David Bikard is the head of the Synthetic Biology group at Institut Pasteur in Paris. He obtained an engineer degree from AgroParisTech and a PhD from Paris Diderot University for his work performed at the Institut Pasteur on the integron bacterial recombination system. He then joined the laboratory of Luciano Marraffini at the Rockefeller University as a postdoctoral fellow where he started to work on CRISPR systems. In 2014 David returned to France to start his academic group at Institut Pasteur where his work focuses on the genetic innovation that emerges as a result of the arms race between bacteria and bacteriophages. In parallel, David co-founded Eligo Bioscience, a biotech that focuses on the development of CRISPR-based therapeutics targeting the microbiome. David is the recipient of several prestigious grants and awards including 2 ERC grants, the EMBO young investigator award, the Pasteur Vallery-Radot award and the EMBO Gold medal.
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2025Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems, Science, 388, 6747, (2025)..
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2025Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems., Science, 2025 May; 388(6747): eads0768.
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2025Incomplete lytic cycle of a widespread Bacteroides bacteriophage leads to the formation of defective viral particles., PLoS Biol 2025 Mar; 23(3): e3002787.
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2024Delivery of functional Cas:DNA nucleoprotein complexes into recipient bacteria through a type IV secretion system., Proc Natl Acad Sci U S A 2024 Oct; 121(43): e2408509121.
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2024A virally-encoded tRNA neutralizes the PARIS antiviral defence system., Nature 2024 Aug; (): .
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2024In situ targeted base editing of bacteria in the mouse gut., Nature 2024 Aug; 632(8026): 877-884.
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2024Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans., Cell Host Microbe 2024 May; (): .
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2024Systematic interrogation of CRISPR antimicrobials in Klebsiella pneumoniae reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity., Nucleic Acids Res 2024 Jun; 52(10): 6079-6091.
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2024Cassette recombination dynamics within chromosomal integrons are regulated by toxin-antitoxin systems., Science Advances , 2024, 10 (2), pp.eadj3498. ⟨10.1126/sciadv.adj3498⟩.
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2023Computational design of novel Cas9 PAM-interacting domains using evolution-based modelling and structural quality assessment., PLoS Comput Biol 2023 Nov; 19(11): e1011621.
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