Drug Discovery & Screening at Institut Pasteur
The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Trafficking and assembly of influenza virus genomic RNAs
A collaboration with the electron microscopy expert Cristina Risco (CSIC, Madrid) led us to propose a model in which the endoplasmic reticulum (ER) plays an essential role in the trafficking of newly synthesized viral […]
Molecular mechanism of transcription by influenza virus polymerase
In the frame of a collaboration with Stephen Cusack (EMBL Grenoble) we showed that the direct interaction of the influenza virus polymerase (FluPol) PA subunit to the phosphorylated C-terminal domain of the cellular RNA […]
Engineered influenza viruses expressing a tagged polymerase subunit
To investigate the molecular processes involved in the synthesis, processing, and trafficking of viral mRNAs and genomic RNAs, we have developed original methods based on engineered viruses expressing a FluPol subunit protein tagged with an affinity […]
High-throughput protein-protein interaction assay based on a split-luciferase
The coverage and robustness of protein-protein interactions (PPI) datasets can be markedly increased by combining orthogonal PPI assays. For this purpose we have recently developed two variations of our High-throughput Gaussia princeps Complementation Assay(HT-GPCA), […]
2022Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD., PLoS Pathog 2022 May; 18(5): e1010328.
2022A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors., Antiviral Res 2022 May; 201(): 105272.
2021Single-Cell and Bulk RNA-Sequencing Reveal Differences in Monocyte Susceptibility to Influenza A Virus Infection Between Africans and Europeans., Front Immunol 2021 ; 12(): 768189.
2018Advances in Analyzing Virus-Induced Alterations of Host Cell Splicing, Trends Microbiol. 2019 Mar;27(3):268-281.
2018Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009, mSphere 2018 04;3(2).
2018Metal-Tagging Transmission Electron Microscopy and Immunogold Labeling on Tokuyasu Cryosections to Image Influenza A Virus Ribonucleoprotein Transport and Packaging, Methods Mol. Biol. 2018;1836:281-301.
2017Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans, mSphere 2017 Nov-Dec;2(6).
2017Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles, Nat Commun 2017 11;8(1):1396.
2016Structural basis of an essential interaction between influenza polymerase and Pol II CTD, Nature 2017 01;541(7635):117-121.
2016Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations, Cell 2016 Oct;167(3):643-656.e17.
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