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About

Dr. Louis Lambrechts is a Research Director in the Department of Virology at Institut Pasteur in Paris. After graduating from Ecole Normale Supérieure in Paris, he obtained a PhD in Ecology in 2006 for his work on interactions between mosquitoes and malaria parasites at University Pierre & Marie Curie in Paris. During his postdoc, he was supported by a European Marie Curie fellowship to study interactions between mosquitoes and dengue viruses at the University of California in Davis and in the Laboratory of Genetics and Evolution of Infectious Diseases in Montpellier, France. In 2010, he joined the Institut Pasteur in Paris where he became a Permanent Research Scientist of the French Centre National de la Recherche Scientifique (CNRS) in 2011, a Junior Group Leader in 2013, and Unit Head in 2019. In 2018, he was awarded a CNRS Bronze Medal. He is currently involved in several international research programs on dengue and Zika.

Transversal Projects

Array

The microbial communities that live with us, the microbiota, are now understood to be a key component of our being, playing roles in metabolism, immunity and behavior. More than a decade has elapsed since […]

INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations

IINCEPTION Goal The Inception aims to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in various health issues (Official website here: https://www.inception-program.fr/en). The inception program uses Integrative Biology, […]

LabEx IBEID – Integrative Biology of Emerging Infectious Diseases

Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart and currently coordinated by Carla Saleh and Philippe Bastin, is to develop a […]

Projects

Project
Ongoing
5 Members

Étude des interactions entre virus et insectes dans les arboviroses : LIPOARBO-IVI (2023-006)

Louis Lambrechts (PI)

Sorry, this entry is only available in FR.
Project
Ongoing
6 Members

CAZIKANO: Preventing and controlling infectious risk of contemporary African Zika virus strains

Louis Lambrechts (PI)

Zika virus (ZIKV) is an arbovirus transmitted to humans by Aedes (Ae.) mosquitoes. ZIKV became a major public health problem in 2013-15 with epidemics in French Polynesia and then in Latin America. Emergence of […]
Project
Ongoing
5 Members

INTRANZIGEANT: Integrated study of Zika virus transmission to identify genetic mechanisms and new antiviral targets

Louis Lambrechts (PI)

Vector-borne pathogens like dengue or Zika viruses are transmitted to a human via the bite of a mosquito infected by a previous bite on an infected human. This transmission cycle is responsible for the […]
Project
Completed
3 Members

ANR BAKOUMBA: Dissecting the genetic basis of a natural dengue resistance phenotype in the mosquito Aedes aegypti

Louis Lambrechts (PI)

Dengue viruses (DENVs) and their main mosquito vector Aedes aegypti are responsible for the most rapidly advancing arboviral disease of humans. Mosquito susceptibility to DENV infection is a quantitative trait that varies between and […]
Project
Ongoing
5 Members

ANR PILGRIM: A panel of inbred lines to disentangle genetic and non-genetic drivers of Aedes aegypti microbiota and vectorial capacity

Louis Lambrechts (PI)

Aedes aegypti is the main mosquito vector of several arboviruses of medical significance. Its vectorial capacity is influenced by manifold genetic and environmental factors, including the microbiota. Disentangling genetic and non-genetic drivers of Ae. […]
Project
Completed
3 Members

Bridge vectors at the sylvatic/human interface of arbovirus transmission cycles in rural Laos

Louis Lambrechts (PI)

Several emerging arthropod-borne viruses (arboviruses) such as dengue, yellow fever, chikungunya and Zika viruses originate from sylvatic transmission cycles where they are transmitted among non-human primates by arboreal mosquitoes. Initial virus spillover from the […]
Project
Completed
2 Members

ACIP DenGen

Myrielle Dupont-rouzeyrol (PI)

Dengue virus genotype replacements: investigating viral fitness differences driving the evolution of dengue epidemics Phylogenetic analyses have revealed that dengue virus (DENV) evolutionary dynamics are often characterized by the replacement of a DENV genotype […]
Project
Completed
2 Members

ANR MOSQUIBIOTA: Contribution of gut bacterial diversity to Aedes aegypti vectorial capacity

Louis Lambrechts (PI)

Host-associated microbes, collectively known as the host microbiota, have manifold effects on host biology. Like other animals, insects establish various symbiotic associations with their microbial communities that shape their individual phenotype and fitness. In […]
Project
Completed
2 Members

ZikaPLAN consortium – Zika Preparedness Latin American Network

Annelies Wilder-Smith (PI)

25 leading research and public health organizations from Latin America, North America, Africa, Asia and Europe united to fight Zika virus today and build long-term outbreak response capacity in Latin America. ZikaPLAN takes a […]
Project
Completed
7 Members

DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe

Anavaj Sakuntabhai (PI)

The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
Project
Completed
8 Members

Mosquito-virus specificity and arboviral emergence

Louis Lambrechts (PI)

Specific interactions between host and pathogen genotypes are commonly found in invertebrate systems, but their genetic basis has not been elucidated. Such insect-virus genetic specificity plays a critical role in the emergence and evolution […]
Project
Completed
2 Members

Quantifying heterogeneities in dengue virus transmission dynamics

Thomas W. Scott (PI)

Current knowledge of dengue virus (DENV) transmission provides, at best, only a partial understanding of a complicated and dynamic system with a public health track record that has more failures than successes. An important […]
Project
Completed
2 Members

Mosquito genetic variation in dose-response to dengue virus

Louis Lambrechts (PI)

This project investigates the entomological genetic determinants of human DENV infectiousness to mosquitoes. Specifically, we are testing the hypothesis that mosquitoes are genetically variable in their dose-response to a DENV-infectious blood meal. We recently […]
Project
Completed
7 Members

Functional characterization of mosquito genes involved in dengue virus transmission identified by RNA-seq at the individual midgut level

Louis Lambrechts (PI)

Dengue is the most rapidly expanding, globally dominant arthropod-borne (arbo) viral disease. It affects close to 400 million people each year in more than 125 countries. Recent reports of autochtonous cases in Southern France […]

CV

Unit Head & Research Director, 2019-present Institut Pasteur, Paris, France

CNRS Bronze Medal, 2018

Junior Group Leader, 2013-2018 Institut Pasteur, Paris, France

CNRS Permanent Research Scientist, 2011-present Institut Pasteur, Paris, France

Postdoctoral Fellow, 2007-11, Arbovirology Institut Pasteur, Paris, France (2010-11); CNRS, Montpellier, France (2009); University of California, Davis, USA (2007-08)

Ph.D., 2006, Ecology University Pierre & Marie Curie, Paris, France

B.S. and M.S., 2002, Biology & Biochemistry Ecole Normale Supérieure, Paris, France

Publications

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