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About

Marc Lecuit, MD, PhD, is a microbiologist and an infectious diseases physician. He is the Director of the Biology of Infection Unit at Institut Pasteur and Inserm (U1117), and the Head of the National Reference Centre and WHO Collaborating Centre Listeria.

He is a Professor at the Paris Descartes University and Deputy Head of the Department of Infectious Diseases and Tropical Medicine at the Necker-Enfants Malades University Hospital.

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Marc LECUIT, MD, PhD

Education
2004  Ability to supervise research (HDR), Paris Descartes University, Paris-F
2002  MD, Paris Descartes University, Necker-Enfants Malades University Hospital, Paris-F
2001  PhD, Paris Diderot University, Institut Pasteur, Paris-F
1996  Master (DEA), Paris Diderot University, Institut Pasteur, Paris-F
1993  Bachelor (Maîtrise), Paris 12 University, Paris-F

Current positions
Since 2013  Head, Biology of Infection Unit, Institut Pasteur, Paris-F
Since 2013  Director, Inserm Unit 1117, Institut Pasteur, Paris-F
Since 2008  Head, National Reference Center & WHO Collaborating Center on Listeria, Institut Pasteur
Since 2006  Professor of Medicine, Paris Descartes University, Paris, France
Since 2006  Deputy Head, Division of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris

Previous positions
2008–2012  Group leader, Microbes and host barriers Group, Institut Pasteur, Paris-F
2006–2012  Group leader, Inserm avenir Group, Institut Pasteur, Paris-F
2003–2005  Chief Assistant, Division of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris
2002–2003  Post-doctoral fellow (Jeff Gordon laboratory), Washington University in St. Louis, MO, USA
1997–2001  PhD student (Pascale Cossart laboratory), Paris Diderot University, Institut Pasteur, Paris-F
1991–2001  Medical Internship and Residency Program, Paris Hospitals, Assistance Publique-Hôpitaux de Paris

Fellowships and awards
2017  EMBO Member
2017  ESCMID Fellow
2016  Grand Prix Robert Debré
2015  ERC Consolidator Grant
2010  Médaille Louis Pasteur, Académie des Sciences
2010  ERC Starting Independent Researcher Grant
2009  Fondation pour la recherche médicale “Equipe” award
2009  Ville de Paris “Equipe” award
2009  Grand Prix Jean Hamburger de la Ville de Paris
2008  Institut Pasteur “Groupe à 5 ans” award
2006  Inserm “Equipe avenir” award
2005  Franco-British Prize of the Académie des Sciences and the Royal Society
2004  European Society of Clinical Microbiology and Infectious Diseases Young Investigator Award
2003  Research Award of the College of Professors of Infectious Diseases and Tropical Medicine
2002  EMBO Long-Term fellowship
2002  Philippe Foundation fellowship
2001  Prix Jean Valade Fondation de France
2000  Gold Medal of the Residency Program (Médaille d’Or du Concours de Médecine de l’Internat)
1999  Research Prize in Nutrition CIDEF

Supervision of graduate students and postdoctoral fellows
Since 2006  11 Postdocs, 5 PhD, 5 Master Students, Paris Diderot University
6 Undergraduate Students

Teaching activities
Since 2008  Courses in Master 1 and 2, Paris Descartes University and Pierre and Marie Curie University
Since 2006  Teaching position, Infectious Diseases, Paris Descartes University Medical School
2004–2006  Courses in Infectious Diseases and Microbiology, Paris Descartes University Medical School
1998–2002  Course in Microbiology, Institut Pasteur, Paris-F
1993–1998  Courses for Interns in Infectious Diseases, Laennec Center, Paris-F

Organisation of scientific meetings
ISOPOL XIX International symposium on listeriosis, Paris, France, 2016 Jun 14-17, scientific committee member
Gordon Research Conference, CNS Infections, Hong Kong, China, 2015 Jun 14-15, scientific committee member
Chikungunya 2013 Conference, Langkawi, Malaysia, 2013 Oct 28-30, scientific committee member
European Congress in Clinical Microbiology & Infectious Diseases 2010, 2011, 2013, program committee member
Metchnikoff’s Legacy, Institut Pasteur, Paris, France, 2008 Apr 28-30, scientific committee member

Institutional responsibilities
Since 2014  Member, steering committee, Center for Translational Research, Institut Pasteur
Since 2014  Member, steering committee, Bio Paris Cité Doctoral School, Infectiology and Microbiology, Paris-F
Since 2013  Member, scientific advisory board, Institut de Microbiologie et des Maladies Infectieuses, Aviesan
2007–2008  Member, award committee, Eur. Soc. Clin. Microbiol. Infect. Dis. (ESCMID)
2007–2011 Member, scientific affairs subcommittee, Eur. Soc. Clin. Microbiol. Infect. Dis. (ESCMID)
2007–2010  Member, steering committee, National prospective survey on encephalitis
Since 2006  Member, steering committee, National Reference Center for Hereditary Immunodeficiency
Since 2006  Member, scientific advisory board, Cochin-Pasteur Clinical Investigation Center in Vaccinology
Since 2004  Member, Necker–Pasteur Center for Infectious Diseases

