Marc Lecuit, MD, PhD, is a microbiologist and an infectious diseases physician. He is the Director of the Biology of Infection Unit at Institut Pasteur and Inserm (U1117), the Head of the National Reference Centre and WHO Collaborating Centre Listeria and the Chair of the Department of Cell Biology and Infection. He is a Professor at Institut Universitaire de France, Universite Paris Cite and Deputy Head of the Department of Infectious Diseases and Tropical Medicine at the Necker-Enfants Malades University Hospital.
Ageing & Longevity
According to the WHO, the global percentage of people aged of more than 60 years will double from 11 to 22% between 2000 and 2050. Nowadays most of the elderly die of non-transmissible diseases […]
Major Federating Program Microbes & Brain
Program general concept Can microbes influence the brain to maintain health or drive pathology? Will our understanding of the microbes and brain connection generate novel therapeutic approaches? The Major Federating Program Microbes & Brain […]
The Southeast Asia encephalitis project
An integrative approach to understand and fight infectious encephalitis in children An encephalitis is an acute inflammation of the central nervous system associated with neurologic dysfunction. The most common etiologies are infections by […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
An infection is defined by the deleterious consequences of the interactions between a pathogen and a host. Thus, studying the biology of infection reveals critical properties of hosts and pathogens, and is a way […]
Infections remain a major cause of mortality in humans. New infections are emerging, and resistance to antimicrobial drugs is widespread and expanding. There is thus an urgent need to develop novel therapeutic strategies based on rationally-designed drugs […]
Communauté des médecins affiliés de l’Institut Pasteur
Please note that this page is under construction This community is composed of MD and MD-PhD who are working in hospitals. They agree to help researchers from Institut Pasteur to identify clinical partners. Choose […]
Think tank: Mucosal Immunology
The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Microbial translocation across the intestinal epithelium (ANR, Organolist)
We use intestinal organoids, live imaging and molecular/cell biology approaches to study Listeria monocytogenes translocation across the intestinal epithelium.
Host responses to microbial intestinal invasion, impact on microbial dissemination
We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Listeria monocytogenes invasion of the placenta
We study the host and bacterial factors involved in Listeria monocytogenes invasion of the placenta. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, cell biology, […]
Listeria monocytogenes invasion of the central nervous system
We study the host and bacterial factors involved in Listeria monocytogenes invasion of the central nervous system. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, […]
Subversive pro- and anti-inflammation trade-offs promote infection by Listeria monocytogenes (Infect-ERA, PROANTILIS)
Listeriosis is a leading cause of death from food-transmitted bacterial pathogens. It can cause infections in the blood stream and brain, and lead to abortion, neonatal infection and fetal death. The causative organism, Listeria […]
When Gut Bacteria Changes Brain Functions
We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
Human and ruminant neurolisteriosis: a comparative study (Swiss National Science Foundation, Sinergia)
Neurolisteriosis is a common and frequently fatal complication of Listeria monocytogenes infection in human and ruminants. It has a high impact on human and animal health, but only little is known about its pathogenesis. […]
The LISTERIAGEN project aims to identify host genetic factors associated with susceptibility to listeriosis.
MONALISA: A Multicentric Observational National Analysis on Listeriosis and Listeria (PHRC)
MONALISA is a prospective national study on invasive listeriosis. It aims to identify risk and prognostic factors for invasive listeriosis and to dissect the clinical and biological features of each form of infection (septicemia, central nervous […]
Chikungunya virus pathogenesis
Structural and functional studies of Chikungunya virus entry into host cells Deciphering Chikungunya virus cell biology by high-throughput / high-content screening Chikungunya virus infection of fibroblasts Chikungunya virus and the central nervous system infection
Enterovirus EV71 pathogenesis
This project aims to study the pathogenesis of EV71-associated encephalitis. It combines in vitro and in vivo approaches.
