Jost studied biochemistry at the University of Hannover and at the Medical School of Hannover (MHH), in Germany. For his Masters thesis and his Ph.D. studies, he joined the Laboratory of Cell Biology at the Rockefeller University, New York City, where he focused on the transport of biological macromolecules between cellular compartments using cell biological approaches. Afterwards, Jost wanted to apply his cell biological knowledge to the investigation of host-pathogen interactions. So in spring 2004 he came to the Institut Pasteur, Paris, to work with Guy Tran Van Nhieu and Philippe Sansonetti on the secretion of type III effectors from Gram negative bacteria. At the beginning of 2008, Jost went on searching for new adventures, so he started his own independent research team in the department of Cell Biology and Infection at the Institut Pasteur in Paris.
Microscopy – Principles and Applications of Fluorescence Microscopy
Fluorescence microscopy has revolutionized researchers’ ability to monitor cellular structures and dynamics. Over the last decades, the spectrum of applications of fluorescence microscopy has been constantly broadened by novel combinations of optics principles supported […]
Single Cell Resources Initiative at Institut Pasteur
Introduction. Cell-to-cell variation affects all biological systems and processes, from stem cells and development, to immunology or cancer. Conventional population (bulk) measurements provide averaged information that does not reveal cellular individuality and masks extreme […]
INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]
The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to […]
LabEx Milieu Intérieur
The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. https://www.youtube.com/watch?v=IXlKElDJMc8 The Milieu Intérieur Project While the […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Next generation of Structured Illumination Microscopy (SIM) for biological imaging
Detection and countermeasures against bacterial toxins
Bacterial protein toxins are molecular nanodevices endowed with the capacity of inducing host specific unparalleled pathophysiological effects. Therefore, major challenges in toxinology include the development of countermeasures other than vaccination against bacterial protein toxins […]
ANR 2015 AutoHostPath
Understanding the molecular basis of host-pathogen interactions is critical for the discovery of new therapeutic approaches to treat infectious diseases, which in the face of increasing antibiotic resistance and emerging pathogens, is a major […]
A common strategy of bacterial pathogens is active or passive uptake into host cells. There, they can localize within a bacterial containing vacuole (BCV) or access the host cytoplasm through BCV rupture. Hence, intracellular […]
Infectious diseases are a major public health problem, and identification of novel potentialtherapeutic candidates is mandatory in a context of growing antibiotic resistance. As classical infection biology approaches are nearly exhausted in their current […]
Dual microscopy assay to discriminate Listeria cellular entry & vacuolar escape
We developed a novel image-based microscopy assay which allows to discriminate Listeria monocytogenes cellular entry from vacuolar escape, enabling high-content screening to identify factors specifically involved in these two steps. We generated a L. […]
2021The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes., Nat Commun 2021 11; 12(1): 6577.
2021Purification of infection-associated macropinosomes by magnetic isolation for proteomic characterization., Nat Protoc 2021 Oct; (): .
2021New methods to decrypt emerging macropinosome functions during the host-pathogen crosstalk., Cell Microbiol 2021 Apr; (): .
2021Salmonella enters a dormant state within human epithelial cells for persistent infection., PLoS Pathog 2021 04; 17(4): e1009550.
2021The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae., Nat Microbiol 2021 02; 6(2): 257-269.
2021SopB- and SifA-dependent shaping of the Salmonella-containing vacuole proteome in the social amoeba Dictyostelium discoideum., Cell Microbiol 2021 01; 23(1): e13263.
2020Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science 2020 10; 370(6515): .
2020Shigella hijacks the exocyst to cluster macropinosomes for efficient vacuolar escape., PLoS Pathog 2020 08; 16(8): e1008822.
2020The best of both worlds- bringing together cell biology and infection at the Institut Pasteur., Microbes Infect ; 21(5-6): 254-262.
2020A role for Taok2 in Listeria monocytogenes vacuolar escape., J. Infect. Dis. 2020 Jun; (): .
+View full list of publications