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© Michel-Robert Popoff
Clostridium difficile en microscopie à contraste de phase. On distingue des bactéries sporulées, non sporulées et d'autres en cours de lyse (destruction). Bactérie de l'environnement (sol, eau, foin, sable), elle est à l'origine d'infections nosocomiales survenant après un traitement antibiotique : Clostridium difficile prédomine alors que les autres bactéries de la flore intestinale ont été détruites. L'infection peut provoquer deux types de pathologies graves : les colites pseudo-membraneuses dont l'origine est quasiment due à 100 % à C. difficile et la diarrhée post-antibiothérapie due à C. difficile dans 30 % des cas de ces diarrhées.

Courses

09:00
06
Jun 2016
Course

Workshop: Bacterial RNAseq

We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […]
2016-06-06 09:00:00 2016-06-10 17:00:00 Europe/Paris Workshop: Bacterial RNAseq We propose a skills training for PhD students on Bacterial RNAseq experiments Using total RNAs, we will i) enrich the mRNAs by depleting the rRNAs ; ii) prepare and sequence cDNA library and iii) analyse […] 28 Rue du Docteur Roux, Paris, France

Projects

project
Ongoing
5 Members

Biology of anaerobic biofilm formed by Clostridium difficile and their role in  infections

Bruno Dupuy (PI)

Biofilms are universal traits of bacteria defined as mixed species communities characterized by high cell density, reduced diffusion and heterogeneous structures. These characteristics induce behaviors and phenotype that are not observed in planktonic microorganisms […]
project
Ongoing
5 Members

The regulatory network of sporulation and spore morphogenesis in Clostridium difficile

Isabelle Martin-Verstraete (PI)

Clostridium difficile, a Gram-positive, anaerobic, spore-forming bacterium, is a major cause of nosocomial infections such as antibiotic-associated diarrhea. Spores are the vector of its transmission and persistence in the environment. Despite the importance of […]
project
Ongoing
8 Members

Control of toxin synthesis and secretion in Clostridium difficile

Bruno Dupuy (PI)

The variable spectrum of diseases caused by C. difficile (CD) is correlated for the severe forms to the level of toxins produced during host infection. This strengthened the idea that regulation of toxin synthesis […]
project
Completed
4 Members

Pathogenomic analysis of high potential virulent strains of C. difficile

Bruno Dupuy (PI)

Clostridium difficile is increasingly associated with infections in hospitals and in the community, and hypervirulent types are emerging. Six research groups from 5 countries undertook this project, aiming to use genomic approaches to study […]
project
Ongoing
7 Members

Biofilms formed by anaerobes

Jean-Marc Ghigo (PI)

Although  many clinically and ecologically relevant processes are known to be  performed by biofilm communities composed of strict or facultative anaerobic bacteria, biofilms were often studied in  aerobic conditions.  We use in vitro anaerobic culture systems […]
project
Ongoing
5 Members

Prophage elements as a significant source of genetic diversity among epidemic C. difficile 027 strains

Marc Monot (PI)

The capacity to rapidly and accurately identify virulent strains of C. difficile in order to prevent severe and fatal infections remains a major chal- lenge for clinicians and investigators. Also, the evolution of an […]

Publications

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