase action on short DNA duplexes reveals requirements for gate and transfer DNA segments, J. Biol. Chem. 2006 Sep;281(35):25407-15.

Izadi-Pruneyre N, Huché F, Lukat-Rodgers GS, Lecroisey A, Gilli R, Rodgers KR, Wandersman C, Delepelaire P, The heme transfer from the soluble HasA hemophore to its membrane-bound receptor HasR is driven by protein-protein interaction from a high to a lower affinity binding site, J. Biol. Chem. 2006 Sep;281(35):25541-50.

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Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM, , The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer., Protein Sci 2006 Jun; 15(6): 1489-93.

Wehenkel A, Fernandez P, Bellinzoni M, Catherinot V, Barilone N, Labesse G, Jackson M, Alzari PM, , The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria., FEBS Lett 2006 May; 580(13): 3018-22.

Pina DG, Gómez J, England P, Craescu CT, Johannes L, Shnyrov VL, Characterization of the non-native trifluoroethanol-induced intermediate conformational state of the Shiga toxin B-subunit, Biochimie 2006 Sep;88(9):1199-207.

Bauche C, Chenal A, Knapp O, Bodenreider C, Benz R, Chaffotte A, Ladant D, Structural and functional characterization of an essential RTX subdomain of Bordetella pertussis adenylate cyclase toxin, J. Biol. Chem. 2006 Jun;281(25):16914-26.

Frénal K, Callebaut I, Wecker K, Prochnicka-Chalufour A, Dendouga N, Zinn-Justin S, Delepierre M, Tomavo S, Wolff N, Structural and functional characterization of the TgDRE multidomain protein, a DNA repair enzyme from Toxoplasma gondii, Biochemistry 2006 Apr;45(15):4867-74.

Duca M, Guianvarc'h D, Oussedik K, Halby L, Garbesi A, Dauzonne D, Monneret C, Osheroff N, Giovannangeli C, Arimondo PB, Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides, Nucleic Acids Res. 2006;34(6):1900-11.

Majlessi L, Simsova M, Jarvis Z, Brodin P, Rojas MJ, Bauche C, Nouzé C, Ladant D, Cole ST, Sebo P, Leclerc C, An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis, Infect. Immun. 2006 Apr;74(4):2128-37.

Nienke Buddelmeijer, Olivera Francetic, Anthony Pugsley, Green Fluorescent Chimeras Indicate Nonpolar Localization of Pullulanase Secreton Components PulL and PulM, Journal of Bacteriology, 2006, 188 (8), pp.2928-2935. ⟨10.1128/JB.188.8.2928-2935.2006⟩.

Chaze T, Bouley J, Chambon C, Barboiron C, Picard B, Mapping of alkaline proteins in bovine skeletal muscle, Proteomics 2006 Apr;6(8):2571-5.

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Mascarell L, Bauche C, Fayolle C, Diop OM, Dupuy M, Nougarede N, Perraut R, Ladant D, Leclerc C, Delivery of the HIV-1 Tat protein to dendritic cells by the CyaA vector induces specific Th1 responses and high affinity neutralizing antibodies in non human primates, Vaccine 2006 Apr;24(17):3490-9.

Prochnicka-Chalufour A, Corzo G, Satake H, Martin-Eauclaire MF, Murgia AR, Prestipino G, D'Suze G, Possani LD, Delepierre M, Solution structure of discrepin, a new K+-channel blocking peptide from the alpha-KTx15 subfamily, Biochemistry 2006 Feb;45(6):1795-804.

Phalipon A, Costachel C, Grandjean C, Thuizat A, Guerreiro C, Tanguy M, Nato F, Vulliez-Le Normand B, Bélot F, Wright K, Marcel-Peyre V, Sansonetti PJ, Mulard LA, Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine, J. Immunol. 2006 Feb;176(3):1686-94.

Hible G, Christova P, Renault L, Seclaman E, Thompson A, Girard E, Munier-Lehmann H, Cherfils J, Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase, Proteins 2006 Feb;62(2):489-500.

Delfederico L, Hollmann A, Martínez M, Iglesias NG, De Antoni G, Semorile L, Molecular identification and typing of lactobacilli isolated from kefir grains, J. Dairy Res. 2006 Feb;73(1):20-7.

Freire T, Lo-Man R, Piller F, Piller V, Leclerc C, Bay S, Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for antitumor vaccination, Glycobiology 2006 May;16(5):390-401.

Buschiazzo A, Goytia M, Schaeffer F, Degrave W, Shepard W, Grégoire C, Chamond N, Cosson A, Berneman A, Coatnoan N, Alzari PM, Minoprio P, Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase, Proc. Natl. Acad. Sci. U.S.A. 2006 Feb;103(6):1705-10.

Guillaumel J, Léonce S, Pierré A, Renard P, Pfeiffer B, Arimondo PB, Monneret C, Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds, Eur J Med Chem 2006 Mar;41(3):379-86.

Janssen ME, Kim E, Liu H, Fujimoto LM, Bobkov A, Volkmann N, Hanein D, , Three-dimensional structure of vinculin bound to actin filaments., Mol Cell 2006 Jan; 21(2): 271-81.

Hardouin J, Duchateau M, Joubert-Caron R, Caron M, Usefulness of an integrated microfluidic device (HPLC-Chip-MS) to enhance confidence in protein identification by proteomics, Rapid Commun. Mass Spectrom. 2006;20(21):3236-44.

Mazouni K, Pehau-Arnaudet G, England P, Bourhy P, Saint Girons I, Picardeau M, The scc spirochetal coiled-coil protein forms helix-like filaments and binds to nucleic acids generating nucleoprotein structures, J. Bacteriol. 2006 Jan;188(2):469-76.

Bedouelle H, Belkadi L, England P, Guijarro JI, Lisova O, Urvoas A, Delepierre M, Thullier P, Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus, FEBS J. 2006 Jan;273(1):34-46.

Prado, S.; Janin, Y. L.; Bost, P. E., A simple two steps ytterbium triflate-catalysed preparation of 2,2-dimethylchromenes from salicylaldehydes and 2-methylpropene, J. Heterocycl. Chem. 2006, 43, 1605-1608.

Hernández B, Boukhalfa-Heniche FZ, Seksek O, Coïc YM, Ghomi M, Secondary conformation of short lysine- and leucine-rich peptides assessed by optical spectroscopies: effect of chain length, concentration, solvent, and time, Biopolymers 2006 Jan;81(1):8-19.

Arimondo PB, Thomas CJ, Oussedik K, Baldeyrou B, Mahieu C, Halby L, Guianvarc'h D, Lansiaux A, Hecht SM, Bailly C, Giovannangeli C, Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates, Mol. Cell. Biol. 2006 Jan;26(1):324-33.

Tekaia F, Yeramian E, Genome trees from conservation profiles, PLoS Comput. Biol. 2005 Dec;1(7):e75.

Janin YL, Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?, J. Med. Chem. 2005 Dec;48(24):7503-12.

Topalis D, Collinet B, Gasse C, Dugué L, Balzarini J, Pochet S, Deville-Bonne D, Substrate specificity of vaccinia virus thymidylate kinase, FEBS J. 2005 Dec;272(24):6254-65.

Watts AG, Oppezzo P, Withers SG, Alzari PM, Buschiazzo A, Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase, J. Biol. Chem. 2006 Feb;281(7):4149-55.

Egile C, Rouiller I, Xu XP, Volkmann N, Li R, Hanein D, , Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions., PLoS Biol 2005 Nov; 3(11): e383.

Clément MJ, Fortuné A, Phalipon A, Marcel-Peyre V, Simenel C, Imberty A, Delepierre M, Mulard LA, Toward a better understanding of the basis of the molecular mimicry of polysaccharide antigens by peptides: the example of Shigella flexneri 5a, J. Biol. Chem. 2006 Jan;281(4):2317-32.

Jestin JL, Vichier-Guerre S, How to broaden enzyme substrate specificity: strategies, implications and applications, Res. Microbiol. 2005 Dec;156(10):961-6.

Quinton L, Le Caer JP, Phan G, Ligny-Lemaire C, Bourdais-Jomaron J, Ducancel F, Chamot-Rooke J, Characterization of toxins within crude venoms by combined use of Fourier transform mass spectrometry and cloning, Anal. Chem. 2005 Oct;77(20):6630-9.

Chamond N, Goytia M, Coatnoan N, Barale JC, Cosson A, Degrave WM, Minoprio P, Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity, Mol. Microbiol. 2005 Oct;58(1):46-60.

Francetić O, Pugsley AP, Towards the identification of type II secretion signals in a nonacylated variant of pullulanase from Klebsiella oxytoca, J. Bacteriol. 2005 Oct;187(20):7045-55.

Tartaglia GG, Cavalli A, Pellarin R, Caflisch A, Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences, Protein Sci. 2005 Oct;14(10):2723-34.

Godfroid F, Denoël P, Poolman J, Are vaccination programs and isolate polymorphism linked to pertussis re-emergence?, Expert Rev Vaccines 2005 Oct; 4(5): 757-78.

Girardin SE, Jéhanno M, Mengin-Lecreulx D, Sansonetti PJ, Alzari PM, Philpott DJ, Identification of the critical residues involved in peptidoglycan detection by Nod1, J. Biol. Chem. 2005 Nov;280(46):38648-56.

Tartaglia GG, Pellarin R, Cavalli A, Caflisch A, Organism complexity anti-correlates with proteomic beta-aggregation propensity, Protein Sci. 2005 Oct;14(10):2735-40.

Volkmann N, Liu H, Hazelwood L, Krementsova EB, Lowey S, Trybus KM, Hanein D, , The structural basis of myosin V processive movement as revealed by electron cryomicroscopy., Mol Cell 2005 Sep; 19(5): 595-605.

Sissoëff L, Mousli M, England P, Tuffereau C, Stable trimerization of recombinant rabies virus glycoprotein ectodomain is required for interaction with the p75NTR receptor, J. Gen. Virol. 2005 Sep;86(Pt 9):2543-52.

Grandjean C, Boutonnier A, Guerreiro C, Fournier JM, Mulard LA, On the preparation of carbohydrate-protein conjugates using the traceless Staudinger ligation, J. Org. Chem. 2005 Sep;70(18):7123-32.

Rohrlich PS, Fazilleau N, Ginhoux F, Firat H, Michel F, Cochet M, Laham N, Roth MP, Pascolo S, Nato F, Coppin H, Charneau P, Danos O, Acuto O, Ehrlich R, Kanellopoulos J, Lemonnier FA, Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function, Proc. Natl. Acad. Sci. U.S.A. 2005 Sep;102(36):12855-60.

Lindahl E, Delarue M, Refinement of docked protein-ligand and protein-DNA structures using low frequency normal mode amplitude optimization, Nucleic Acids Res. 2005;33(14):4496-506.

Mascarell L, Fayolle C, Bauche C, Ladant D, Leclerc C, Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis, J. Virol. 2005 Aug;79(15):9872-84.

Durán R, Villarino A, Bellinzoni M, Wehenkel A, Fernandez P, Boitel B, Cole ST, Alzari PM, Cerveñansky C, , Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases., Biochem Biophys Res Commun 2005 Aug; 333(3): 858-67.

Villarino A, Duran R, Wehenkel A, Fernandez P, England P, Brodin P, Cole ST, Zimny-Arndt U, Jungblut PR, Cerveñansky C, Alzari PM, Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions, J. Mol. Biol. 2005 Jul;350(5):953-63.

Coïc YM, Vincent M, Gallay J, Baleux F, Mousson F, Beswick V, Neumann JM, de Foresta B, Single-spanning membrane protein insertion in membrane mimetic systems: role and localization of aromatic residues, Eur. Biophys. J. 2005 Dec;35(1):27-39.

Duca M, Oussedik K, Ceccaldi A, Halby L, Guianvarc'h D, Dauzonne D, Monneret C, Sun JS, Arimondo PB, Triple helix-forming oligonucleotides conjugated to new inhibitors of topoisomerase II: synthesis and binding properties, Bioconjug. Chem. 2005 Jul-Aug;16(4):873-84.

Sauvage E, Herman R, Petrella S, Duez C, Bouillenne F, Frère JM, Charlier P, Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins, J. Biol. Chem. 2005 Sep;280(35):31249-56.

Chenal A, Vernier G, Savarin P, Bushmarina NA, Gèze A, Guillain F, Gillet D, Forge V, Conformational states and thermodynamics of alpha-lactalbumin bound to membranes: a case study of the effects of pH, calcium, lipid membrane curvature and charge, J. Mol. Biol. 2005 Jun;349(4):890-905.

Froment C, Uttenweiler-Joseph S, Bousquet-Dubouch MP, Matondo M, Borges JP, Esmenjaud C, Lacroix C, Monsarrat B, Burlet-Schiltz O, A quantitative proteomic approach using two-dimensional gel electrophoresis and isotope-coded affinity tag labeling for studying human 20S proteasome heterogeneity, Proteomics 2005 Jun;5(9):2351-63.

