Dr. Louis Lambrechts is a Research Director in the Department of Virology at Institut Pasteur in Paris. After graduating from Ecole Normale Supérieure in Paris, he obtained a PhD in Ecology in 2006 for his work on interactions between mosquitoes and malaria parasites at University Pierre & Marie Curie in Paris. During his postdoc, he was supported by a European Marie Curie fellowship to study interactions between mosquitoes and dengue viruses at the University of California in Davis and in the Laboratory of Genetics and Evolution of Infectious Diseases in Montpellier, France. In 2010, he joined the Institut Pasteur in Paris where he became a Permanent Research Scientist of the French Centre National de la Recherche Scientifique (CNRS) in 2011, a Junior Group Leader in 2013, and Unit Head in 2019. In 2018, he was awarded a CNRS Bronze Medal. He is currently involved in several international research programs on dengue and Zika.
The microbial communities that live with us, the microbiota, are now understood to be a key component of our being, playing roles in metabolism, immunity and behavior. More than a decade has elapsed since […]
INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception aims to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in various health issues (Official website here: https://www.inception-program.fr/en). The inception program uses Integrative Biology, […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart and currently coordinated by Carla Saleh and Philippe Bastin, is to develop a […]
Étude du rôle des lipoprotéines humaines dans la transmission des arbovirus par les moustiques : DABO-LIPO-ARBO.
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INTRANZIGEANT: Integrated study of Zika virus transmission to identify genetic mechanisms and new antiviral targets
Vector-borne pathogens like dengue or Zika viruses are transmitted to a human via the bite of a mosquito infected by a previous bite on an infected human. This transmission cycle is responsible for the […]
ANR BAKOUMBA: Dissecting the genetic basis of a natural dengue resistance phenotype in the mosquito Aedes aegypti
Dengue viruses (DENVs) and their main mosquito vector Aedes aegypti are responsible for the most rapidly advancing arboviral disease of humans. Mosquito susceptibility to DENV infection is a quantitative trait that varies between and […]
ANR PILGRIM: A panel of inbred lines to disentangle genetic and non-genetic drivers of Aedes aegypti microbiota and vectorial capacity
Aedes aegypti is the main mosquito vector of several arboviruses of medical significance. Its vectorial capacity is influenced by manifold genetic and environmental factors, including the microbiota. Disentangling genetic and non-genetic drivers of Ae. […]
Bridge vectors at the sylvatic/human interface of arbovirus transmission cycles in rural Laos
Several emerging arthropod-borne viruses (arboviruses) such as dengue, yellow fever, chikungunya and Zika viruses originate from sylvatic transmission cycles where they are transmitted among non-human primates by arboreal mosquitoes. Initial virus spillover from the […]
Dengue virus genotype replacements: investigating viral fitness differences driving the evolution of dengue epidemics Phylogenetic analyses have revealed that dengue virus (DENV) evolutionary dynamics are often characterized by the replacement of a DENV genotype […]
ANR MOSQUIBIOTA: Contribution of gut bacterial diversity to Aedes aegypti vectorial capacity
Host-associated microbes, collectively known as the host microbiota, have manifold effects on host biology. Like other animals, insects establish various symbiotic associations with their microbial communities that shape their individual phenotype and fitness. In […]
ZikaPLAN consortium – Zika Preparedness Latin American Network
25 leading research and public health organizations from Latin America, North America, Africa, Asia and Europe united to fight Zika virus today and build long-term outbreak response capacity in Latin America. ZikaPLAN takes a […]
DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe
The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
Mosquito-virus specificity and arboviral emergence
Specific interactions between host and pathogen genotypes are commonly found in invertebrate systems, but their genetic basis has not been elucidated. Such insect-virus genetic specificity plays a critical role in the emergence and evolution […]
Quantifying heterogeneities in dengue virus transmission dynamics
Current knowledge of dengue virus (DENV) transmission provides, at best, only a partial understanding of a complicated and dynamic system with a public health track record that has more failures than successes. An important […]
Mosquito genetic variation in dose-response to dengue virus
This project investigates the entomological genetic determinants of human DENV infectiousness to mosquitoes. Specifically, we are testing the hypothesis that mosquitoes are genetically variable in their dose-response to a DENV-infectious blood meal. We recently […]
Functional characterization of mosquito genes involved in dengue virus transmission identified by RNA-seq at the individual midgut level
Dengue is the most rapidly expanding, globally dominant arthropod-borne (arbo) viral disease. It affects close to 400 million people each year in more than 125 countries. Recent reports of autochtonous cases in Southern France […]
Unit Head & Research Director, 2019-present Institut Pasteur, Paris, France
CNRS Bronze Medal, 2018
Junior Group Leader, 2013-2018 Institut Pasteur, Paris, France
CNRS Permanent Research Scientist, 2011-present Institut Pasteur, Paris, France
Postdoctoral Fellow, 2007-11, Arbovirology Institut Pasteur, Paris, France (2010-11); CNRS, Montpellier, France (2009); University of California, Davis, USA (2007-08)
Ph.D., 2006, Ecology University Pierre & Marie Curie, Paris, France
B.S. and M.S., 2002, Biology & Biochemistry Ecole Normale Supérieure, Paris, France
2023Direct mosquito feedings on dengue-2 virus-infected people reveal dynamics of human infectiousness., PLoS Negl Trop Dis 2023 Sep; 17(9): e0011593.
2023Multifaceted contributions of Dicer2 to arbovirus transmission by Aedes aegypti., Cell Rep 2023 Aug; 42(8): 112977.
2023Does arbovirus emergence in humans require adaptation to domestic mosquitoes?, Curr Opin Virol 2023 Jun; 60(): 101315.
2023Quantifying heterogeneities in arbovirus transmission: Description of the rationale and methodology for a prospective longitudinal study of dengue and Zika virus transmission in Iquitos, Peru (2014-2019)., PLoS One 2023 ; 18(2): e0273798.
2022Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic., PLoS Biol 2022 10; 20(10): e3001864.
2022Yearly variations of the genetic structure of Aedes aegypti (Linnaeus) (Diptera: Culicidae) in the Philippines (2017-2019)., Infect Genet Evol 2022 08; 102(): 105296.
2022Mosquito-bacteria interactions during larval development trigger metabolic changes with carry-over effects on adult fitness., Mol Ecol 2022 Mar; 31(5): 1444-1460.
2022Larval habitat determines the bacterial and fungal microbiota of the mosquito vector Aedes aegypti., FEMS Microbiol Ecol 2022 02; 98(1): .
2022Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs., PLoS Pathog 2022 Jan; 18(1): e1010202.
2021Potential role of vector-mediated natural selection in dengue virus genotype/lineage replacements in two epidemiologically contrasted settings., Emerg Microbes Infect 2021 Dec; 10(1): 1346-1357.
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