With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is nevertheless a serious disease. It is one of the main causes of death on an international scale and killed more than 10 million people in 2020. It has been the leading cause of death in France since 2004 and is responsible for more than one in four deaths. In fact, despite the progress made in cancer treatment over the last 30 years, the disease is still claiming as many victims, with the number of new cases diagnosed each year constantly increasing. Current treatments are, moreover, particularly long and expensive and have a heavy impact on the economy of countries. More than 1,000 billion dollars are spent each year on treatment and support for patients. France spends 2 billion euros annually on anti-cancer molecules and 6 billion on hospital costs. Most patients are not completely cured and the risk of recurrence remains high. It is therefore crucial to optimize existing therapies and to develop innovative strategies that accelerate and improve patient management and cure them once and for all. To achieve this, it is essential to identify the causes of resistance to existing treatments, to develop innovative therapeutic strategies based on an in-depth knowledge of the mechanisms of tumor development and also to prevent the disease by determining the risk factors.
Click to view graph
Connections
Coordination
![](https://research.pasteur.fr/wp-content/uploads/2016/07/research.pasteur.fr_sans-titre-150x150.jpg)
Ludovic Deriano
Head of Structure
Director
Steering Committee
Teams
Platform
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_institutpasteur_14287-300x135.jpg)
Chemogenomic and Biological Screening Platform (PF-CCB)
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_image010-150x150.jpg)
Fabrice Agou
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_s-pombe-2_789-4-300x135.jpg)
Dynamics of the Genome
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_benoit-150x150.jpeg)
Benoit Arcangioli
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2020/04/research_pasteur-unite-p-arimondo-300x135.jpg)
Epigenetic Chemical Biology
![](https://research.pasteur.fr/wp-content/uploads/2017/10/research_pasteur-p-arimondo_5757-150x150.jpg)
Paola Arimondo
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2016/09/research.pasteur.fr_statistical-genetics-300x135.jpg)
Statistical Genetics
![](https://research.pasteur.fr/wp-content/uploads/2016/11/research.pasteur.fr_p8191439-150x150.jpg)
Hugues Aschard
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2016/02/research_pasteur-enzebrafish-neurogeneticsfrneurogenetique-du-poisson-zebre-research-pasteur-enzebrafish-neurogeneticsfrneurogenetique-du-poisson-zebre-bandeau-unite-l-bally-cuif-300x135.jpg)
Zebrafish Neurogenetics
![](https://research.pasteur.fr/wp-content/uploads/2016/04/research.pasteur.fr_laure_bally-cuiff-150x150.png)
Laure Bally-Cuif
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2022/12/research_pasteur-pawel-czerwinski-f-rcfqp7ze4-unsplash-300x135.jpg)
Physical Microfluidics and Bioengineering
![](https://research.pasteur.fr/wp-content/uploads/2017/12/research_pasteur-dsc0120-150x150.jpg)
Charles Baroud
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research.pasteur.fr_dynamics-of-immune-responses4-300x135.jpg)
Dynamics of Immune Responses
![](https://research.pasteur.fr/wp-content/uploads/2015/09/research.pasteur.fr_photopb-150x150.jpg)
Philippe Bousso
Laboratory
UMR
![](https://research.pasteur.fr/wp-content/uploads/2018/03/research_pasteur-photo-unite-anne-dejean-2018-300x135.png)
Nuclear Organization and Oncogenesis
![](https://research.pasteur.fr/wp-content/uploads/2016/03/research.pasteur.fr_anne-dejean-4-150x150.png)
Anne Dejean
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_institutpasteur_423851-300x135.jpg)
Architecture and Dynamics of Biological Macromolecules
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_marc2-150x150.jpg)
Marc Delarue
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research_pasteur-enimmunobiology-and-therapyfrimmunobiologie-et-therapie-institutpasteur-i04790-300x135.jpg)
Immunobiology and Therapy
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research_pasteur-caroline-demangel-id-caro2-2018-150x150.jpg)
Caroline Demangel
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2019/05/research_pasteur-unite-deriano-300x135.jpg)
