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© Emmanuel Lemichez
Microscopy image showing the formation of large tunnels in a blood vessel endothelial cell induced by a group of bacterial toxins

Transversal Projects

Array

The microbial communities that live with us, the microbiota, are now understood to be a key component of our being, playing roles in metabolism, immunity and behavior. More than a decade has elapsed since […]

LabEx IBEID – Integrative Biology of Emerging Infectious Diseases

Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart and currently coordinated by Carla Saleh and Philippe Bastin, is to develop a […]

Projects

Project
Ongoing
6 Members

Chronic carriage of CNF1-producing bacteria in the gut and development of colorectal cancer

Emmanuel Lemichez (PI)

CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]
Project
Ongoing
5 Members

Landscape of protein ubiquitylation during infection by CNF1-producing uropathogenic E. coli

Emmanuel Lemichez (PI)

CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]
Project
Ongoing
7 Members

Endothelium disruption by toxin-induced transcellular tunnels

Emmanuel Lemichez (PI)

Crossing of the epithelium and endothelium barriers by pathogens and their toxins represents essential steps in pejorative evolution of infections. We have discovered that several exotoxins from S. aureus and C. botulinum disrupt epithelium and endothelium barriers by targeting […]
Project
Ongoing
6 Members

CNF1 and Rho GTPases ubiquitylation in cellular invasion by uropathogenic E. coli

Emmanuel Lemichez (PI)

CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]
Project
Ongoing
11 Members

Detection and countermeasures against bacterial toxins

Emmanuel Lemichez (PI)

Bacterial protein toxins are molecular nanodevices endowed with the capacity of inducing host specific unparalleled pathophysiological effects. Therefore, major challenges in toxinology include the development of countermeasures other than vaccination against bacterial protein toxins […]

Publications

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