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Marc LECUIT, MD, PhD Education 2004  Ability to supervise research (HDR), Paris Descartes University, Paris-F 2002  MD, Paris Descartes University, Necker-Enfants Malades University Hospital, Paris-F 2001  PhD, Paris Diderot University, Institut Pasteur, Paris-F 1996  Master (DEA), Paris Diderot University, Institut Pasteur, Paris-F 1993  Bachelor (Maîtrise), Paris 12 University, Paris-F Current positions Since 2013  Head, Biology of Infection Unit, Institut Pasteur, Paris-F Since 2013  Director, Inserm Unit 1117, Institut Pasteur, Paris-F Since 2008  Head, National Reference Center & WHO Collaborating Center on Listeria, Institut Pasteur Since 2006  Professor of Medicine, Paris Descartes University, Paris, France Since 2006  Deputy Head, Division of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris Previous positions 2008–2012  Group leader, Microbes and host barriers Group, Institut Pasteur, Paris-F 2006–2012  Group leader, Inserm avenir Group, Institut Pasteur, Paris-F 2003–2005  Chief Assistant, Division of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris 2002–2003  Post-doctoral fellow (Jeff Gordon laboratory), Washington University in St. Louis, MO, USA 1997–2001  PhD student (Pascale Cossart laboratory), Paris Diderot University, Institut Pasteur, Paris-F 1991–2001  Medical Internship and Residency Program, Paris Hospitals, Assistance Publique-Hôpitaux de Paris Fellowships and awards 2017  Prix Duquesne 2017  EMBO Member
2017 ESCMID Fellow 2016  Grand Prix Robert Debré 2015  ERC Consolidator Grant 2010  Médaille Louis Pasteur, Académie des Sciences 2010  ERC Starting Independent Researcher Grant 2009  Fondation pour la recherche médicale “Equipe” award 2009  Ville de Paris “Equipe” award 2009  Grand Prix Jean Hamburger de la Ville de Paris 2008  Institut Pasteur “Groupe à 5 ans” award 2006  Inserm “Equipe avenir” award 2005  Franco-British Prize of the Académie des Sciences and the Royal Society 2004  European Society of Clinical Microbiology and Infectious Diseases Young Investigator Award 2003  Research Award of the College of Professors of Infectious Diseases and Tropical Medicine 2002  EMBO Long-Term fellowship 2002  Philippe Foundation fellowship 2001  Prix Jean Valade Fondation de France 2000  Gold Medal of the Residency Program (Médaille d’Or du Concours de Médecine de l’Internat) 1999  Research Prize in Nutrition CIDEF Supervision of graduate students and postdoctoral fellows Since 2006  11 Postdocs, 5 PhD, 5 Master Students, Paris Diderot University 6 Undergraduate Students Teaching activities Since 2008  Courses in Master 1 and 2, Paris Descartes University and Pierre and Marie Curie University Since 2006  Teaching position, Infectious Diseases, Paris Descartes University Medical School 2004–2006  Courses in Infectious Diseases and Microbiology, Paris Descartes University Medical School 1998–2002  Course in Microbiology, Institut Pasteur, Paris-F 1993–1998  Courses for Interns in Infectious Diseases, Laennec Center, Paris-F Organisation of scientific meetings ISOPOL XIX International symposium on listeriosis, Paris, France, 2016 Jun 14-17, scientific committee member Gordon Research Conference, CNS Infections, Hong Kong, China, 2015 Jun 14-15, scientific committee member Chikungunya 2013 