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© Antoinette Ryter
Serratia marcescens avec présence de flagelles (cils) péritriches. Famille des Enterobacteriaceae, bacille à Gram négatif, non sporulé, anaérobie facultatif, mobile, parfois encapsulé, pouvant synthétiser un pigment rouge ou rose. Présent dans les végétaux , le sol, et l'eau. A l'origine d'infections nosocomiales et résistant à de nombreux antibiotiques. Image colorisée.

About

The Synthetic Biology Group is interested in applying genetic engineering technologies to better understand pathogenic bacteria and fight them.

The rise of emerging pathogens and antibiotic resistances is becoming a major public health issue. Using engineering principles we are creating new strategies to quickly decipher the mechanisms of bacterial virulence and provide tools to specifically kill antibiotic resistant and virulent bacteria. In particular we are studying the bacterial immune system known as CRISPR, and developing novel CRISPR tools to edit bacterial genomes, control their gene expression and specifically eliminate dangerous bacteria.

Check out the CRISPR 2021 conference happening online June 1-10!!  https://www.crispr2021.conferences-pasteur.org/

We are currently seeking to hire a postdoc: https://research.pasteur.fr/en/job/post-doctoral-position-crispr-biology-and-technologies-in-bacteria/

Engineering bacteria with CRISPR (iBiology talk)

 

Members

David Bikard
Head of Structure
Head
Florence Depardieu
Research Engineer
Baptiste Saudemont
Research Engineer
Florence Dumonteil
Administrative Staff
Cyril Malbranke
Visiting Scientist
Raphaël Laurenceau
Post-doc
William Rostain
Post-doc
Solange Miele
Post-doc
Amandine Maire
Graduate Student
Laura Maria De Plano
Post-doc
Loic Charpenay
Visiting Scientist
Fabien Fuche
Visiting Scientist
Matthieu Galtier
Visiting Scientist
Mariangela Malerba
Visiting Scientist
Chloé Marie Poquet
Visiting Scientist

Former Members

2000
2000
Name
Position
2015
2020
Elise Siouve
PhD Student
2015
2020
Gayetri Ramachandran
Post-doc
2015
2020
Aude Bernheim
PhD Student
2015
2020
Belen Gutierrez Soriano
Post-doc
2015
2020
Arthur Chen
Undergraduate Student
2015
2020
Jerome Wong Ng
Post-doc
2015
2020
Igor Stzepourginski
Visiting Scientist
2015
2020
Lun Cui
Post-doc

Projects

Project
Ongoing
2 Members

ERC starting grant – CRISPAIR: Study of the interplay between CRISPR interference and DNA repair pathways towards the development of novel CRISPR tools

David Bikard (PI)

CRISPR-Cas loci are the adaptive immune system of archaea and bacteria. They can capture pieces of invading DNA and use this information to degrade target DNA through the action of RNA-guided nucleases. The consequences […]
Project
Ongoing
2 Members

Studying and fighting pathogenic bacteria with the help of CRISPR

Studying and fighting pathogenic bacteria with the help of CRISPR (PI)

CRISPR loci and the associated Cas genes are the adaptive immune system of archeae and bacteria. They have the ability to capture pieces of DNA from viruses and other invading genetic elements [1], and […]

Transversal Project

Fighting Antibiotic Resistance

Antibiotics are highly efficient drugs to kill pathogenic bacteria with low side effects. For more than 70 years, the massive use of these miracle drugs has saved millions of human and animal lives. Unfortunately […]

Quantitative biology

The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to […]

Pasteur-Weizmann Consortium

The main idea behind the consortium is to pull together a set of strong experimental approaches and expertise that were developed in the laboratories of Pascale Cossart  at the Pasteur Institute in Paris and […]

The institut Carnot Pasteur MS

Carnot, label of excellence Founded in 2006, the Carnot Label, granted by the French government, was designed to develop partnership-based research, meaning research conducted by public laboratories in partnership with socio-economic players, primarily industry […]

LabEx IBEID – Integrative Biology of Emerging Infectious Diseases

Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]

Fundings

Publications

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Contact

Phone: +33 1 40 61 39 24 Email: david.bikard@pasteur.fr Address: Jacob Building (26), Floor 4 25-28 Rue du Docteur Roux 75015, Paris France