About

Presentation

The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs).

The LabEx core group is hosted on the Institut Pasteur campus with partners at Institut Cochin, Hôpital Necker and Hôpital Georges Pompidou in Paris. This strong scientific coalition focused on emerging infections is embedded in a network of institutions that are on the frontline of surveillance, analysis and control of emerging infectious diseases. Indeed strong partnerships have been established with Santé publique France (ex InVS) in charge of infectious diseases surveillance and prevention in France, Ecole Nationale Vétérinaire de Maisons-Alfort (ENVA) and Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (ANSES) that focuses on infections in the animal world, including understanding how pathogens breach host species barriers.

Download the Labex IBEID presentation document (PDF, 2.1MB)

Project outline

Research project
The major research orientations of the IBEID project are:

Exploring microbial diversity/complexity, detecting emergence
Surveillance of emerging infections needs to be based on a broad, exhaustive and evolving knowledge of the microbial world in its taxonomical, genetic and physiological dimensions, including mechanisms of resistance to drugs.
In this Labex, emphasis will be on:

  • Exploring complex flora in man and his environment.
  • Basic microbial genetics, physiology and metabolism with emphasis on the novel aspects of microbiology.
  • Diagnostic of emerging microorganisms and of the microbiological etiology of (chronic, inflammatory) diseases.
  • Resistance to anti-infectious agents.

Exploring host diversity/complexity upon confrontation with microbes
Medicine of tomorrow will become increasingly «personalized»; thus, genetic, environmental and physiological (i.e. age) parameters will be incorporated in preventive and therapeutic schemes. This will be true as well for infectious diseases and for the emerging theme of diseases appearing following individuals losing tolerance to their symbiotic microflora. Some situations like aging of the immune systems might create a new reservoir for infectious emergence.
In this Labex, emphasis will be on:

  • Genetics of host susceptibility to infectious agents and to severity of infections. Building a coherent and complementary approach in mice and men.
  • Age-dependent susceptibility to infections, the very young, the elderly.
  • Microbiota in health and disease.

Exploring host-microbe interactions, defining the species barrier to transmission of infectious agents, vectors, finding novel targets for vaccinology and therapeutics
Understanding disease mechanismsis key to understand « le génie des maladies infectieuses » as stated by Charles Nicolle to qualify the birth (emergence), life and death of infectious diseases.
In this Labex, emphasis will be on:

  • Exploring the disease mechanisms of emerging viruses (HIV, HCV, Flu, Dengue).
  • Understanding the molecular mechanisms by which pathogens cross the species barrier.
  • Strengthening knowledge of insect vectors that play a major role in emergence.
  • Revisiting disease mechanisms to find novel targets for vaccinology and therapeutics.

Creating the epidemiological, technological and integrative environment to support major scientific advances in the field of emerging infectious diseases
None of the above domains can be addressed without an unprecedented effort to establish research in modeling of epidemics, conditions of data management and integration and state of the art technological platforms.
In this Labex, emphasis will be on:

  • Developing mathematical modeling of emerging infectious diseases.
  • Strengthening and diversifying the Genopole activities.
  • Building up proteomics.
  • Developing imaging in tandem with high-throughput screening.
  • Integrating information technologies and complex systems in biology, strengthening bioinformatics.

Training and Recruitment
In addition to the creation of two new Units and five new 5-year groups (G5), a recruitment program for post-doctoral scientists and PhD students has been set up.
As conceived, the LabEx represents a strong potential for outstanding training of master, PhD and post-doctoral scientists, and for the generation of new knowledge that will quickly be integrated into the various courses.

News

Events

SaMMBA seminar: Thibaut Jombart, Building the next generation of statistical tools for outbreak response using R

Room: Jean Paul Aubert – Address: Institut Pasteur, 25 Rue du Docteur Roux, Paris, France
2017-10-04 12:00:00 2017-10-04 14:00:00 Europe/London SaMMBA seminar: Thibaut Jombart, Building the next generation of statistical tools for outbreak response using R Title: The R Epidemics Consortium: building the next generation of statistical tools for outbreak response using R Abstract: The recent West African Ebola outbreak has been a terrible reminder for the need to gain […] Institut Pasteur, 25 Rue du Docteur Roux, Paris, France

Principal Investigators

Teams created in the framework of IBEID

Valorization and diffusion of knowledge

Valorization
The IBEID project aims to improve host and microbial physiology knowledge and contribute to the development of new antimicrobial strategies. An important proportion of the knowledge resulting from the IBEID LabEx will be exploited with the prospects of creating vaccines, drugs and biologics in the fields of infectious diseases and microbiology applied to healthcare. The strong partnership within the project will help to bridge the gap in translational research between Academia and Industry

Diffusion of knowledge
Beyond traditional scientific communication through publications and seminars, IBEID will represent a central point to generate the objective information to be disseminated to authorities and to the public. The issue of communication will be a major theme, with a group of scientists, epidemiologists, medical doctors and representatives of communication offices of partner institutions meeting regularly and during crisis periods to integrate updated information and optimize its dissemination.

Governance

In order to maintain its coherence and identify the new challenges in its fields of expertise, the LabEx will benefit from an International Scientific Advisory Board (ISAB) chaired by the coordinators. The ISAB will be composed of outstanding experts with a good balance of scientists in basic life sciences, bioinformatics, technologies, communication and representatives of the sectors of public health, medicine, industry and major French scientific institutions. A representation of Labex partners will also participate and a Bureau will be elected. ISAB members include: Ruedi Aebersold (ETH Zürich, CH), Jeff Almond (Sanofi-Pasteur Lyon, FR), Fernando Baquero (IRYCIS Madrid, ES), Jean-François Delfraissy (AVIESAN Paris, FR), Gérard Dénariaz (Danone Palaiseau, FR), Vincent Deubel (Institut Pasteur du Cambodge Phnom-Penh, KH), Anne Fagot-Largeault (Collège de France Paris, FR), Alain Fischer (Hôpital Necker Paris, FR), Antoine Flahault (Institut de Santé Globale Genève, CH), Laurent Fraisse (Sanofi Toulouse, FR), George Griffin (SGUL London, UK), Antonio Lanzavecchia (IRB Bellinzona, CH), Marc Mortureux (ANSES Maison-Alfort, FR), Bruno Coignard (InVS Saint-Maurice, FR) and Jacques Schrenzel (Hôpitaux Universitaires Genève, CH).

Partners