Conference, Langkawi, Malaysia, 2013 Oct 28-30, scientific committee member European Congress in Clinical Microbiology & Infectious Diseases 2010, 2011, 2013, program committee member Metchnikoff’s Legacy, Institut Pasteur, Paris, France, 2008 Apr 28-30, scientific committee member Institutional responsibilities Since 2014  Member, steering committee, Center for Translational Research, Institut Pasteur Since 2014  Member, steering committee, Bio Paris Cité Doctoral School, Infectiology and Microbiology, Paris-F Since 2013  Member, scientific advisory board, Institut de Microbiologie et des Maladies Infectieuses, Aviesan 2007–2008  Member, award committee, Eur. Soc. Clin. Microbiol. Infect. Dis. (ESCMID) 2007–2011 Member, scientific affairs subcommittee, Eur. Soc. Clin. Microbiol. Infect. Dis. (ESCMID) 2007–2010  Member, steering committee, National prospective survey on encephalitis Since 2006  Member, steering committee, National Reference Center for Hereditary Immunodeficiency Since 2006  Member, scientific advisory board, Cochin-Pasteur Clinical Investigation Center in Vaccinology Since 2004  Member, Necker–Pasteur Center for Infectious Diseases Commissions of trust Since 2006  Member, Faculty of 1000 Biology, Section Microbiology, Cellular Microbiology & Pathogenesis Since 2014  Scientific Advisory Board, Ville de Paris awards and Emergence grants Since 2013  Editorial board member: Virulence, Journal of Visualized Experiments, Microbial Pathogenesis Since 2013  Advisory board member: F1000Research Since 2008  Reviewer: Nature, ScienceNature Medicine, N Engl J Med, LancetPNAS, eLifeCell Host MicrobeLancet Infect DisPLOS PathogensMolecular MicrobiologyCellular Microbiology, Journal of Infectious Diseases, Emerging Infectious Diseases, Infection and Immunity, … Since 2008  Regular review panel member:  ANR, Inserm, Institut Pasteur, ERC, PHRC Membership of scientific societies Since 2007  Member, European Society of Clinical Microbiology and Infectious Diseases Since 2004  Member, American Society for Microbiology Since 2004  Member, American Society for Cell Biology List of selected publications * indicates senior authorship, 254 entries in PubMed, h-index 70 (Google scholar), Oct 2018 Disson O, Blériot C, Jacob JM, Serafini N, Dulauroy S, Jouvion G, Fevre C, Gessain G, Thouvenot P, Eberl G, Di Santo JP, Peduto L, Lecuit M* Peyer’s patch myeloid cells infection by Listeria signals through gp38+ stromal cells and locks intestinal villus invasion. J Exp Med. 2018 Nov 5;215(11):2936-2954. Gladwyn-Ng I, Cordon Barris L, Alfano C, Creppe C, Couderc T, Morelli G, Thelen N, America M, Bessières B, Encha-Razavi F, Bonnière M, Suzuki IK, Flamand M, Vanderhaeghen P, Thiry M, Lecuit M*, Nguyen L* Stress-induced unfolded protein response contributes to Zika virus-associated microcephaly Nat Neurosci. 2018 Jan;21(1):63-71. Moura A, Tourdjman M, Leclercq A, Hamelin E, Laurent E, Fredriksen N, Van Cauteren D, Bracq-Dieye H, Thouvenot P, Vales G, Tessaud-Rita N, Maury MM, Alexandru A, Criscuolo A, Quevillon E, Donguy MP, Enouf V, de Valk H, Brisse S, Lecuit M* Real-Time Whole-Genome Sequencing for Surveillance of Listeria monocytogenes, France Emerg Infect Dis. 2017 Sep 15;23(9) Charlier C, Perrodeau E, Leclercq A, Cazenave B, Pilmis B, Henry B, Lopes A, Maury M, Moura A, Goffinet F, Bracq Dieye H, Thouvenot