Commissions of trust
Since 2006  Member, Faculty of 1000 Biology, Section Microbiology, Cellular Microbiology & Pathogenesis
Since 2014  Scientific Advisory Board, Ville de Paris awards and Emergence grants
Since 2013  Editorial board member: Virulence, Journal of Visualized Experiments, Microbial Pathogenesis
Since 2013  Advisory board member: F1000Research
Since 2008  Reviewer: Nature, Nature Medicine, N Engl J Med, LancetPNAS, Cell Host MicrobeLancet Infect DisPLOS PathogensMolecular MicrobiologyCellular Microbiology, Journal of Infectious Diseases, Emerging Infectious Diseases, Infection and Immunity, …
Since 2008  Regular review panel member:  ANR, Inserm, Institut Pasteur, ERC, PHRC

Membership of scientific societies
Since 2007  Member, European Society of Clinical Microbiology and Infectious Diseases
Since 2004  Member, American Society for Microbiology
Since 2004  Member, American Society for Cell Biology

List of selected publications
* indicates senior authorship, 231 entries in PubMed, h-index 62 (Google scholar), Jun 2017

Moura A, Tourdjman M, Leclercq A, Hamelin E, Laurent E, Fredriksen N, Van Cauteren D, Bracq-Dieye H, Thouvenot P, Vales G, Tessaud-Rita N, Maury MM, Alexandru A, Criscuolo A, Quevillon E, Donguy MP, Enouf V, de Valk H, Brisse S, Lecuit M*
Real-Time Whole-Genome Sequencing for Surveillance of Listeria monocytogenes, France
Emerg Infect Dis. 2017 Sep 15;23(9)

Charlier C, Perrodeau E, Leclercq A, Cazenave B, Pilmis B, Henry B, Lopes A, Maury M, Moura A, Goffinet F, Bracq Dieye H, Thouvenot P, Ungeheuer MN, Tourdjman M, Goulet V, de Valk H, Lortholary O, Ravaud P, Lecuit M*
Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study
Lancet Infect Dis. 201710.1016/S1473-3099(16)30521-7

Moura A, Criscuolo A, Pouseele H, Maury MM, Leclercq A, Tarr C, Björkman JT, Dallman T, Reimer A, Enouf V, Larsonneur E, Carleton H, Bracq-Dieye H, Katz LS, Jones L, Touchon M, Tourdjman M, Walker M, Stroika S, Cantinelli T, Chenal-Francisque V, Kucerova Z, Rocha EPC, Nadon C, Grant K, Nielsen EM, Pot B, Gerner-Smidt P, Lecuit M*, Brisse S*
Whole genome-based population biology and epidemiological surveillance of Listeria monocytogenes
Nat Microbiol 2016 Oct 10;2:16185

Karlas A, Berre S, Couderc T, Varjak M, Braun P, Meyer M, Gangneux N, Karo-Astover L, Weege F, Raftery M, Schönrich G, Klemm U, Wurzlbauer A, Bracher F, Merits A, Meyer TF*, Lecuit M*
A host genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs
Nat Commun 2016 May 12;7:11320

Maury MM, Tsai YH, Charlier C, Touchon M, Chenal-Francisque V, Leclercq A, Criscuolo A, Gaultier C, Roussel S, Brisabois A, Disson O, Rocha EP, Brisse S*, Lecuit M*
Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity.
Nat Genet 2016 Mar;48(3):308-13

Weaver S*, Lecuit M*
Chikungunya virus and the global spread of a mosquito-borne disease
N Engl J Med 2015 372(13):1231-1239

Gessain G, Tsai YH, Travier L, Bonazzi M, Grayo S, Cossart P, Charlier C, Disson O, Lecuit M*
PI3-kinase activation is critical for host barriers permissiveness to Listeria monocytogenes
J Exp Med 2015 212(2):165-83

Blériot C, Dupuis T, Jouvion G, Eberl G. Disson O, Lecuit M*
Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection
Immunity 2015 42(1):145-58

Tsai Yu-Huan, Disson O, Bierne H, Lecuit M*
Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses
PLOS Pathog 2013 9(5):e1003381

Travier L, Guadagnini S, Gouin E, Dufour A, Chenal-Francisque V, Cossart P, Olivo-Marin JC, Ghigo JM, Disson O, Lecuit M*
ActA promotes Listeria monocytogenes aggregation, intestinal colonization and carriage
PLOS Pathog 2013 9(1):e1003131

Judith D, Mostowy S, Bouraï M, Gangneux N, Lelek M, Lucas-Hourani M, Cayet N, Jacob Y, Prévost MC, Pierre P, Tangy F, Zimmer C, Vidalain PO, Couderc T, Lecuit M*
Species-specific impact of the autophagy machinery on Chikungunya virus infection
EMBO Rep 2013 14(6):534-44

Archambaud C, Nahori MA, Soubigou G, Bécavin C, Laval L, Lechat P, Smkvina T, Langella P, Lecuit M*, Cossart P*
Impact of lactobacilli on orally acquired listeriosis
Proc Natl Acad Sci U S A 2012 109(41):16684-9