Our main objective is to increase the knowledge regarding the human virome during homeostasis and diseases. We mainly focus on: immunocompromised patients, where new pathogens and new associations between known pathogens and diseases at found at higher frequency than […]
Marc LECUIT, MD, PhD Education 2004 Ability to supervise research (HDR), Paris Descartes University, Paris-F 2002 MD, Paris Descartes University, Necker-Enfants Malades University Hospital, Paris-F 2001 PhD, Paris Diderot University, Institut Pasteur, Paris-F 1996 Master (DEA), Paris Diderot University, Institut Pasteur, Paris-F 1993 Bachelor (Maîtrise), Paris 12 University, Paris-F Current positions Since 2019 Chair, Department of Cell Biology and Infection, Institut Pasteur, Paris-F Since 2013 Head, Biology of Infection Unit, Institut Pasteur, Paris-F Since 2013 Director, Inserm Unit 1117, Institut Pasteur, Paris-F Since 2008 Head, National Reference Center & WHO Collaborating Center on Listeria, Institut Pasteur, Paris-F Since 2006 Professor of Medicine, Université Paris Cité, Paris, France Since 2006 Deputy Head, Division of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-F Past positions 2008–2012 Group leader, Microbes and host barriers Group, Institut Pasteur, Paris-F 2006–2012 Group leader, Inserm avenir Group, Institut Pasteur, Paris-F 2003–2005 Chief Assistant, Division of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-F 2002–2003 Post-doctoral fellow (with Jeffrey I. Gordon), Washington University in St. Louis, MO, USA 1997–2001 PhD student (with Pascale Cossart), Paris Diderot University, Institut Pasteur, Paris-F 1991–2001 Medical Internship and Residency Program, Paris Hospitals, Assistance Publique-Hôpitaux de Paris Fellowships and awards 2020 Prix Eloi Collery, Académie Nationale de Médecine 2020 Senior Member, Institut Universitaire de France 2019 Member of Academia Europaea 2017 Prix Duquesne 2017 EMBO Member 2017 ESCMID Fellow 2016 Grand Prix Robert Debré 2015 ERC Consolidator Grant 2010 Médaille Louis Pasteur, Académie des Sciences 2010 ERC Starting Independent Researcher Grant 2009 Fondation pour la recherche médicale “Equipe” award 2009 Ville de Paris “Equipe” award 2009 Grand Prix Jean Hamburger de la Ville de Paris 2008 Institut Pasteur “Groupe à 5 ans” award 2006 Inserm “Equipe avenir” award 2005 Franco-British Prize of the Académie des Sciences and the Royal Society 2004 European Society of Clinical Microbiology and Infectious Diseases Young Investigator Award 2003 Research Award of the College of Professors of Infectious Diseases and Tropical Medicine 2002 EMBO Long-Term fellowship 2002 Philippe Foundation fellowship 2001 Prix Jean Valade Fondation de France 2000 Gold Medal of the Residency Program (Médaille d’Or du Concours de Médecine de l’Internat) 1999 Research Prize in Nutrition CIDEF Supervision of graduate students and postdoctoral fellows Since 2006 13 Postdocs, 8 PhD, 7 Master Students, 8 Undergraduate Students Teaching activities Since 2008 Courses in Master 1 and 2, Paris Descartes University and Pierre and Marie Curie University Since 2006 Teaching position, Infectious Diseases, Paris Descartes University Medical School 2004–2006 Courses in Infectious Diseases and Microbiology, Paris Descartes University Medical School 1998–2002 Course in Microbiology, Institut Pasteur, Paris-F 1993–1998 Courses for Interns in Infectious Diseases, Laennec Center, Paris-F Organization of scientific meetings ISOPOL XX International symposium on listeriosis, Toronto, Canada, 2019 Sep 24-27, scientific committee member ISOPOL XIX International symposium on listeriosis, Paris, France, 2016 Jun 14-17, scientific