Moulédous L, Neasta J, Uttenweiler-Joseph S, Stella A, Matondo M, Corbani M, Monsarrat B, Meunier JC, Long-term morphine treatment enhances proteasome-dependent degradation of G beta in human neuroblastoma SH-SY5Y cells: correlation with onset of adenylate cyclase sensitization, Mol. Pharmacol. 2005 Aug;68(2):467-76.

Guimarães BG, Souchon H, Honoré N, Saint-Joanis B, Brosch R, Shepard W, Cole ST, Alzari PM, Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress, J. Biol. Chem. 2005 Jul;280(27):25735-42.

Blisnick T, Vincensini L, Barale JC, Namane A, Braun Breton C, LANCL1, an erythrocyte protein recruited to the Maurer’s clefts during Plasmodium falciparum development, Mol. Biochem. Parasitol. 2005 May;141(1):39-47.

Guerin ME, Buschiazzo A, Korduláková J, Jackson M, Alzari PM, Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2005 May;61(Pt 5):518-20.

Matamoros T, Deval J, Guerreiro C, Mulard L, Canard B, Menéndez-Arias L, Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues, J. Mol. Biol. 2005 Jun;349(3):451-63.

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Bay S, Huteau V, Zarantonelli ML, Pires R, Ughetto-Monfrin J, Taha MK, England P, Lafaye P, , Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections., J Med Chem 2004 Jul; 47(16): 3916-9.

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Lo-Man R, Vichier-Guerre S, Perraut R, Dériaud E, Huteau V, BenMohamed L, Diop OM, Livingston PO, Bay S, Leclerc C, A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates, Cancer Res. 2004 Jul;64(14):4987-94.

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Benarroch D, Egloff MP, Mulard L, Guerreiro C, Romette JL, Canard B, A structural basis for the inhibition of the NS5 dengue virus mRNA 2′-O-methyltransferase domain by ribavirin 5′-triphosphate, J. Biol. Chem. 2004 Aug;279(34):35638-43.

Amaya MF, Watts AG, Damager I, Wehenkel A, Nguyen T, Buschiazzo A, Paris G, Frasch AC, Withers SG, Alzari PM, Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase, Structure 2004 May;12(5):775-84.

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Suspène R, Sommer P, Henry M, Ferris S, Guétard D, Pochet S, Chester A, Navaratnam N, Wain-Hobson S, Vartanian JP, APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase, Nucleic Acids Res. 2004;32(8):2421-9.

Wright K, Guerreiro C, Laurent I, Baleux F, Mulard LA, Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease, Org. Biomol. Chem. 2004 May;2(10):1518-27.

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Delarue M, Dumas P, On the use of low-frequency normal modes to enforce collective movements in refining macromolecular structural models, Proc. Natl. Acad. Sci. U.S.A. 2004 May;101(18):6957-62.

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Marsh BJ, Volkmann N, McIntosh JR, Howell KE, , Direct continuities between cisternae at different levels of the Golgi complex in glucose-stimulated mouse islet beta cells., Proc Natl Acad Sci U S A 2004 Apr; 101(15): 5565-70.

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Bajramovic JJ, Volmer R, Syan S, Pochet S, Gonzalez-Dunia D, 2′-fluoro-2′-deoxycytidine inhibits Borna disease virus replication and spread, Antimicrob. Agents Chemother. 2004 Apr;48(4):1422-5.

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Karimova G, Ladant D, Ullmann A, Relief of catabolite repression in a cAMP-independent catabolite gene activator mutant of Escherichia coli, Res. Microbiol. 2004 Mar;155(2):76-9.

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Gallay J, Vincent M, Li de la Sierra IM, Munier-Lehmann H, Renouard M, Sakamoto H, Bârzu O, Gilles AM, Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy, Eur. J. Biochem. 2004 Feb;271(4):821-33.

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Miron S, Munier-Lehmann H, Craescu CT, Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity, Biochemistry 2004 Jan;43(1):67-77.

Hommais F, Krin E, Coppée JY, Lacroix C, Yeramian E, Danchin A, Bertin P, GadE (YhiE): a novel activator involved in the response to acid environment in Escherichia coli, Microbiology (Reading, Engl.) 2004 Jan;150(Pt 1):61-72.

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Uzureau P, Barale JC, Janse CJ, Waters AP, Breton CB, Gene targeting demonstrates that the Plasmodium berghei subtilisin PbSUB2 is essential for red cell invasion and reveals spontaneous genetic recombination events, Cell. Microbiol. 2004 Jan;6(1):65-78.

Dam J, Blondel A, Effect of multiple symmetries on the association of R67 DHFR subunits bearing interfacial complementing mutations, Protein Sci. 2004 Jan;13(1):1-14.

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Petrella S, Pernot L, Sougakoff W, Crystallization and preliminary X-ray diffraction study of the class A beta-lactamase SED-1 and its mutant SED-G238C from Citrobacter sedlakii, Acta Crystallogr. D Biol. Crystallogr. 2004 Jan;60(Pt 1):125-8.

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Givens RM, Lin MH, Taylor DJ, Mechold U, Berry JO, Hernandez VJ, Inducible expression, enzymatic activity, and origin of higher plant homologues of bacterial RelA/SpoT stress proteins in Nicotiana tabacum, J. Biol. Chem. 2004 Feb;279(9):7495-504.

Dadaglio G, Morel S, Bauche C, Moukrim Z, Lemonnier FA, Van Den Eynde BJ, Ladant D, Leclerc C, Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes, Int. Immunol. 2003 Dec;15(12):1423-30.

Pochet S, Kaminski PA, Van Aerschot A, Herdewijn P, Marlière P, Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo, C. R. Biol. 2003 Dec;326(12):1175-84.

Moura IC, Lepelletier Y, Arnulf B, England P, Baude C, Beaumont C, Bazarbachi A, Benhamou M, Monteiro RC, Hermine O, A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients, Blood 2004 Mar;103(5):1838-45.

Létoffé S, Debarbieux L, Izadi N, Delepelaire P, Wandersman C, Ligand delivery by haem carrier proteins: the binding of Serratia marcescens haemophore to its outer membrane receptor is mediated by two distinct peptide regions, Mol. Microbiol. 2003 Oct;50(1):77-88.

Nicaise M, Valerio-Lepiniec M, Izadi-Pruneyre N, Adjadj E, Minard P, Desmadril M, Role of the tyrosine corner motif in the stability of neocarzinostatin, Protein Eng. 2003 Oct;16(10):733-8.

Scheiden R, Wagener C, Knolle U, Wehenkel A, Dippel W, Capesius C, Cervical screening in Luxembourg: 1990-1999, Cytopathology 2003 Oct;14(5):235-40.

Deniau C, Gilli R, Izadi-Pruneyre N, Létoffé S, Delepierre M, Wandersman C, Briand C, Lecroisey A, Thermodynamics of heme binding to the HasA(SM) hemophore: effect of mutations at three key residues for heme uptake, Biochemistry 2003 Sep;42(36):10627-33.

Vanheusden V, Van Rompaey P, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S, Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, Bioorg. Med. Chem. Lett. 2003 Sep;13(18):3045-8.

Strobel H, Ladant D, Jestin JL, In vitro selection for enzymatic activity: a model study using adenylate cyclase, J. Mol. Biol. 2003 Sep;332(1):1-7.

Boitel B, Ortiz-Lombardía M, Durán R, Pompeo F, Cole ST, Cerveñansky C, Alzari PM, PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis, Mol. Microbiol. 2003 Sep;49(6):1493-508.

Vichier-Guerre S, Lo-Man R, BenMohamed L, Dériaud E, Kovats S, Leclerc C, Bay S, Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: a potential anti cancer vaccine for human use, J. Pept. Res. 2003 Sep;62(3):117-24.

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Vanheusden V, Munier-Lehmann H, Froeyen M, Dugué L, Heyerick A, De Keukeleire D, Pochet S, Busson R, Herdewijn P, Van Calenbergh S, 3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, J. Med. Chem. 2003 Aug;46(18):3811-21.

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Dautin N, Karimova G, Ladant D, Human immunodeficiency virus (HIV) type 1 transframe protein can restore activity to a dimerization-deficient HIV protease variant, J. Virol. 2003 Aug;77(15):8216-26.

Pochet S, Dugué L, Labesse G, Delepierre M, Munier-Lehmann H, Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans, Chembiochem 2003 Aug;4(8):742-7.

Van Rompaey, P., Nauwelaerts, K., Vanheusden, V., Rozenski, J., Munier-Lehmann, H., Herdewijn, P. and Van Calenbergh, S., Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors: Biological evaluation and conformational analysis of 2 ‘- and 3 ‘-modified thymidine analogues, Eur. J. Org. Chem., 2003: 2911–2918. doi: 10.1002/ejoc.200300177.

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Yeramian E, Jones L, GeneFizz: A web tool to compare genetic (coding/non-coding) and physical (helix/coil) segmentations of DNA sequences. Gene discovery and evolutionary perspectives, Nucleic Acids Res. 2003 Jul;31(13):3843-9.

Watts AG, Damager I, Amaya ML, Buschiazzo A, Alzari P, Frasch AC, Withers SG, Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile, J. Am. Chem. Soc. 2003 Jun;125(25):7532-3.

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Ehsani P, Meunier A, Nato F, Jafari A, Nato A, Lafaye P, Expression of anti human IL-4 and IL-6 scFvs in transgenic tobacco plants, Plant Mol. Biol. 2003 May;52(1):17-29.

Strobel H, Ladant D, Jestin JL, Efficient display of two enzymes on filamentous phage using an improved signal sequence, Mol. Biotechnol. 2003 May;24(1):1-10.

Munier-Lehmann H, Pochet S, Dugue L, Dutruel O, Labesse G, Douget D, Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors, Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):801-4.

Pochet S, Dugué L, Strobel H, Synthesis and recognition by DNA polymerases of a reactive nucleoside for DNA diversification, Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):1665-7.

Hollenstein M, Gautschi D, Leumann CJ, Fluorinated peptide nucleic acid, Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):1191-4.

Sophie Vichier-Guerre, jean-Luc Jestin, Iterative cycles of in vitro protein selection for DNA polymerase activity, Biocatal. Biotransfor. 2003;21(2):75-78.

Fioravanti E, Haouz A, Ursby T, Munier-Lehmann H, Delarue M, Bourgeois D, Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway, J. Mol. Biol. 2003 Apr;327(5):1077-92.

Fioravanti E, Haouz A, Ursby T, Munier-Lehmann H, Delarue M, Bourgeois D., Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway. Fioravanti E, Haouz A, Ursby T, Munier-Lehmann H, Delarue M, Bourgeois D., J Mol Biol. 2003 Apr 11;327(5):1077-92..

Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D, Reaction of human UMP-CMP kinase with natural and analog substrates, Eur. J. Biochem. 2003 Apr;270(8):1784-90.

Volkmann N, Ouyang G, Trybus KM, DeRosier DJ, Lowey S, Hanein D, , Myosin isoforms show unique conformations in the actin-bound state., Proc Natl Acad Sci U S A 2003 Mar; 100(6): 3227-32.

Quevillon E, Spielmann T, Brahimi K, Chattopadhyay D, Yeramian E, Langsley G, The Plasmodium falciparum family of Rab GTPases, Gene 2003 Mar;306:13-25.

Gallois-Montbrun S, Chen Y, Dutartre H, Sophys M, Morera S, Guerreiro C, Schneider B, Mulard L, Janin J, Veron M, Deville-Bonne D, Canard B, Structural analysis of the activation of ribavirin analogs by NDP kinase: comparison with other ribavirin targets, Mol. Pharmacol. 2003 Mar;63(3):538-46.

Lagoja IM, Pochet S, Boudou V, Little R, Lescrinier E, Rozenski J, Herdewijn P, A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides, J. Org. Chem. 2003 Mar;68(5):1867-71.

Guerin ME, Buschiazzo A, Ugalde JE, Ugalde RA, Alzari PM, Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens, Acta Crystallogr. D Biol. Crystallogr. 2003 Mar;59(Pt 3):526-8.

Babino A, Tello D, Rojas A, Bay S, Osinaga E, Alzari PM, The crystal structure of a plant lectin in complex with the Tn antigen, FEBS Lett. 2003 Feb;536(1-3):106-10.

Haouz A, Vanheusden V, Munier-Lehmann H, Froeyen M, Herdewijn P, Van Calenbergh S, Delarue M, Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism, J. Biol. Chem. 2003 Feb;278(7):4963-71.

Ortiz-Lombardía M, Pompeo F, Boitel B, Alzari PM, Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis, J. Biol. Chem. 2003 Apr;278(15):13094-100.

Amaya MF, Buschiazzo A, Nguyen T, Alzari PM, The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase, J. Mol. Biol. 2003 Jan;325(4):773-84.

Chanteau S, Rahalison L, Ralafiarisoa L, Foulon J, Ratsitorahina M, Ratsifasoamanana L, Carniel E, Nato F, Development and testing of a rapid diagnostic test for bubonic and pneumonic plague, Lancet 2003 Jan;361(9353):211-6.

