Major Federating Program Microbes & Brain
Program general concept Can microbes influence the brain to maintain health or drive pathology? Will our understanding of the microbes and brain connection generate novel therapeutic approaches? The Major Federating Program Microbes & Brain […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Adult neurogenesis and brain plasticity
The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]
Think tank: Mucosal Immunology
The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
When Gut Bacteria Changes Brain Functions
We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
Symbiotic microbiota and the development and regulation of the immune system
The symbiotic microbiota plays an essential role at many levels of host physiology, and germfree mice develop a large number of defects. In the intestine, the microbiota metabolises nutrients and toxins to generate an […]
The role of Intestinal lymphoid cells (ILCs) in defense and physiology
Innate lymphoid cells (ILCs) are a newly discovered family of lymphocytes that is mobilizing the immunological community worldwide. Three types of ILCs have been described, termed ILC1, 2 and 3, which phenocopy T helper […]
2019Excess calorie intake early in life increases susceptibility to colitis in adulthood, Nat Metab (2019) doi:10.1038/s42255-019-0129-5.
2019A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut, Sci Immunol 2019 Oct;4(40).
2019Characterization of the developmental landscape of murine RORγt+ iNKT cells, Int. Immunol. 2019 Sep;.
2019Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2, Nature 2019 Apr;568(7752):405-409.
2019A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult, Immunity 2019 05;50(5):1276-1288.e5.
2019Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner, Brain Behav. Immun. 2019 Aug;80:179-192.
2019Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth, Nat. Immunol. 2019 Mar;20(3):257-264.
2018Peyer’s patch myeloid cells infection by signals through gp38 stromal cells and locks intestinal villus invasion, J. Exp. Med. 2018 11;215(11):2936-2954.
2018Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3RORγt Regulatory T Cells, Cell Rep 2018 10;25(1):19-28.e5.
2018The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure, Gut 2019 07;68(7):1190-1199.
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