Genome integrity, Immunity and Cancer
![](https://research.pasteur.fr/wp-content/uploads/2016/07/research.pasteur.fr_sans-titre-150x150.jpg)
Ludovic Deriano
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_hepvir-300x135.jpg)
Innate Immunity
![](https://research.pasteur.fr/wp-content/uploads/2016/05/research.pasteur.fr_photojd-150x150.jpg)
James Di Santo
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2022/12/research_pasteur-pawel-czerwinski-f-rcfqp7ze4-unsplash-300x135.jpg)
Translational Immunology
![](https://research.pasteur.fr/wp-content/uploads/2020/02/research_pasteur-duffy_photo-1-150x150.png)
Darragh Duffy
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_hiv-infected-h9-t-cell-300x135.jpg)
Microenvironment and Immunity
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_eberl-150x150.jpg)
Gérard Eberl
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_mtra-300x135.jpg)
Membrane Traffic and Cell Division
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research_pasteur-arnaud-echard-aechard-v2-2-150x150.jpg)
Arnaud Echard
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_453295a-f1.2-300x135.jpg)
Dynamics of Host-Pathogen Interactions
![](https://research.pasteur.fr/wp-content/uploads/2016/06/research.pasteur.fr_jost2015-3-150x150.jpg)
Jost Enninga
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research.pasteur.fr_cell-polarity-migration-and-cancer-300x135.jpg)
Cell Polarity, Migration And Cancer
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_sandrine_etienne-manneville-150x150.jpg)
Sandrine Etienne-Manneville
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research.pasteur.fr_oncogenic-virus-epidemiology-and-pathophysiology-300x135.jpg)
Oncogenic Virus Epidemiology and Pathophysiology
![](https://research.pasteur.fr/wp-content/uploads/2015/09/research.pasteur.fr_a.g-150x150.jpg)
Antoine Gessain
Platform
![](https://research.pasteur.fr/wp-content/uploads/2016/11/research.pasteur.fr_biomaterials-300x135.jpg)
Biomaterials and Microfluidics
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research_pasteur-samy-gobaa-gobaa-samy-1510-e1634550888980-150x150.jpg)
Samy Gobaa
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research.pasteur.fr_biology-and-genetics-of-bacterial-cell-wall-300x135.jpg)
Biology and Genetics of Bacterial Cell Wall
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research_pasteur-ivo-gomperts-boneca-p9090188-copie-150x150.jpg)
Ivo Gomperts Boneca
UTechS
Platform
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_technical-core-300x135.jpg)
UTechS Single Cell Biomarkers
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_institutpasteur_43068-150x150.jpg)
Milena Hasan
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2022/12/research_pasteur-pawel-czerwinski-f-rcfqp7ze4-unsplash-300x135.jpg)
Bioorganic chemistry of nucleic acids
![](https://research.pasteur.fr/wp-content/uploads/2016/01/research.pasteur.fr_thrashmanlessthrash-150x150.jpg)
Marcel Hollenstein
Group
![](https://research.pasteur.fr/wp-content/uploads/2022/12/research_pasteur-pawel-czerwinski-f-rcfqp7ze4-unsplash-300x135.jpg)
Mucosal Inflammation and Immunity
![](https://research.pasteur.fr/wp-content/uploads/2015/08/research.pasteur.fr_icdphoto-150x150.jpg)
Molly Ingersoll
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_spatial-genome-300x135.jpg)
Spatial Regulation of Genomes
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_romain-koszul-sc201-150x150.jpg)
Romain Koszul
Platform
![](https://research.pasteur.fr/wp-content/uploads/2015/02/research.pasteur.fr_antibody-engineering-300x135.jpg)
Antibody Engineering
![](https://research.pasteur.fr/wp-content/uploads/2015/01/Lafaye-150x150.jpg)
Pierre Lafaye
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2018/01/research_pasteur-unite-lemichez1-300x135.png)
Bacterial Toxins
![](https://research.pasteur.fr/wp-content/uploads/2017/07/research_pasteur-lemichez-2-150x150.jpg)
Emmanuel Lemichez
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2017/01/research.pasteur.fr_bandeau-g5-r-levayer-300x135.jpg)
Cell death and epithelial homeostasis
![](https://research.pasteur.fr/wp-content/uploads/2016/11/research.pasteur.fr_dsc_0008-001-1-1-150x150.jpg)
Romain Levayer
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_cancercell-300x135.jpg)