Muzerelle A, Alberts P, Martinez-Arca S, Jeannequin O, Lafaye P, Mazié JC, Galli T, Gaspar P, Tetanus neurotoxin-insensitive vesicle-associated membrane protein localizes to a presynaptic membrane compartment in selected terminal subsets of the rat brain, Neuroscience 2003;122(1):59-75.

Janin, Y. L., Peptides with anticancer use or potential, Amino Acids 2003, 25, 1-40.

Nizard P, Gross DA, Babon A, Chenal A, Beaumelle B, Kosmatopoulos K, Gillet D, Anchoring cytokines to tumor cells for the preparation of anticancer vaccines without gene transfection in mice, J. Immunother. 2003 Jan-Feb;26(1):63-71.

Terwilliger TC, Park MS, Waldo GS, Berendzen J, Hung LW, Kim CY, Smith CV, Sacchettini JC, Bellinzoni M, Bossi R, De Rossi E, Mattevi A, Milano A, Riccardi G, Rizzi M, Roberts MM, Coker AR, Fossati G, Mascagni P, Coates AR, Wood SP, Goulding CW, Apostol MI, Anderson DH, Gill HS, Eisenberg DS, Taneja B, Mande S, Pohl E, Lamzin V, Tucker P, Wilmanns M, Colovos C, Meyer-Klaucke W, Munro AW, McLean KJ, Marshall KR, Leys D, Yang JK, Yoon HJ, Lee BI, Lee MG, Kwak JE, Han BW, Lee JY, Baek SH, Suh SW, Komen MM, Arcus VL, Baker EN, Lott JS, Jacobs W, Alber T, Rupp B, The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology, Tuberculosis (Edinb) 2003;83(4):223-49.

Guillaumel J, Léonce S, Pierré A, Renard P, Pfeiffer B, Peruchon L, Arimondo PB, Monneret C, Synthesis and antiproliferative activity of basic ethers of 1,2-dihydropyrrolo[1,2-a]indole, 6H-isoindolo[2,1-a]indole, and 6H-benz[5,6]isoindolo[2,1-a]indole, Oncol. Res. 2003;13(12):537-49.

Vinogradov S, Roig V, Sergueeva Z, Nguyen CH, Arimondo P, Thuong NT, Bisagni E, Sun JS, Hélène C, Asseline U, Synthesis and binding properties of oligo-2′-deoxyribonucleotides conjugated with triple-helix-specific intercalators: benzo[e] and benzo[g] pyridoindoles, Bioconjug. Chem. 2003 Jan-Feb;14(1):120-35.

Volkmann N, Hanein D, , Docking of atomic models into reconstructions from electron microscopy., Methods Enzymol 2003 ; 374(): 204-25.

Volkmann N, Hanein D, , Electron microscopy., Methods Biochem Anal 2003 ; 44(): 115-33.

Alberti P, Arimondo PB, Mergny JL, Garestier T, Hélène C, Sun JS, A directional nucleation-zipping mechanism for triple helix formation, Nucleic Acids Res. 2002 Dec;30(24):5407-15.

Strobel H, Dugué L, Marlière P, Pochet S, A parallel synthesis scheme for generating libraries of DNA polymerase substrates and inhibitors, Chembiochem 2002 Dec;3(12):1251-6.

Chanel C, Staropoli I, Baleux F, Amara A, Valenzuela-Fernandez A, Virelizier JL, Arenzana-Seisdedos F, Altmeyer R, Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells, AIDS 2002 Nov;16(17):2337-40.

Mousson F, Coïc YM, Baleux F, Beswick V, Sanson A, Neumann JM, Deciphering the role of individual acyl chains in the interaction network between phosphatidylserines and a single-spanning membrane protein, Biochemistry 2002 Nov;41(46):13611-6.

Wendt TG, Volkmann N, Skiniotis G, Goldie KN, Müller J, Mandelkow E, Hoenger A, , Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd., EMBO J 2002 Nov; 21(22): 5969-78.

Guermonprez P, Fayolle C, Rojas MJ, Rescigno M, Ladant D, Leclerc C, In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells., Eur J Immunol 2002 Nov; 32(11): 3071-81.

De Rossi E, Arrigo P, Bellinzoni M, Silva PA, Martín C, Aínsa JA, Guglierame P, Riccardi G, , The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis., Mol Med 2002 Nov; 8(11): 714-24.

Roulland E, Magiatis P, Arimondo P, Bertounesque E, Monneret C, Hemi-synthesis and biological activity of new analogues of podophyllotoxin, Bioorg. Med. Chem. 2002 Nov;10(11):3463-71.

Volkmann N, , A novel three-dimensional variant of the watershed transform for segmentation of electron density maps., J Struct Biol ; 138(1-2): 123-9.

Bélot F, Costachel C, Wright K, Phalipon A, Mulard LA, Synthesis of the methyl glycoside of a branched octasaccharide fragment specific for the Shigella flexneri serotype 2a O-antigen, Tetrahedron Lett. 2002; 43: 8215-8.

Buschiazzo A, Amaya MF, Cremona ML, Frasch AC, Alzari PM, The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis, Mol. Cell 2002 Oct;10(4):757-68.

Mercereau-Puijalon O, Barale JC, Bischoff E, Three multigene families in Plasmodium parasites: facts and questions, Int. J. Parasitol. 2002 Oct;32(11):1323-44.

Vanheusden V, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S, Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, Bioorg. Med. Chem. Lett. 2002 Oct;12(19):2695-8.

Jamin N, Coïc YM, Landon C, Ovtracht L, Baleux F, Neumann JM, Sanson A, Most of the structural elements of the globular domain of murine prion protein form fibrils with predominant beta-sheet structure, FEBS Lett. 2002 Oct;529(2-3):256-60.

Dautin N, Karimova G, Ladant D, Bordetella pertussis adenylate cyclase toxin: a versatile screening tool, Toxicon 2002 Oct;40(10):1383-7.

Almici C, Imberti L, Lanfranchi A, Verardi R, Bellinzoni M, Berta S, Izzi T, , Reconstitution of T-cell receptor repertoire diversity following non-myeloablative allogeneic stem cell transplantation in an acute myeloid leukemia patient., Haematologica 2002 Oct; 87(10): ECR31.

Mo F, Mathiesen RH, Alzari PM, Lescar J, Rasmussen B, Physical estimation of triplet phases from two new proteins, Acta Crystallogr. D Biol. Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1780-6.

Marvaud JC, Stiles BG, Chenal A, Gillet D, Gibert M, Smith LA, Popoff MR, Clostridium perfringens iota toxin. Mapping of the Ia domain involved in docking with Ib and cellular internalization, J. Biol. Chem. 2002 Nov;277(46):43659-66.

Bedouelle H, Renard M, Belkadi L, England P, Harnessing malE for the study of antigen/antibody recognitions, Res. Microbiol. 2002 Sep;153(7):395-8.

Pirovano S, Bellinzoni M, Matteelli A, Ballerini C, Albertini A, Imberti L, , High prevalence of a variant of SENV in intravenous drug user HIV-infected patients., J Med Virol 2002 Sep; 68(1): 18-23.

Mills M, Lacroix L, Arimondo PB, Leroy JL, François JC, Klump H, Mergny JL, Unusual DNA conformations: implications for telomeres, Curr Med Chem Anticancer Agents 2002 Sep;2(5):627-44.

Pollard TD, Hanein D, Volkmann N, , Arp2/3 plays no role in muscle contraction., Nature 2002 Aug; 418(6901): 915.

Schmidt A, Gonzalez A, Morris RJ, Costabel M, Alzari PM, Lamzin VS, Advantages of high-resolution phasing: MAD to atomic resolution, Acta Crystallogr. D Biol. Crystallogr. 2002 Sep;58(Pt 9):1433-41.

Chenal A, Savarin P, Nizard P, Guillain F, Gillet D, Forge V, Membrane protein insertion regulated by bringing electrostatic and hydrophobic interactions into play. A case study with the translocation domain of diphtheria toxin, J. Biol. Chem. 2002 Nov;277(45):43425-32.

Gallois-Montbrun S, Schneider B, Chen Y, Giacomoni-Fernandes V, Mulard L, Morera S, Janin J, Deville-Bonne D, Veron M, Improving nucleoside diphosphate kinase for antiviral nucleotide analogs activation, J. Biol. Chem. 2002 Oct;277(42):39953-9.

Allignet J, England P, Old I, El Solh N, Several regions of the repeat domain of the Staphylococcus caprae autolysin, AtlC, are involved in fibronectin binding, FEMS Microbiol. Lett. 2002 Aug;213(2):193-7.

Bellinzoni M, De Rossi E, Branzoni M, Milano A, Peverali FA, Rizzi M, Riccardi G, , Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase., Protein Expr Purif 2002 Aug; 25(3): 547-57.

Delarue M*, Sanejouand YH., Simplified normal mode analysis of conformational transitions in DNA-dependent polymerases: the elastic network model., J Mol Biol. 2002 Jul 26;320(5):1011-24..

Guimarães BG, Souchon H, Lytle BL, David Wu JH, Alzari PM, The crystal structure and catalytic mechanism of cellobiohydrolase CelS, the major enzymatic component of the Clostridium thermocellum Cellulosome, J. Mol. Biol. 2002 Jul;320(3):587-96.

Mulard LA, Clément MJ, Imberty A, Delepierre M, Convergent synthesis, NMR and conformational analysis of tetra- and pentasaccharide haptens of the Shigella flexneri 5a O-specific polysaccharide, Eur. J. Org. Chem. 2002, 2486-98.

Johansen TN, Janin YL, Nielsen B, Frydenvang K, Bräuner-Osborne H, Stensbøl TB, Vogensen SB, Madsen U, Krogsgaard-Larsen P, 2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors, Bioorg. Med. Chem. 2002 Jul;10(7):2259-66.

Manallack DT, Pitt WR, Herdewijn P, Balzarini J, De Clercq E, Sanderson MR, Sohi M, Wien F, Munier-Lehmann H, Haouz A, Delarue M, Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods, J Enzyme Inhib Med Chem 2002 Jun;17(3):167-74.

Maté MJ, Ortiz-Lombardía M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM, The crystal structure of the mouse apoptosis-inducing factor AIF, Nat. Struct. Biol. 2002 Jun;9(6):442-6.

Karimova G, Ladant D, Ullmann A, Two-hybrid systems and their usage in infection biology, Int. J. Med. Microbiol. 2002 Jun;292(1):17-25.

Mechold U, Murphy H, Brown L, Cashel M, Intramolecular regulation of the opposing (p)ppGpp catalytic activities of Rel(Seq), the Rel/Spo enzyme from Streptococcus equisimilis, J. Bacteriol. 2002 Jun;184(11):2878-88.

Montagna G, Cremona ML, Paris G, Amaya MF, Buschiazzo A, Alzari PM, Frasch AC, The trans-sialidase from the african trypanosome Trypanosoma brucei, Eur. J. Biochem. 2002 Jun;269(12):2941-50.

Strobel H, Dugué L, Marlière P, Pochet S, Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-imidazole-4-hydrazide, Nucleic Acids Res. 2002 May;30(9):1869-78.

Chenal A, Nizard P, Forge V, Pugnière M, Roy MO, Mani JC, Guillain F, Gillet D, Does fusion of domains from unrelated proteins affect their folding pathways and the structural changes involved in their function? A case study with the diphtheria toxin T domain, Protein Eng. 2002 May;15(5):383-91.

Smith SP, Béguin P, Alzari PM, Gehring K, 1H, 13C, 15N NMR sequence-specific resonance assignment of a Clostridium thermocellum type II cohesin module, J. Biomol. NMR 2002 May;23(1):73-4.

Renard M, Belkadi L, Hugo N, England P, Altschuh D, Bedouelle H, Knowledge-based design of reagentless fluorescent biosensors from recombinant antibodies, J. Mol. Biol. 2002 Apr;318(2):429-42.

Carpena X, Guarné A, Ferrer JC, Alzari PM, Fita I, Loewen PC, Crystallization and preliminary X-ray analysis of the hydroperoxidase I C-terminal domain from Escherichia coli, Acta Crystallogr. D Biol. Crystallogr. 2002 May;58(Pt 5):853-5.

Mowat CG, Leys D, McLean KJ, Rivers SL, Richmond A, Munro AW, Ortiz Lombardia M, Alzari PM, Reid GA, Chapman SK, Walkinshaw MD, Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis, Acta Crystallogr. D Biol. Crystallogr. 2002 Apr;58(Pt 4):704-5.

Ursby T, Weik M, Fioravanti E, Delarue M, Goeldner M, Bourgeois D, Cryophotolysis of caged compounds: a technique for trapping intermediate states in protein crystals, Acta Crystallogr. D Biol. Crystallogr. 2002 Apr;58(Pt 4):607-14.

Chernyak A, Kondo S, Wade TK, Meeks MD, Alzari PM, Fournier JM, Taylor RK, Kovác P, Wade WF, Induction of protective immunity by synthetic Vibrio cholerae hexasaccharide derived from V. cholerae O1 Ogawa lipopolysaccharide bound to a protein carrier, J. Infect. Dis. 2002 Apr;185(7):950-62.