committee member Gordon Research Conference, CNS Infections, Hong Kong, China, 2015 Jun 14-15, scientific committee member Chikungunya 2013 Conference, Langkawi, Malaysia, 2013 Oct 28-30, scientific committee member European Congress in Clinical Microbiology & Infectious Diseases 2010, 2011, 2013, program committee member Metchnikoff’s Legacy, Institut Pasteur, Paris, France, 2008 Apr 28-30, scientific committee member Institutional responsibilities Since 2014 Member, steering committee, Center for Translational Research, Institut Pasteur Since 2014 Member, steering committee, Bio Paris Cité Doctoral School, Infectiology and Microbiology, Paris-F Since 2013 Member, scientific advisory board, Institut de Microbiologie et des Maladies Infectieuses, Aviesan 2007–2008 Member, award committee, Eur. Soc. Clin. Microbiol. Infect. Dis. (ESCMID) 2007–2011 Member, scientific affairs subcommittee, Eur. Soc. Clin. Microbiol. Infect. Dis. (ESCMID) 2007–2010 Member, steering committee, National prospective survey on encephalitis Since 2006 Member, steering committee, National Reference Center for Hereditary Immunodeficiency Since 2006 Member, scientific advisory board, Cochin-Pasteur Clinical Investigation Center in Vaccinology Since 2004 Member, Necker–Pasteur Center for Infectious Diseases Commissions of trust Since 2006 Member, Faculty of 1000 Biology, Section Microbiology, Cellular Microbiology & Pathogenesis Since 2014 Scientific Advisory Board, Ville de Paris awards and Emergence grants Since 2013 Editorial board member: Virulence, Journal of Visualized Experiments, Microbial Pathogenesis Since 2013 Advisory board member: F1000Research Since 2008 Reviewer: Nature, Science, Nature Medicine, N Engl J Med, Lancet, PNAS, eLife, Cell Host Microbe, Lancet Infect Dis, PLOS Pathogens, Molecular Microbiology, Cellular Microbiology, Journal of Infectious Diseases, Emerging Infectious Diseases, Infection and Immunity, … Since 2008 Regular review panel member: ANR, Inserm, Institut Pasteur, ERC, PHRC Membership of scientific societies Since 2007 Member, European Society of Clinical Microbiology and Infectious Diseases Since 2004 Member, American Society for Microbiology Since 2004 Member, American Society for Cell Biology
2022Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence., Nature volume 603, pages 900–906 (2022).
2022Epithelial colonization by gut dendritic cells promotes their functional diversification., Immunity 2022 Jan; 55(1): 129-144.e8.
2022Neonatal Listeriosis Presentation and Outcome: A Prospective Study of 189 Cases., Clin Infect Dis 2022 Jan; 74(1): 8-16.
2021Listeriosis, a model infection to study host-pathogen interactions in vivo., Curr Opin Microbiol 2021 Dec; 66(): 11-20.
2021Overexpression of IgG2 in patients resembling IgG4-related disease with normal IgG4., Scand J Immunol 2021 Dec; (): e13126.
2021Ruminant-associated Listeria monocytogenes isolates belong preferentially to dairy-associated hypervirulent clones: a longitudinal study in 19 farms., Environ Microbiol 2021 Dec; (): .
2021Emergence and global spread of Listeria monocytogenes main clinical clonal complex., Sci Adv 2021 Dec; 7(49): eabj9805.
2021The Clinicopathological Spectrum of Kidney Lesions in Chikungunya Fever: A Report of 5 Cases With Kidney Biopsy., Am J Kidney Dis 2021 12; 78(6): 902-906.
2021Listeria monocytogenes faecal carriage is common and depends on the gut microbiota., Nat Commun 2021 11; 12(1): 6826.
2021Poor outcome and high prevalence of invasive fungal infections in patients with adult T-cell leukemia/lymphoma exposed to zidovudine and interferon alfa., Ann Hematol 2021 Nov; 100(11): 2813-2824.
+View full list of publications