Cellular plasticity in age-related pathologies
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_han_li_small-150x150.jpg)
Han Li
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2022/12/research_pasteur-pawel-czerwinski-f-rcfqp7ze4-unsplash-300x135.jpg)
Institut Pasteur-TheraVectys Joint Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_fig10-150x150.jpeg)
Pierre Charneau
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_institutpasteur_14282-300x135.jpg)
Integrative Neurobiology of Cholinergic Systems
![](https://research.pasteur.fr/wp-content/uploads/2015/12/research.pasteur.fr_um_1-3-150x150.jpg)
Uwe Maskos
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2022/12/research_pasteur-pawel-czerwinski-f-rcfqp7ze4-unsplash-300x135.jpg)
Decision and Bayesian Computation – Epiméthée
![](https://research.pasteur.fr/wp-content/uploads/2018/06/research_pasteur-jbm_photo_serieux_low_res-150x150.jpg)
Jean-Baptiste Masson
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_institutpasteur_383851-300x135.jpg)
Chemistry of Biomolecules
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research.pasteur.fr_fig5-150x150.jpeg)
Laurence Mulard
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2019/10/research_pasteur-unite-navarro-gil_bandeau-300x135.jpg)
Epigenomics, Proliferation and the Identity of Cells – EPIC
![](https://research.pasteur.fr/wp-content/uploads/2019/10/research_pasteur-institut-pasteur_portraits-studio_gcc_162-150x150.jpg)
Pablo Navarro Gil
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research.pasteur.fr_structural-bioinformatics-300x135.jpg)
Structural Bioinformatics
![](https://research.pasteur.fr/wp-content/uploads/2017/02/research.pasteur.fr_dsc3513-copy-1-150x150.jpg)
Michael Nilges
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research_pasteur-group-lucie-peduto-image-unite-lucie-peduto-2-300x135.png)
Stroma, Inflammation and Tissue Repair
![](https://research.pasteur.fr/wp-content/uploads/2015/09/research.pasteur.fr_lp-3-150x150.jpg)
Lucie Peduto
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_system-biology1-300x135.jpg)
Computational Systems Biomedicine
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_photo-3-150x150.jpg)
Benno Schwikowski
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_neural-stem-cell-300x135.jpg)
Structures and signals in the neurogenic niche
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_dsc5160_2-150x150.jpg)
Pauline Speder
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research.pasteur.fr_biology-of-cell-interactions-300x135.jpg)
Cellular Biology of Microbial Infection
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_photo-a-subtil-150x150.jpg)
Agathe Subtil
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_induced-pluripotent-stem-cells-300x135.jpg)
Stem Cells And Development
![](https://research.pasteur.fr/wp-content/uploads/2015/05/research_pasteur-shahragim-tajbakhsh-tajbakhsh-photo2024-150x150.jpg)
Shahragim Tajbakhsh
Group
![](https://research.pasteur.fr/wp-content/uploads/2016/09/research.pasteur.fr_research.pasteur.fr_helicobacter-pathogenesis-1024x684-2-300x135.jpg)
Group: Infection, Genotoxicity and Cancer
![](https://research.pasteur.fr/wp-content/uploads/2015/09/research.pasteur.fr_diapositive15-150x150.jpg)
Eliette Touati
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2017/01/research.pasteur.fr_membrane-biochemistry-and-transport-1-300x135.jpg)
Membrane Biochemistry and Transport
![](https://research.pasteur.fr/wp-content/uploads/2017/01/research.pasteur.fr_portrait-cover-image-1-150x150.jpg)
Thomas Wollert
Laboratory
![](https://research.pasteur.fr/wp-content/uploads/2015/06/research.pasteur.fr_golgi-300x135.jpg)
Membrane Traffic and Pathogenesis
![](https://research.pasteur.fr/wp-content/uploads/2018/11/research_pasteur-chiara-zurzolo-150x150.jpg)
Chiara Zurzolo
Principal Investigators
Animation and Support
The coordinators of the Cancer Initiative are supported by Mallory Perrin-Wolff and Sylvie Gratepanche (Scientific Programming and Incentive Actions Department – SPAIS) for the organization of different actions: communication, workshops, incentive actions, training, etc…
Featured Publications
Download-
2021Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain., Cell Stem Cell 2021 Aug; 28(8): 1457-1472.e12.
