Dr. Louis Lambrechts is a Research Director in the Department of Virology at Institut Pasteur in Paris. After graduating from Ecole Normale Supérieure in Paris, he obtained a PhD in Ecology in 2006 for his work on interactions between mosquitoes and malaria parasites at University Pierre & Marie Curie in Paris. During his postdoc, he was supported by a European Marie Curie fellowship to study interactions between mosquitoes and dengue viruses at the University of California in Davis and in the Laboratory of Genetics and Evolution of Infectious Diseases in Montpellier, France. In 2010, he joined the Institut Pasteur in Paris where he became a Permanent Research Scientist of the French Centre National de la Recherche Scientifique (CNRS) in 2011, a Junior Group Leader in 2013, and Unit Head in 2019. In 2018, he was awarded a CNRS Bronze Medal. He is currently involved in several international research programs on dengue and Zika.
INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]
300 to 400 million cases of dengue fever occur each year worldwide. Spreading rapidly, more than 40% of the world’s population is now at risk of contracting dengue This transversal program brings together talents […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Bridge vectors at the sylvatic/human interface of arbovirus transmission cycles in rural Laos
Several emerging arthropod-borne viruses (arboviruses) such as dengue, yellow fever, chikungunya and Zika viruses originate from sylvatic transmission cycles where they are transmitted among non-human primates by arboreal mosquitoes. Initial virus spillover from the […]
Dengue virus genotype replacements: investigating viral fitness differences driving the evolution of dengue epidemics Phylogenetic analyses have revealed that dengue virus (DENV) evolutionary dynamics are often characterized by the replacement of a DENV genotype […]
Host-associated microbes, collectively known as the host microbiota, have manifold effects on host biology. Like other animals, insects establish various symbiotic associations with their microbial communities that shape their individual phenotype and fitness. In […]
ZikaPLAN consortium – Zika Preparedness Latin American Network
25 leading research and public health organizations from Latin America, North America, Africa, Asia and Europe united to fight Zika virus today and build long-term outbreak response capacity in Latin America. ZikaPLAN takes a […]
DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe
The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
Mosquito-virus specificity and arboviral emergence
Specific interactions between host and pathogen genotypes are commonly found in invertebrate systems, but their genetic basis has not been elucidated. Such insect-virus genetic specificity plays a critical role in the emergence and evolution […]
Quantifying heterogeneities in dengue virus transmission dynamics
Current knowledge of dengue virus (DENV) transmission provides, at best, only a partial understanding of a complicated and dynamic system with a public health track record that has more failures than successes. An important […]
Mosquito genetic variation in dose-response to dengue virus
This project investigates the entomological genetic determinants of human DENV infectiousness to mosquitoes. Specifically, we are testing the hypothesis that mosquitoes are genetically variable in their dose-response to a DENV-infectious blood meal. We recently […]
Functional characterization of mosquito genes involved in dengue virus transmission identified by RNA-seq at the individual midgut level
Dengue is the most rapidly expanding, globally dominant arthropod-borne (arbo) viral disease. It affects close to 400 million people each year in more than 125 countries. Recent reports of autochtonous cases in Southern France […]
Unit Head & Research Director, 2019-present Institut Pasteur, Paris, France
CNRS Bronze Medal, 2018
Junior Group Leader, 2013-2018 Institut Pasteur, Paris, France
CNRS Permanent Research Scientist, 2011-present Institut Pasteur, Paris, France
Postdoctoral Fellow, 2007-11, Arbovirology Institut Pasteur, Paris, France (2010-11); CNRS, Montpellier, France (2009); University of California, Davis, USA (2007-08)
Ph.D., 2006, Ecology University Pierre & Marie Curie, Paris, France
B.S. and M.S., 2002, Biology & Biochemistry Ecole Normale Supérieure, Paris, France
2020Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations., Science 2020 Nov; 370(6519): 991-996.
2020Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection., Sci Rep 2020 10; 10(1): 18404.
2020BiteOscope, an open platform to study mosquito biting behavior., Elife 2020 Sep; 9(): .
2020Non-retroviral Endogenous Viral Element Limits Cognate Virus Replication in Aedes aegypti Ovaries., Curr. Biol. 2020 Sep; 30(18): 3495-3506.e6.
2020Exome-wide association study reveals largely distinct gene sets underlying specific resistance to dengue virus types 1 and 3 in Aedes aegypti., PLoS Genet. 2020 May; 16(5): e1008794.
2020Risk of arbovirus emergence via bridge vectors: case study of the sylvatic mosquito Aedes malayensis in the Nakai district, Laos, Sci Rep 2020 May;10(1):7750.
2020A satellite repeat-derived piRNA controls embryonic development of Aedes, Nature 2020 04;580(7802):274-277.
2020Tudor-SN Promotes Early Replication of Dengue Virus in the Aedes aegypti Midgut, iScience 2020 Feb;23(2):100870.
2020Taking Insect Immunity to the Single-Cell Level, Trends Immunol. 2020 Feb;.
2020Novel genome sequences of cell-fusing agent virus allow comparison of virus phylogeny with the genetic structure of Aedes aegypti populations., Virus Evol 2020 Jan; 6(1): veaa018.
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