Education and qualifications 2015-now: head of the unit of Pathogenesis of Vascular Infections at the Pasteur Institute 2009-2015: group leader at the Paris Cardiovascular Research Center (PARCC) 2002-2008: research fellow, Necker Hospital, Paris, France (Xavier Nassif’s group) 1999-2002: Post Doc, Tufts Medical School, Boston, USA (Ralph Isberg’s group) 1994-1999: PhD, Pasteur Institute, Paris, France (Philippe Sansonetti’s group) 1992-1994: MSc in cancer biology, Thomas Jefferson University, Philadelphia, USA 1988-1992: BSc in cellular and molecular biology, Parix XI University, Orsay, France Awards and honours – Médaille Louis Pasteur de l’Académie des Sciences (2013) – Grand Prix de médecine et de recherche médicale “Jean Hamburger” de la Ville de Paris (2014) – Prix Pasteur Vallery Radot (2019)
The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
The use of new technological approaches including microfluidics and organ-on-chip strategies has permitted the design of advanced in vitro assays to address a variety of questions including in the study of human infections. These […]
ERC-2012-StG-Blood Vessels as a Target for Infection
One of the major challenges in bacterial infectious disease relates to infections taking place in the bloodstream (septicemia). Despite availability of antibiotics these types of infections lead to extremely severe conditions such as septic […]
Welcome to the club! Welcome to Microfluidics@Pasteur! Our goal is to serve as the major entry point to all the scientists on the campus (beginners and experts) interested in undertaking projects where microfluidics is involved. Our […]
Cross-linking Mass Spectrometry
Covalent cross-linking combined to mass spectrometry is a powerful approach to address both the structure and composition of protein complexes. To improve the crucial stage of detection and characterization of cross-linked peptides, we have […]
2019The Many Faces of Bacterium-Endothelium Interactions during Systemic Infections, Microbiol Spectr 2019 03;7(2).
2018Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting, Nat Commun 2018 10;9(1):4450.
2018Intermittent Pili-Mediated Forces Fluidize Neisseria meningitidis Aggregates Promoting Vascular Colonization, Cell 2018 06;174(1):143-155.e16.
2016Microbial pathogenesis meets biomechanics, Curr. Opin. Cell Biol. 2016 Feb;38:31-7.
2015Neisseria meningitidis Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation, PLoS Pathog. 2015 Sep;11(9):e1005162.
2014The number of Neisseria meningitidis type IV pili determines host cell interaction, EMBO J. 2014 Aug;33(16):1767-83.
2014Humanized mouse model to study bacterial infections targeting the microvasculature, J Vis Exp 2014;(86).
2014Complete posttranslational modification mapping of pathogenic Neisseria meningitidis pilins requires top-down mass spectrometry, Proteomics 2014 May;14(10):1141-51.
2013Early sequence of events triggered by the interaction of Neisseria meningitidis with endothelial cells, Cell. Microbiol. 2014 Jun;16(6):878-95.
2013A combined mass spectrometry strategy for complete posttranslational modification mapping of Neisseria meningitidis major pilin, J Mass Spectrom 2013 Nov;48(11):1199-206.
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