I currently lead a junior group in the Virology department of Institut Pasteur. My research interests lie in RNA virus discovery, emergence, transmission, and evolution. Within the group, we use viral genomics to study evolutionary processes of RNA viruses, with a focus on arboviruses such as dengue and Zika. Like many others, we are also contributing to the fight against COVID-19. We combine molecular epidemiology studies thanks to amazing collaborations within the Institut Pasteur International Network and experimental work, both in vitro and in vivo. We work a lot with our great colleagues at the Mouse Genetics laboratory and the French National Reference Center for viruses of respiratory infections.
INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Mouse models for Covid-19
Mice are not naturally susceptible to SARS-CoV-2 due to poor binding of the virus spike to the mouse cellular receptor ACE2. We have developed a mouse-adapted strain of SARS-CoV-2 which efficiently replicates in the […]
Evolutionary Mechanisms underlying Yellow fever Resurgence in Africa – ANR JCJC
Arthropod-borne viruses (arboviruses) pose a major threat to public health worldwide and are continuously (re-)emerging or spreading to uninfected areas. Recent examples notably include dengue, Chikungunya, yellow fever, and Zika virus disease. In addition […]
Study of immune crosstalk in COVID-19 COVIMUNE
Our overall goal is to understand the cellular and molecular aspects of immune response to SARS-CoV-2 virus in terms of activation of over-reactive immunity and induction of immune protection. COVIMUNE is designed to target […]
Host genetic susceptibility to Zika virus
Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]
Pasteur International Center for Research on Emerging Infectious Diseases
We established an Emerging Infectious Disease Research Center in Southeast Asia and West/Central Africa with an inter-continental one-health approach designed to improve the capacity to respond rapidly and effectively to outbreaks. We built on […]
MICROTONE – Microbial and viral circulations among people and wild and domesticated animals in an ecotone, Democratic Republic of Congo
Zoonotic transmissions are a major global health risk, with human-animal contact frequently raised as a driver of emergence. Studies of zoonotic transmission risks are often piecemeal, targeting bushmeat, specific animal reservoirs, or single pathogens. […]
A Zika virus chimeric polyepitope comprising non-structural proteins and its use in immunogenic composition (EP 17 306553.3)
The present invention is directed to a Zika virus (ZIKV) chimeric polyepitope composed of fragments of structural and non-structural proteins and its use in an immunogenic composition. The present invention provides means, in particular […]
Maîtrise/D.E.A. (Masters) Microbiology – Basic virology , 2004. Université Paris VII – Denis Diderot, France PhD in Virology and Molecular Biology, 2009. Université Paris VI – Pierre et Marie Curie, France. Laboratory of Matteo Negroni. Postdoctoral Fellow, 2009-2012. Laboratory of Edward C. Holmes , The Pennsylvania State University, USA.
2022Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2., J Exp Med 2022 Jul; 219(7): .
2022Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2, J Exp Med . 2022 Jul 4;219(7):e20220638. doi: 10.1084/jem.20220638. Epub 2022 Jun 15. .
2022Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen., Nat Commun 2022 May; 13(1): 2442.
2022Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH., Life Sci Alliance 2022 04; 5(4): .
2022Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies., Nat Med 2022 Mar; (): .
2022Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2., EBioMedicine 2022 Mar; 77(): 103934.
2022Considerable escape of SARS-CoV-2 Omicron to antibody neutralization., Nature 2022 02; 602(7898): 671-675.
2021A novel SARS-CoV-2 related coronavirus in bats from Cambodia., Nat Commun 2021 11; 12(1): 6563.
2021A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters., Nat Commun 2021 11; 12(1): 6277.
2021Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization., Nature 2021 08; 596(7871): 276-280.
+View full list of publications