Didier Guillemot

As recently acknowledged by the WHO, sepsis is the number one killer from infectious diseases, mostly bacterial infections, and as such has emerged as a major public health priority.  Global estimates ascribe to sepsis […]

Antibiotic resistance rates are increasing worldwide, especially for Gram-negative bacteria, potentially responsible for difficult-to-treat infections and therapeutic failures. While the high prevalence of resistance in hospitals is a long-lived concern, resistance is now spreading […]

Project MOD-COV (Modelling of the hOspital Dissemination of SARS-CoV-2) In the context of SARS-CoV-2 pandemic, healthcare institutions are confronted to major challenges. First the community spread is leading to a large demand in available […]

I-Share is an Internet-based Students HeAlth Research Enterprise. It is an entirely new, prospective cohort of 30,000 students registered in the first years of study at the Universities of Bordeaux and Versailles-Saint-Quentin during five years and followed […]

Despite advances in modern biology and medicine, antibiotic-resistant bacteria (ARB) have spread in the community and in hospitals over the last decades, becoming a major public health problem. Mathematical modeling and computer simulations are […]

Since 2002 a centralized storage of therapeutic or preventive medications of bacterial infections in the community (MIBAC) has been initiated. Reimbursements for all systemic antibiotics (class J01 of the Anatomical Therapeutic classification), as well […]

Bacterial resistance to antibiotics has become a major public health issue. A recent report, delivered to the Minister of Health in September 2015, pointed out 158,000 cases of infections by antibiotic-resistant bacteria annually in […]

The i-Bird program was devoted to explore the ability of MRSA and ER3GC to disseminate within hospital clinical departments. This program involved tracing the clonal dissemination of MRSA and ER3GC among hospitalized patients and […]

Current research investigations  Antibiotic use and Staphylococcus aureus resistant to antibiotics, ASAR This study is a prospective pharmacoepidemiological investigation involving the establishment of a cohort of hospitalized individuals not initially colonized with S. aureus. […]

  Challenges in understanding the determinants of anti-infection agent escape New antibiotic components are being developed and, provided the necessary investments are made, new antibiotics may therefore become available within the next few years. […]

  Determinants of the spread and competitiveness of multiresistant bacteria  In 2000, we investigated whether pneumococcal resistance to penicillin G in a child population could be controlled by modifying the use of antibiotics in […]