After my training in Biology at the Ecole Normale Supérieure in Paris, I obtained a PhD in Ecology in 2006 at University Pierre & Marie Curie (Paris 6). My PhD research dealt with the ecology and evolution of interactions between anopheline mosquitoes and malaria parasites. I then spent three years as a European Marie Curie Postdoctoral Fellow at the University of California in Davis (USA) and in the Laboratory of Genetics and Evolution of Infectious Diseases (IRD-CNRS) in Montpellier (France). During my postdoc I studied the interactions between Aedes aegypti mosquitoes and dengue viruses using various approaches of quantitative and evolutionary genetics. In 2010, I joined Institut Pasteur in Paris where I became a CNRS Faculty Research Scientist in 2011. In 2013, I was appointed as a Junior Group Leader at Institut Pasteur. In 2018, I was awarded the CNRS Bronze Medal. I am currently involved in several national and international research programs on mosquito-virus interactions, with an emphasis on dengue and Zika.
Bridge vectors at the sylvatic/human interface of arbovirus transmission cycles in rural Laos
Several emerging arthropod-borne viruses (arboviruses) such as dengue, yellow fever, chikungunya and Zika viruses originate from sylvatic transmission cycles where they are transmitted among non-human primates by arboreal mosquitoes. Initial virus spillover from the […]
Dengue virus genotype replacements: investigating viral fitness differences driving the evolution of dengue epidemics Phylogenetic analyses have revealed that dengue virus (DENV) evolutionary dynamics are often characterized by the replacement of a DENV genotype […]
Host-associated microbes, collectively known as the host microbiota, have manifold effects on host biology. Like other animals, insects establish various symbiotic associations with their microbial communities that shape their individual phenotype and fitness. In […]
ZikaPLAN consortium – Zika Preparedness Latin American Network
25 leading research and public health organizations from Latin America, North America, Africa, Asia and Europe united to fight Zika virus today and build long-term outbreak response capacity in Latin America. ZikaPLAN takes a […]
DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe
The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
Mosquito-virus specificity and arboviral emergence
Specific interactions between host and pathogen genotypes are commonly found in invertebrate systems, but their genetic basis has not been elucidated. Such insect-virus genetic specificity plays a critical role in the emergence and evolution […]
Quantifying heterogeneities in dengue virus transmission dynamics
Current knowledge of dengue virus (DENV) transmission provides, at best, only a partial understanding of a complicated and dynamic system with a public health track record that has more failures than successes. An important […]
Mosquito genetic variation in dose-response to dengue virus
This project investigates the entomological genetic determinants of human DENV infectiousness to mosquitoes. Specifically, we are testing the hypothesis that mosquitoes are genetically variable in their dose-response to a DENV-infectious blood meal. We recently […]
Functional characterization of mosquito genes involved in dengue virus transmission identified by RNA-seq at the individual midgut level
Dengue is the most rapidly expanding, globally dominant arthropod-borne (arbo) viral disease. It affects close to 400 million people each year in more than 125 countries. Recent reports of autochtonous cases in Southern France […]
Junior Group Leader, 2013-present
Institut Pasteur, Paris, France
CNRS Faculty Research Scientist, 2011-present
Institut Pasteur, Paris, France
Postdoctoral Fellow, 2007-11, Arbovirology
Institut Pasteur, Paris, France (2010-11)
CNRS, Montpellier, France (2009)
University of California, Davis, USA (2007-08)
Ph.D., 2006, Ecology
University Pierre & Marie Curie, Paris, France
B.S. and M.S., 2002, Biology & Biochemistry
Ecole Normale Supérieure, Paris, France
2018Epidemiological significance of dengue virus genetic variation in mosquito infection dynamics, PLoS Pathog. 2018 Jul;14(7):e1007187.
2018Development and validation of four one-step real-time RT-LAMP assays for specific detection of each dengue virus serotype, PLoS Negl Trop Dis 2018 May;12(5):e0006381.
2018Contributions from the silent majority dominate dengue virus transmission, PLoS Pathog. 2018 May;14(5):e1006965.
2018Diverse laboratory colonies of Aedes aegypti harbor the same adult midgut bacterial microbiome, Parasit Vectors 2018 Mar;11(1):207.
2018Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects, Cell Host Microbe 2018 Mar;23(3):353-365.e8.
2018A Survey of Virus Recombination Uncovers Canonical Features of Artificial Chimeras Generated During Deep Sequencing Library Preparation, G3 (Bethesda) 2018 Feb;.
2018Aedes Mosquitoes and Aedes-Borne Arboviruses in Africa: Current and Future Threats, Int J Environ Res Public Health 2018 Jan;15(2).
2017Individual co-variation between viral RNA load and gene expression reveals novel host factors during early dengue virus infection of the Aedes aegypti midgut, PLoS Negl Trop Dis 2017 Dec;11(12):e0006152.
2017Full-genome dengue virus sequencing in mosquito saliva shows lack of convergent positive selection during transmission by, Virus Evol 2017 Jul;3(2):vex031.
2017Extensive Genetic Differentiation between Homomorphic Sex Chromosomes in the Mosquito Vector, Aedes aegypti, Genome Biol Evol 2017 Sep;9(9):2322-2335.
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