Marc Lecuit, MD, PhD, is a microbiologist and an infectious diseases physician. He is the Director of the Biology of Infection Unit at Institut Pasteur and Inserm (U1117), and the Head of the National Reference Centre and WHO Collaborating Centre Listeria.
An infection is defined by the deleterious consequences of the interactions between a pathogen and a host. Thus, studying the biology of infection reveals critical properties of hosts and pathogens, and is a way […]
Infections remain a major cause of mortality in humans. New infections are emerging, and resistance to antimicrobial drugs is widespread and expanding. There is thus an urgent need to develop novel therapeutic strategies based on rationally-designed drugs […]
Communauté des médecins affiliés de l’Institut Pasteur
Please note that this page is under construction This community is composed of MD and MD-PhD who are working in hospitals. They agree to help researchers from Institut Pasteur to identify clinical partners. Choose […]
Think tank: Mucosal Immunology
The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Microbial translocation across the intestinal epithelium (ANR, Organolist)
We use intestinal organoids, live imaging and molecular/cell biology approaches to study Listeria monocytogenes translocation across the intestinal epithelium.
Host responses to microbial intestinal invasion, impact on microbial dissemination
We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Listeria monocytogenes invasion of the placenta
We study the host and bacterial factors involved in Listeria monocytogenes invasion of the placenta. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, cell biology, […]
Listeria monocytogenes invasion of the central nervous system
We study the host and bacterial factors involved in Listeria monocytogenes invasion of the central nervous system. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, […]
Subversive pro- and anti-inflammation trade-offs promote infection by Listeria monocytogenes (Infect-ERA, PROANTILIS)
Listeriosis is a leading cause of death from food-transmitted bacterial pathogens. It can cause infections in the blood stream and brain, and lead to abortion, neonatal infection and fetal death. The causative organism, Listeria […]
When Gut Bacteria Changes Brain Functions
We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
Human and ruminant neurolisteriosis: a comparative study (Swiss National Science Foundation, Sinergia)
Neurolisteriosis is a common and frequently fatal complication of Listeria monocytogenes infection in human and ruminants. It has a high impact on human and animal health, but only little is known about its pathogenesis. […]
Modelling the dynamics of infection within the host
A large number of groups at the Institut Pasteur perform state-of-the-art research documenting the dynamics of infection in vivo for a variety of pathogens. These dynamics are often complex and the data may […]
The LISTERIAGEN project aims to identify host genetic factors associated with susceptibility to listeriosis.
MONALISA: A Multicentric Observational National Analysis on Listeriosis and Listeria (PHRC)
MONALISA is a prospective national study on invasive listeriosis. It aims to identify risk and prognostic factors for invasive listeriosis and to dissect the clinical and biological features of each form of infection (septicemia, central nervous […]
Chikungunya virus pathogenesis
Structural and functional studies of Chikungunya virus entry into host cells Deciphering Chikungunya virus cell biology by high-throughput / high-content screening Chikungunya virus infection of fibroblasts Chikungunya virus and the central nervous system infection
Enterovirus EV71 pathogenesis
This project aims to study the pathogenesis of EV71-associated encephalitis. It combines in vitro and in vivo approaches.
