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About

After my training in Biology at the Ecole Normale Supérieure in Paris, I obtained a PhD in Ecology in 2006 at University Pierre & Marie Curie (Paris 6). My PhD research dealt with the ecology and evolution of interactions between anopheline mosquitoes and malaria parasites. I then spent three years as a European Marie Curie Postdoctoral Fellow at the University of California in Davis (USA) and in the Laboratory of Genetics and Evolution of Infectious Diseases (IRD-CNRS) in Montpellier (France). During my postdoc I studied the interactions between Aedes aegypti mosquitoes and dengue viruses using various approaches of quantitative and evolutionary genetics. In 2010, I joined Institut Pasteur in Paris where I became a CNRS Faculty Research Scientist in 2011. In 2013, I was appointed as a Junior Group Leader at Institut Pasteur. In 2018, I was awarded the CNRS Bronze Medal. I am currently involved in several national and international research programs on mosquito-virus interactions, with an emphasis on dengue and Zika.

Projects

project
Ongoing
3 Members

Bridge vectors at the sylvatic/human interface of arbovirus transmission cycles in rural Laos

Louis Lambrechts (PI)

Several emerging arthropod-borne viruses (arboviruses) such as dengue, yellow fever, chikungunya and Zika viruses originate from sylvatic transmission cycles where they are transmitted among non-human primates by arboreal mosquitoes. Initial virus spillover from the […]
project
Ongoing
2 Members

ACIP DenGen

Myrielle Dupont-rouzeyrol (PI)

Dengue virus genotype replacements: investigating viral fitness differences driving the evolution of dengue epidemics Phylogenetic analyses have revealed that dengue virus (DENV) evolutionary dynamics are often characterized by the replacement of a DENV genotype […]
project
Ongoing
4 Members

ANR MOSQUIBIOTA

Louis Lambrechts (PI)

Host-associated microbes, collectively known as the host microbiota, have manifold effects on host biology. Like other animals, insects establish various symbiotic associations with their microbial communities that shape their individual phenotype and fitness. In […]
project
Ongoing
2 Members

ZikaPLAN consortium – Zika Preparedness Latin American Network

Annelies Wilder-Smith (PI)

25 leading research and public health organizations from Latin America, North America, Africa, Asia and Europe united to fight Zika virus today and build long-term outbreak response capacity in Latin America. ZikaPLAN takes a […]
project
Ongoing
7 Members

DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe

Anavaj Sakuntabhai (PI)

The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
project
Ongoing
8 Members

Mosquito-virus specificity and arboviral emergence

Louis Lambrechts (PI)

Specific interactions between host and pathogen genotypes are commonly found in invertebrate systems, but their genetic basis has not been elucidated. Such insect-virus genetic specificity plays a critical role in the emergence and evolution […]
project
Ongoing
2 Members

Quantifying heterogeneities in dengue virus transmission dynamics

Thomas W. Scott (PI)

Current knowledge of dengue virus (DENV) transmission provides, at best, only a partial understanding of a complicated and dynamic system with a public health track record that has more failures than successes. An important […]
project
Ongoing
2 Members

Mosquito genetic variation in dose-response to dengue virus

Louis Lambrechts (PI)

This project investigates the entomological genetic determinants of human DENV infectiousness to mosquitoes. Specifically, we are testing the hypothesis that mosquitoes are genetically variable in their dose-response to a DENV-infectious blood meal. We recently […]
project
Ongoing
7 Members

Functional characterization of mosquito genes involved in dengue virus transmission identified by RNA-seq at the individual midgut level

Louis Lambrechts (PI)

Dengue is the most rapidly expanding, globally dominant arthropod-borne (arbo) viral disease. It affects close to 400 million people each year in more than 125 countries. Recent reports of autochtonous cases in Southern France […]

CV

Junior Group Leader, 2013-present
Institut Pasteur, Paris, France

CNRS Faculty Research Scientist, 2011-present
Institut Pasteur, Paris, France

Postdoctoral Fellow, 2007-11, Arbovirology
Institut Pasteur, Paris, France (2010-11)
CNRS, Montpellier, France (2009)
University of California, Davis, USA (2007-08)

Ph.D., 2006, Ecology
University Pierre & Marie Curie, Paris, France

B.S. and M.S., 2002, Biology & Biochemistry
Ecole Normale Supérieure, Paris, France

Publications

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