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© Xavier Montagutelli, Institut Pasteur
Member: Head of Structure

Xavier Montagutelli

• Mouse Genetics

Laboratory: Mouse Genetics
Scientific Fields
Diseases
Organisms
Applications
Technique

About

My recent work focuses on the genetic and functional dissection of complex traits using the mouse genetic toolbox. After developing a collection of interspecific congenic strains which were instrumental in exploring the genetic control of skull shape, I am now taking advantage of the genetic diversity of the Collaborative Cross which was imported at the Institut Pasteur when I was the director of the animal facilities. My team uses this cutting-edge genetic resource to investigate the role of host genes in the susceptibility to infectious diseases. I am also involved in teaching, being co-director of the Institut Pasteur Mouse Genetics course since 1995.

Courses

09:00
08
Jan 2024
Course

Mouse Genetics Course

  This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […]
Mouse Genetics
Early Mammalian Development & Stem Cell Biology
Epigenomics, Proliferation and the Identity of Cells – EPIC
Developmental and Stem Cell Biology
Genomes and Genetics
Xavier Montagutelli
Michel Cohen-Tannoudji
2024-01-08 09:00:00 2024-02-13 18:00:00 Europe/Paris Mouse Genetics Course   This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Projects

Project
Ongoing
5 Members

INTRANZIGEANT: Integrated study of Zika virus transmission to identify genetic mechanisms and new antiviral targets

Louis Lambrechts (PI)

Vector-borne pathogens like dengue or Zika viruses are transmitted to a human via the bite of a mosquito infected by a previous bite on an infected human. This transmission cycle is responsible for the […]
Project
Ongoing
7 Members

Mouse models for Covid-19

Xavier Montagutelli (PI)

Mice are not naturally susceptible to SARS-CoV-2 due to poor binding of the virus spike to the mouse cellular receptor ACE2. We have developed a mouse-adapted strain of SARS-CoV-2 which efficiently replicates in the […]
Project
Ongoing
3 Members

Collaborative Cross initiatives

Xavier Montagutelli (PI)

Although mouse models have been invaluable to study human diseases, classical mouse laboratory strains (figure, left panel, colored dots) present much smaller genetic diversity than the human population, limiting the range of phenotypic variations […]
Project
Ongoing
5 Members

Host genetic susceptibility to Salmonelloses

Jean Jaubert (PI)

Salmonella enterica infections in humans are responsible for three major clinical syndromes, typhoid fever caused by host-specific Salmonella, a diarrheal disease known as salmonellosis caused by several non-typhoidal Salmonella (NTS) and invasive NTS (iNTS) […]
Project
Ongoing
8 Members

Host genetic susceptibility to Zika virus

Xavier Montagutelli (PI)

Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]
Project
Ongoing
19 Members

Pasteur International Center for Research on Emerging Infectious Diseases

Anavaj Sakuntabhai (PI)

We established an Emerging Infectious Disease Research Center in Southeast Asia and West/Central Africa with an inter-continental one-health approach designed to improve the capacity to respond rapidly and effectively to outbreaks. We built on […]
Project
Ongoing
8 Members

Pathogenicity and resistance to Rift Valley Fever virus.

Xavier Montagutelli (PI)

Rift Valley fever (RVF) is a an arthropod-borne emerging viral disease that primarily affects domesticated animals (such as cattle, sheep and goats) and humans, with recent outbreaks in sub-Saharan Africa, Madagascar, and the Arabian […]

CV

Since 2017: Head of the Mouse Genetics Laboratory, Institut Pasteur
Since 2005: Research Director, Institut Pasteur.
2004-2017: Researcher in the Mouse functional Genetics Unit (head: J.-J. Panthier)
2004: Habilitation in Genetics, University Pierre & Marie Curie – Paris, France
2003: Diplomate of the European College of Laboratory Animal Medicine
2000-2018: Head of the Central Animal Facilities, Institut Pasteur
Since 1995: Co-director of the annual course in Mouse Genetics, Institut Pasteur.
1995: PhD in Genetics, University Pierre & Marie Curie – Paris, France
1994-1995: Visiting scientist at The Jackson Laboratory (Maine, USA)
1987-2004: Fellow of the Roux Foundation (1987-1989), Research Assistant (1990-1993) and Junior Researcher (CR, 1994-2004), Mammalian Genetics Unit (head: J.-L. Guénet), Institut Pasteur
1986: DVM, Alfort Veterinary School and Créteil Medical University
1984–1986: Teaching assistant in microbiology and immunology at the Ecole Nationale Vétérinaire d’Alfort

Publications

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