300 to 400 million cases of dengue fever occur each year worldwide. Spreading rapidly, more than 40% of the world’s population is now at risk of contracting dengue This transversal program brings together talents […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Protected: Pasteur Human Genome
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Effect of host-parasite interaction on the outcome of malaria infection
It is well accepted that the outcome of infection in malaria depends upon interaction between the human host and Plasmodium spp. This is the result of forces of selection and escape acting on the […]
DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe
The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
CoSimmGen : Constitution of a prospective cohort of healthy and diseased individuals with an associated human biological resources collection for the purpose of studying of genetic, immunological and environmental factors in human diseases
Context : Studying physiopathology of human diseases, focused in particular on genetic, immunological and environmental factors necessitate to access to human cohorts of healthy and diseased individuals and the corresponding bioresources. The rarity of […]
A Zika virus chimeric polyepitope comprising non-structural proteins and its use in immunogenic composition (EP 17 306553.3)
The present invention is directed to a Zika virus (ZIKV) chimeric polyepitope composed of fragments of structural and non-structural proteins and its use in an immunogenic composition. The present invention provides means, in particular […]
A dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection (E14305984.8)
The present invention is directed to a dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection. The present invention provides means, in […]
2019Genetic diversity of Collaborative Cross mice controls viral replication, clinical severity and brain pathology induced by Zika virus infection, independently of Oas1b, DOI: 10.1128/JVI.01034-19.
2019A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice, Front. Immunol. 2019 Jun;10 (1424).
2018Estimating Frequency of Probable Autochthonous Cases of Dengue, Japan, Emerging Infect. Dis. 2018 Sep;24(9):1705-1708.
2018Genetic Characterization of Enterovirus A71 Circulating in Africa, Emerg Infect Dis. 2018;24(4):754-757.
2018Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome, PLoS Negl Trop Dis 2018 02;12(2):e0006202.
2018The SRC-family tyrosine kinase HCK shapes the landscape of SKAP2 interactome, Oncotarget 2018 Mar;9(17):13102-13115.
2017Increased adaptive immune responses and proper feedback regulation protect against clinical dengue, Sci Transl Med 2017 Aug;9(405).
2017Paper-based RNA detection and multiplexed analysis for Ebola virus diagnostics, Sci Rep 2017 May;7(1):1347.
2017Autochthonous Japanese Encephalitis with Yellow Fever Coinfection in Africa, N. Engl. J. Med. 2017 04;376(15):1483-1485.
2017OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans, PLoS Pathog. 2017 Feb;13(2):e1006220.
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