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  • program_project
  • nrc
  • whocc
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  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
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  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
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© Research
External Partner

Anne Hosmalin

Scientific Fields
Diseases
Organisms
Applications
Technique
27 Rue du Faubourg Saint-Jacques, 75014 Paris, France

About

Institut Cochin
U 1016 INSERM, UMR 8104 CNRS, Université Paris Descartes Immunology Départment

Research area of the Unit The group works on antigen presentation by dendritic cells (DC), showing that the housekeeping enzyme TPP2 can replace the proteasome to process an epitope from HIV Nef (Seifert Nat Immunol 2003), that DC can crosspresent HIV antigens from live infected CD4+ T cells (Marañón PNAS 2004)4, that human plasmacytoid DC can cross present, and that humans, like mice, have a specialized DC population for antigen cross-presentation, the BDCA3+ DC population. The group discovered the loss of circulating DC in HIV infection (Grassi AIDS 1999; Pacanowski Blood 2001), and conversely the accumulation of proinflammatory MDC8+ monocytes7, the early impairment of IFN-a productive capacity and the imbalance between IL-12 and IL-23 productions during the primary stage of HIV infection, when a balance between the host immune system and the virus is set6. In comparative and collaborative studies between HIV in patient cohorts and simian models, it has established that plasmacytoid DC specifically home into lymphoid organs during pathogenic infection.