After my training in Biology at the Ecole Normale Supérieure in Paris, I obtained a PhD in Ecology in 2006 at University Pierre & Marie Curie (Paris 6). My PhD research dealt with the ecology and evolution of interactions between anopheline mosquitoes and malaria parasites. I then spent three years as a European Marie Curie Postdoctoral Fellow at the University of California in Davis (USA) and in the laboratory of Genetics and Evolution of Infectious Diseases (IRD-CNRS) in Montpellier (France). During my postdoc I studied the interactions between Aedes aegypti mosquitoes and dengue viruses using various approaches of quantitative and evolutionary genetics. In 2010, I founded my own research group at Institut Pasteur in Paris. In 2011, I became a CNRS Faculty Research Scientist. In 2013, I was appointed as a Junior Group Leader at Institut Pasteur. I am currently involved in several national and international research programs on mosquito-virus interactions, with an emphasis on dengue.
Bridge vectors at the sylvatic/human interface of arbovirus transmission cycles in rural Laos
Several emerging arthropod-borne viruses (arboviruses) such as dengue, yellow fever, chikungunya and Zika viruses originate from sylvatic transmission cycles where they are transmitted among non-human primates by arboreal mosquitoes. Initial virus spillover from the […]
Dengue virus genotype replacements: investigating viral fitness differences driving the evolution of dengue epidemics Phylogenetic analyses have revealed that dengue virus (DENV) evolutionary dynamics are often characterized by the replacement of a DENV genotype […]
Host-associated microbes, collectively known as the host microbiota, have manifold effects on host biology. Like other animals, insects establish various symbiotic associations with their microbial communities that shape their individual phenotype and fitness. In […]
ZikaPLAN consortium – Zika Preparedness Latin American Network
25 leading research and public health organizations from Latin America, North America, Africa, Asia and Europe united to fight Zika virus today and build long-term outbreak response capacity in Latin America. ZikaPLAN takes a […]
DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe
The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
Mosquito-virus specificity and arboviral emergence
Specific interactions between host and pathogen genotypes are commonly found in invertebrate systems, but their genetic basis has not been elucidated. Such insect-virus genetic specificity plays a critical role in the emergence and evolution […]
Quantifying heterogeneities in dengue virus transmission dynamics
Current knowledge of dengue virus (DENV) transmission provides, at best, only a partial understanding of a complicated and dynamic system with a public health track record that has more failures than successes. An important […]
Mosquito genetic variation in dose-response to dengue virus
This project investigates the entomological genetic determinants of human DENV infectiousness to mosquitoes. Specifically, we are testing the hypothesis that mosquitoes are genetically variable in their dose-response to a DENV-infectious blood meal. We recently […]
Functional characterization of mosquito genes involved in dengue virus transmission identified by RNA-seq at the individual midgut level
Dengue is the most rapidly expanding, globally dominant arthropod-borne (arbo) viral disease. It affects close to 400 million people each year in more than 125 countries. Recent reports of autochtonous cases in Southern France […]
Junior Group Leader, 2013-present
Institut Pasteur, Paris, France
CNRS Faculty Research Scientist, 2011-present
Institut Pasteur, Paris, France
Postdoctoral Fellow, 2007-11, Arbovirology
Institut Pasteur, Paris, France (2010-11)
CNRS, Montpellier, France (2009)
University of California, Davis, USA (2007-08)
Ph.D., 2006, Ecology
University Pierre & Marie Curie, Paris, France
B.S. and M.S., 2002, Biology & Biochemistry
Ecole Normale Supérieure, Paris, France
2017Dengue virus replicates and accumulates in Aedes aegypti salivary glands, Virology 2017 Apr;507:75-81.
2017Discovery of flavivirus-derived endogenous viral elements in Anopheles mosquito genomes supports the existence of Anopheles-associated insect-specific flaviviruses, Virus Evol 2017 Jan;3(1):vew035.
2016Virus-derived DNA drives mosquito vector tolerance to arboviral infection, Nat Commun 2016 Sep;7:12410.
2016Evolutionary dynamics of dengue virus populations within the mosquito vector, Curr Opin Virol 2016 Aug;21:47-53.
2016Targeted full-genome amplification and sequencing of dengue virus types 1-4 from South America, J. Virol. Methods 2016 Jun;235:158-167.
2016Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes, PLoS Genet. 2016 Jun;12(6):e1006111.
2016Determinants of Arbovirus Vertical Transmission in Mosquitoes, PLoS Pathog. 2016 May;12(5):e1005548.
2016Excretion of dengue virus RNA by Aedes aegypti allows non-destructive monitoring of viral dissemination in individual mosquitoes, Sci Rep 2016;6:24885.
2016No evidence for local adaptation of dengue viruses to mosquito vector populations in Thailand, Evol Appl 2016 Apr;9(4):608-18.
2015Asymptomatic humans transmit dengue virus to mosquitoes, Proc. Natl. Acad. Sci. U.S.A. 2015 Nov;112(47):14688-93.
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