Christophe d’Enfert, a Professor at Institut Pasteur, is the Chair of the Mycology Department and the Head of the Fungal Biology and Pathogenicity Unit. Christophe d’Enfert gained his PhD at Institut Pasteur working on protein secretion in Gram-negative bacteria with Prof. Maxime Schwartz and Prof. Anthony Pugsley. During his post-doctoral training at the University of California at Berkeley with Prof. Randy Schekman, he studied protein secretion in yeast. Since 1992, he joined Institut Pasteur to study human pathogenic fungi and has developed both fundamental and applied research on two major fungal pathogens, Candida albicans and Aspergillus fumigatus. Current research in his laboratory focuses on the development of tools for functional genomics of C. albicans and the study of C. albicans genome dynamics and diversity, biofilm formation and morphogenesis.
Candida albicans genomic diversity and its underlying mechanisms
Following our introduction of Multi-Locus Sequence Typing (MLST) as the state-of-the-art methodology for molecular epidemiology studies of C. albicans, the Fungal Biology and Pathogenicity Unit at Institut Pasteur is now progressing into population genomics […]
Candida albicans colonization of abiotic and biotic surfaces
Biofilms formed by C. albicans on indwelling devices play a major role in the persistence of nosocomial infections, largely because of their elevated tolerance to antifungals. The Fungal Biology and Pathogenicity Unit at Institut […]
Regulation of Candida albicans morphogenesis
The Fungal Biology and Pathogenicity Unit at Institut Pasteur is interested in the regulation of the yeast-to-hypha transition in C. albicans because of its role in biofilm formation and, more generally, in virulence. While […]
Fungal infections have emerged over the past three decades as a considerable threat to human health. These deadly fungal infections are almost all due to species from three genera: Aspergillus, Candida and Cryptococcus. The […]
FunComPath is a network within the Infect-ERA programme (www.infect-era.eu). Infect-ERA is an ERA-Net on human infectious diseases funded under the EU 7th Research Framework Programme (2013 – 2016). It is a continuation of the […]
2017The two-component response regulator Skn7 belongs to a network of transcription factors regulating morphogenesis in Candida albicans and independently limits morphogenesis-induced ROS accumulation, Mol. Microbiol. 2017 Jul;.
2017Selective BET bromodomain inhibition as an antifungal therapeutic strategy, Nat Commun 2017 May;8:15482.
2017The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity, Mucosal Immunol 2017 Feb;.
2016Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome, MBio 2016 Oct;7(5).
2016Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin, Antimicrob. Agents Chemother. 2016 Oct;60(10):5631-9.
2016Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin., Antimicrob Agents Chemother. 2016 Jul 11.
2016Prospective Evaluation of Serum β-Glucan Testing in Patients With Probable or Proven Fungal Diseases, Open Forum Infect Dis 2016 Sep;3(3):ofw128.
2016Mechanisms Underlying the Delayed Activation of the Cap1 Transcription Factor in Candida albicans following Combinatorial Oxidative and Cationic Stress Important for Phagocytic Potency, MBio 2016 Mar;7(2):e00331.
2016Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence, Biochem. J. 2016 Jun;473(11):1537-52.
2016Comparison of E,E-Farnesol Secretion and the Clinical Characteristics of Candida albicans Bloodstream Isolates from Different Multilocus Sequence Typing Clades, PLoS ONE 2016;11(2):e0148400.
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