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© Antoinette Ryter
Serratia marcescens avec présence de flagelles (cils) péritriches. Famille des Enterobacteriaceae, bacille à Gram négatif, non sporulé, anaérobie facultatif, mobile, parfois encapsulé, pouvant synthétiser un pigment rouge ou rose. Présent dans les végétaux , le sol, et l'eau. A l'origine d'infections nosocomiales et résistant à de nombreux antibiotiques. Image colorisée.
Member: Head of Structure

David Bikard

• Synthetic Biology

Laboratory: Synthetic Biology

About

David is a young investigator at the Institut Pasteur in the department of Microbiology where he started his group in 2014. David obtained a engineer degree from AgroParisTech as well as a master degree and PhD from Paris Diderot University for his work performed at the Institut Pasteur on the integron bacterial recombination system. He then joined the laboratory of Luciano Marraffini at the Rockefeller University as a postdoctoral fellow where he started to work on CRISPR systems. David is interested in applying engineering principles to better understand and fight pathogenic bacteria.

Projects

Project
Ongoing
2 Members

ERC CoG: In situ genetic perturbation of gut bacteria with engineered phage vectors and CRISPR

David Bikard (PI)

Humans live in a symbiotic relationship with trillions of microorganisms that inhabit our bodies and play an important role in health and disease. There is a growing interest in manipulating the microbiome to improve […]
Project
Ongoing
5 Members

Impact of chromosomal integrons on bacterial life and evolution (Chromintevol)

Céline Loot (PI)

Bacteria exchange and recombine DNA to accelerate their evolution and adapt to new stress. Their evolvability is illustrated by the rapid emergence of multi resistant bacteria after the introduction of antibiotics. The most powerful […]
Project
Ongoing
2 Members

ERC starting grant – CRISPAIR: Study of the interplay between CRISPR interference and DNA repair pathways towards the development of novel CRISPR tools

David Bikard (PI)

CRISPR-Cas loci are the adaptive immune system of archaea and bacteria. They can capture pieces of invading DNA and use this information to degrade target DNA through the action of RNA-guided nucleases. The consequences […]
Project
Ongoing
5 Members

Prophage elements as a significant source of genetic diversity among epidemic C. difficile 027 strains

Marc Monot (PI)

The capacity to rapidly and accurately identify virulent strains of C. difficile in order to prevent severe and fatal infections remains a major chal- lenge for clinicians and investigators. Also, the evolution of an […]
Project
Ongoing
2 Members

Studying and fighting pathogenic bacteria with the help of CRISPR

Studying and fighting pathogenic bacteria with the help of CRISPR (PI)

CRISPR loci and the associated Cas genes are the adaptive immune system of archeae and bacteria. They have the ability to capture pieces of DNA from viruses and other invading genetic elements [1], and […]

Publications

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