300 to 400 million cases of dengue fever occur each year worldwide. Spreading rapidly, more than 40% of the world’s population is now at risk of contracting dengue This transversal program brings together talents […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Emergency response to global threats of emerging and re-emerging pathogens
With over 125 years’ experience with infectious diseases, the Institut Pasteur and the Institut Pasteur International Network (IPIN), which is composed of 33 research institutes in 26 countries and five continents, are ideally positioned […]
Cell-Cell fusion in fertilization and developmental biology: a structural biology approach. My group has made seminal contributions in the past toward understanding the mechanism of membrane fusion used by enveloped viruses to infect a […]
DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe
The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
Protein Data Bank depositions
PDB Crystal Structures Resolution (A) Year NON-VIRAL proteins Eukariotyc cell-cell fusion 4OJC Wild-type full-length trimeric ectodomain of C. elegans fusion protein EFF-1 2.93 2014 4OJD C-ter truncated trimeric ectodomain of C. elegans fusion protein […]
Rubella virus E1 envelope glycoprotein
Little is known about the three-dimensional organization of rubella virus, which causes a relatively mild measles-like disease in children but leads to serious congenital health problems when contracted in utero. Although rubella virus […]
Respiratory Syncytial virus
Respiratory Syncytial Virus Nucleoprotein-RNA complex Human respiratory syncytial virus (RSV) is the most important viral agent of pediatric respiratory tract disease worldwide, causing pneumonia and bronchiolitis in infants. No vaccine is currently […]
Picobirnavirus capsid protein
Double-stranded (ds) RNA virus particles are organized around a central icosahedral core capsid made of 120 identical subunits. This core capsid is unable to invade cells from outside, and animal dsRNA viruses have […]
Bovine Viral Diarrhea virus envelop protein E(rns) Pestiviruses, which belong to the Flaviviridae family of RNA viruses, are important agents of veterinary diseases causing substantial economical losses in animal farming worldwide. Pestivirus particles display […]
Herpesviruses envelop glycoproteins Herpesviridae are a large family of double-stranded DNA viruses, counting more than 200 members that infect humans and a wide range of invertebrates and vertebrates. Herpesviruses carry a […]
Hepatitis C virus
Hepatitis C virus E2 envelop glycoprotein The hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide, leading to cirrhosis and hepatocellular carcinoma. In spite of being the focus […]
Dengue virus E envelop glycoprotein The dengue virus (DENV) is a mosquito-borne member of the flavivirus genus responsible for roughly 50 million human infections each year. DENV is composed of four distinct but […]
Chikungunya virus p62-E1 envelope glycoproteins The Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has caused widespread outbreaks of a debilitating human disease in the last 5 years. CHIKV invasion of susceptible cells […]
C. elegans Eff-1
Cell-cell fusion proteins are essential in development. We show that the C. elegans cell-cell fusion protein EFF-1 is structurally homologous to viral class II fusion proteins. The 2.6 Ang. crystal structure of the […]
Lymphocytic choriomeningitis virus GP2 envelop protein Arenaviruses are important agents of zoonotic disease worldwide. The virions expose a tripartite envelope glycoprotein complex (GPC) at their surface, formed by the glycoprotein subunits GP1, GP2 and […]
Chikungunya virus pathogenesis
Structural and functional studies of Chikungunya virus entry into host cells Deciphering Chikungunya virus cell biology by high-throughput / high-content screening Chikungunya virus infection of fibroblasts Chikungunya virus and the central nervous system infection
2019X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications, J. Mol. Biol. 2019 Nov;.
2017The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein., Cell. 2017 Feb 23;168(5):904-915.e10. doi: 10.1016/j.cell.2017.01.024..
2015The replication defect of pseudorabies virus induced by targeted α-helix distortion in the syntaxin-like bundle of glycoprotein H (V275P) is corrected by an adjacent compensatory mutation (V271A), J. Gen. Virol. 2015 Apr;.
2015X-ray structure of the pestivirus NS3 helicase and its conformation in solution, J. Virol. 2015 Apr;89(8):4356-71.
2015Recognition determinants of broadly neutralizing human antibodies against dengue viruses, Nature 2015 Apr;520(7545):109-13.
2014A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus, Nat. Immunol. 2015 Feb;16(2):170-7.
2014Rubella virus: first calcium-requiring viral fusion protein, PLoS Pathog. 2014 Dec;10(12):e1004530.
2014Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies, J. Virol. 2015 Feb;89(4):2170-81.
2014Structure-based functional analyses of domains II and III of pseudorabies virus glycoprotein H, J. Virol. 2015 Jan;89(2):1364-76.
2014The highly conserved proline at position 438 in pseudorabies virus gH is important for regulation of membrane fusion, J. Virol. 2014 Nov;88(22):13064-72.
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