Guijarro JI, Pintar A, Prochnicka-Chalufour A, Guez V, Gilquin B, Bedouelle H, Delepierre M, Structure and dynamics of the anticodon arm binding domain of Bacillus stearothermophilus Tyrosyl-tRNA synthetase, Structure 2002 Mar;10(3):311-7.

Guérin DM, Lascombe MB, Costabel M, Souchon H, Lamzin V, Béguin P, Alzari PM, Atomic (0.94 A) resolution structure of an inverting glycosidase in complex with substrate, J. Mol. Biol. 2002 Mar;316(5):1061-9.

Pirovano S, Bellinzoni M, Ballerini C, Cariani E, Duse M, Albertini A, Imberti L, , Transmission of SEN virus from mothers to their babies., J Med Virol 2002 Mar; 66(3): 421-7.

Raynal BD, Hardingham TE, Thornton DJ, Sheehan JK, , Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva., Biochem J 2002 Mar; 362(Pt 2): 289-96.

Valenzuela-Fernández A, Planchenault T, Baleux F, Staropoli I, Le-Barillec K, Leduc D, Delaunay T, Lazarini F, Virelizier JL, Chignard M, Pidard D, Arenzana-Seisdedos F, Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4, J. Biol. Chem. 2002 May;277(18):15677-89.

Miras I, Schaeffer F, Béguin P, Alzari PM, Mapping by site-directed mutagenesis of the region responsible for cohesin-dockerin interaction on the surface of the seventh cohesin domain of Clostridium thermocellum CipA, Biochemistry 2002 Feb;41(7):2115-9.

Schaeffer F, Matuschek M, Guglielmi G, Miras I, Alzari PM, Béguin P, Duplicated dockerin subdomains of Clostridium thermocellum endoglucanase CelD bind to a cohesin domain of the scaffolding protein CipA with distinct thermodynamic parameters and a negative cooperativity, Biochemistry 2002 Feb;41(7):2106-14.

Mulard LA, Clément MJ, Segat-Dioury F, Delepierre M, Synthesis and NMR study of a linear pentasaccharide fragment of the Shigella flexneri 5a O-specific polysaccharide, Tetrahedron 2002; 58: 2593-604.

Bertrand T, Briozzo P, Assairi L, Ofiteru A, Bucurenci N, Munier-Lehmann H, Golinelli-Pimpaneau B, Bârzu O, Gilles AM, Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme, J. Mol. Biol. 2002 Feb;315(5):1099-110.

Delarue M, Boulé JB, Lescar J, Expert-Bezançon N, Jourdan N, Sukumar N, Rougeon F, Papanicolaou C., Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase., EMBO J. 2002 Feb 1;21(3):427-39..

Mills M, Arimondo PB, Lacroix L, Garestier T, Klump H, Mergny JL, Chemical modification of the third strand: differential effects on purine and pyrimidine triple helix formation, Biochemistry 2002 Jan;41(1):357-66.

Pochet S, Dugue L, Douguet D, Labesse G, Munier-Lehmann H, Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications, Chembiochem 2002 Jan;3(1):108-10.

Kamiya H, Dugué L, Yakushiji H, Pochet S, Nakabeppu Y, Harashima H, Substrate recognition by the human MTH1 protein, Nucleic Acids Res. Suppl. 2002;(2):85-6.

Mulard L, Alonso JM, Fournier JM, Vaccins polysaccharidiques, Annales de l'Institut Pasteur, Editions scientifiques et médicales Elsevier SAS 2002 p. 37-54.

Yeramian E, Bonnefoy S, Langsley G, Physics-based gene identification: proof of concept for Plasmodium falciparum, Bioinformatics 2002 Jan;18(1):190-3.

Gmira S, Karimova G, Ladant D, Characterization of recombinant Bordetella pertussis adenylate cyclase toxins carrying passenger proteins, Res. Microbiol. 2001 Dec;152(10):889-900.

Arimondo PB, Boutorine A, Baldeyrou B, Bailly C, Kuwahara M, Hecht SM, Sun JS, Garestier T, Hélène C, Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I, J. Biol. Chem. 2002 Feb;277(5):3132-40.

Izadi-Pruneyre N, Quiniou E , Blouquit Y, Perez J, Minard P, Desmadril M, Mispelter J, Adjadj E , Key interactions in the immunoglobulin-like structure of apo-neocarzinostatin: evidence from nuclear magnetic resonance relaxation data and molecular dynamics simulations, Protein Sci. 2001 Nov;10(11):2228-40.

Nyholm PG, Mulard LA, Miller CE, Lew T, Olin R, Glaudemans CP, Conformation of the O-specific polysaccharide of Shigella dysenteriae type 1: molecular modeling shows a helical structure with efficient exposure of the antigenic determinant alpha-L-Rhap-(1–>2)-alpha-D-Galp, Glycobiology 2001 Nov;11(11):945-55.

Arimondo PB, Hélène C, Design of new anti-cancer agents based on topoisomerase poisons targeted to specific DNA sequences, Curr Med Chem Anticancer Agents 2001 Nov;1(3):219-35.

Arimondo PB, Baldeyrou B, Laine W, Bal C, Alphonse FA, Routier S, Coudert G, Mérour JY, Colson P, Houssier C, Bailly C, DNA interaction and cytotoxicity of a new series of indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole derivatives, Chem. Biol. Interact. 2001 Oct;138(1):59-75.

Mousson F, Beswick V, Coïc YM, Huynh-Dinh T, Sanson A, Neumann JM, Investigating the conformational coupling between the transmembrane and cytoplasmic domains of a single-spanning membrane protein. A 1H-NMR study, FEBS Lett. 2001 Sep;505(3):431-5.

Mousson F, Beswick V, Coïc YM, Baleux F, Huynh-Dinh T, Sanson A, Neumann JM, Concerted influence of key amino acids on the lipid binding properties of a single-spanning membrane protein: NMR and mutational analysis, Biochemistry 2001 Aug;40(33):9993-10000.

Sekowska A, Mulard L, Krogh S, Tse JK, Danchin A, MtnK, methylthioribose kinase, is a starvation-induced protein in Bacillus subtilis, BMC Microbiol. 2001;1:15.

Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M., X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution., J Mol Biol. 2001 Aug 3;311(1):87-100..

Thullier P, Demangel C, Bedouelle H, Mégret F, Jouan A, Deubel V, Mazié JC, Lafaye P, Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanism, J. Gen. Virol. 2001 Aug;82(Pt 8):1885-92.

Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M, X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution, J. Mol. Biol. 2001 Aug;311(1):87-100.

Vastmans K, Froeyen M, Kerremans L, Pochet S, Herdewijn P, Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides, Nucleic Acids Res. 2001 Aug;29(15):3154-63.

Petrella S, Clermont D, Casin I, Jarlier V, Sougakoff W, Novel class A beta-lactamase Sed-1 from Citrobacter sedlakii: genetic diversity of beta-lactamases within the Citrobacter genus, Antimicrob. Agents Chemother. 2001 Aug;45(8):2287-98.

Pernot L, Frénois F, Rybkine T, L'Hermite G, Petrella S, Delettré J, Jarlier V, Collatz E, Sougakoff W, Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem, J. Mol. Biol. 2001 Jul;310(4):859-74.

Arimondo PB, Bailly C, Boutorine AS, Moreau P, Prudhomme M, Sun JS, Garestier T, Hélène C, Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase I-mediated DNA cleavage to a specific site, Bioconjug. Chem. 2001 Jul-Aug;12(4):501-9.

Nizard P, Chenal A, Beaumelle B, Fourcade A, Gillet D, Prolonged display or rapid internalization of the IgG-binding protein ZZ anchored to the surface of cells using the diphtheria toxin T domain, Protein Eng. 2001 Jun;14(6):439-46.

Munier-Lehmann H, Chaffotte A, Pochet S, Labesse G, Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes, Protein Sci. 2001 Jun;10(6):1195-205.

Eckenberg R, Rose T, Moreau JL, Weil R, Gesbert F, Dubois S, Tello D, Bossus M, Gras H, Tartar A, Bertoglio J, Chouaïb S, Jacques Y, Alzari PM, Thèze J, Characterization of an IL-2 mimetic with therapeutic potential, Cell. Mol. Biol. (Noisy-le-grand) 2001 Jun;47(4):703-7.

Seddiki N, Nato F, Lafaye P, Amoura Z, Piette JC, Mazié JC, Calreticulin, a potential cell surface receptor involved in cell penetration of anti-DNA antibodies, J. Immunol. 2001 May;166(10):6423-9.

Schneider B, Meyer P, Sarfati S, Mulard L, Guerreiro C, Boretto J, Janin J, Véron M, Deville-Bonne D, Canard B, Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: improvement by alpha-boranophosphate substitution, Nucleosides Nucleotides Nucleic Acids 2001 Apr-Jul;20(4-7):297-306.

Paris G, Cremona ML, Amaya MF, Buschiazzo A, Giambiagi S, Frasch AC, Alzari PM, Probing molecular function of trypanosomal sialidases: single point mutations can change substrate specificity and increase hydrolytic activity, Glycobiology 2001 Apr;11(4):305-11.

Mergny JL, Lacroix L, Teulade-Fichou MP, Hounsou C, Guittat L, Hoarau M, Arimondo PB, Vigneron JP, Lehn JM, Riou JF, Garestier T, Hélène C, Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay, Proc. Natl. Acad. Sci. U.S.A. 2001 Mar;98(6):3062-7.

Pitcovsky TA, Mucci J, Alvarez P, Leguizamón MS, Burrone O, Alzari PM, Campetella O, Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants, Infect. Immun. 2001 Mar;69(3):1869-75.

Koeppel F, Riou JF, Laoui A, Mailliet P, Arimondo PB, Labit D, Petitgenet O, Hélène C, Mergny JL, Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes, Nucleic Acids Res. 2001 Mar;29(5):1087-96.

Lo-Man R, Vichier-Guerre S, Bay S, Dériaud E, Cantacuzène D, Leclerc C, Anti-tumor immunity provided by a synthetic multiple antigenic glycopeptide displaying a tri-Tn glycotope, J. Immunol. 2001 Feb;166(4):2849-54.

Arimondo PB, Garestier T, Hélène C, Sun JS, Detection of competing DNA structures by thermal gradient gel electrophoresis: from self-association to triple helix formation by (G,A)-containing oligonucleotides, Nucleic Acids Res. 2001 Feb;29(4):E15.

Inoue M, Takahashi S, Yamashina I, Kaibori M, Okumura T, Kamiyama Y, Vichier-Guerre S, Cantacuzène D, Nakada H, High density O-glycosylation of the MUC2 tandem repeat unit by N-acetylgalactosaminyltransferase-3 in colonic adenocarcinoma extracts, Cancer Res. 2001 Feb;61(3):950-6.

Nizard P, Gross DA, Chenal A, Beaumelle B, Kosmatopoulos K, Gillet D, [Anchoring cytokines to cancer cells using diphtheria toxin: better than immunotherapy by gene transfer?], J. Soc. Biol. 2001;195(3):229-34.

Miron S, Munier-Lehmann H, Craescu CT, 1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase, J. Biomol. NMR 2001 Jan;19(1):89-90.

Karimova G, Ullmann A, Ladant D, Protein-protein interaction between Bacillus stearothermophilus tyrosyl-tRNA synthetase subdomains revealed by a bacterial two-hybrid system, J. Mol. Microbiol. Biotechnol. 2001 Jan;3(1):73-82.

Arimondo PB, Bailly C, Boutorine AS, Ryabinin VA, Syniakov AN, Sun JS, Garestier T, Hélène C, Directing topoisomerase I mediated DNA cleavage to specific sites by camptothecin tethered to minor- and major-groove ligands, Angew. Chem. Int. Ed. Engl. 2001;40(16):3045-8.

Selmi B, Boretto J, Navarro JM, Sire J, Longhi S, Guerreiro C, Mulard L, Sarfati S, Canard B, The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance, J. Biol. Chem. 2001 Apr;276(17):13965-74.

Francetic O, Belin D, Badaut C, Pugsley AP, Expression of the endogenous type II secretion pathway in Escherichia coli leads to chitinase secretion, EMBO J. 2000 Dec;19(24):6697-703.

Arimondo PB, Riou JF, Mergny JL, Tazi J, Sun JS, Garestier T, Hélène C, Interaction of human DNA topoisomerase I with G-quartet structures, Nucleic Acids Res. 2000 Dec;28(24):4832-8.

Dautin N, Karimova G, Ullmann A, Ladant D, Sensitive genetic screen for protease activity based on a cyclic AMP signaling cascade in Escherichia coli, J. Bacteriol. 2000 Dec;182(24):7060-6.

Pritsch O, Magnac C, Dumas G, Bouvet JP, Alzari P, Dighiero G, Can isotype switch modulate antigen-binding affinity and influence clonal selection?, Eur. J. Immunol. 2000 Dec;30(12):3387-95.

