The microbial communities that live with us, the microbiota, are now understood to be a key component of our being, playing roles in metabolism, immunity and behavior. More than a decade has elapsed since […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
PTR OmNega: A multi-disciplinary investigation of the Negativicutes: atypical Firmicutes with LPS-outer membranes that inhabit the human gut
The Negativicutes are a poorly studied lineage of bacteria that include common inhabitants of the human oral and gut microbiome such as the anaerobe Veillonella, and which can also develop into opportunistic pathogens. Despite […]
ANR-Arch-Evol: Phylogenomic approaches to investigate the origin and evolution of the Archaea
The Archaea represent an understudied but important fraction of microbial diversity present in a wide variety of environments and ecosystems, including the human body. They have key ecological roles and a unique place in […]
Alterations of the gut microbiota are associated with numerous diseases, of which many involve impaired immune tolerance, such as allergies. However, the role of specific microorganisms and underlying molecular mechanisms remain poorly characterised. Archaeal […]
FRM- Human-associated archaea: evolution, adaptation, interactions
The Archaea are largely known as microorganisms thriving in extreme environments, but are in fact ubiquitouly found in nature. Importantly, archaeal methanogens are also stable members of the human gastrointestinal tract (GIT), where they […]
The outer membrane (OM) is an essential element in Gram-negative (diderm) bacteria. Its integrity is maintained by the control of lipids asymmetry via LPS and phospholipids transport by the Lpt and Mla systems, respectively. […]
ANR-VIROMET-Uncovering the VIRome of archaeal METhanogens
Methanogenic archaea are phylogenetically diverse, ancient and environmentally widespread. They are common inhabitants of the gastrointestinal tract of humans and other animals, and produce methane, a potent green-house gas, as a metabolic by-product. Despite […]
ANR Fir-OM: Firmicutes with an outer membrane: toward new models to study the diderm/monoderm cell envelope transition
The bacterial envelope is one of the oldest and most essential cellular components, being involved in key housekeeping functions, such as physical integrity, cell division, motility, substrate uptake and secretion, and cell-cell communication. It […]
BMGE: Block Mapping and Gathering with Entropy
The quality of multiple sequence alignments plays an important role in the accuracy of phylogenetic inference. It has been shown that removing ambiguously aligned regions, but also other sources of bias such as highly […]
2022Cryptosporulation in Kurthia spp. forces a rethinking of asporogenesis in Firmicutes., Environ Microbiol 2022 Dec; 24(12): 6320-6335.
2022Ancient origin and constrained evolution of the division and cell wall gene cluster in Bacteria., Nat Microbiol 2022 Dec; 7(12): 2114-2127.
2022Growth temperature and chromatinization in archaea., Nat Microbiol 2022 Nov; 7(11): 1932-1942.
2022An early origin of iron-sulfur cluster biosynthesis machineries before Earth oxygenation., Nat Ecol Evol 2022 Oct; 6(10): 1564-1572.
2022Diversity and Evolution of Methane-Related Pathways in Archaea., Annu Rev Microbiol 2022 Sep; 76(): 727-755.
2022Factors shaping the abundance and diversity of the gut archaeome across the animal kingdom., Nat Commun 2022 Jun; 13(1): 3358.
2022Localization and Functional Characterization of the Alternative Oxidase in Naegleria., J Eukaryot Microbiol 2022 Mar; (): e12908.
2022Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host., Elife 2022 Mar; 11(): .
2022An ancient divide in outer membrane tethering systems in bacteria suggests a mechanism for the diderm-to-monoderm transition., Nat Microbiol 2022 Mar; 7(3): 411-422.
2022Publisher Correction: A catalogue of 1,167 genomes from the human gut archaeome., Nat Microbiol 2022 Feb; 7(2): 339.
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