P, Ungeheuer MN, Tourdjman M, Goulet V, de Valk H, Lortholary O, Ravaud P, Lecuit M* Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study Lancet Infect Dis. 201710.1016/S1473-3099(16)30521-7 Moura A, Criscuolo A, Pouseele H, Maury MM, Leclercq A, Tarr C, Björkman JT, Dallman T, Reimer A, Enouf V, Larsonneur E, Carleton H, Bracq-Dieye H, Katz LS, Jones L, Touchon M, Tourdjman M, Walker M, Stroika S, Cantinelli T, Chenal-Francisque V, Kucerova Z, Rocha EPC, Nadon C, Grant K, Nielsen EM, Pot B, Gerner-Smidt P, Lecuit M*, Brisse S* Whole genome-based population biology and epidemiological surveillance of Listeria monocytogenes Nat Microbiol 2016 Oct 10;2:16185 Karlas A, Berre S, Couderc T, Varjak M, Braun P, Meyer M, Gangneux N, Karo-Astover L, Weege F, Raftery M, Schönrich G, Klemm U, Wurzlbauer A, Bracher F, Merits A, Meyer TF*, Lecuit M* A host genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs Nat Commun 2016 May 12;7:11320 Maury MM, Tsai YH, Charlier C, Touchon M, Chenal-Francisque V, Leclercq A, Criscuolo A, Gaultier C, Roussel S, Brisabois A, Disson O, Rocha EP, Brisse S*, Lecuit M* Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity. Nat Genet 2016 Mar;48(3):308-13 Weaver S*, Lecuit M* Chikungunya virus and the global spread of a mosquito-borne disease N Engl J Med 2015 372(13):1231-1239 Gessain G, Tsai YH, Travier L, Bonazzi M, Grayo S, Cossart P, Charlier C, Disson O, Lecuit M* PI3-kinase activation is critical for host barriers permissiveness to Listeria monocytogenes J Exp Med 2015 212(2):165-83 Blériot C, Dupuis T, Jouvion G, Eberl G. Disson O, Lecuit M* Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection Immunity 2015 42(1):145-58 Tsai Yu-Huan, Disson O, Bierne H, Lecuit M* Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses PLOS Pathog 2013 9(5):e1003381 Travier L, Guadagnini S, Gouin E, Dufour A, Chenal-Francisque V, Cossart P, Olivo-Marin JC, Ghigo JM, Disson O, Lecuit M* ActA promotes Listeria monocytogenes aggregation, intestinal colonization and carriage PLOS Pathog 2013 9(1):e1003131 Judith D, Mostowy S, Bouraï M, Gangneux N, Lelek M, Lucas-Hourani M, Cayet N, Jacob Y, Prévost MC, Pierre P, Tangy F, Zimmer C, Vidalain PO, Couderc T, Lecuit M* Species-specific impact of the autophagy machinery on Chikungunya virus infection EMBO Rep 2013 14(6):534-44 Archambaud C, Nahori MA, Soubigou G, Bécavin C, Laval L, Lechat P, Smkvina T, Langella P, Lecuit M*, Cossart P* Impact of lactobacilli on orally acquired listeriosis Proc Natl Acad Sci U S A 2012 109(41):16684-9 Nikitas G, Deschamps C, Disson O, Niault T, Cossart P, Lecuit M* Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin J Exp Med 2011 208(11):2263-77 Tazi A, Disson O, Bellais S, Bouaboud A, Dmytruk N, Dramsi S, Mistou M-Y, Khun H, Mechler C, Tardieux I, Trieu-Cuot P, Lecuit M*, Poyart C* The surface protein HvgA mediates Group B streptococcus hypervirulence and meningeal tropism in neonates J Exp Med 2010 207(11):2313-22 Schilte C, Couderc T, Chrétien F, Sourisseau M, Gangneux N, Guivel-Benhassine F, Gruber A, Tschopp J, Higgs S, Michault A, Arenzana-Seisdedos F, Colonna M, Schwartz O, Lecuit M*, Albert M* Type I IFN controls chikungunya virus via its action on non-hematopoetic cells. J Exp Med 2010 207(2):429-42 Mostowy S, Bonazzi M, Hamon MA, Tham TN, Mallet A, Lelek M, Gouin E, Demangel