Arimondo P, Boukarim C, Bailly C, Dauzonne D, Monneret C, Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity, Anticancer Drug Des. 2000 Dec;15(6):413-21.

Sukumar N, Boulé JB, Expert-Bezançon N, Jourdan N, Lescar J, Rougeon F, Papanicolaou C, Delarue M., Crystallization of the catalytic domain of murine terminal deoxynucleotidyl transferase., Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1662-4..

Sadir R, Baleux F, Grosdidier A, Imberty A, Lortat-Jacob H, Characterization of the stromal cell-derived factor-1alpha-heparin complex, J. Biol. Chem. 2001 Mar;276(11):8288-96.

Arimondo PB, Gelus N, Hamy F, Payet D, Travers A, Bailly C, The chromosomal protein HMG-D binds to the TAR and RBE RNA of HIV-1, FEBS Lett. 2000 Nov;485(1):47-52.

Arnoux P, Haser R, Izadi-Pruneyre N, Lecroisey A, Czjzek M, Functional aspects of the heme bound hemophore HasA by structural analysis of various crystal forms, Proteins 2000 Nov;41(2):202-10.

Roux M, Beswick V, Coïc YM, Huynh-Dinh T, Sanson A, Neumann JM, PMP1 18-38, a yeast plasma membrane protein fragment, binds phosphatidylserine from bilayer mixtures with phosphatidylcholine: a (2)H-NMR study, Biophys. J. 2000 Nov;79(5):2624-31.

Ladant D, Karimova G, Genetic systems for analyzing protein-protein interactions in bacteria, Res. Microbiol. 2000 Nov;151(9):711-20.

Scheiden R, Knolle U, Wagener C, Wehenkel AM, Capesius C, Cervical cancer screening in Luxembourg, Eur. J. Cancer 2000 Nov;36(17):2240-3.

Delarue M, Orland H., General formalism for phase combination and phase refinement: a statistical thermodynamics approach in reciprocal space., Acta Crystallogr A. 2000 Nov;56(Pt 6):562-74. Erratum in: Acta Crystallogr A. 2001 Jan;57(Pt 1):118..

Delarue M., Resolution of the phase-ambiguity problem in the centrosymmetric P [1] space group by Monte Carlo methods., Acta Crystallogr A. 2000 Nov;56(Pt 6):554-61..

Vastmans K, Pochet S, Peys A, Kerremans L, Van Aerschot A, Hendrix C, Marlière P, Herdewijn P, Enzymatic incorporation in DNA of 1,5-anhydrohexitol nucleotides, Biochemistry 2000 Oct;39(42):12757-65.

Karimova G, Ullmann A, Ladant D, Bordetella pertussis adenylate cyclase toxin as a tool to analyze molecular interactions in a bacterial two-hybrid system, Int. J. Med. Microbiol. 2000 Oct;290(4-5):441-5.

Costachel C, Sansonetti PJ, Mulard LA, Linear synthesis of the methyl glycosides of tetra- and pentasaccharide fragments specific for the Shigella flexneri serotype 2a O-antigen, J. Carbohydr. Chem. 2000; 19: 1131-50.

Arimondo P, Bailly C, Boutorine A, Asseline U, Sun JS, Garestier T, Hélène C, Linkage of a triple helix-forming oligonucleotide to amsacrine-4-carboxamide derivatives modulates the sequence-selectivity of topoisomerase II-mediated DNA cleavage, Nucleosides Nucleotides Nucleic Acids 2000 Aug;19(8):1205-18.

Villeneuve S, Souchon H, Riottot MM, Mazie JC, Lei P, Glaudemans CP, Kovác P, Fournier JM, Alzari PM, Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity, Proc. Natl. Acad. Sci. U.S.A. 2000 Jul;97(15):8433-8.

Lascombe MB, Grégoire C, Poncet P, Tavares GA, Rosinski-Chupin I, Rabillon J, Goubran-Botros H, Mazié JC, David B, Alzari PM, Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes, J. Biol. Chem. 2000 Jul;275(28):21572-7.

Bada M, Walther D, Arcangioli B, Doniach S, Delarue M., Solution structural studies and low-resolution model of the Schizosaccharomyces pombe sap1 protein., J Mol Biol. 2000 Jul 14;300(3):563-74..

Rees B, Webster G, Delarue M, Boeglin M, Moras D., Aspartyl tRNA-synthetase from Escherichia coli: flexibility and adaptability to the substrates., J Mol Biol. 2000 Jun 23;299(5):1157-64..

D. Franz, M. Hollenstein, Ch. Hollenstein, Diborane nitrogenrammonia plasma chemistry investigated by infrared absorption spectroscopy, Thin Solid Films 2000, 379, 37-44.

Oppezzo P, Osinaga E, Tello D, Bay S, Cantacuzene D, Irigoín F, Ferreira A, Roseto A, Cayota A, Alzari P, Pritsch O, Production and functional characterization of two mouse/human chimeric antibodies with specificity for the tumor-associated Tn-antigen, Hybridoma 2000 Jun;19(3):229-39.

Lacroix L, Arimondo PB, Takasugi M, Hélène C, Mergny JL, Pyrimidine morpholino oligonucleotides form a stable triple helix in the absence of magnesium ions, Biochem. Biophys. Res. Commun. 2000 Apr;270(2):363-9.

Cardoso DF, Nato F, England P, Ferreira ML, Vaughan TJ, Mota I, Mazie JC, Choumet V, Lafaye P, Neutralizing human anti crotoxin scFv isolated from a nonimmunized phage library, Scand. J. Immunol. 2000 Apr;51(4):337-44.

Arimondo PB, Moreau P, Boutorine A, Bailly C, Prudhomme M, Sun JS, Garestier T, Hélène C, Recognition and cleavage of DNA by rebeccamycin- or benzopyridoquinoxaline conjugated of triple helix-forming oligonucleotides, Bioorg. Med. Chem. 2000 Apr;8(4):777-84.

Francetic O, Badaut C, Rimsky S, Pugsley AP, The ChiA (YheB) protein of Escherichia coli K-12 is an endochitinase whose gene is negatively controlled by the nucleoid-structuring protein H-NS, Mol. Microbiol. 2000 Mar;35(6):1506-17.

Mispelter J, Izadi-Pruneyre N, Quiniou E, Adjadj E, Simple and accurate determination of global tau(R) in proteins using (13)C or (15)N relaxation data, J. Magn. Reson. 2000 Mar;143(1):229-32.

Osinaga E, Bay S, Tello D, Babino A, Pritsch O, Assemat K, Cantacuzene D, Nakada H, Alzari P, Analysis of the fine specificity of Tn-binding proteins using synthetic glycopeptide epitopes and a biosensor based on surface plasmon resonance spectroscopy, FEBS Lett. 2000 Mar;469(1):24-8.

Medeiros A, Bianchi S, Calvete JJ, Balter H, Bay S, Robles A, Cantacuzène D, Nimtz M, Alzari PM, Osinaga E, Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds, Eur. J. Biochem. 2000 Mar;267(5):1434-40.

Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M, Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis, Acta Crystallogr. D Biol. Crystallogr. 2000 Feb;56(Pt 2):226-8.

Vichier-Guerre S, Lo-Man R, Bay S, Deriaud E, Nakada H, Leclerc C, Cantacuzène D, Short synthetic glycopeptides successfully induce antibody responses to carcinoma-associated Tn antigen, J. Pept. Res. 2000 Feb;55(2):173-80.

Eckenberg R, Rose T, Moreau JL, Weil R, Gesbert F, Dubois S, Tello D, Bossus M, Gras H, Tartar A, Bertoglio J, Chouaïb S, Goldberg M, Jacques Y, Alzari PM, Thèze J, The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells, J. Exp. Med. 2000 Feb;191(3):529-40.

Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M., Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis., Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):226-8..

Morfin R, Lafaye P, Cotillon AC, Nato F, Chmielewski V, Pompon D, 7 alpha-hydroxy-dehydroepiandrosterone and immune response, Ann. N. Y. Acad. Sci. 2000;917:971-82.

Lazarini F, Casanova P, Tham TN, De Clercq E, Arenzana-Seisdedos F, Baleux F, Dubois-Dalcq M, Differential signalling of the chemokine receptor CXCR4 by stromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes, Eur. J. Neurosci. 2000 Jan;12(1):117-25.

Castellani RJ, Harris PL, Lecroisey A, Izadi-Pruneyre N, Wandersman C, Perry G, Smith MA, Evidence for a novel heme-binding protein, HasAh, in Alzheimer disease, Antioxid. Redox Signal. 2000;2(1):137-42.

Mulard LA, Ughetto-Monfrin J, Linear synthesis of the methyl glycosides of tri-, tetra-, and pentasaccharide fragments of the Shigella flexneri serotype 5a O-antigen, J Carbohydr Chem 2000; 19: 503-26.

Mulard LA, Ughetto-Monfrin J, First synthesis of a branched pentasaccharide representative of the repeating unit of the Shigella flexneri serotype 5a O-antigen, J Carbohydr Chem 2000; 19: 193-220.

Karimova G, Ullmann A, Ladant D, A bacterial two-hybrid system that exploits a cAMP signaling cascade in Escherichia coli, Meth. Enzymol. 2000;328:59-73.

Guermonprez P, Fayolle C, Karimova G, Ullmann A, Leclerc C, Ladant D, Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells., Methods Enzymol 2000 ; 326(): 527-42.

Buschiazzo A, Tavares GA, Campetella O, Spinelli S, Cremona ML, París G, Amaya MF, Frasch AC, Alzari PM, Structural basis of sialyltransferase activity in trypanosomal sialidases, EMBO J. 2000 Jan;19(1):16-24.

Delepierre M, Prochnicka-Chalufour A, Boisbouvier J, Possani LD, Pi7, an orphan peptide from the scorpion Pandinus imperator: a 1H-NMR analysis using a nano-NMR Probe, Biochemistry 1999 Dec;38(51):16756-65.

Radoja S, Francetić O, Stojićević N, Morić I, Glisin V, Konstantinović M, DNA region responsible for transcriptional regulation of the Escherichia coli penicillin amidase (pac) gene by CRP and PAA, Genet. Anal. 1999 Dec;15(6):235-8.

Lafaye P, Chmielewski V, Nato F, Mazié JC, Morfin R, The 7alpha-hydroxysteroids produced in human tonsils enhance the immune response to tetanus toxoid and Bordetella pertussis antigens, Biochim. Biophys. Acta 1999 Oct;1472(1-2):222-31.

Braun L, Nato F, Payrastre B, Mazié JC, Cossart P, The 213-amino-acid leucine-rich repeat region of the listeria monocytogenes InlB protein is sufficient for entry into mammalian cells, stimulation of PI 3-kinase and membrane ruffling, Mol. Microbiol. 1999 Oct;34(1):10-23.

Mills M, Arimondo PB, Lacroix L, Garestier T, Hélène C, Klump H, Mergny JL, Energetics of strand-displacement reactions in triple helices: a spectroscopic study, J. Mol. Biol. 1999 Sep;291(5):1035-54.

Villeneuve S, Boutonnier A, Mulard LA, Fournier JM, Immunochemical characterization of an Ogawa-Inaba common antigenic determinant of Vibrio cholerae O1, Microbiology (Reading, Engl.) 1999 Sep;145 ( Pt 9):2477-84.

Arimondo PB, Bailly C, Boutorine A, Sun JS, Garestier T, Hélène C, Targeting topoisomerase I cleavage to specific sequences of DNA by triple helix-forming oligonucleotide conjugates. A comparison between a rebeccamycin derivative and camptothecin, C. R. Acad. Sci. III, Sci. Vie 1999 Sep;322(9):785-90.

Amara A, Lorthioir O, Valenzuela A, Magerus A, Thelen M, Montes M, Virelizier JL, Delepierre M, Baleux F, Lortat-Jacob H, Arenzana-Seisdedos F, Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine, J. Biol. Chem. 1999 Aug;274(34):23916-25.

Létoffé S, Nato F, Goldberg ME, Wandersman C, Interactions of HasA, a bacterial haemophore, with haemoglobin and with its outer membrane receptor HasR, Mol. Microbiol. 1999 Aug;33(3):546-55.

Munier-Lehmann H, Burlacu-Miron S, Craescu CT, Mantsch HH, Schultz CP, A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study, Proteins 1999 Aug;36(2):238-48.

Pistotnik E, Sakamoto H, Pochet S, Namane A, Bârzu O, Assay of nucleoside 2-deoxyribosyltransferase activity with pyruvate kinase/lactate dehydrogenase coupling system, Anal. Biochem. 1999 Jul;271(2):192-3.

Izadi-Pruneyre N, Wolff N, Castagné C, Czisch M, Wandersman C, Delepierre M, Lecroisey A, Backbone NMR assignment and secondary structure of the 19 kDa hemophore HasA, J. Biomol. NMR 1999 Jun;14(2):193-4.