Our main objective is to increase the knowledge regarding the human virome during homeostasis and diseases.We mainly focus on: immunocompromised patients, where new pathogens and new associations between known pathogens and diseases at found at higher frequency than in […]
Marc LECUIT, MD, PhD Education 2004 Ability to supervise research (HDR), Paris Descartes University, Paris-F 2002 MD, Paris Descartes University, Necker-Enfants Malades University Hospital, Paris-F 2001 PhD, Paris Diderot University, Institut Pasteur, Paris-F 1996 Master (DEA), Paris Diderot University, Institut Pasteur, Paris-F 1993 Bachelor (Maîtrise), Paris 12 University, Paris-F Current positions Since 2013 Head, Biology of Infection Unit, Institut Pasteur, Paris-F Since 2013 Director, Inserm Unit 1117, Institut Pasteur, Paris-F Since 2008 Head, National Reference Center & WHO Collaborating Center on Listeria, Institut Pasteur Since 2006 Professor of Medicine, Paris Descartes University, Paris, France Since 2006 Deputy Head, Division of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris Previous positions 2008–2012 Group leader, Microbes and host barriers Group, Institut Pasteur, Paris-F 2006–2012 Group leader, Inserm avenir Group, Institut Pasteur, Paris-F 2003–2005 Chief Assistant, Division of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris 2002–2003 Post-doctoral fellow (Jeff Gordon laboratory), Washington University in St. Louis, MO, USA 1997–2001 PhD student (Pascale Cossart laboratory), Paris Diderot University, Institut Pasteur, Paris-F 1991–2001 Medical Internship and Residency Program, Paris Hospitals, Assistance Publique-Hôpitaux de Paris Fellowships and awards 2017 Prix Duquesne 2017 EMBO Member
2017 ESCMID Fellow 2016 Grand Prix Robert Debré 2015 ERC Consolidator Grant 2010 Médaille Louis Pasteur, Académie des Sciences 2010 ERC Starting Independent Researcher Grant 2009 Fondation pour la recherche médicale “Equipe” award 2009 Ville de Paris “Equipe” award 2009 Grand Prix Jean Hamburger de la Ville de Paris 2008 Institut Pasteur “Groupe à 5 ans” award 2006 Inserm “Equipe avenir” award 2005 Franco-British Prize of the Académie des Sciences and the Royal Society 2004 European Society of Clinical Microbiology and Infectious Diseases Young Investigator Award 2003 Research Award of the College of Professors of Infectious Diseases and Tropical Medicine 2002 EMBO Long-Term fellowship 2002 Philippe Foundation fellowship 2001 Prix Jean Valade Fondation de France 2000 Gold Medal of the Residency Program (Médaille d’Or du Concours de Médecine de l’Internat) 1999 Research Prize in Nutrition CIDEF Supervision of graduate students and postdoctoral fellows Since 2006 11 Postdocs, 5 PhD, 5 Master Students, Paris Diderot University 6 Undergraduate Students Teaching activities Since 2008 Courses in Master 1 and 2, Paris Descartes University and Pierre and Marie Curie University Since 2006 Teaching position, Infectious Diseases, Paris Descartes University Medical School 2004–2006 Courses in Infectious Diseases and Microbiology, Paris Descartes University Medical School 1998–2002 Course in Microbiology, Institut Pasteur, Paris-F 1993–1998 Courses for Interns in Infectious Diseases, Laennec Center, Paris-F Organisation of scientific meetings ISOPOL XIX International symposium on listeriosis, Paris, France, 2016 Jun 14-17, scientific committee member Gordon Research Conference, CNS Infections, Hong Kong, China, 2015 Jun 14-15, scientific committee member Chikungunya 2013 Conference, Langkawi, Malaysia, 2013 Oct 28-30, scientific committee member European Congress in Clinical Microbiology & Infectious Diseases 2010, 2011, 2013, program committee member