Human Population and Evolutionary Genetics MOOC
This Mooc aims to provide basic knowledge on population genetics and the help of genetics in the study of human migrations and human adaptation to extreme conditions. At the end of this course, […]
Chaire Génomique Humaine et Évolution / Cours Évolution humaine et génétique des populations – Lluis Quintana-Murci – les vendredis du 04 au 25 mars 2022
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. https://www.youtube.com/watch?v=IXlKElDJMc8 The Milieu Intérieur Project While the […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Protected: Pasteur Human Genome
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Human Evolutionary Immunogenomics: population genetic variation in immune responses Recent genome-wide association studies have successfully identified rare and common variants that correlate with complex traits. However, they have provided us with little insight into […]
The footprints of natural selection in the human genome
The wide range of phenotypic variation in human populations may reflect distinctive processes of selection/adaptation to variable environmental conditions (e.g. climate, pathogens, nutritional resources). The advent of genome-wide datasets allows testing different hypotheses concerning […]
Evolutionary genomics of innate immunity in humans
Inferences concerning the action of selection provide a powerful tool for predicting regions of the genome associated with disease. As infectious diseases exert strong selection pressures, the identification of immunity-related genes targeted by selection […]
Genetics of gene expression in immunity to infection
By integrating cutting-edge knowledge and technology in the fields of genomics, population genetics, immunology and bioinformatics, our aim is to establish a thorough understanding of how variable the human immune response is in the […]
Human lifestyle and genetic and epigenetic variation
The most important cultural innovation witnessed by modern humans has probably been the transition from a hunter-gatherer nomadic mode of subsistence to an agricultural sedentary lifestyle. This transition occurred in many parts of the […]
2022The genomic landscape of contemporary western Remote Oceanians., Curr Biol 2022 Sep; (): .
2022Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia., J Exp Med 2022 Aug; 219(8): .
2022Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency., J Exp Med 2022 Jul; 219(7): .
2022The genetic and evolutionary determinants of COVID-19 susceptibility., Eur J Hum Genet 2022 Jun; (): .
2022Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation., Cell Rep 2022 Jun; 39(13): 110989.
2022Variability in primary Sjögren’s syndrome is driven by interferon alpha, and genetically associated with the class II HLA DQ locus., Arthritis Rheumatol 2022 Jun; (): .
2022Paleogenomics: The demographic past of prehistoric Europeans., Curr Biol 2022 Jun; 32(11): R535-R538.
2022A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes., J Exp Med 2022 Jun; 219(6): .
2022The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies., Proc Natl Acad Sci U S A 2022 05; 119(21): e2200413119.
2022Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster., Nat Ecol Evol 2022 05; 6(5): 565-578.
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