Arnoux P, Haser R, Izadi N, Lecroisey A, Delepierre M, Wandersman C, Czjzek M, The crystal structure of HasA, a hemophore secreted by Serratia marcescens, Nat. Struct. Biol. 1999 Jun;6(6):516-20.

Barale JC, Blisnick T, Fujioka H, Alzari PM, Aikawa M, Braun-Breton C, Langsley G, Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase, Proc. Natl. Acad. Sci. U.S.A. 1999 May;96(11):6445-50.

Choumet V, Lafaye P, Demangel C, Bon C, Mazié JC, Molecular mimicry between a monoclonal antibody and one subunit of crotoxin, a heterodimeric phospholipase A2 neurotoxin, Biol. Chem. 1999 May;380(5):561-8.

Thullier P, Lafaye P, Mégret F, Deubel V, Jouan A, Mazié JC, A recombinant Fab neutralizes dengue virus in vitro, J. Biotechnol. 1999 Apr;69(2-3):183-90.

Izadi-Pruneyre N, Wolff N, Redeker V, Wandersman C, Delepierre M, Lecroisey A, NMR studies of the C-terminal secretion signal of the haem-binding protein, HasA, Eur. J. Biochem. 1999 Apr;261(2):562-8.

Lo-Man R, Bay S, Vichier-Guerre S, Dériaud E, Cantacuzène D, Leclerc C, A fully synthetic immunogen carrying a carcinoma-associated carbohydrate for active specific immunotherapy, Cancer Res. 1999 Apr;59(7):1520-4.

Marina A, Alzari PM, Bravo J, Uriarte M, Barcelona B, Fita I, Rubio V, Carbamate kinase: New structural machinery for making carbamoyl phosphate, the common precursor of pyrimidines and arginine, Protein Sci. 1999 Apr;8(4):934-40.

Grégoire C, Tavares GA, Lorenzo HK, Dandeu JP, David B, Alzari PM, Crystallization and preliminary crystallographic analysis of the major horse allergen Equ c 1, Acta Crystallogr. D Biol. Crystallogr. 1999 Apr;55(Pt 4):880-2.

Saint-Joanis B, Souchon H, Wilming M, Johnsson K, Alzari PM, Cole ST, Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis, Biochem. J. 1999 Mar;338 ( Pt 3):753-60.

Guermonprez P, Ladant D, Karimova G, Ullmann A, Leclerc C, Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway., J Immunol 1999 Feb; 162(4): 1910-6.

Maté MJ, Zamocky M, Nykyri LM, Herzog C, Alzari PM, Betzel C, Koller F, Fita I, Structure of catalase-A from Saccharomyces cerevisiae, J. Mol. Biol. 1999 Feb;286(1):135-49.

Susin SA, Lorenzo HK, Zamzami N, Marzo I, Brenner C, Larochette N, Prévost MC, Alzari PM, Kroemer G, Mitochondrial release of caspase-2 and -9 during the apoptotic process, J. Exp. Med. 1999 Jan;189(2):381-94.

Beswick V, Guerois R, Cordier-Ochsenbein F, Coïc YM, Tam HD, Tostain J, Noël JP, Sanson A, Neumann JM, Dodecylphosphocholine micelles as a membrane-like environment: new results from NMR relaxation and paramagnetic relaxation enhancement analysis, Eur. Biophys. J. 1999;28(1):48-58.

Mulard LA, Ughetto-Monfrin J, Synthesis of the methyl glycosides of a tri- and tetrasaccharide fragment specific for the Shigella flexneri serotype 5a O-antigen. A reinvestigation, J Carbohydr Chem 1999; 18: 721-53.

Arimondo PB, Barcelo F, Sun JS, Maurizot JC, Garestier T, Hélène C, Triple helix formation by (G,A)-containing oligonucleotides: asymmetric sequence effect, Biochemistry 1998 Nov;37(47):16627-35.

Delepierre M, Prochnicka-Chalufour A, Possani LD, 1H NMR structural analysis of novel potassium blocking toxins using a nano-NMR probe, Toxicon 1998 Nov;36(11):1599-608.

Arimondo PB, Calderazzo F, Hiemeyer R, Maichle-Mössmer C, Marchetti F, Pampaloni G, Strähle J, Synthesis and Crystal Structure of a Self-Assembled, Octanuclear Oxo-Tantalum(V) Derivative Containing the First Example of a Transition Metal M(8)(&mgr;-O)(12) Cage, Inorg Chem 1998 Oct;37(21):5507-5511.

Karimova G, Fayolle C, Gmira S, Ullmann A, Leclerc C, Ladant D, Charge-dependent translocation of Bordetella pertussis adenylate cyclase toxin into eukaryotic cells: implication for the in vivo delivery of CD8(+) T cell epitopes into antigen-presenting cells, Proc. Natl. Acad. Sci. U.S.A. 1998 Oct;95(21):12532-7.

Boisbouvier J, Prochnicka-Chalufour A, Nieto AR, Torres JA, Nanard N, Rodriguez MH, Possani LD, Delepierre M, Structural information on a cecropin-like synthetic peptide, Shiva-3 toxic to the sporogonic development of Plasmodium berghei, Eur. J. Biochem. 1998 Oct;257(1):263-73.

Mulard LA, Glaudemans CP, Synthesis of tri- and tetrasaccharide fragments of the Shigella dysenteriae type 1 O-antigen deoxygenated and fluorinated at position 3 of the methyl alpha-D-galactopyranoside terminus, Carbohydr. Res. 1998 Sep;311(3):121-33.

Terenzi H, Alzari PM, Zakin MM, Structural features involved in the formation of a complex between the monomeric or the dimeric form of the rev-erb beta DNA-binding domain and its DNA reactive sites, Biochemistry 1998 Aug;37(33):11488-95.

Choumet V, Lafaye P, Mazié JC, Bon C, A monoclonal antibody directed against the non-toxic subunit of a dimeric phospholipase A2 neurotoxin, crotoxin, neutralizes its toxicity, Biol. Chem. 1998 Jul;379(7):899-906.

Wehmeier L, Schäfer A, Burkovski A, Krämer R, Mechold U, Malke H, Pühler A, Kalinowski J, The role of the Corynebacterium glutamicum rel gene in (p)ppGpp metabolism, Microbiology (Reading, Engl.) 1998 Jul;144 ( Pt 7):1853-62.

Miller CE, Mulard LA, Padlan EA, Glaudemans CP, Binding of modified fragments of the Shigella dysenteriae type 1 O-specific polysaccharide to monoclonal IgM 3707 E9 and docking of the immunodeterminant to its modeled Fv, Carbohydr. Res. 1998 Jul;309(3):219-26.

Koehl P, and Delarue M., Minimisation of protein lattice distortion based on self-consitent mean-field theory., J. Chem. Phys. 1998 108:9540-49..

Karimova G, Pidoux J, Ullmann A, Ladant D, A bacterial two-hybrid system based on a reconstituted signal transduction pathway, Proc. Natl. Acad. Sci. U.S.A. 1998 May;95(10):5752-6.

Beswick V, Roux M, Navarre C, Coïc YM, Huynh-Dinh T, Goffeau A, Sanson A, Neumann JM, 1H- and 2H-NMR studies of a fragment of PMP1, a regulatory subunit associated with the yeast plasma membrane H(+)-ATPase. Conformational properties and lipid-peptide interactions, Biochimie 1998 May-Jun;80(5-6):451-9.

Béguin P, Alzari PM, The cellulosome of Clostridium thermocellum, Biochem. Soc. Trans. 1998 May;26(2):178-85.

Geuijen CA, Willems RJ, Hoogerhout P, Puijk WC, Meloen RH, Mooi FR, Identification and characterization of heparin binding regions of the Fim2 subunit of Bordetella pertussis., Infect Immun 1998 May; 66(5): 2256-63.

Pugsley AP, Francetic O, Protein secretion in Escherichia coli K-12: dead or alive?, Cell. Mol. Life Sci. 1998 Apr;54(4):347-52.

Francetić O, Lory S, Pugsley AP, A second prepilin peptidase gene in Escherichia coli K-12, Mol. Microbiol. 1998 Feb;27(4):763-75.

Guijarro JI, Djavadi-Ohaniance L, Baleux F, Delepierre M, Goldberg ME, Does a peptide bound to a monoclonal antibody always adopt a unique conformation?, Res. Immunol. 1998 Feb;149(2):127-37.

Wang J, Villeneuve S, Zhang J, Lei P, Miller CE, Lafaye P, Nato F, Szu SC, Karpas A, Bystricky S, Robbins JB, Kovác P, Fournier JM, Glaudemans CP, On the antigenic determinants of the lipopolysaccharides of Vibrio cholerae O:1, serotypes Ogawa and Inaba, J. Biol. Chem. 1998 Jan;273(5):2777-83.

Demangel C, Rouyre S, Alzari PM, Nato F, Longacre S, Lafaye P, Mazie JC, Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate, Biol. Chem. 1998 Jan;379(1):65-70.

Guillouard I, Alzari PM, Saliou B, Cole ST, The carboxy-terminal C2-like domain of the alpha-toxin from Clostridium perfringens mediates calcium-dependent membrane recognition, Mol. Microbiol. 1997 Dec;26(5):867-76.

Tavares GA, Béguin P, Alzari PM, The crystal structure of a type I cohesin domain at 1.7 A resolution, J. Mol. Biol. 1997 Oct;273(3):701-13.

Muller BH, Lafay F, Demangel C, Perrin P, Tordo N, Flamand A, Lafaye P, Guesdon JL, Phage-displayed and soluble mouse scFv fragments neutralize rabies virus, J. Virol. Methods 1997 Sep;67(2):221-33.

Barale JC, Candelle D, Attal-Bonnefoy G, Dehoux P, Bonnefoy S, Ridley R, Pereira da Silva L, Langsley G, Plasmodium falciparum AARP1, a giant protein containing repeated motifs rich in asparagine and aspartate residues, is associated with the infected erythrocyte membrane, Infect. Immun. 1997 Aug;65(8):3003-10.

Babino A, Pritsch O, Oppezzo P, Du Pasquier R, Roseto A, Osinaga E, Alzari PM, Molecular cloning of a monoclonal anti-tumor antibody specific for the Tn antigen and expression of an active single-chain Fv fragment, Hybridoma 1997 Aug;16(4):317-24.

Osinaga E, Tello D, Batthyany C, Bianchet M, Tavares G, Durán R, Cerveñansky C, Camoin L, Roseto A, Alzari PM, Amino acid sequence and three-dimensional structure of the Tn-specific isolectin B4 from Vicia villosa, FEBS Lett. 1997 Jul;412(1):190-6.

Lorenzo HK, Farber D, Germain V, Acuto O, Alzari PM, The MBP fusion protein restores the activity of the first phosphatase domain of CD45, FEBS Lett. 1997 Jul;411(2-3):231-5.

Eckenberg R, Xu D, Moreau JL, Bossus M, Mazie JC, Tartar A, Liu XY, Alzari PM, Bertoglio J, Theze J, Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix-A of IL-2, Cytokine 1997 Jul;9(7):488-98.

Pugsley AP, Francetic O, Possot OM, Sauvonnet N, Hardie KR, Recent progress and future directions in studies of the main terminal branch of the general secretory pathway in Gram-negative bacteria–a review, Gene 1997 Jun;192(1):13-9.

Izadi N, Henry Y, Haladjian J, Goldberg ME, Wandersman C, Delepierre M, Lecroisey A, Purification and characterization of an extracellular heme-binding protein, HasA, involved in heme iron acquisition, Biochemistry 1997 Jun;36(23):7050-7.

Lafaye P, Choumet V, Demangel C, Bon C, Mazié JC, Biologically active human anti-crotoxin scFv isolated from a semi-synthetic phage library, Immunotechnology 1997 Jun;3(2):117-25.

Karimova G, Ullmann A, Characterization of DNA binding sites for the BvgA protein of Bordetella pertussis, J. Bacteriol. 1997 Jun;179(11):3790-2.

Delarue M, Koehl P., The inverse protein folding problem: self-consistent mean field optimisation of a structure specific mutation matrix., Pac Symp Biocomput. 1997:109-21..

Koehl P, Delarue M., The native sequence determines sidechain packing in a protein, but does optimal sidechain packing determine the native sequence?, Pac Symp Biocomput. 1997:198-209..

Mechold U, Malke H, Characterization of the stringent and relaxed responses of Streptococcus equisimilis, J. Bacteriol. 1997 Apr;179(8):2658-67.

Delepierre M, Prochnicka-Chalufour A, Possani LD, A novel potassium channel blocking toxin from the scorpion Pandinus imperator: A 1H NMR analysis using a nano-NMR probe, Biochemistry 1997 Mar;36(9):2649-58.

Berthet S, Nykyri LM, Bravo J, Mate MJ, Berthet-Colominas C, Alzari PM, Koller F, Fita I, Crystallization and preliminary structural analysis of catalase A from Saccharomyces cerevisiae, Protein Sci. 1997 Feb;6(2):481-3.

