300 to 400 million cases of dengue fever occur each year worldwide. Spreading rapidly, more than 40% of the world’s population is now at risk of contracting dengue This transversal program brings together talents […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Study of immune crosstalk in COVID-19 COVIMUNE
Our overall goal is to understand the cellular and molecular aspects of immune response to SARS-CoV-2 virus in terms of activation of over-reactive immunity and induction of immune protection. COVIMUNE is designed to target […]
Host genetic susceptibility to Zika virus
Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]
Pasteur International Center for Research on Emerging Infectious Diseases
We established an Emerging Infectious Disease Research Center in Southeast Asia and West/Central Africa with an inter-continental one-health approach designed to improve the capacity to respond rapidly and effectively to outbreaks. We built on […]
Protected: Pasteur Human Genome
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Effect of host-parasite interaction on the outcome of malaria infection
It is well accepted that the outcome of infection in malaria depends upon interaction between the human host and Plasmodium spp. This is the result of forces of selection and escape acting on the […]
DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe
The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
CoSimmGen : Constitution of a prospective cohort of healthy and diseased individuals with an associated human biological resources collection for the purpose of studying of genetic, immunological and environmental factors in human diseases
Context : Studying physiopathology of human diseases, focused in particular on genetic, immunological and environmental factors necessitate to access to human cohorts of healthy and diseased individuals and the corresponding bioresources. The rarity of […]
A Zika virus chimeric polyepitope comprising non-structural proteins and its use in immunogenic composition (EP 17 306553.3)
The present invention is directed to a Zika virus (ZIKV) chimeric polyepitope composed of fragments of structural and non-structural proteins and its use in an immunogenic composition. The present invention provides means, in particular […]
A dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection (E14305984.8)
The present invention is directed to a dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection. The present invention provides means, in […]
2020Dengue viremia kinetics in asymptomatic and symptomatic infection., Int J Infect Dis 2020 Dec; 101(): 90-97.
2020Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection., Sci Rep 2020 10; 10(1): 18404.
2020Comparison of dengue case classification schemes and evaluation of biological changes in different dengue clinical patterns in a longitudinal follow-up of hospitalized children in Cambodia., PLoS Negl Trop Dis 2020 Sep; 14(9): e0008603.
2020Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b., J. Virol. 2020 01; 94(3): .
2019A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice, Front. Immunol. 2019 Jun;10 (1424).
2019IPCAPS: an R package for iterative pruning to capture population structure., Source Code Biol Med 2019 ; 14(): 2.
2018Estimating Frequency of Probable Autochthonous Cases of Dengue, Japan, Emerging Infect. Dis. 2018 Sep;24(9):1705-1708.
2018Host genetic control of mosquito-borne Flavivirus infections., Mamm. Genome 2018 08; 29(7-8): 384-407.
2018Genetic Characterization of Enterovirus A71 Circulating in Africa., Emerging Infect. Dis. 2018 04; 24(4): 754-757.
2018Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome, PLoS Negl Trop Dis 2018 02;12(2):e0006202.
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