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© Michel-Robert Popoff
Clostridium difficile en microscopie à contraste de phase. On distingue des bactéries sporulées, non sporulées et d'autres en cours de lyse (destruction). Bactérie de l'environnement (sol, eau, foin, sable), elle est à l'origine d'infections nosocomiales survenant après un traitement antibiotique : Clostridium difficile prédomine alors que les autres bactéries de la flore intestinale ont été détruites. L'infection peut provoquer deux types de pathologies graves : les colites pseudo-membraneuses dont l'origine est quasiment due à 100 % à C. difficile et la diarrhée post-antibiothérapie due à C. difficile dans 30 % des cas de ces diarrhées.

Courses

09:00
06
Jun 2016
Course

Workshop: Bacterial RNAseq

We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […]
Pathogenesis of Bacterial Anaerobes
Biomics
Center of Informatics for Biology
Transcriptome and EpiGenome
Microbiology
Marc Monot
Isabelle Martin-Verstraete
Olga Soutourina
Bruno Dupuy
Odile Sismeiro
Rachel Legendre
Fabien Mareuil
Olivia Doppelt-Azeroual
2016-06-06 09:00:00 2016-06-10 17:00:00 Europe/Paris Workshop: Bacterial RNAseq We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […] 28 Rue du Docteur Roux, Paris, France

Projects

project
Completed
7 Members

Evolution of the Pathogenicity Locus of C. difficile

Bruno Dupuy (PI)

The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been […]
project
Ongoing
5 Members

Biology of anaerobic biofilm formed by C. difficile and their role in the CD infections

Bruno Dupuy (PI)

We recently showed that CD forms biofilms in vitro either individually on abiotic surfaces or mixed with other intestinal anaerobic bacteria. We have started to identify the key functions required for CD biofilm formation […]
project
Ongoing
3 Members

Comparative genomics clostridium strains involved in necrotizing enterocolitis of the preterm newborn

Julio Aires (PI)

Necrotizing enterocolitis (NEC) is the most common and serious gastrointestinal disorder among preterm neonates. We aimed to assess specific gut microbes associated with NEC. In 2002, an outbreak of NEC occurred in six neonates within […]
project
Completed
8 Members

Characterization of the SigmaS network by RNA sequencing and identification of SigmaS-controlled small regulatory RNAs in Salmonella

Françoise Norel-Bozouklian (PI)

We have used directional RNA-sequencing and complementary assays to explore the SigmaS-dependent transcriptome of Salmonella enterica serovar Typhimurium. This study confirms the large regulatory scope of SigmaS and provides insights into its physiological functions […]
project
Ongoing
3 Members

C. difficile toxin synthesis and secretion

Bruno Dupuy (PI)

All virulent strains of CD produce two toxin proteins (TcdA and TcdB). The genes encoding both toxins are located within a 19.6 kb region of the chromosome (PaLoc) in addition with three accessory gene […]
project
Completed
6 Members

Global regulation of C. difficile toxin production

Bruno Dupuy (PI)

We elucidated the role of the carbon catabolite repression system (CCR) in the control of CD toxin synthesis and demonstrated that CcpA, the global regulator of the CCR, is a key factor controlling in […]
project
Ongoing
4 Members

Pathogenomic analysis of high potential virulent strains of C. difficile

Bruno Dupuy (PI)

Clostridium difficile is increasingly associated with infections in hospitals and in the community, and hypervirulent types are emerging. Six research groups from 5 countries undertook this project, aiming to use genomic approaches to study […]
project
Completed
3 Members

C. difficile toxin B detection by real-time PCR

Frederic Barbut (PI)

Rapid detection of toxigenic Clostridium difficile strains is crucial for optimal management of patient with C. difficile infection (CDI). Currently, the « gold standards » for the diagnosis of CDI are the cytotoxicity assay […]

Publications