Metchnikoff’s Legacy, Institut Pasteur, Paris, France, 2008 Apr 28-30, scientific committee member Institutional responsibilities Since 2014 Member, steering committee, Center for Translational Research, Institut Pasteur Since 2014 Member, steering committee, Bio Paris Cité Doctoral School, Infectiology and Microbiology, Paris-F Since 2013 Member, scientific advisory board, Institut de Microbiologie et des Maladies Infectieuses, Aviesan 2007–2008 Member, award committee, Eur. Soc. Clin. Microbiol. Infect. Dis. (ESCMID) 2007–2011 Member, scientific affairs subcommittee, Eur. Soc. Clin. Microbiol. Infect. Dis. (ESCMID) 2007–2010 Member, steering committee, National prospective survey on encephalitis Since 2006 Member, steering committee, National Reference Center for Hereditary Immunodeficiency Since 2006 Member, scientific advisory board, Cochin-Pasteur Clinical Investigation Center in Vaccinology Since 2004 Member, Necker–Pasteur Center for Infectious Diseases Commissions of trust Since 2006 Member, Faculty of 1000 Biology, Section Microbiology, Cellular Microbiology & Pathogenesis Since 2014 Scientific Advisory Board, Ville de Paris awards and Emergence grants Since 2013 Editorial board member: Virulence, Journal of Visualized Experiments, Microbial Pathogenesis Since 2013 Advisory board member: F1000Research Since 2008 Reviewer: Nature, Science, Nature Medicine, N Engl J Med, Lancet, PNAS, eLife, Cell Host Microbe, Lancet Infect Dis, PLOS Pathogens, Molecular Microbiology, Cellular Microbiology, Journal of Infectious Diseases, Emerging Infectious Diseases, Infection and Immunity, … Since 2008 Regular review panel member: ANR, Inserm, Institut Pasteur, ERC, PHRC Membership of scientific societies Since 2007 Member, European Society of Clinical Microbiology and Infectious Diseases Since 2004 Member, American Society for Microbiology Since 2004 Member, American Society for Cell Biology List of selected publications * indicates senior authorship, 254 entries in PubMed, h-index 70 (Google scholar), Oct 2018 Disson O, Blériot C, Jacob JM, Serafini N, Dulauroy S, Jouvion G, Fevre C, Gessain G, Thouvenot P, Eberl G, Di Santo JP, Peduto L, Lecuit M* Peyer’s patch myeloid cells infection by Listeria signals through gp38+ stromal cells and locks intestinal villus invasion. J Exp Med. 2018 Nov 5;215(11):2936-2954. Gladwyn-Ng I, Cordon Barris L, Alfano C, Creppe C, Couderc T, Morelli G, Thelen N, America M, Bessières B, Encha-Razavi F, Bonnière M, Suzuki IK, Flamand M, Vanderhaeghen P, Thiry M, Lecuit M*, Nguyen L* Stress-induced unfolded protein response contributes to Zika virus-associated microcephaly Nat Neurosci. 2018 Jan;21(1):63-71. Moura A, Tourdjman M, Leclercq A, Hamelin E, Laurent E, Fredriksen N, Van Cauteren D, Bracq-Dieye H, Thouvenot P, Vales G, Tessaud-Rita N, Maury MM, Alexandru A, Criscuolo A, Quevillon E, Donguy MP, Enouf V, de Valk H, Brisse S, Lecuit M* Real-Time Whole-Genome Sequencing for Surveillance of Listeria monocytogenes, France Emerg Infect Dis. 2017 Sep 15;23(9) Charlier C, Perrodeau E, Leclercq A, Cazenave B, Pilmis B, Henry B, Lopes A, Maury M, Moura A, Goffinet F, Bracq Dieye H, Thouvenot P, Ungeheuer MN, Tourdjman M, Goulet V, de Valk H, Lortholary O, Ravaud P, Lecuit M* Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study Lancet Infect Dis. 201710.1016/S1473-3099(16)30521-7 Moura A, Criscuolo A, Pouseele H, Maury MM, Leclercq A, Tarr C, Björkman JT, Dallman T, Reimer A, Enouf V, Larsonneur E, Carleton H, Bracq-Dieye H, Katz LS, Jones L, Touchon M, Tourdjman M, Walker M, Stroika S, Cantinelli T, Chenal-Francisque V, Kucerova Z, Rocha EPC, Nadon C, Grant K, Nielsen EM, Pot B, Gerner-Smidt P, Lecuit M*, Brisse