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© Emmanuel Lemichez
Microscopy image showing the formation of large tunnels in a blood vessel endothelial cell induced by a group of bacterial toxins

Projects

project
Ongoing
4 Members

Toxins and epithelial barrier

Michel-Robert Popoff (PI)

A large number of pathogenic bacteria, notably toxigenic strains of bacteria, reside or pass through the digestive compartment. Some toxins act systemically. Their passage through the epithelial barrier, the first essential step in the […]
project
Ongoing
4 Members

Toxins and endothelial barrier

Emmanuel Lemichez (PI)

We have discovered a new mode of permeabilization of the endothelium barrier by induction of transcellular tunnels in response to a group of toxins capable of disrupting the organization of the actin cytoskeleton. This […]
project
Ongoing
7 Members

Toxins targeting the actin cytoskeleton regulators

Emmanuel Lemichez (PI)

A large number of bacterial toxins catalyze post-translational modifications of small GTPases of the Ras superfamily. Some Gram-negative bacteria such as Escherichia coli, Yersinia pseudotuberculosis, and Bordetella spp produce deamidase toxins capable of catalyzing […]
project
Ongoing
3 Members

Neurotoxins and countermeasures

Michel-Robert Popoff (PI)

EuroBioTox is a large European project focusing on biological toxins of potential bioterrorism risk involving 60 expert institutions from 23 countries. Recent incidents in France (Paris, May 2018) and in Germany (Cologne, June 2018) […]

Publications

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