Jost studied biochemistry at the University of Hannover and at the Medical School of Hannover (MHH), in Germany. For his Masters thesis and his Ph.D. studies, he joined the Laboratory of Cell Biology at the Rockefeller University, New York City, where he focused on the transport of biological macromolecules between cellular compartments using cell biological approaches. Afterwards, Jost wanted to apply his cell biological knowledge to the investigation of host-pathogen interactions. So in spring 2004 he came to the Institut Pasteur, Paris, to work with Guy Tran Van Nhieu and Philippe Sansonetti on the secretion of type III effectors from Gram negative bacteria. At the beginning of 2008, Jost went on searching for new adventures, so he started his own independent research team in the department of Cell Biology and Infection at the Institut Pasteur in Paris.
Seminar “Salmonella single-cell biology in complex host tissues”
Principles and Applications of fluorescence Microscopy
Together with David DiGregorio and Gael Moneron (both members of the Neuroscience department) we organize a course of Advanced Imaging entitled “Principles and Applications of fluorescence Microscopy”.This event is propose for Master and for […]
ANR 2015 AutoHostPath
Understanding the molecular basis of host-pathogen interactions is critical for the discovery of new therapeutic approaches to treat infectious diseases, which in the face of increasing antibiotic resistance and emerging pathogens, is a major […]
A common strategy of bacterial pathogens is active or passive uptake into host cells. There, they can localize within a bacterial containing vacuole (BCV) or access the host cytoplasm through BCV rupture. Hence, intracellular […]
Infectious diseases are a major public health problem, and identification of novel potentialtherapeutic candidates is mandatory in a context of growing antibiotic resistance. As classical infection biology approaches are nearly exhausted in their current […]
Dual microscopy assay to discriminate Listeria cellular entry & vacuolar escape
We developed a novel image-based microscopy assay which allows to discriminate Listeria monocytogenes cellular entry from vacuolar escape, enabling high-content screening to identify factors specifically involved in these two steps. We generated a L. […]
2017The Shigella type III effector IpgD recodes Ca(2+) signals during invasion of epithelial cells, EMBO J. 2017 Sep;36(17):2567-2580.
2017Imaging macropinosomes during Shigella infections, Methods 2017 May;.
2017Tracing a fat or sweet lifestyle – New insights on catabolic paths of intracellular Salmonella, Virulence 2017 Jan;.
2017Assessing Vacuolar Escape of Listeria Monocytogenes, Methods Mol. Biol. 2017;1535:173-195.
2016Diverted recycling- Shigella subversion of Rabs, Small GTPases 2016 Oct;.
2016Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses, Cell Rep 2016 Sep;16(10):2777-91.
2016Manipulation of host membranes by the bacterial pathogens Listeria, Francisella, Shigella and Yersinia, Semin. Cell Dev. Biol. 2016 Jul;.
2016Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access, Cell. Microbiol. 2016 May;.
2016Macropinosomes are Key Players in Early Shigella Invasion and Vacuolar Escape in Epithelial Cells, PLoS Pathog. 2016 May;12(5):e1005602.
2016Visualizing the Translocation and Localization of Bacterial Type III Effector Proteins by Using a Genetically Encoded Reporter System, Appl. Environ. Microbiol. 2016 May;82(9):2700-8.
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