Diaw L, Magnac C, Pritsch O, Buckle M, Alzari PM, Dighiero G, Structural and affinity studies of IgM polyreactive natural autoantibodies, J. Immunol. 1997 Jan;158(2):968-76.

Pugsley AP, Francetic O, Hardie K, Possot OM, Sauvonnet N, Seydel A, Pullulanase: model protein substrate for the general secretory pathway of gram-negative bacteria, Folia Microbiol. (Praha) 1997;42(3):184-92.

Steiner K, Mechold U, Malke H, Elicitation of high (p)ppGpp levels in Streptococcus equisimilis without imposing nutritional deprivation, Adv. Exp. Med. Biol. 1997;418:991-3.

Coxon B, Sari N, Mulard LA, Kovàc P, Pozsgay V, Glaudemans CPJ, Investigation by NMR spectroscopy and molecular modeling of the conformations of some modified disaccharide antigens for Shigella dysenteriae type 1, J Carbohydr Chem 1997; 16: 927-46.

Gregoire C, Rosinski-Chupin I, Rabillon J, Alzari PM, David B, Dandeu JP, cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamily, J. Biol. Chem. 1996 Dec;271(51):32951-9.

Mengaud J, Lecuit M, Lebrun M, Nato F, Mazie JC, Cossart P, , Antibodies to the leucine-rich repeat region of internalin block entry of Listeria monocytogenes into cells expressing E-cadherin., Infect Immun 1996 Dec; 64(12): 5430-3.

Francetic O, Kumamoto CA, Escherichia coli SecB stimulates export without maintaining export competence of ribose-binding protein signal sequence mutants, J. Bacteriol. 1996 Oct;178(20):5954-9.

Thèze J, Alzari PM, Bertoglio J, Interleukin 2 and its receptors: recent advances and new immunological functions, Immunol. Today 1996 Oct;17(10):481-6.

Snewin VA, Khouri E, Mattei D, Tekaia F, Delarue M, Mendis KN, David PH., Cloning and characterisation of a gene from Plasmodium vivax and P. knowlesi: homology with valine-tRNA synthetase., Gene. 1996 Sep 16;173(2):137-45..

Sala M, Pezo V, Pochet S, Wain-Hobson S, Ambiguous base pairing of the purine analogue 1-(2-deoxy-beta-D-ribofuranosyl)-imidazole-4-carboxamide during PCR, Nucleic Acids Res. 1996 Sep;24(17):3302-6.

Lebrun M, Mengaud J, Ohayon H, Nato F, Cossart P, Internalin must be on the bacterial surface to mediate entry of Listeria monocytogenes into epithelial cells, Mol. Microbiol. 1996 Aug;21(3):579-92.

Demangel C, Lafaye P, Mazie JC, Reproducing the immune response against the Plasmodium vivax merozoite surface protein 1 with mimotopes selected from a phage-displayed peptide library, Mol. Immunol. 1996 Aug;33(11-12):909-16.

Francetic O, Pugsley AP, The cryptic general secretory pathway (gsp) operon of Escherichia coli K-12 encodes functional proteins, J. Bacteriol. 1996 Jun;178(12):3544-9.

Béguin P, Raynaud O, Chaveroche MK, Dridi A, Alzari PM, Subcloning of a DNA fragment encoding a single cohesin domain of the Clostridium thermocellum cellulosome-integrating protein CipA: purification, crystallization, and preliminary diffraction analysis of the encoded polypeptide, Protein Sci. 1996 Jun;5(6):1192-4.

Poch O, Delarue M., Converting sequence block alignments into structural insights., Methods Enzymol. 1996 266:662-80. Review..

Karimova G, Bellalou J, Ullmann A, Phosphorylation-dependent binding of BvgA to the upstream region of the cyaA gene of Bordetella pertussis, Mol. Microbiol. 1996 May;20(3):489-96.

Souchon H, Béguin P, Alzari PM, Crystallization of a family 8 cellulase from Clostridium thermocellum, Proteins 1996 May;25(1):134-6.

Domínguez R, Souchon H, Lascombe M, Alzari PM, The crystal structure of a family 5 endoglucanase mutant in complexed and uncomplexed forms reveals an induced fit activation mechanism, J. Mol. Biol. 1996 Apr;257(5):1042-51.

Koehl P, Delarue M., Mean-field minimization methods for biological macromolecules., Curr Opin Struct Biol. 1996 Apr;6(2):222-6. Review..

Alzari PM, Souchon H, Dominguez R, The crystal structure of endoglucanase CelA, a family 8 glycosyl hydrolase from Clostridium thermocellum, Structure 1996 Mar;4(3):265-75.

Mechold U, Cashel M, Steiner K, Gentry D, Malke H, Functional analysis of a relA/spoT gene homolog from Streptococcus equisimilis, J. Bacteriol. 1996 Mar;178(5):1401-11.

Strynadka NC, Jensen SE, Alzari PM, James MN, A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex, Nat. Struct. Biol. 1996 Mar;3(3):290-7.

Lafaye P, Nato F, Mazié JC, Doyen N, Similar binding properties for a neutralizing anti-tetanus toxoid human monoclonal antibody and its bacterially expressed Fab, Res. Immunol. 1996 Jan;147(1):61.

Pochet S, Marlière P, Construction of a self-complementary nucleoside from deoxyguanosine, C. R. Acad. Sci. III, Sci. Vie 1996 Jan;319(1):1-7.

Saul FA, Alzari PM, Crystallographic studies of antigen-antibody interactions, Methods Mol. Biol. 1996;66:11-23.

Assemat K, Alzari PM, Clément-Métral J, Conservative substitutions in the hydrophobic core of Rhodobacter sphaeroides thioredoxin produce distinct functional effects, Protein Sci. 1995 Dec;4(12):2510-6.

Guijarro JI, González-Pastor JE, Baleux F, San Millán JL, Castilla MA, Rico M, Moreno F, Delepierre M, Chemical structure and translation inhibition studies of the antibiotic microcin C7, J. Biol. Chem. 1995 Oct;270(40):23520-32.

Mulard LA, Claudemans CP, Synthesis of specifically deoxygenated disaccharide derivatives of the Shigella dysenteriae type 1 O-antigen, Carbohydr. Res. 1995 Sep;274:209-22.

Lescar J, Pellegrini M, Souchon H, Tello D, Poljak RJ, Peterson N, Greene M, Alzari PM, Crystal structure of a cross-reaction complex between Fab F9.13.7 and guinea fowl lysozyme, J. Biol. Chem. 1995 Jul;270(30):18067-76.

Lafaye P, Nato F, Mazié JC, Doyen N, Similar binding properties for a neutralizing anti-tetanus toxoid human monoclonal antibody and its bacterially expressed Fab, Res. Immunol. 1995 Jul-Aug;146(6):373-82.

Dominguez R, Souchon H, Spinelli S, Dauter Z, Wilson KS, Chauvaux S, Béguin P, Alzari PM, A common protein fold and similar active site in two distinct families of beta-glycanases, Nat. Struct. Biol. 1995 Jul;2(7):569-76.

Mosyak L, Reshetnikova L, Goldgur Y, Delarue M, Safro MG., Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus., Nat Struct Biol. 1995 Jul;2(7):537-47..

Delarue M., Partition of aminoacyl-tRNA synthetases in two different structural classes dating back to early metabolism: implications for the origin of the genetic code and the nature of protein sequences., J Mol Evol. 1995 Dec;41(6):703-11..

Delarue M, Koehl P., Atomic environment energies in proteins defined from statistics of accessible and contact surface areas., J Mol Biol. 1995 Jun 9;249(3):675-90..

Chitarra V, Souchon H, Spinelli S, Juy M, Béguin P, Alzari PM, Multiple crystal forms of endoglucanase CelD: signal peptide residues modulate lattice formation, J. Mol. Biol. 1995 Apr;248(2):225-32.

Chauvaux S, Souchon H, Alzari PM, Chariot P, Beguin P, Structural and functional analysis of the metal-binding sites of Clostridium thermocellum endoglucanase CelD, J. Biol. Chem. 1995 Apr;270(17):9757-62.

Smith LA, Olson MA, Lafaye PJ, Dolly JO, Cloning and expression of mamba toxins, Toxicon 1995 Apr;33(4):459-74.

Koehl P, Delarue M., A self consistent mean field approach to simultaneous gap closure and side-chain positioning in homology modelling., Nat Struct Biol. 1995 Feb;2(2):163-70..

Delarue M., Aminoacyl-tRNA synthetases., Curr Opin Struct Biol. 1995 Feb;5(1):48-55. Review..

Malke H, Steiner K, Gase K, Mechold U, Ellinger T, The streptokinase gene: allelic variation, genomic environment and expression control, Dev. Biol. Stand. 1995;85:183-93.

Heym B, Alzari PM, Honoré N, Cole ST, Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis, Mol. Microbiol. 1995 Jan;15(2):235-45.

Poterszman A*, Delarue M*, Thierry JC, Moras D., Synthesis and recognition of aspartyl-adenylate by Thermus thermophilus aspartyl-tRNA synthetase., J Mol Biol. 1994 Nov 25;244(2):158-67..

Jung S, Miranda EA, de Murcia JM, Niedergang C, Delarue M, Schulz GE, de Murcia GM., Crystallization and X-ray crystallographic analysis of recombinant chicken poly(ADP-ribose) polymerase catalytic domain produced in Sf9 insect cells., J Mol Biol. 1994 Nov 18;244(1):114-6..

Koehl P, Delarue M., Polar and nonpolar atomic environments in the protein core: implications for folding and binding., Proteins. 1994 Nov;20(3):264-78..

Lone YC, Bellio M, Prochnicka-Chalufour A, Ojcius DM, Boissel N, Ottenhoff TH, Klausner RD, Abastado JP, Kourilsky P, Role of the CDR1 region of the TCR beta chain in the binding to purified MHC-peptide complex, Int. Immunol. 1994 Oct;6(10):1561-5.

Guelpa-Fonlupt V, Bossy D, Alzari P, Fumoux F, Fougereau M, Schiff C, The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain, Mol. Immunol. 1994 Oct;31(14):1099-108.

Delarue M, Poterszman A, Nikonov S, Garber M, Moras D, Thierry JC., Crystal structure of a prokaryotic aspartyl tRNA-synthetase., EMBO J. 1994 Jul 15;13(14):3219-29..

Koehl P, Delarue M., Application of a self-consistent mean field theory to predict protein side-chains conformation and estimate their conformational entropy., J Mol Biol. 1994 Jun 3;239(2):249-75..

Mulard LA, Kovác P, Glaudemans CP, Synthesis of specifically monofluorinated ligands related to the O-polysaccharide of Shigella dysenteriae type 1, Carbohydr. Res. 1994 Jun;259(1):21-34.

Mulard LA, Kovác P, Glaudemans CP, Fluorination at position 6 of derivatives of methyl alpha-D-galactopyranoside, Carbohydr. Res. 1994 Jun;259(1):117-29.

Dominguez R, Souchon H, Alzari PM, Characterization of two crystal forms of Clostridium thermocellum endoglucanase CelC, Proteins 1994 Jun;19(2):158-60.

Müller R, Poch O, Delarue M, Bishop DH, Bouloy M., Rift Valley fever virus L segment: correction of the sequence and possible functional role of newly identified regions conserved in RNA-dependent polymerases., J Gen Virol. 1994 Jun;75 (Pt 6):1345-52..

Lescar J, Souchon H, Alzari PM, Crystal structures of pheasant and guinea fowl egg-white lysozymes, Protein Sci. 1994 May;3(5):788-98.

Hoog SS, Pawlowski JE, Alzari PM, Penning TM, Lewis M, Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily, Proc. Natl. Acad. Sci. U.S.A. 1994 Mar;91(7):2517-21.

Mazel D, Pochet S, Marlière P, Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation, EMBO J. 1994 Feb;13(4):914-23.

Malke H, Mechold U, Gase K, Gerlach D, Inactivation of the streptokinase gene prevents Streptococcus equisimilis H46A from acquiring cell-associated plasmin activity in the presence of plasminogen, FEMS Microbiol. Lett. 1994 Feb;116(1):107-12.

Souchon H, Spinelli S, Béguin P, Alzari PM, Crystallization and preliminary diffraction analysis of the catalytic domain of xylanase Z from Clostridium thermocellum, J. Mol. Biol. 1994 Jan;235(4):1348-50.

Mulard LA, Kovác P, Glaudemans CP, Synthesis of methyl O-alpha-L-rhamnopyranosyl-(1–>2)-alpha-D-galactopyranosides specifically deoxygenated at position 3, 4, or 6 of the galactose residue, Carbohydr. Res. 1994 Jan;251:213-32.

Spinelli S, Alzari PM, Structural implications of somatic mutations during the immune response to 2-phenyloxazolone, Res. Immunol. 1994 Jan;145(1):41-5.

Richaud C, Mengin-Lecreulx D, Pochet S, Johnson EJ, Cohen GN, Marlière P, Directed evolution of biosynthetic pathways. Recruitment of cysteine thioethers for constructing the cell wall of Escherichia coli, J. Biol. Chem. 1993 Dec;268(36):26827-35.

