Brain connectivity and neurodegenerative diseases
The brain is a complex organ, and its well-being depends on the harmonic interactions with the rest of our body. Nearly all brain disorders manifest themselves in the dysfunction of communication between brain cells […]
Major Federating Program Microbes & Brain
Program general concept Can microbes influence the brain to maintain health or drive pathology? Will our understanding of the microbes and brain connection generate novel therapeutic approaches? The Major Federating Program Microbes & Brain […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. https://www.youtube.com/watch?v=IXlKElDJMc8 The Milieu Intérieur Project While the […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Alterations of the gut microbiota are associated with numerous diseases, of which many involve impaired immune tolerance, such as allergies. However, the role of specific microorganisms and underlying molecular mechanisms remain poorly characterised. Archaeal […]
CoNCEPT – Clinical NeurosCiencE & PsychiaTry
CoNCEPT is an international research collaboration between the PM Lledo and G Eberl’s Labs (Institut Pasteur, Paris), and the McMaster University and St Joseph’s Hospital (Canada). This international collaboration, endorsed by the French Embassy in […]
Adult neurogenesis and brain plasticity
The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]
Think tank: Mucosal Immunology
The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
When Gut Bacteria Changes Brain Functions
We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
Symbiotic microbiota and the development and regulation of the immune system
The symbiotic microbiota plays an essential role at many levels of host physiology, and germfree mice develop a large number of defects. In the intestine, the microbiota metabolises nutrients and toxins to generate an […]
The role of Intestinal lymphoid cells (ILCs) in defense and physiology
Innate lymphoid cells (ILCs) are a newly discovered family of lymphocytes that is mobilizing the immunological community worldwide. Three types of ILCs have been described, termed ILC1, 2 and 3, which phenocopy T helper […]
2022The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding., Mucosal Immunol 2022 04; 15(4): 629-641.
2022Bacterial sensing via neuronal Nod2 regulates appetite and body temperature., Science 2022 04; 376(6590): eabj3986.
2020Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system., Nat Commun 2020 12; 11(1): 6363.
2020Metabolic regulation by PPARγ is required for IL-33-mediated activation of ILC2s in lung and adipose tissue., Mucosal Immunol 2020 Oct; (): .
2020Beware of whom you live with: Your intestinal IgA may depend on it., Eur. J. Immunol. 2020 Jun; 50(6): 779-782.
2020Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine., Cell Rep 2020 03; 30(11): 3682-3690.e6.
2020Imprinting of the immune system by the microbiota early in life, Mucosal Immunol (2020). https://doi.org/10.1038/s41385-020-0257-y.
2019Excess calorie intake early in life increases susceptibility to colitis in adulthood, Nat Metab (2019) doi:10.1038/s42255-019-0129-5.
2019A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut, Sci Immunol 2019 Oct;4(40).
2019Characterization of the developmental landscape of murine RORγt+ iNKT cells., Int Immunol 2020 02; 32(2): 105-116.
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