Roland Brosch obtained his PhD at the University of Salzburg in Austria and after some years of postdoctoral training at the University of Wisconsin in Madison and the Institut Pasteur in Paris, he integrated into the scientific staff of the Institut Pasteur in 2000. He is now Professor and Head of the Integrated Mycobacterial Pathogenomics Unit at the Institut Pasteur. He gained broad experience in mycobacterial research in the tuberculosis (TB) research field, where he had important impact on groundbreaking genome projects of Mycobacterium tuberculosis, the etiological agent of TB, the BCG vaccine, and the ancestral gene pool of TB-causing mycobacteria (Mycobacterium canettii). He was also involved in pioneering work on the evolution of the M. tuberculosis complex and the discovery and functional characterization of the ESX / type VII secretion system of M. tuberculosis. He continues to be very interested in these topics, which remain key issues for the identification of new virulence mechanisms of M. tuberculosis, for elucidating the extraordinary evolutionary success of M. tuberculosis, and for gaining new insights and perspectives into host-pathogen interaction, new vaccine concepts and therapeutic interventions.
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2022The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence., Proc Natl Acad Sci U S A 2022 Mar; 119(11): e2122161119.
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2022The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy., Mol Ther Nucleic Acids 2022 Mar; 27(): 1235-1248.
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2022The MtZ Strain: Molecular Characteristics and Outbreak Investigation of the Most Successful Mycobacterium tuberculosis Strain in Aragon Using Whole-Genome Sequencing., Front Cell Infect Microbiol 2022 ; 12(): 887134.
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2021Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli., Nat Microbiol 2021 Aug; 6(8): 1082-1093.
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2021Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: Molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response., J Proteomics 2021 07; 244(): 104276.
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2021ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains., mBio 2021 May; 12(3): .
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2021IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo., mSphere 2021 May; 6(3): .
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2021Breaching the phagosome, the case of the tuberculosis agent., Cell Microbiol 2021 Apr; (): e13344.
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2021Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts., Microb Genom 2021 02; 7(2): .
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2020Mucosal delivery of ESX-1-expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes., Proc. Natl. Acad. Sci. U.S.A. 2020 Aug; 117(34): 20848-20859.
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