C, Brosch R, Zimmer C, Sartori A, Kinoshita M, Lecuit M, Cossart P Entrapment of intracytosolic bacteria by septin cage-like structures Cell Host Microbe 2010 8(5):433-44 Toledo-Arana A, Dussurget O, Nikitas G, Sesto N, Guet-Revillet H, Balestrino D, Loh E, Gripenland J, Tiensuu T, Vaitkevicius K, Barthelemy M, Vergassola M, Nahori M-A, Soubigou G, Régnault B, Coppée J-Y, Lecuit M, Johansson J, Cossart P The Listeria transcriptional landscape from saprophytism to virulence Nature 2009 59(7249):950-6 Disson O, Grayo S, Huillet E, Nikitas G, Langa-Vives F, Dussurget O, Ragon M, Le Monnier A, Babinet C, Cossart P, Lecuit M* Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis Nature 2008 455(7216):1114-8 Couderc T, Chrétien F,Schilte C, Disson O, Brigitte M, Guivel-Benhassine F, Touret Y, Barau G, Prévost MC, Schuffenecker I, Desprès P, Arenzana-Seisdedos F, Michault A, Albert ML*, Lecuit M* A mouse model for Chikungunya infection: young age and inefficient type-I interferon signaling are risk factors for severe disease PLOS Pathog 2008 4(2): p. e29 Gérardin P, Barau G, Michault A, Bintner M, Randrianaivo H, Choker G, Lenglet Y, Touret Y, Bouveret A, Grivard P, Le Roux K, Blanc S, Schuffenecker I, Couderc T, Arenzana-Seisdedos F, Lecuit M*, Robillard PY Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Réunion PLOS Medicine 2008 5(3): p. e60 Boneca IG, Dussurget O, Cabanes D, Nahori MA, Sousa S, Lecuit M, Psylinakis E, Bouriotis V, Hugot JP, Giovannini M, Coyle A, Bertin J, Namane A, Rousselle JC, Cayet N, Prevost MC, Balloy V, Chignard M, Philpott DJ, Cossart P, Girardin SE. A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system Proc Natl Acad Sci U S A  2007 104(3):997-1002 Lecuit M, Sonnenburg JL, Cossart P, Gordon JI Functional genomic studies of the intestinal response to a foodborne enteropathogen in a humanized gnotobiotic mouse model J Biol Chem 2007 282(20):15065-72 Sousa S, Cabanes D, Archambaud C, Colland F, Lemichez E, Popoff M, Boisson-Dupuis S, Gouin E, Lecuit M, Legrain P, Cossart P. ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion. Nat Cell Biol  2005 7(10):954-60 Lecuit M*, Nelson DM, Smith SD, Khun H, Huerre M, Vacher-Lavenu MC, Gordon JI, Cossart P. Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin. Proc Natl Acad Sci U S A 2004 101(16):6152-7 Lecuit M*, Abachin E, Martin A, Poyart C, Pochart P, Suarez F, Bengoufa D, Feuillard J, Lavergne A, Gordon JI, Berche P, Guillevin L, Lortholary O. Immunoproliferative small intestinal disease associated with Campylobacter jejuni. N Engl J Med 2004 350(3):239-48 Lecuit M, Vandormael-Pournin S, Lefort J, Huerre M, Gounon P, Dupuy C, Babinet C, Cossart P. A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier. Science 2001 292(5522):1722-5 Kussel-Andermann P, El-Amraoui A, Safieddine S, Nouaille S, Perfettini I, Lecuit M, Cossart P, Wolfrum U, Petit C. Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. EMBO J 2000 19(22):6020-9 Lecuit M, Hurme R, Pizarro-Cerda J, Ohayon H, Geiger B, Cossart P. A role for alpha-and beta-catenins in bacterial uptake. Proc Natl Acad Sci U S A 2000 97(18):10008-13 Lecuit M, Dramsi S, Gottardi C, Fedor-Chaiken M, Gumbiner B, Cossart P. A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes. EMBO J 1999 18(14):3956-63

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