S* Whole genome-based population biology and epidemiological surveillance of Listeria monocytogenes Nat Microbiol 2016 Oct 10;2:16185 Karlas A, Berre S, Couderc T, Varjak M, Braun P, Meyer M, Gangneux N, Karo-Astover L, Weege F, Raftery M, Schönrich G, Klemm U, Wurzlbauer A, Bracher F, Merits A, Meyer TF*, Lecuit M* A host genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs Nat Commun 2016 May 12;7:11320 Maury MM, Tsai YH, Charlier C, Touchon M, Chenal-Francisque V, Leclercq A, Criscuolo A, Gaultier C, Roussel S, Brisabois A, Disson O, Rocha EP, Brisse S*, Lecuit M* Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity. Nat Genet 2016 Mar;48(3):308-13 Weaver S*, Lecuit M* Chikungunya virus and the global spread of a mosquito-borne disease N Engl J Med 2015 372(13):1231-1239 Gessain G, Tsai YH, Travier L, Bonazzi M, Grayo S, Cossart P, Charlier C, Disson O, Lecuit M* PI3-kinase activation is critical for host barriers permissiveness to Listeria monocytogenes J Exp Med 2015 212(2):165-83 Blériot C, Dupuis T, Jouvion G, Eberl G. Disson O, Lecuit M* Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection Immunity 2015 42(1):145-58 Tsai Yu-Huan, Disson O, Bierne H, Lecuit M* Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses PLOS Pathog 2013 9(5):e1003381 Travier L, Guadagnini S, Gouin E, Dufour A, Chenal-Francisque V, Cossart P, Olivo-Marin JC, Ghigo JM, Disson O, Lecuit M* ActA promotes Listeria monocytogenes aggregation, intestinal colonization and carriage PLOS Pathog 2013 9(1):e1003131 Judith D, Mostowy S, Bouraï M, Gangneux N, Lelek M, Lucas-Hourani M, Cayet N, Jacob Y, Prévost MC, Pierre P, Tangy F, Zimmer C, Vidalain PO, Couderc T, Lecuit M* Species-specific impact of the autophagy machinery on Chikungunya virus infection EMBO Rep 2013 14(6):534-44 Archambaud C, Nahori MA, Soubigou G, Bécavin C, Laval L, Lechat P, Smkvina T, Langella P, Lecuit M*, Cossart P* Impact of lactobacilli on orally acquired listeriosis Proc Natl Acad Sci U S A 2012 109(41):16684-9 Nikitas G, Deschamps C, Disson O, Niault T, Cossart P, Lecuit M* Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin J Exp Med 2011 208(11):2263-77 Tazi A, Disson O, Bellais S, Bouaboud A, Dmytruk N, Dramsi S, Mistou M-Y, Khun H, Mechler C, Tardieux I, Trieu-Cuot P, Lecuit M*, Poyart C* The surface protein HvgA mediates Group B streptococcus hypervirulence and meningeal tropism in neonates J Exp Med 2010 207(11):2313-22 Schilte C, Couderc T, Chrétien F, Sourisseau M, Gangneux N, Guivel-Benhassine F, Gruber A, Tschopp J, Higgs S, Michault A, Arenzana-Seisdedos F, Colonna M, Schwartz O, Lecuit M*, Albert M* Type I IFN controls chikungunya virus via its action on non-hematopoetic cells. J Exp Med 2010 207(2):429-42 Mostowy S, Bonazzi M, Hamon MA, Tham TN, Mallet A, Lelek M, Gouin E, Demangel C, Brosch R, Zimmer C, Sartori A, Kinoshita M, Lecuit M, Cossart P Entrapment of intracytosolic bacteria by septin cage-like structures Cell Host Microbe 2010 8(5):433-44 Toledo-Arana A, Dussurget O, Nikitas G, Sesto N, Guet-Revillet H, Balestrino D, Loh E, Gripenland J, Tiensuu T, Vaitkevicius K, Barthelemy M, Vergassola M, Nahori M-A, Soubigou G, Régnault B, Coppée J-Y, Lecuit M, Johansson J, Cossart P The Listeria transcriptional landscape from saprophytism to virulence Nature 2009 59(7249):950-6 Disson O, Grayo S, Huillet E, Nikitas G, Langa-Vives F, Dussurget O, Ragon M, Le Monnier A, Babinet C, Cossart P, Lecuit M* Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis Nature 2008 455(7216):1114-8 Couderc T, Chrétien F,Schilte C, Disson O, Brigitte M, Guivel-Benhassine F, Touret Y, Barau G, Prévost MC, Schuffenecker I, Desprès P, Arenzana-Seisdedos F, Michault A, Albert