INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues. Inception program uses Integrative Biology, Social Science […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Protected: Pasteur Human Genome
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Human Evolutionary Immunogenomics: population genetic variation in immune responses Recent genome-wide association studies have successfully identified rare and common variants that correlate with complex traits. However, they have provided us with little insight into […]
The footprints of natural selection in the human genome
The wide range of phenotypic variation in human populations may reflect distinctive processes of selection/adaptation to variable environmental conditions (e.g. climate, pathogens, nutritional resources). The advent of genome-wide datasets allows testing different hypotheses concerning […]
Evolutionary genomics of innate immunity in humans
Inferences concerning the action of selection provide a powerful tool for predicting regions of the genome associated with disease. As infectious diseases exert strong selection pressures, the identification of immunity-related genes targeted by selection […]
Genetics of gene expression in immunity to infection
By integrating cutting-edge knowledge and technology in the fields of genomics, population genetics, immunology and bioinformatics, our aim is to establish a thorough understanding of how variable the human immune response is in the […]
Human lifestyle and genetic and epigenetic variation
The most important cultural innovation witnessed by modern humans has probably been the transition from a hunter-gatherer nomadic mode of subsistence to an agricultural sedentary lifestyle. This transition occurred in many parts of the […]
2019Defining the genetic and evolutionary architecture of alternative splicing in response to infection, Nat Commun 2019 04;10(1):1671.
2019Diversity of Killer Cell Ig-Like Receptor, HLA Class I, and Their Interactions in Seven Populations of Sub-Saharan Africans, J. Immunol. 2019 Mar;.
2019Human Immunology through the Lens of Evolutionary Genetics, Cell 2019 Mar;177(1):184-199.
2019Recent Adaptive Acquisition by African Rainforest Hunter-Gatherers of the Late Pleistocene Sickle-Cell Mutation Suggests Past Differences in Malaria Exposure, Am. J. Hum. Genet. 2019 Mar;104(3):553-561.
2018Blacklisting variants common in private cohorts but not in public databases optimizes human exome analysis, Proc. Natl. Acad. Sci. U.S.A. 2019 Jan;116(3):950-959.
2018Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23, Sci Immunol 2018 Dec;3(30).
2018Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant, Sci Immunol 2018 Dec;3(30).
2018Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation, Genome Biol. 2018 12;19(1):222.
2018Editorial overview: The history, geography and adaptation of human genes: A tribute to L. Luca Cavalli-Sforza, Curr. Opin. Genet. Dev. 2018 Dec;53:iii-v.
2018Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers, Proc. Natl. Acad. Sci. U.S.A. 2018 Nov;115(48):E11256-E11263.
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