My recent work focuses on the genetic and functional dissection of complex traits using the mouse genetic toolbox. After developing a collection of interspecific congenic strains which were instrumental in exploring the genetic control of skull shape, I am now taking advantage of the genetic diversity of the Collaborative Cross which was imported at the Institut Pasteur when I was the director of the animal facilities. My team uses this cutting-edge genetic resource to investigate the role of host genes in the susceptibility to infectious diseases. I am also involved in teaching, being co-director of the Institut Pasteur Mouse Genetics course since 1995.
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Courses
Mouse Genetics Course
This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […]
2021-01-04 09:00:00
2021-02-09 18:00:00
Europe/Paris
Mouse Genetics Course
This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. […]
Institut Pasteur, Rue du Docteur Roux, Paris, France
Transversal Projects
Projects
CV
Since 2017: Head of the Mouse Genetics Laboratory, Institut Pasteur
Since 2005: Research Director, Institut Pasteur.
2004-2017: Researcher in the Mouse functional Genetics Unit (head: J.-J. Panthier)
2004: Habilitation in Genetics, University Pierre & Marie Curie – Paris, France
2003: Diplomate of the European College of Laboratory Animal Medicine
2000-2018: Head of the Central Animal Facilities, Institut Pasteur
Since 1995: Co-director of the annual course in Mouse Genetics, Institut Pasteur.
1995: PhD in Genetics, University Pierre & Marie Curie – Paris, France
1994-1995: Visiting scientist at The Jackson Laboratory (Maine, USA)
1987-2004: Fellow of the Roux Foundation (1987-1989), Research Assistant (1990-1993) and Junior Researcher (CR, 1994-2004), Mammalian Genetics Unit (head: J.-L. Guénet), Institut Pasteur
1986: DVM, Alfort Veterinary School and Créteil Medical University
1984–1986: Teaching assistant in microbiology and immunology at the Ecole Nationale Vétérinaire d’Alfort
Publications
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2021A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters, Nat Commun . 2021 Nov 1;12(1):6277.
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2021Host genetic control of natural killer cell diversity revealed in the Collaborative Cross., Proc Natl Acad Sci U S A 2021 03; 118(10): .
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2021Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains., Nat Commun 2021 02; 12(1): 916.
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2021The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice., Mamm Genome 2021 02; 32(1): 30-37.
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2020Host genetic susceptibility to viral infections: the role of type I interferon induction., Genes Immun 2020 12; 21(6-8): 365-379.
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2020Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations., Science 2020 11; 370(6519): 991-996.
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2020Animal and translational models of SARS-CoV-2 infection and COVID-19., Mucosal Immunol 2020 Aug; (): .
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2020NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice., Nat Commun 2020 07; 11(1): 3281.
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2020Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis., Sci Rep 2020 May; 10(1): 8734.
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202033rd international mammalian genome conference: meeting highlights., Mamm. Genome 2020 04; 31(3-4): 69-76.
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