Human Population and Evolutionary Genetics MOOC
This Mooc aims to provide basic knowledge on population genetics and the help of genetics in the study of human migrations and human adaptation to extreme conditions. At the end of this course, […]
Chaire Génomique Humaine et Évolution / Cours Évolution humaine et génétique des populations – Lluis Quintana-Murci – les vendredis du 04 au 25 mars 2022
INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. https://www.youtube.com/watch?v=IXlKElDJMc8 The Milieu Intérieur Project While the […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Protected: Pasteur Human Genome
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Human Evolutionary Immunogenomics: population genetic variation in immune responses Recent genome-wide association studies have successfully identified rare and common variants that correlate with complex traits. However, they have provided us with little insight into […]
The footprints of natural selection in the human genome
The wide range of phenotypic variation in human populations may reflect distinctive processes of selection/adaptation to variable environmental conditions (e.g. climate, pathogens, nutritional resources). The advent of genome-wide datasets allows testing different hypotheses concerning […]
Evolutionary genomics of innate immunity in humans
Inferences concerning the action of selection provide a powerful tool for predicting regions of the genome associated with disease. As infectious diseases exert strong selection pressures, the identification of immunity-related genes targeted by selection […]
Genetics of gene expression in immunity to infection
By integrating cutting-edge knowledge and technology in the fields of genomics, population genetics, immunology and bioinformatics, our aim is to establish a thorough understanding of how variable the human immune response is in the […]
Human lifestyle and genetic and epigenetic variation
The most important cultural innovation witnessed by modern humans has probably been the transition from a hunter-gatherer nomadic mode of subsistence to an agricultural sedentary lifestyle. This transition occurred in many parts of the […]
2022Studying severe long COVID to understand post-infectious disorders beyond COVID-19., Nat Med 2022 Apr; (): .
2022Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster., Nat Ecol Evol 2022 Mar; (): .
2022Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes., Genome Med 2022 Mar; 14(1): 28.
2022The genomic signatures of natural selection in admixed human populations., Am J Hum Genet 2022 Mar; (): .
2022Human genetic and immunological determinants of critical COVID-19 pneumonia., Nature 2022 Jan; (): .
2022The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies., Res Sq 2022 Jan; (): .
2021Sporadic occurrence of recent selective sweeps from standing variation in humans as revealed by an approximate Bayesian computation approach., Genetics 2021 Dec; 219(4): .
2021Author Correction: A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection., Nat Immunol 2021 Nov; (): .
2021A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection., Nat Immunol 2021 Oct; (): .
2021Ancestral diversity is limited in published T cell receptor sequencing studies., Immunity 2021 Oct; 54(10): 2177-2179.
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