Major Federating Program Microbes & Brain
Program general concept Can microbes influence the brain to maintain health or drive pathology? Will our understanding of the microbes and brain connection generate novel therapeutic approaches? The Major Federating Program Microbes & Brain […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Adult neurogenesis and brain plasticity
The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]
Think tank: Mucosal Immunology
The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
When Gut Bacteria Changes Brain Functions
We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
Symbiotic microbiota and the development and regulation of the immune system
The symbiotic microbiota plays an essential role at many levels of host physiology, and germfree mice develop a large number of defects. In the intestine, the microbiota metabolises nutrients and toxins to generate an […]
The role of Intestinal lymphoid cells (ILCs) in defense and physiology
Innate lymphoid cells (ILCs) are a newly discovered family of lymphocytes that is mobilizing the immunological community worldwide. Three types of ILCs have been described, termed ILC1, 2 and 3, which phenocopy T helper […]
2019Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth, Nat. Immunol. 2019 Mar;20(3):257-264.
2017GAPs in early life facilitate immune tolerance, Sci Immunol 2017 Dec;2(18).
2017Macrophages Induce Long-Term Trapping of γδ T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State, J. Immunol. 2017 09;199(6):1998-2007.
2017CD34+ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury, Proc. Natl. Acad. Sci. U.S.A. 2017 01;114(4):E506-E513.
2016Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner, Sci Rep 2016 Dec;6:39117.
2016RORγt, a multitask nuclear receptor at mucosal surfaces, Mucosal Immunol 2016 Oct;.
2016The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome, Cell 2016 Aug;166(5):1231-1246.
2016Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence, Nature 2016 Jul;.
2016Immunity by equilibrium, Nat. Rev. Immunol. 2016 Jul;.
2016SLAM-associated protein favours the development of iNKT2 over iNKT17 cells, Eur. J. Immunol. 2016 Jun;.
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