Workshop: Bacterial RNAseq
We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Evolution of the Pathogenicity Locus of C. difficile
The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been […]
Biology of anaerobic biofilm formed by C. difficile and their role in the CD infections
Biofilms are universal traits of bacteria defined as mixed species communities characterized by high cell density, reduced diffusion and heterogeneous structures. These characteristics induce behaviors and phenotype that are not observed in planktonic microorganisms […]
Comparative genomics clostridium strains involved in necrotizing enterocolitis of the preterm newborn
Necrotizing enterocolitis (NEC) is the most common and serious gastrointestinal disorder among preterm neonates. We aimed to assess specific gut microbes associated with NEC. In 2002, an outbreak of NEC occurred in six neonates within […]
Characterization of the SigmaS network by RNA sequencing and identification of SigmaS-controlled small regulatory RNAs in Salmonella
We have used directional RNA-sequencing and complementary assays to explore the SigmaS-dependent transcriptome of Salmonella enterica serovar Typhimurium. This study confirms the large regulatory scope of SigmaS and provides insights into its physiological functions […]
C. difficile toxin synthesis and secretion
The variable spectrum of diseases caused by C. difficile (CD) is correlated for the severe forms to the level of toxins produced during host infection. This strengthened the idea that regulation of toxin synthesis […]
Global regulation of C. difficile toxin production
We elucidated the role of the carbon catabolite repression system (CCR) in the control of CD toxin synthesis and demonstrated that CcpA, the global regulator of the CCR, is a key factor controlling in […]
Pathogenomic analysis of high potential virulent strains of C. difficile
Clostridium difficile is increasingly associated with infections in hospitals and in the community, and hypervirulent types are emerging. Six research groups from 5 countries undertook this project, aiming to use genomic approaches to study […]
C. difficile toxin B detection by real-time PCR
Rapid detection of toxigenic Clostridium difficile strains is crucial for optimal management of patient with C. difficile infection (CDI). Currently, the « gold standards » for the diagnosis of CDI are the cytotoxicity assay […]
COV2HTML is an interactive web interface, which is addressed to biologists, and allows performing both coverage visualization and analysis of NGS alignments performed on prokaryotic organisms (bacteria and phages). It combines two processes: a […]
2018CotL, a new morphogenetic spore coat protein of Clostridium difficile, Environ Microbiol. 2018 Dec 16. doi: 10.1111/1462-2920.14505.
2018Clostridium difficile biofilm: remodeling metabolism and cell surface to build a sparse and heterogeneously aggregated architecture, Front Microbiol. 2018 Sep 12;9:2084. doi: 10.3389/fmicb.2018.02084. eCollection 2018..
2018Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in, MBio 2018 Jun;9(3).
2018Micro-nano-bio acoustic system for the detection of foodborne pathogens in real samples, Biosens Bioelectron 2018 Jul;111:52-58.
2018Pleiotropic roles of Clostridium difficile sin locus, PLoS Pathog. 2018 03;14(3):e1006940.
2018Discovery of new type I toxin-antitoxin systems adjacent to CRISPR arrays in Clostridium difficile, Nucleic Acids Res. 2018 May;46(9):4733-4751.
2017High prevalence and genetic diversity of large phiCD211/phiCDIF1296T-like prophages in Clostridioides difficile, Appl. Environ. Microbiol. 2017 Nov;.
2017Advanced immunocapture of milk-borne Salmonella by microfluidic magnetically stabilized fluidized bed, Electrophoresis 2017 Sep;.
2017The alternative sigma factor σ plays a crucial role in adaptive strategies of Clostridium difficile during gut infection, Environ. Microbiol. 2017 May;19(5):1933-1958.
2017Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291, Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291 Brintha P. Girinathan, Marc Monot, Daniel Boyle, Kathleen N. McAllister, Joseph A. Sorg, Bruno Dupuy, Revathi Govind mSphere Feb 2017, 2 (1) e00383-16; DOI: 10.1128/mSphere.00383-16.
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