-
2021Multiscale rheology of glioma cells., Biomaterials 2021 08; 275(): 120903.
-
2021Multimodal imaging as optical biopsy system for gastritis diagnosis in humans, and input of the mouse model., EBioMedicine 2021 Jul; 69(): 103462.
-
2021Multifaceted modes of action of the anticancer probiotic Enterococcus hirae., Cell Death Differ 2021 Jul; 28(7): 2276-2295.
-
2021A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress., Cancers (Basel) 2021 Jul; 13(13): .
-
2021Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia., Int J Mol Sci 2021 Jun; 22(13): .
-
2021A preoperative nomogram for predicting long-term survival after resection of large hepatocellular carcinoma (>10 cm)., HPB (Oxford) 2021 Jun; (): .
-
2021The viral restriction factor tetherin/BST2 tethers cytokinetic midbody remnants to the cell surface., Curr Biol 2021 May; 31(10): 2203-2213.e5.
-
2021Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients., Cell Death Differ 2021 May; 28(5): 1532-1547.
-
2021A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity., Sci Immunol 2021 Mar; 6(57): .
-
2021Partial breast resection for multifocal lower quadrant breast tumour using virtual reality., BMJ Case Rep 2021 Mar; 14(3): .
-
2021Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry, Oncotarget. 2021; 12:475-492.
-
2021CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumors., J Immunother Cancer 2021 Mar; 9(3):e001948.
-
2021Natural Occurrence of Mycotoxin-Producing Fusaria in Market-Bought Peruvian Cereals: A Food Safety Threat for Andean Populations., Toxins (Basel) 2021 02; 13(2): .
-
2021Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis., Sci Adv 2021 Feb; 7(8): .
-
2021Proteomic Analysis Uncovers Measles Virus Protein C Interaction With p65-iASPP Protein Complex., Mol Cell Proteomics 2021 ; 20(): 100049.
-
2021Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids., Biochem J 2021 01; 478(1): 21-39.
-
2021Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers., J Exp Med 2021 Jan; 218(1): .
-
2020The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis., Nat Commun 2020 Apr; 11(1): 1941.
-
2020Multispectral imaging detects gastritis consistently in mouse model and in humans., Sci Rep 2020 11; 10(1): 20047.
-
2020Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions., Front Cell Dev Biol 2020 ; 8(): 591348.
-
2020Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ., Nat Commun 2020 Oct; 11(1): 5239.
-
2020Nicotinic Receptor Subunits Atlas in the Adult Human Lung., Int J Mol Sci 2020 Oct; 21(20): .
-
2020Tunneling Nanotubes: The Fuel of Tumor Progression?, Trends Cancer 2020 Oct; 6(10): 874-888.
-
2020DIVA, a 3D virtual reality platform, improves undergraduate craniofacial trauma education., J Stomatol Oral Maxillofac Surg 2020 Sep; (): .
-
2020Genuage: visualize and analyze multidimensional single-molecule point cloud data in virtual reality., Nat. Methods 2020 Sep; (): .
-
2020An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency., Oncogene 2020 Sep; (): .