Mechold U, Steiner K, Vettermann S, Malke H, Genetic organization of the streptokinase region of the Streptococcus equisimilis H46A chromosome, Mol. Gen. Genet. 1993 Oct;241(1-2):129-40.

Delarue M, Moras D. Bioessays. 1993 Oct;15(10):675-87. Review, The aminoacyl-tRNA synthetase family: modules at work., Bioessays. 1993 Oct;15(10):675-87. Review.

Chitarra V, Alzari PM, Bentley GA, Bhat TN, Eiselé JL, Houdusse A, Lescar J, Souchon H, Poljak RJ, Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex, Proc. Natl. Acad. Sci. U.S.A. 1993 Aug;90(16):7711-5.

Mourey L, Samama JP, Delarue M, Petitou M, Choay J, Moras D., Crystal structure of cleaved bovine antithrombin III at 3.2 A resolution., J Mol Biol. 1993 Jul 5;232(1):223-41..

Francetić O, Hanson MP, Kumamoto CA, prlA suppression of defective export of maltose-binding protein in secB mutants of Escherichia coli, J. Bacteriol. 1993 Jul;175(13):4036-44.

Smith LA, Lafaye PJ, LaPenotiere HF, Spain T, Dolly JO, Cloning and functional expression of dendrotoxin K from black mamba, a K+ channel blocker, Biochemistry 1993 Jun;32(21):5692-7.

Simonin F, Poch O, Delarue M, de Murcia G., Identification of potential active-site residues in the human poly(ADP-ribose) polymerase., J Biol Chem. 1993 Apr 25;268(12):8529-35..

McFarland L, Francetić O, Kumamoto CA, A mutation of Escherichia coli SecA protein that partially compensates for the absence of SecB, J. Bacteriol. 1993 Apr;175(8):2255-62.

Kumamoto CA, Francetić O, Highly selective binding of nascent polypeptides by an Escherichia coli chaperone protein in vivo, J. Bacteriol. 1993 Apr;175(8):2184-8.

Eiselé JL, Tello D, Osinaga E, Roseto A, Alzari PM, Crystallization and preliminary crystallographic analysis of a tetrameric isolectin from Vicia villosa, specific for the Tn antigen, J. Mol. Biol. 1993 Mar;230(2):670-2.

Lescar J, Riottot MM, Souchon H, Chitarra V, Bentley GA, Navaza J, Alzari PM, Poljak RJ, Crystallization, preliminary X-ray diffraction study, and crystal packing of a complex between anti-hen lysozyme antibody F9.13.7 and guinea-fowl lysozyme, Proteins 1993 Feb;15(2):209-12.

Canica MM, Nato F, du Merle L, Mazie JC, Baranton G, Postic D, Monoclonal antibodies for identification of Borrelia afzelii sp. nov. associated with late cutaneous manifestations of Lyme borreliosis, Scand. J. Infect. Dis. 1993;25(4):441-8.

Czernecki S, Mulard L, Valery JM, Commercon A, Synthesis of 2′-deoxy-2′-spirocyclopropyl cytidine as potential inhibitor of Ribonucleoside Diphosphate Reductase, Can J Chem 1993; 71: 413-6.

Lascombe MB, Alzari PM, Poljak RJ, Nisonoff A, Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody, Proc. Natl. Acad. Sci. U.S.A. 1992 Oct;89(20):9429-33.

Reshetnikova L, Chernaya M, Ankilova V, Lavrik O, Delarue M, Thierry JC, Moras D, Safro M., Three-dimensional structure of phenylalanyl-transfer RNA synthetase from Thermus thermophilus HB8 at 0.6- nm resolution., Eur J Biochem. 1992 Sep 1;208(2):411-7..

Jaulin C, Romero P, Luescher IF, Casanova JL, Prochnicka-Chalufour A, Langlade-Demoyen P, Maryanski JL, Kourilsky P, Most residues on the floor of the antigen binding site of the class I MHC molecule H-2Kd influence peptide presentation, Int. Immunol. 1992 Aug;4(8):945-53.

Wiertz EJ, van Gaans-van den Brink JA, Gausepohl H, Prochnicka-Chalufour A, Hoogerhout P, Poolman JT, Identification of T cell epitopes occurring in a meningococcal class 1 outer membrane protein using overlapping peptides assembled with simultaneous multiple peptide synthesis, J. Exp. Med. 1992 Jul;176(1):79-88.

Pearce AM, Irons LI, Robinson A, Seabrook RN, Effects of guanidinium hydrochloride on the structure and immunological properties of Bordetella pertussis fimbriae., Biochem J 1992 May; 283 ( Pt 3)(Pt 3): 823-8.

M. Delarue, D. Moras, Aminoacyl-tRNA Synthetases: Partition into two Classes, Nucleic Acids and Molecular Biology vol 6 pp 203-224.

Nato F, Reich K, Lhopital S, Rouyre S, Geoffroy C, Mazie JC, Cossart P, Production and characterization of neutralizing and nonneutralizing monoclonal antibodies against listeriolysin O, Infect. Immun. 1991 Dec;59(12):4641-6.

Cherepanov PA, Mikhaĭlova TG, Karimova GA, Zakharova NM, Ershov IuV, Volkovoĭ KI, [Cloning and detailed mapping of the fra-ymt region of the Yersinia pestis pFra plasmid], Mol. Gen. Mikrobiol. Virusol. 1991 Dec;(12):19-26.

Delepierre M, Larvor MP, Baleux F, Goldberg ME, 1H-NMR conformational analysis of a high-affinity antigenic 11-residue peptide from the tryptophan synthase beta 2 subunit, Eur. J. Biochem. 1991 Nov;201(3):681-93.

Spinelli S, Liu QZ, Alzari PM, Hirel PH, Poljak RJ, The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU, Biochimie 1991 Nov;73(11):1391-6.

Brunel F, Alzari PM, Ferrara P, Zakin MM, Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein, Nucleic Acids Res. 1991 Oct;19(19):5237-45.

Devaux C, Defendini ML, Alzari PM, Abergel C, Granier C, Fontecilla-Camps JC, Alzar PM, Crystallization and preliminary X-ray diffraction data of the Fab fragment of a monoclonal antibody against apamin, a bee venom neurotoxin, FEBS Lett. 1991 Jul;286(1-2):64-6.

Tabary T, Prochnicka-Chalufour A, Cornillet P, Lehoang P, Betuel H, Cohen JH, [HLA-A29 sub-types and “Birdshot” choroido-retinopathy susceptibility: a possible “resistance motif” in the HLA-A29.1 molecule], C. R. Acad. Sci. III, Sci. Vie 1991;313(13):599-605.

Shmelev VA, Cherepanov PA, Nosova LIu, Karimova GA, Popov SG, Noskov AN, [Specific proteolysis by fibrinolysin-coagulase from Yersinia pestis of Yersinia pseudotuberculosis outer membrane proteins coded by the Ca(2+)-dependence plasmid], Mol. Gen. Mikrobiol. Virusol. 1991 Jan;(1):21-4.

Pochet S, D'Ari R, Synthesis and enzymatic polymerisation of 5-amino-1-(2′-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide-5′- triphosphate, Nucleic Acids Res. 1990 Dec;18(23):7127-31.

Jores R, Alzari PM, Meo T, Resolution of hypervariable regions in T-cell receptor beta chains by a modified Wu-Kabat index of amino acid diversity, Proc. Natl. Acad. Sci. U.S.A. 1990 Dec;87(23):9138-42.

Alzari PM, Spinelli S, Mariuzza RA, Boulot G, Poljak RJ, Jarvis JM, Milstein C, Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response, EMBO J. 1990 Dec;9(12):3807-14.

González-Quintial R, Baccalà R, Alzari PM, Nahmias C, Mazza G, Fougereau M, Avrameas S, Poly(Glu60Ala30Tyr10) (GAT)-induced IgG monoclonal antibodies cross-react with various self and non-self antigens through the complementarity determining regions. Comparison with IgM monoclonal polyreactive natural antibodies, Eur. J. Immunol. 1990 Nov;20(11):2383-7.

Eriani G, Delarue M, Poch O, Gangloff J, Moras D., Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs., Nature. 1990 Sep 13;347(6289):203-6..

Mourey L, Samama JP, Delarue M, Choay J, Lormeau JC, Petitou M, Moras D., Antithrombin III: structural and functional aspects., Biochimie. 1990 Aug;72(8):599-608. Review..

Delarue M, Samama J-P, Mourey L and Moras D., Crystal structure of cleaved bovine antithrombin III at 3.2 A resolution, Acta Cryst. (1990). B46: 550-556..

Delarue M, Poch O, Tordo N, Moras D, Argos P., An attempt to unify the structure of polymerases., Protein Eng. 1990 May;3(6):461-7..

Emod I, Lafaye P, Planchenault T, Lambert Vidmar S, Imhoff JM, Keil-Dlouha V, Potential proteolytic activity of fibronectin: fibronectin laminase and its substrate specificity, Biol. Chem. Hoppe-Seyler 1990 Feb;371(2):129-35.

Samama JP, Delarue M, Mourey L, Choay J, Moras D., Crystallization and preliminary crystallographic data for bovine antithrombin III., J Mol Biol. 1989 Dec 20;210(4):877-9..

Poch O, Sauvaget I, Delarue M, Tordo N., Identification of four conserved motifs among the RNA-dependent polymerase encoding elements., EMBO J. 1989 Dec 1;8(12):3867-74..

Bentley GA, Alzari PM, Amit AG, Boulot G, Guillon-Chitarra V, Fischmann T, Lascombe MB, Mariuzza RA, Poljak RJ, Riottot MM, Studies of structure and specificity of some antigen-antibody complexes, Philos. Trans. R. Soc. Lond., B, Biol. Sci. 1989 Jun;323(1217):487-94.

Leroy P, Alzari P, Sassoon D, Wolgemuth D, Fellous M, The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase, Cell 1989 May;57(4):549-59.

Prochnicka-Chalufour A, Casanova JL, Kourilsky P, Claverie JM, Extensive structural homology between H-2 K/D/L antigens and non-polymorphic class I Qa, Tla and “37” molecules suggests they may act as peptide carriers, Res. Immunol. 1989 Feb;140(2):133-44.

Arcangioli B, Pochet S, Sousa R, Huynh-Dinh T, Preparation and use of a universal primed Sepharose for the purification of DNA-binding proteins, Eur. J. Biochem. 1989 Feb;179(2):359-63.

M. Delarue and D. Moras, RNA Structure, Nucleic Acids and Molecular Biology vol. 3 pp 182-196.

Kourilsky P, Claverie JM, Prochnicka-Chalufour A, Spetz-Hagberg AL, Larsson-Sciard EL, How important is the direct recognition of polymorphic MHC residues by TCR in the generation of the T-cell repertoire?, Cold Spring Harb. Symp. Quant. Biol. 1989;54 Pt 1:93-103.

Claverie JM, Prochnicka-Chalufour A, Bougueleret L, Implications of a Fab-like structure for the T-cell receptor, Immunol. Today 1989 Jan;10(1):10-4.

Lascombe MB, Alzari PM, Boulot G, Saludjian P, Tougard P, Berek C, Haba S, Rosen EM, Nisonoff A, Poljak RJ, Three-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate group, Proc. Natl. Acad. Sci. U.S.A. 1989 Jan;86(2):607-11.

Adam S, Ridoux JP, Bourtayre P, Taillandier E, Pochet S, Huynh-Dinh T, Igolen J, IR and UV studies on stability and conformations of short DNA duplexes containing a no-base residue: coexistence of B and Z conformations, J. Biomol. Struct. Dyn. 1988 Aug;6(1):167-79.

Lafaye P, Lapresle C, Identification of two fixation sites for penicilloyl groups on the albumin molecule from penicillin-treated patients, FEBS Lett. 1988 Jul;234(2):305-8.

Lafaye P, Lapresle C, Fixation of penicilloyl groups to albumin and appearance of anti-penicilloyl antibodies in penicillin-treated patients, J. Clin. Invest. 1988 Jul;82(1):7-12.

, Diazepam for inappetence., Vet Rec 1988 Jun; 122(26): 640.

Pochet S, Arcangioli B, Huynh-Dinh T, Solid-supported ligation primer, Nucleic Acids Res. 1988 Feb;16(4):1619.

Alzari PM, Lascombe MB, Poljak RJ, Three-dimensional structure of antibodies, Annu. Rev. Immunol. 1988;6:555-80.

Guillon V, Alzari PM, Poljak RJ, Preliminary crystallographic study of a complex between an heteroclitic anti-hen egg-white lysozyme antibody and the heterologous antigen pheasant egg-white lysozyme, J. Mol. Biol. 1987 Sep;197(2):375-6.

Chalufour A, Bougueleret L, Claverie JM, Kourilsky P, Rare sequence motifs are common constituents of hypervariable antibody regions, Ann. Inst. Pasteur Immunol. 1987 Sep-Oct;138(5):671-85.

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