Human Population and Evolutionary Genetics
This Mooc aims to provide basic knowledge on population genetics and the help of genetics in the study of human migrations and human adaptation to extreme conditions. At the end of this course, […]
Chaire Génomique Humaine et Évolution / Cours Évolution humaine et génétique des populations – Lluis Quintana-Murci – les vendredis du 04 au 25 mars 2022
INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. https://www.youtube.com/watch?v=IXlKElDJMc8 The Milieu Intérieur Project While the […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Protected: Pasteur Human Genome
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Human Evolutionary Immunogenomics: population genetic variation in immune responses Recent genome-wide association studies have successfully identified rare and common variants that correlate with complex traits. However, they have provided us with little insight into […]
The footprints of natural selection in the human genome
The wide range of phenotypic variation in human populations may reflect distinctive processes of selection/adaptation to variable environmental conditions (e.g. climate, pathogens, nutritional resources). The advent of genome-wide datasets allows testing different hypotheses concerning […]
Evolutionary genomics of innate immunity in humans
Inferences concerning the action of selection provide a powerful tool for predicting regions of the genome associated with disease. As infectious diseases exert strong selection pressures, the identification of immunity-related genes targeted by selection […]
Genetics of gene expression in immunity to infection
By integrating cutting-edge knowledge and technology in the fields of genomics, population genetics, immunology and bioinformatics, our aim is to establish a thorough understanding of how variable the human immune response is in the […]
Human lifestyle and genetic and epigenetic variation
The most important cultural innovation witnessed by modern humans has probably been the transition from a hunter-gatherer nomadic mode of subsistence to an agricultural sedentary lifestyle. This transition occurred in many parts of the […]
2021A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection., Nat Immunol 2021 Oct; (): .
2021Ancestral diversity is limited in published T cell receptor sequencing studies., Immunity 2021 Oct; 54(10): 2177-2179.
2021Towards a functional understanding of adaptive phenotypes in humans., J Anthropol Sci 2021 Sep; 99(): .
2021Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths., Sci Immunol 2021 08; 6(62): .
2021X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19., Sci Immunol 2021 08; 6(62): .
2021Reconstructing 50,000 years of human history from our DNA: lessons from modern genomics., C R Biol 2021 Jul; 344(2): 177-187.
2021Diversity in immunogenomics: the value and the challenge., Nat Methods 2021 May; (): .
2021New insights into human immunity from ancient genomics., Curr Opin Immunol 2021 May; 72(): 116-125.
2021Genomic insights into population history and biological adaptation in Oceania., Nature 2021 Apr; 592(7855): 583-589.
2021Genetic origins, singularity, and heterogeneity of Basques., Curr Biol 2021 Mar; (): .
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