My recent work focuses on the genetic and functional dissection of complex traits using the mouse genetic toolbox. After developing a collection of interspecific congenic strains which were instrumental in exploring the genetic control of skull shape, I am now taking advantage of the genetic diversity of the Collaborative Cross which was imported at the Institut Pasteur when I was the director of the animal facilities. My team uses this cutting-edge genetic resource to investigate the role of host genes in the susceptibility to infectious diseases. I am also involved in teaching, being co-director of the Institut Pasteur Mouse Genetics course since 1995.
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Courses
Mouse Genetics Course
This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […]
2021-01-04 09:00:00
2021-02-09 18:00:00
Europe/Paris
Mouse Genetics Course
This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […]
Institut Pasteur, Rue du Docteur Roux, Paris, France
Transversal Projects
Projects
CV
Since 2017: Head of the Mouse Genetics Laboratory, Institut Pasteur
Since 2005: Research Director, Institut Pasteur.
2004-2017: Researcher in the Mouse functional Genetics Unit (head: J.-J. Panthier)
2004: Habilitation in Genetics, University Pierre & Marie Curie – Paris, France
2003: Diplomate of the European College of Laboratory Animal Medicine
2000-2018: Head of the Central Animal Facilities, Institut Pasteur
Since 1995: Co-director of the annual course in Mouse Genetics, Institut Pasteur.
1995: PhD in Genetics, University Pierre & Marie Curie – Paris, France
1994-1995: Visiting scientist at The Jackson Laboratory (Maine, USA)
1987-2004: Fellow of the Roux Foundation (1987-1989), Research Assistant (1990-1993) and Junior Researcher (CR, 1994-2004), Mammalian Genetics Unit (head: J.-L. Guénet), Institut Pasteur
1986: DVM, Alfort Veterinary School and Créteil Medical University
1984–1986: Teaching assistant in microbiology and immunology at the Ecole Nationale Vétérinaire d’Alfort
Publications
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2021Host genetic control of natural killer cell diversity revealed in the Collaborative Cross., Proc Natl Acad Sci U S A 2021 Mar; 118(10): .
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2021Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains., Nat Commun 2021 02; 12(1): 916.
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2020Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations., Science 2020 Nov; 370(6519): 991-996.
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2020Animal and translational models of SARS-CoV-2 infection and COVID-19., Mucosal Immunol 2020 Aug; (): .
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2020NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice., Nat Commun 2020 07; 11(1): 3281.
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2020Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis., Sci Rep 2020 May; 10(1): 8734.
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202033rd international mammalian genome conference: meeting highlights., Mamm. Genome 2020 04; 31(3-4): 69-76.
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2020Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b., J. Virol. 2020 01; 94(3): .
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2019A Loss-of-Function Mutation in the Integrin Alpha L (Itgal) Gene Contributes to Susceptibility to Salmonella enterica Serovar Typhimurium Infection in Collaborative Cross Strain CC042., Infect. Immun. 2019 12; 88(1): .
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2019IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise., Science 2019 07; 365(6449): 176-180.
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