INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Protected: Pasteur Human Genome
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Human Evolutionary Immunogenomics: population genetic variation in immune responses Recent genome-wide association studies have successfully identified rare and common variants that correlate with complex traits. However, they have provided us with little insight into […]
The footprints of natural selection in the human genome
The wide range of phenotypic variation in human populations may reflect distinctive processes of selection/adaptation to variable environmental conditions (e.g. climate, pathogens, nutritional resources). The advent of genome-wide datasets allows testing different hypotheses concerning […]
Evolutionary genomics of innate immunity in humans
Inferences concerning the action of selection provide a powerful tool for predicting regions of the genome associated with disease. As infectious diseases exert strong selection pressures, the identification of immunity-related genes targeted by selection […]
Genetics of gene expression in immunity to infection
By integrating cutting-edge knowledge and technology in the fields of genomics, population genetics, immunology and bioinformatics, our aim is to establish a thorough understanding of how variable the human immune response is in the […]
Human lifestyle and genetic and epigenetic variation
The most important cultural innovation witnessed by modern humans has probably been the transition from a hunter-gatherer nomadic mode of subsistence to an agricultural sedentary lifestyle. This transition occurred in many parts of the […]
2021Negative selection on human genes underlying inborn errors depends on disease outcome and both the mode and mechanism of inheritance., Proc Natl Acad Sci U S A 2021 Jan; 118(3): .
2021Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers., J Exp Med 2021 Jan; 218(1): .
2020Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria., Cell 2020 Dec; 183(7): 1826-1847.e31.
2020Associations between untargeted plasma metabolomic signatures and gut microbiota composition in the Milieu Intérieur population of healthy adults., Br J Nutr 2020 Dec; (): 1-11.
2020Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo., Ann Rheum Dis 2020 Dec; (): .
2020Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science 2020 10; 370(6515): .
2020Editorial overview: Evolutionary and systems immunology – methods to understand human immune system variation., Curr Opin Immunol 2020 Aug; 65(): iv.
2020Population variation in miRNAs and isomiRs and their impact on human immunity to infection., Genome Biol. 2020 Jul; 21(1): 187.
2020Recent common origin, reduced population size, and marked admixture have shaped European Roma genomes., Mol. Biol. Evol. 2020 Jun; (): .
2020A trans-eQTL network regulates osteoclast multinucleation and bone mass., Elife 2020 06; 9(): .
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