Adeline Mallet has worked for over 20 years at the Institut Pasteur in the fields of biotechnology and imaging. She holds a PhD from Sorbonne University, Paris, France. Her doctoral research focused on intraflagellar transport pathways in trypanosomes, using various imaging methods, including state-of-the-art electron microscopy techniques, to locate and study the distribution of particles specific to intraflagellar transport. She is currently in charge of the ultrastructural bio-imaging platform at Institut Pasteur France, a position she will take up in 2021. Her work focuses on advanced electron microscopy techniques, including biological sample preparation, protein immunolocalization with colloidal gold particles and three-dimensional FIB-SEM imaging. In addition, she focuses on integrating fluorescence microscopy with nanoscale imaging to study biological phenomena, making significant contributions to fields such as cell biology and host-pathogen interactions. Her work illustrates the intersection between cutting-edge technology and fundamental biological research to develop new methodological workflows.
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Since 2021 Head of the Ultrastructural BioImaging Platform, Institut Pasteur, Paris, France
2020 : Ph.D. thesis in cell Biology, Institut Pasteur and Parasitology deprtement (PIV) – Trypanosome cell biology Unit, Paris, France (Bastin Philippe group) – Sorbonne Université, France
2013 : Master of science: Biotechnology and bioIformatic, Paris Cité Université, France
Publications
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2025A Lyme disease mRNA vaccine targeting Borrelia burgdorferi OspA induces strong immune responses and prevents transmission in mice, Molecular Therapy - Nucleic Acids, 2025, 36 (2), pp.102514. ⟨10.1016/j.omtn.2025.102514⟩.
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2025Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism., Adv Sci (Weinh) 2025 Feb; (): e2410776.
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2024A free intravesicular C-terminal of otoferlin is essential for synaptic vesicle docking and fusion at auditory inner hair cell ribbon synapses., Prog Neurobiol 2024 Aug; 240(): 102658.
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2023Three-dimensional images reveal the impact of the endosymbiont Midichloria mitochondrii on the host mitochondria., Nat Commun 2023 Jul; 14(1): 4133.
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2023Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies., Proc Natl Acad Sci U S A 2023 Jun; 120(26): e2221744120.
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2023Solid-state NMR molecular snapshots of Aspergillus fumigatus cell wall architecture during a conidial morphotype transition., Proc Natl Acad Sci U S A 2023 Feb; 120(6): e2212003120.
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2022Restriction of intraflagellar transport to some microtubule doublets: An opportunity for cilia diversification?, Bioessays 2022 May; (): e2200031.
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2021Salmonella enters a dormant state within human epithelial cells for persistent infection., PLoS Pathog 2021 Apr; 17(4): e1009550.
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2021Ultrastructural Changes of the Mitochondrion During the Life Cycle of Trypanosoma brucei., J Eukaryot Microbiol 2021 Feb; (): e12846.
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2020Intraflagellar transport during assembly of flagella of different length in Trypanosoma brucei isolated from tsetse flies., J Cell Sci 2020 Sep; 133(18): .
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