Lucy Glover joined the Institut Pasteur in March 2016 as a G5 group leader to set up the Trypanosome Molecular Biology group. Lucy completed her Ph.D at the London School of Hygiene and Tropical Medicine (LSHTM) in David Horn`s laboratory in 2007 where she looked at the role of the telomere in antigenic variation in Trypanosoma brucei. She then went on to complete several post docs both at LSHTM and the University of Dundee studying the role of DNA repair and recombination in antigenic variation and establishing RNAi library screens to look for novel factors required for monoallelic expression in T. brucei.
SHERLOCK4HAT African trypanosomes are transmitted by the bite of the tsetse fly and cause the debilitating, and often fatal, neglected tropical disease sleeping sickness, or Human African Trypanosomiasis (HAT). Trypanosoma brucei gambiense, the parasites […]
- September 2013 – February 2016: Senior Research Associate, College of Life Sciences, University of Dundee
- January 2008 – August 2013: Post-Doctoral Research Assistant, London School of Hygiene and Tropical Medicine, UK
- January 2007-September 2007: Research Assistant, University of Cambridge, UK
- June 2003 – December 2006: Research Assistant, London School of Hygiene and Tropical Medicine , UK
- 2017: HDR, Université Paris Descartes
- 2003-2007: Ph.D in Molecular Biology; London School of Hygiene and Tropical Medicine, London, UK
- 1998-2002: 1st Class BSc (Hons); Rhodes University, Grahmastown, South Africa
Honours and Awards:
- 2014: Project of the Year, BCDD, College of Life Science, Univerisity of Dundee.
- 2007: Garnham Award for achievements of an outstanding research student completing a doctoral thesis, London School of Hygiene and Tropical Medicine, UK.
- 2003: Academic colours, Rhodes university, South Africa.
- 2002: Awarded a National Research Foundation Scarce Skills Scholarship.
- 2001: Placed on Deans Merit list for Law III and awarded the Muirhead and Rosenberg class prize for Microbiology III.
- 2000: Awarded the Irwin and Johnson Scolarship for Microbiology II
1) Using an RNAi library in combination with high-throughput sequencing to:
- Identify the components of the ‘Infectome’, the ‘druggable’ targets in brucei in an in vivo screen with The Sanger Centre, Cambridge, UK
2) Investigating DNA damage and antigenic variation in T. brucei with Dr Richard McCulloch at the Wellcome Trust Centre for Molecular Parasitology, University of Glasgow.
3) RNAi screen set up with Keith Matthews at the University of Edinburgh
2019Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex, Nature Communications. In press..
2019Persistent DNA damage foci and DNA replication with a broken chromosome in the African trypanosome, mBio in press.
2019A post-transcriptional respiratome regulon in trypanosomes, Nucleic Acids Research, 2019 May.
2019CRISPR in Parasitology: Not Exactly Cut and Dried!, Bryant, Jessica M. et al. Trends in Parasitology, Volume 35, Issue 6, 409 - 422.
2018Insights into antitrypanosomal drug mode-of-action from cytology-based profiling, PLoS Negl Trop Dis. 2018 Nov 26.
2016The nuclear envelope and gene organization in parasitic protozoa: Specializations associated with disease, Mol. Biochem. Parasitol. 2016 Sep - Oct;209(1-2):104-113.
2016VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes, Proc. Natl. Acad. Sci. U.S.A. 2016 Jun;113(26):7225-30.
2014Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes, Nat Protoc 2015 Jan;10(1):106-33.
2014Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome, Nucleic Acids Res. 2014 Nov;42(20):12600-13.
2013Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control, Cell. Microbiol. 2013 Dec;15(12):1984-93.
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