Jost Enninga

Correlative Light, Electron & X-ray Microscopy (CLEXM) project offers unique opportunities to early career researchers to work with exciting imaging technologies and at the same time address important biological questions in health and disease. […]

Intracellular bacterial pathogens enter host cells to form a bacterial containing vacuole (BCV). Then, the BCV matures or ruptures leading to two distinct pathogen-dependent intracellular niches; one vacuolar and one cytosolic. The specific intracellular […]

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Bacterial protein toxins are molecular nanodevices endowed with the capacity of inducing host specific unparalleled pathophysiological effects. Therefore, major challenges in toxinology include the development of countermeasures other than vaccination against bacterial protein toxins […]

Understanding the molecular basis of host-pathogen interactions is critical for the discovery of new therapeutic approaches to treat infectious diseases, which in the face of increasing antibiotic resistance and emerging pathogens, is a major […]

A common strategy of bacterial pathogens is active or passive uptake into host cells. There, they can localize within a bacterial containing vacuole (BCV) or access the host cytoplasm through BCV rupture. Hence, intracellular […]

Infectious diseases are a major public health problem, and identification of novel potentialtherapeutic candidates is mandatory in a context of growing antibiotic resistance. As classical infection biology approaches are nearly exhausted in their current […]

We developed a novel image-based microscopy assay which allows to discriminate Listeria monocytogenes cellular entry from vacuolar escape, enabling high-content screening to identify factors specifically involved in these two steps. We generated a L. […]