Nikitas G, Deschamps C, Disson O, Niault T, Cossart P, Lecuit M*
Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin
J Exp Med 2011 208(11):2263-77

Tazi A, Disson O, Bellais S, Bouaboud A, Dmytruk N, Dramsi S, Mistou M-Y, Khun H, Mechler C, Tardieux I, Trieu-Cuot P, Lecuit M*, Poyart C*
The surface protein HvgA mediates Group B streptococcus hypervirulence and meningeal tropism in neonates
J Exp Med 2010 207(11):2313-22

Schilte C, Couderc T, Chrétien F, Sourisseau M, Gangneux N, Guivel-Benhassine F, Gruber A, Tschopp J, Higgs S, Michault A, Arenzana-Seisdedos F, Colonna M, Schwartz O, Lecuit M*, Albert M*
Type I IFN controls chikungunya virus via its action on non-hematopoetic cells.
J Exp Med 2010 207(2):429-42

Mostowy S, Bonazzi M, Hamon MA, Tham TN, Mallet A, Lelek M, Gouin E, Demangel C, Brosch R, Zimmer C, Sartori A, Kinoshita M, Lecuit M, Cossart P
Entrapment of intracytosolic bacteria by septin cage-like structures
Cell Host Microbe 2010 8(5):433-44

Toledo-Arana A, Dussurget O, Nikitas G, Sesto N, Guet-Revillet H, Balestrino D, Loh E, Gripenland J, Tiensuu T, Vaitkevicius K, Barthelemy M, Vergassola M, Nahori M-A, Soubigou G, Régnault B, Coppée J-Y, Lecuit M, Johansson J, Cossart P
The Listeria transcriptional landscape from saprophytism to virulence
Nature 2009 59(7249):950-6

Disson O, Grayo S, Huillet E, Nikitas G, Langa-Vives F, Dussurget O, Ragon M, Le Monnier A, Babinet C, Cossart P, Lecuit M*
Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis
Nature 2008 455(7216):1114-8

Couderc T, Chrétien F,Schilte C, Disson O, Brigitte M, Guivel-Benhassine F, Touret Y, Barau G, Prévost MC, Schuffenecker I, Desprès P, Arenzana-Seisdedos F, Michault A, Albert ML*, Lecuit M*
A mouse model for Chikungunya infection: young age and inefficient type-I interferon signaling are risk factors for severe disease
PLOS Pathog 2008 4(2): p. e29

Gérardin P, Barau G, Michault A, Bintner M, Randrianaivo H, Choker G, Lenglet Y, Touret Y, Bouveret A, Grivard P, Le Roux K, Blanc S, Schuffenecker I, Couderc T, Arenzana-Seisdedos F, Lecuit M*, Robillard PY
Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Réunion
PLOS Medicine 2008 5(3): p. e60

Boneca IG, Dussurget O, Cabanes D, Nahori MA, Sousa S, Lecuit M, Psylinakis E, Bouriotis V, Hugot JP, Giovannini M, Coyle A, Bertin J, Namane A, Rousselle JC, Cayet N, Prevost MC, Balloy V, Chignard M, Philpott DJ, Cossart P, Girardin SE.
A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system
Proc Natl Acad Sci U S A  2007 104(3):997-1002

Lecuit M, Sonnenburg JL, Cossart P, Gordon JI
Functional genomic studies of the intestinal response to a foodborne enteropathogen in a humanized gnotobiotic mouse model
J Biol Chem 2007 282(20):15065-72

Sousa S, Cabanes D, Archambaud C, Colland F, Lemichez E, Popoff M, Boisson-Dupuis S, Gouin E, Lecuit M, Legrain P, Cossart P.
ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion.
Nat Cell Biol  2005 7(10):954-60

Lecuit M*, Nelson DM, Smith SD, Khun H, Huerre M, Vacher-Lavenu MC, Gordon JI, Cossart P.
Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin.
Proc Natl Acad Sci U S A 2004 101(16):6152-7

Lecuit M*, Abachin E, Martin A, Poyart C, Pochart P, Suarez F, Bengoufa D, Feuillard J, Lavergne A, Gordon JI, Berche P, Guillevin L, Lortholary O.
Immunoproliferative small intestinal disease associated with Campylobacter jejuni.
N Engl J Med 2004 350(3):239-48

Lecuit M, Vandormael-Pournin S, Lefort J, Huerre M, Gounon P, Dupuy C, Babinet C, Cossart P.
A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier.
Science 2001 292(5522):1722-5

Kussel-Andermann P, El-Amraoui A, Safieddine S, Nouaille S, Perfettini I, Lecuit M, Cossart P, Wolfrum U, Petit C.
Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex.
EMBO J 2000 19(22):6020-9

Lecuit M, Hurme R, Pizarro-Cerda J, Ohayon H, Geiger B, Cossart P.
A role for alpha-and beta-catenins in bacterial uptake.
Proc Natl Acad Sci U S A 2000 97(18):10008-13

Lecuit M, Dramsi S, Gottardi C, Fedor-Chaiken M, Gumbiner B, Cossart P.
A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes.
EMBO J 1999 18(14):3956-63

Publications