LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
Deciphering the virulence of Legionella pneumophila in vivo in the zebrafish model
L. pneumophila -host interactions have been studied in several animal models, but they all have their weaknesses and except the guinea pig model that is rarely used, they do not well recall human infection. […]
Investigation how eukaryotic domain capture might work: the evolution of a bacterial effector
Legionella pneumophila is a gram-negative environmental intracellular bacterium which causes a severe pneumonia. It survives and replicates in the environment in protozoa and during human infection in alveolar macrophages. This is achieved by a […]
Biogenesis, trafficking, and roles of Legionella pneumophila extracellular vesicles during infection (BioEV)
Extracellular vesicles (EVs), produced by eukaryotes, bacteria and archaea are increasingly recognized as important mediators of intercellular communication via transfer of a wide variety of molecular cargoes. Recently EVs of several intracellular pathogens have […]
A common phenomenon in most microbial infections is the attenuation of the host’s immediate immune response, allowing for long-term colonization. We and others have shown that many pathogens achieve this by manipulating the epigenetic […]
Molecular, genetic and cellular basis of the infection by Legionella
Our Unit investigates and characterises the molecular, genetic and cellular basis of the infection by Legionella. Legionella are environmental bacteria but some species like Legionella pneumophila or Legionella longbeachae are also opportunistic pathogens that […]
2023Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins., Nat Commun 2023 Jan; 14(1): 102.
2022Longitudinal analysis of serum neutralization of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 in patients receiving monoclonal antibodies., Cell Rep Med 2022 Nov; (): 100850.
2022Chromosome-scale assemblies of Acanthamoeba castellanii genomes provide insights into Legionella pneumophila infection-related chromatin reorganization., Genome Res 2022 Sep; (): .
2022Bacterial methyltransferases: targeting bacterial genomes to host epigenetics, microLife.
2022Genomic erosion and horizontal gene transfer shape functional differences of the ExlA toxin in Pseudomonas spp., iScience 2022 Jul; 25(7): 104596.
2022Microbe Profile: Legionella pneumophila – a copycat eukaryote., Microbiology (Reading) 2022 Mar; 168(3): .
2022The evolution and role of eukaryotic-like domains in environmental intracellular bacteria: the battle with a eukaryotic cell., FEMS Microbiol Rev 2022 Feb; (): .
2022Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response., Nat Commun 2022 Feb; 13(1): 762.
2021Reverting the mode of action of the mitochondrial F O F 1-ATPase by Legionella pneumophila preserves its replication niche, Elife. 2021 Dec 9;10:e71978. doi: 10.7554/eLife.71978. Online ahead of print.
2021Patho-epigenetics: histone deacetylases as targets of pathogens and therapeutics, microLife, uqab013.
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