ML*, Lecuit M* A mouse model for Chikungunya infection: young age and inefficient type-I interferon signaling are risk factors for severe disease PLOS Pathog 2008 4(2): p. e29 Gérardin P, Barau G, Michault A, Bintner M, Randrianaivo H, Choker G, Lenglet Y, Touret Y, Bouveret A, Grivard P, Le Roux K, Blanc S, Schuffenecker I, Couderc T, Arenzana-Seisdedos F, Lecuit M*, Robillard PY Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Réunion PLOS Medicine 2008 5(3): p. e60 Boneca IG, Dussurget O, Cabanes D, Nahori MA, Sousa S, Lecuit M, Psylinakis E, Bouriotis V, Hugot JP, Giovannini M, Coyle A, Bertin J, Namane A, Rousselle JC, Cayet N, Prevost MC, Balloy V, Chignard M, Philpott DJ, Cossart P, Girardin SE. A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system Proc Natl Acad Sci U S A 2007 104(3):997-1002 Lecuit M, Sonnenburg JL, Cossart P, Gordon JI Functional genomic studies of the intestinal response to a foodborne enteropathogen in a humanized gnotobiotic mouse model J Biol Chem 2007 282(20):15065-72 Sousa S, Cabanes D, Archambaud C, Colland F, Lemichez E, Popoff M, Boisson-Dupuis S, Gouin E, Lecuit M, Legrain P, Cossart P. ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion. Nat Cell Biol 2005 7(10):954-60 Lecuit M*, Nelson DM, Smith SD, Khun H, Huerre M, Vacher-Lavenu MC, Gordon JI, Cossart P. Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin. Proc Natl Acad Sci U S A 2004 101(16):6152-7 Lecuit M*, Abachin E, Martin A, Poyart C, Pochart P, Suarez F, Bengoufa D, Feuillard J, Lavergne A, Gordon JI, Berche P, Guillevin L, Lortholary O. Immunoproliferative small intestinal disease associated with Campylobacter jejuni. N Engl J Med 2004 350(3):239-48 Lecuit M, Vandormael-Pournin S, Lefort J, Huerre M, Gounon P, Dupuy C, Babinet C, Cossart P. A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier. Science 2001 292(5522):1722-5 Kussel-Andermann P, El-Amraoui A, Safieddine S, Nouaille S, Perfettini I, Lecuit M, Cossart P, Wolfrum U, Petit C. Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. EMBO J 2000 19(22):6020-9 Lecuit M, Hurme R, Pizarro-Cerda J, Ohayon H, Geiger B, Cossart P. A role for alpha-and beta-catenins in bacterial uptake. Proc Natl Acad Sci U S A 2000 97(18):10008-13 Lecuit M, Dramsi S, Gottardi C, Fedor-Chaiken M, Gumbiner B, Cossart P. A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes. EMBO J 1999 18(14):3956-63
2018Peyer’s patch myeloid cells infection by Listeria signals through gp38 stromal cells and locks intestinal villus invasion, J. Exp. Med. 2018 Oct;.
2018Imaging of Human Neurolisteriosis: A Prospective Study of 71 Cases, Clin. Infect. Dis. 2018 Oct;67(9):1419-1426.
2018Correction: Epistatic control of intrinsic resistance by virulence genes in Listeria, PLoS Genet. 2018 Oct;14(10):e1007727.
2018Epistatic control of intrinsic resistance by virulence genes in Listeria, PLoS Genet. 2018 Sep;14(9):e1007525.
2018Lessons learnt from the emergence of Zika virus, Nat Microbiol 2018 Sep;3(9):966-968.
2018Retrospective validation of whole genome sequencing-enhanced surveillance of listeriosis in Europe, 2010 to 2015, Euro Surveill. 2018 08;23(33).
2018Zika virus infects human testicular tissue and germ cells, J. Clin. Invest. 2018 Oct;128(10):4697-4710.
2018A clinical and histopathological study of malformations observed in fetuses infected by the Zika virus, Brain Pathol. 2018 Jul;.
2018Detection of Japanese Encephalitis Virus RNA in Human Throat Samples in Laos – A Pilot study, Sci Rep 2018 May;8(1):8018.
2018Listeria monocytogenes-associated respiratory infections: a study of 38 consecutive cases, Clin. Microbiol. Infect. 2018 Mar;.
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