LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
A common phenomenon in most microbial infections is the attenuation of the host’s immediate immune response, allowing for long-term colonization. We and others have shown that many pathogens achieve this by manipulating the epigenetic […]
What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]
Therapeutic tools based on nucleic acids
An important research axis of the laboratory is to modify nucleic acids with chemical groups in order to improve their therapeutic usefulness. Particularly, modified aptamers (i.e. oligonucleotides capable of binding to targets with high […]
2021Histone H3 deacetylation promotes host cell viability for efficient infection by Listeria monocytogenes., PLoS Pathog 2021 Dec; 17(12): e1010173.
2021The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae., Nat Microbiol 2021 02; 6(2): 257-269.
2020Pathogenic Biohacking: Induction, Modulation and Subversion of Host Transcriptional Responses by, Toxins (Basel) 2020 May;12(5).
2020Targeting host epigenetic machinery: The Listeria paradigm, Cell. Microbiol. 2020 Apr;22(4):e13169.
2020Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase, Cell Rep 2020 Mar;30(12):4016-4026.e4.
2020Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins, Sci Rep 2020 Feb;10(1):2034.
2020Revealing eukaryotic histone-modifying mechanisms through bacterial infection, Semin Immunopathol 2020 Feb;.
2019H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation, Cell Rep 2019 Dec;29(12):3933-3945.e3.
2019Customizing Host Chromatin: a Bacterial Tale, Microbiol Spectr 2019 03;7(2).
2018Rapid Remodeling of the Host Epithelial Cell Proteome by the Listeriolysin O (LLO) Pore-forming Toxin, Mol. Cell Proteomics 2018 08;17(8):1627-1636.
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