INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
Inception Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues. Inception program uses Integrative Biology, Social Science […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
Protected: Pasteur Human Genome
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Human Evolutionary Immunogenomics: population genetic variation in immune responses Recent genome-wide association studies have successfully identified rare and common variants that correlate with complex traits. However, they have provided us with little insight into […]
The footprints of natural selection in the human genome
The wide range of phenotypic variation in human populations may reflect distinctive processes of selection/adaptation to variable environmental conditions (e.g. climate, pathogens, nutritional resources). The advent of genome-wide datasets allows testing different hypotheses concerning […]
Evolutionary genomics of innate immunity in humans
Inferences concerning the action of selection provide a powerful tool for predicting regions of the genome associated with disease. As infectious diseases exert strong selection pressures, the identification of immunity-related genes targeted by selection […]
Genetics of gene expression in immunity to infection
By integrating cutting-edge knowledge and technology in the fields of genomics, population genetics, immunology and bioinformatics, our aim is to establish a thorough understanding of how variable the human immune response is in the […]
Human lifestyle and genetic and epigenetic variation
The most important cultural innovation witnessed by modern humans has probably been the transition from a hunter-gatherer nomadic mode of subsistence to an agricultural sedentary lifestyle. This transition occurred in many parts of the […]
2018Human thymopoiesis is influenced by a common genetic variant within the locus, Sci Transl Med 2018 Sep;10(457).
2018The demographic and adaptive history of central African hunter-gatherers and farmers, Curr. Opin. Genet. Dev. 2018 Aug;53:90-97.
2018Host and viral genetic diversity can help explain mortality during the 1918-21 influenza pandemic in the Pacific region, Lancet Infect Dis 2018 Aug;18(8):833-834.
2018Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines, Genome Med 2018 07;10(1):59.
2018Publisher Correction: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors, Nat. Immunol. 2018 Jun;19(6):645.
2018IRF4 haploinsufficiency in a family with Whipple’s disease, Elife 2018 Mar;7.
2018The demographic history and mutational load of African hunter-gatherers and farmers, Nat Ecol Evol 2018 Apr;2(4):721-730.
2018Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors, Nat. Immunol. 2018 Mar;19(3):302-314.
2018Parallel derivation of isogenic human primed and naive induced pluripotent stem cells, Nat Commun 2018 01;9(1):360.
2017Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges, Proc. Natl. Acad. Sci. U.S.A. 2018 01;115(3):E488-E497.
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