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© Marie-Christine Prévost, Anne Derbise
Bactéries Yersinia pestis en microscopie electronique à balayage.

Transversal Projects

Array

The microbial communities that live with us, the microbiota, are now understood to be a key component of our being, playing roles in metabolism, immunity and behavior. More than a decade has elapsed since […]

LabEx IBEID – Integrative Biology of Emerging Infectious Diseases

Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart and currently coordinated by Carla Saleh and Philippe Bastin, is to develop a […]

Projects

Project
Ongoing
5 Members

Development of a new vaccine against Plague

Christian Demeure (PI)

Although an effort towards vaccination is ongoing, no efficient and safe vaccine against plague is currently available. During the last decade, we developed a new vaccine against plague. The project was funded by a […]
Project
Ongoing
6 Members

Étude des interactions des bactéries intracellulaires pathogènes avec les globules blancs humains : NEUTROPat

Javier Pizarro-Cerda (PI)

Sorry, this entry is only available in FR.
Project
Not started
9 Members

RETRACE – ANR PRC AAPG2023

Anne-Sophie Le Guern (PI)

Retracing the global spread of Yersinia enterocolitica & the evolution of pathogenicity within its lineages, from a One Health perspective Abstract:The Yersinia species are instrumental models to investigate the emergence of pathogenicity in the […]
Project
Ongoing
16 Members

Organ-on-Chip Center

Samy Gobaa (PI)

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]
Project
Completed
3 Members

Systems biology of cell infection by the bacterial pathogen Listeria monocytogenes

Javier Pizarro-Cerda (PI)

In the context of the Swiss consortium InfectX (www.infectx.ch), we have previously performed siRNA, microRNA and drug screens  to investigate signaling pathways modulating invasion of host cells by the bacterial pathogen Listeria monocytogenes. In […]
Project
Ongoing
5 Members

Host microbiota modification by epidemic Listeria monocytogenes

Javier Pizarro-Cerda (PI)

Listeriolysin S is a bacteriocin specifically produced in the intestine of orally infected mice and necessary for Listeria monocytogenes survival in this organ. In order to investigate whether this toxin might influence the composition […]
Project
Ongoing
15 Members

Microfluidics@Pasteur

Samy Gobaa (PI)

Welcome to the club! Welcome to Microfluidics@Pasteur! Our goal is to serve as the major entry point to all the scientists on the campus (beginners and experts) interested in undertaking projects where microfluidics is involved. Our […]
Project
Ongoing
2 Members

PTR521-2015 microRNAs & Listeria

Javier Pizarro-Cerda (PI)

In collaboration with the swiss consortium InfectX (https://www.infectX.ch) we have previously performed high through-put microRNA screens to identify novel gene networks modulating the infection of host cells by Listeria. We are now : 1) […]
Project
Completed
4 Members

ANR-2015 StopBugEntry

Javier Pizarro-Cerda (PI)

Infectious diseases are a major public health problem, and identification of novel potentialtherapeutic candidates is mandatory in a context of growing antibiotic resistance. As classical infection biology approaches are nearly exhausted in their current […]
Project
Ongoing
2 Members

Diversity of Listeria spp. in Costa Rica

Javier Pizarro-Cerda (PI)

Incidence of listeriosis in Costa Rica or Central America has not been previously studied. The only listeriosis outbreak reported in Costa Rica was described in 1989 (Schuchat et al., 1991). Nevertheless, the Costa Rican […]

Tools

Tool
Ongoing
7 Members

Dual microscopy assay to discriminate Listeria cellular entry & vacuolar escape

Javier Pizarro-Cerda (PI)

We developed a novel image-based microscopy assay which allows to discriminate Listeria monocytogenes cellular entry from vacuolar escape, enabling high-content screening to identify factors specifically involved in these two steps. We generated a L. […]
Tool
Ongoing
2 Members

InlC as a tool to label late cellular infection stages by Listeria

Javier Pizarro-Cerda (PI)

Bacterial intracellular pathogens can be conceived as molecular tools to dissect cellular signaling cascades due to their capacity to exquisitely manipulate and subvert cell functions which are required for the infection of host target […]
Tool
Ongoing
2 Members

Medium-Throughput Gentamicin Invasion Assay

Javier Pizarro-Cerda (PI)

This gentamicin invasion assay protocol to measure bacterial invasion of mammalian in vitro cultures is compatible with medium-throughput small interfering RNA screens in 96-well plates (Kühbacher et al. 2014. Internalization Assays for Listeria monocytogenes. Methods in […]

CV

Javier Pizarro-Cerda obtained B.Sc. and M.Sc. degrees from the University of Costa Rica while working in the laboratory of Edgardo Moreno, studying the adaptations of the outer membrane of the Gram-negative pathogen Brucella abortus to cationic peptides. He then obtained a D.E.A. and a Ph.D. from the University of Aix-Marseilles while working in the laboratory of Jean-Pierre Gorvel, identifying the intracellular trafficking of Brucella abortus in epithelial cells. Subsequently, he joined the laboratory of Pascale Cossart at the Pasteur Institute in Paris to investigate signaling cascades triggered by the Gram-positive pathogen Listeria monocytogenes during invasion of host mammalian cells. In 2002 Javier Pizarro-Cerda joins the Pasteur Institute as a permanent researcher and obtains his first grant from the French Ministry of Research. Since, he has been involved in local (Pasteur Institute Transversal Programs), national (French National Agency for Research, Defense Innovation Agency) and international (ERANET, Systems X, National Institutes of Health) research initiatives, investigating the adaptations of bacterial pathogens to intracellular life. He has been actively involved in teaching and has participated in practical and theoretical courses in France, Argentina, Costa Rica, Grèce and China. During his career, Javier Pizarro-Cerda has developed his research as invited investigator in different international laboratories including the Center for Microscopy & Microanalysis (Queensland University, Australia), the Weizmann Institute (Rehovot, Israel), the University of Texas-Southwestern Medical Center (Dallas, USA), the Max Planck Institute for Infection Biology (Berlin, Germany) and the Biozentrum (Basel, Switzerland). In 1998, Javier Pizarro-Cerda obtains the Costarrican National Award for Science ‘Clodomiro Picado-Twight’, in 2012 he becomes member of the Costarrican Academy of Sciences and in 2015 he receives the High Chamber Medal from the French Senate for his contribution fostering interactions between France and Latin America. In 2016, Javier Pizarro-Cerda becomes head of the ‘Systems Biology of Bacterial Infections’ Group and is promoted as Research Director at the Pasteur Institute. In 2017 he receives the ‘Canetti Prize’ from the Pasteur Institute Scientific Council for his global contributions to the field of infectious diseases and becomes head of the Yersinia Research Unit as well as Director of the World Health Organization (WHO) Collaborating Reference and Research Centre for Yersinia.  In 2018 he becomes member of the WHO International Roster of Experts (Plague Panel) while in 2019 Javier Pizarro-Cerda is admited as member of the Academia Europaea. In 2022 Javier Pizarro-Cerda becomes deputy director of the National Reference Laboratory ‘Plague and Other Yersinioses’.

Publications

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