My recent work focuses on the genetic and functional dissection of complex traits using the mouse genetic toolbox. After developing a collection of interspecific congenic strains which were instrumental in exploring the genetic control of skull shape, I am now taking advantage of the genetic diversity of the Collaborative Cross which was imported at the Institut Pasteur when I was the director of the animal facilities. My team uses this cutting-edge genetic resource to investigate the role of host genes in the susceptibility to infectious diseases. I am also involved in teaching, being co-director of the Institut Pasteur Mouse Genetics course since 1995.
Mouse Genetics Course
This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart and currently coordinated by Carla Saleh and Philippe Bastin, is to develop a […]
INTRANZIGEANT: Integrated study of Zika virus transmission to identify genetic mechanisms and new antiviral targets
Vector-borne pathogens like dengue or Zika viruses are transmitted to a human via the bite of a mosquito infected by a previous bite on an infected human. This transmission cycle is responsible for the […]
Mouse models for Covid-19
Mice are not naturally susceptible to SARS-CoV-2 due to poor binding of the virus spike to the mouse cellular receptor ACE2. We have developed a mouse-adapted strain of SARS-CoV-2 which efficiently replicates in the […]
Collaborative Cross initiatives
Although mouse models have been invaluable to study human diseases, classical mouse laboratory strains (figure, left panel, colored dots) present much smaller genetic diversity than the human population, limiting the range of phenotypic variations […]
Host genetic susceptibility to Salmonelloses
Salmonella enterica infections in humans are responsible for three major clinical syndromes, typhoid fever caused by host-specific Salmonella, a diarrheal disease known as salmonellosis caused by several non-typhoidal Salmonella (NTS) and invasive NTS (iNTS) […]
Host genetic susceptibility to Zika virus
Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]
Pasteur International Center for Research on Emerging Infectious Diseases
We established an Emerging Infectious Disease Research Center in Southeast Asia and West/Central Africa with an inter-continental one-health approach designed to improve the capacity to respond rapidly and effectively to outbreaks. We built on […]
Pathogenicity and resistance to Rift Valley Fever virus.
Rift Valley fever (RVF) is a an arthropod-borne emerging viral disease that primarily affects domesticated animals (such as cattle, sheep and goats) and humans, with recent outbreaks in sub-Saharan Africa, Madagascar, and the Arabian […]
Since 2017: Head of the Mouse Genetics Laboratory, Institut Pasteur
Since 2005: Research Director, Institut Pasteur.
2004-2017: Researcher in the Mouse functional Genetics Unit (head: J.-J. Panthier)
2004: Habilitation in Genetics, University Pierre & Marie Curie – Paris, France
2003: Diplomate of the European College of Laboratory Animal Medicine
2000-2018: Head of the Central Animal Facilities, Institut Pasteur
Since 1995: Co-director of the annual course in Mouse Genetics, Institut Pasteur.
1995: PhD in Genetics, University Pierre & Marie Curie – Paris, France
1994-1995: Visiting scientist at The Jackson Laboratory (Maine, USA)
1987-2004: Fellow of the Roux Foundation (1987-1989), Research Assistant (1990-1993) and Junior Researcher (CR, 1994-2004), Mammalian Genetics Unit (head: J.-L. Guénet), Institut Pasteur
1986: DVM, Alfort Veterinary School and Créteil Medical University
1984–1986: Teaching assistant in microbiology and immunology at the Ecole Nationale Vétérinaire d’Alfort
2023Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo., PLoS Pathog 2023 Sep; 19(9): e1011446.
2023SARS-CoV-2-related bat virus behavior in human-relevant models sheds light on the origin of COVID-19., EMBO Rep 2023 Apr; 24(4): e56055.
2022Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response., J Neuroinflammation 2022 Dec; 19(1): 307.
2022Intranasal Exposure to Rift Valley Fever Virus Live-Attenuated Strains Leads to High Mortality Rate in Immunocompetent Mice., Viruses 2022 Nov; 14(11): .
2022stuart: an R package for the curation of SNP genotypes from experimental crosses., G3 (Bethesda) 2022 Nov; 12(11): .
2022SARS-CoV-2 infection in domestic rats after transmission from their infected owner, 2023.
2022Olfactory outcomes in Zika virus-associated Guillain-Barré syndrome., Eur J Neurol 2022 Sep; 29(9): 2823-2831.
2022Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2., J Exp Med 2022 Jul; 219(7): .
2022Rapid characterization of a Delta-Omicron SARS-CoV-2 recombinant detected in Europe, 2022.
2022SARS-CoV-2 Omicron emergence urges for reinforced One-Health surveillance., EMBO Mol Med 2022 Mar; 14(3): e15558.
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