Dr. Louis Lambrechts is a Research Director in the Department of Virology at Institut Pasteur in Paris. After graduating from Ecole Normale Supérieure in Paris, he obtained a PhD in Ecology in 2006 for his work on interactions between mosquitoes and malaria parasites at University Pierre & Marie Curie in Paris. During his postdoc, he was supported by a European Marie Curie fellowship to study interactions between mosquitoes and dengue viruses at the University of California in Davis and in the Laboratory of Genetics and Evolution of Infectious Diseases in Montpellier, France. In 2010, he joined the Institut Pasteur in Paris where he became a Permanent Research Scientist of the French Centre National de la Recherche Scientifique (CNRS) in 2011, a Junior Group Leader in 2013, and Unit Head in 2019. In 2018, he was awarded a CNRS Bronze Medal. He is currently involved in several international research programs on dengue and Zika.
INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues. Inception program uses Integrative Biology, Social Science […]
300 to 400 million cases of dengue fever occur each year worldwide. Spreading rapidly, more than 40% of the world’s population is now at risk of contracting dengue This transversal program brings together talents […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Bridge vectors at the sylvatic/human interface of arbovirus transmission cycles in rural Laos
Several emerging arthropod-borne viruses (arboviruses) such as dengue, yellow fever, chikungunya and Zika viruses originate from sylvatic transmission cycles where they are transmitted among non-human primates by arboreal mosquitoes. Initial virus spillover from the […]
Dengue virus genotype replacements: investigating viral fitness differences driving the evolution of dengue epidemics Phylogenetic analyses have revealed that dengue virus (DENV) evolutionary dynamics are often characterized by the replacement of a DENV genotype […]
Host-associated microbes, collectively known as the host microbiota, have manifold effects on host biology. Like other animals, insects establish various symbiotic associations with their microbial communities that shape their individual phenotype and fitness. In […]
ZikaPLAN consortium – Zika Preparedness Latin American Network
25 leading research and public health organizations from Latin America, North America, Africa, Asia and Europe united to fight Zika virus today and build long-term outbreak response capacity in Latin America. ZikaPLAN takes a […]
DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe
The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
Mosquito-virus specificity and arboviral emergence
Specific interactions between host and pathogen genotypes are commonly found in invertebrate systems, but their genetic basis has not been elucidated. Such insect-virus genetic specificity plays a critical role in the emergence and evolution […]
Quantifying heterogeneities in dengue virus transmission dynamics
Current knowledge of dengue virus (DENV) transmission provides, at best, only a partial understanding of a complicated and dynamic system with a public health track record that has more failures than successes. An important […]
Mosquito genetic variation in dose-response to dengue virus
This project investigates the entomological genetic determinants of human DENV infectiousness to mosquitoes. Specifically, we are testing the hypothesis that mosquitoes are genetically variable in their dose-response to a DENV-infectious blood meal. We recently […]
Functional characterization of mosquito genes involved in dengue virus transmission identified by RNA-seq at the individual midgut level
Dengue is the most rapidly expanding, globally dominant arthropod-borne (arbo) viral disease. It affects close to 400 million people each year in more than 125 countries. Recent reports of autochtonous cases in Southern France […]
Unit Head, 2019-present
Institut Pasteur, Paris, France
Junior Group Leader, 2013-2018
Institut Pasteur, Paris, France
CNRS Research Scientist, 2011-present
Institut Pasteur, Paris, France
Postdoctoral Fellow, 2007-11, Arbovirology
Institut Pasteur, Paris, France (2010-11)
CNRS, Montpellier, France (2009)
University of California, Davis, USA (2007-08)
Ph.D., 2006, Ecology
University Pierre & Marie Curie, Paris, France
B.S. and M.S., 2002, Biology & Biochemistry
Ecole Normale Supérieure, Paris, France
2020Tudor-SN Promotes Early Replication of Dengue Virus in the Aedes aegypti Midgut, iScience 2020 Feb;23(2):100870.
2020Taking Insect Immunity to the Single-Cell Level, Trends Immunol. 2020 Feb;.
2019A peridomestic Aedes malayensis population in Singapore can transmit yellow fever virus, PLoS Negl Trop Dis 2019 Oct;13(10):e0007783.
2019Manipulating Mosquito Tolerance for Arbovirus Control, Cell Host Microbe 2019 09;26(3):309-313.
2019Cell-fusing agent virus reduces arbovirus dissemination in mosquitoes, J. Virol. 2019 Jun;.
2019Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus, Nat Microbiol 2019 Mar;.
2019Feasibility of feeding Aedes aegypti mosquitoes on dengue virus-infected human volunteers for vector competence studies in Iquitos, Peru, PLoS Negl Trop Dis 2019 Feb;13(2):e0007116.
2019Acceptability of Aedes aegypti blood feeding on dengue virus-infected human volunteers for vector competence studies in Iquitos, Peru, PLoS Negl Trop Dis 2019 Feb;13(2):e0007090.
2019RNA Structure Duplication in the Dengue Virus 3′ UTR: Redundancy or Host Specificity?, MBio 2019 Jan;10(1).
2019ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas, Glob Health Action 2019;12(1):1666566.
+View full list of publications