-
2020Extensive SUMO Modification of Repressive Chromatin Factors Distinguishes Pluripotent from Somatic Cells., Cell Rep 2020 09; 32(11): 108146.
-
2020The role of hepatitis C virus genotypes and core mutations in hepatocellular carcinoma in Cameroon., J Viral Hepat 2020 09; 27(9): 880-885.
-
2020USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis., Gut 2020 09; 69(9): 1582-1591.
-
2020Bisubstrate inhibitors: the promise of a selective and potent chemical inhibition of epigenetic ‘writers’., Epigenomics 2020 09; 12(17): 1479-1482.
-
2020Identification of Four Immune Subtypes Characterized by Distinct Composition and Functions of Tumor Microenvironment in Intrahepatic Cholangiocarcinoma., Hepatology 2020 09; 72(3): 965-981.
-
2020Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage., Science 2020 08; 369(6506): 936-942.
-
2020Pathogenesis of Helicobacter pylori infection, Helicobacter 2020;00:e12736..
-
2020Cytoskeletal Crosstalk in Cell Migration., Trends Cell Biol. 2020 Jul; (): .
-
2020Wandering along the epigenetic timeline., Clin Epigenetics 2020 07; 12(1): 97.
-
2020Intermediate filaments against actomyosin: the david and goliath of cell migration., Curr. Opin. Cell Biol. 2020 Jul; 66(): 79-88.
-
2020AP-1 imprints a reversible transcriptional programme of senescent cells., 2020 07; 22(7): 842-855.
-
2020Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions., Immunohorizons 2020 06; 4(6): 363-381.
-
2020DIVA: Natural Navigation inside 3D Images Using Virtual Reality., J. Mol. Biol. 2020 Jun; (): .
-
2020Associations of the -238(G/A) and -308(G/A) TNF-α Promoter Polymorphisms and TNF-α Serum Levels with the Susceptibility to Gastric Precancerous Lesions and Gastric Cancer Related to Helicobacter pylori Infection in a Moroccan Population., Asian Pac J Cancer Prev 2020 Jun; 21(6): 1623-1629.
-
2020Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer., Nat Med 2020 Jun; 26(6): 919-931.
-
2020Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array., Cell Rep 2020 05; 31(8): 107670.
-
2020Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort., Am. J. Clin. Nutr. 2020 May; (): .
-
2020P120catenin tuning of VE-cadherin endocytosis controls collective cell behavior during angiogenesis., J. Cell Biol. 2020 May; 219(5): .
-
2020Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways., Nat Commun 2020 04; 11(1): 1973.
-
2020Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells., EMBO J 2020 04; 39(8): e102166.
-
2020Bisubstrate-Type Chemical Probes Identify GRP94 as a Potential Target of Cytosine-Containing Adenosine Analogs., ACS Chem Biol 2020 04; 15(4): 952-961.
-
2020ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation., Cell Rep 2020 Mar; 30(10): 3434-3447.e6.
-
2020Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment., Nat Cancer 2020 Mar; 1(3): 302-314.
-
2020Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation, Cancers (Basel) 2020 Feb;12(2).
-
2020Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy, Proc. Natl. Acad. Sci. U.S.A. 2020 Feb;117(8):4169-4179.
-
2020Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer., Chem Sci 2020 Jan; 11(10): 2657-2663.
-
2020Frequent Homozygous Deletions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus., J Thorac Oncol 2020 May; 15(5): 827-842.
-
2019The timeline of epigenetic drug discovery: from reality to dreams, Clin Epigenetics 2019 12;11(1):174.
-
2019Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells., Eur J Med Chem 2020 Jan; 186(): 111829.
-
2019Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity., J Exp Med 2019 05; 216(5): 1038-1049.
-
2019Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors, Nucleic Acids Res. 2019 Feb;.
-
2018The immune system profoundly restricts intratumor genetic heterogeneity, Sci Immunol 2018 Nov;3(29).
-
+View full list of featured publications