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  • Physician
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  • Director of Center
  • Director of Department
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About

 

The objective of the platform is to bridge biology and engineering in order to help the development of biomedical projects with a strong technological focus. Practically we provide the campus with essential technological bricks and expertise in microfluidics and biomaterials. Since May 2015 we developed in-house capabilities in the field of microfabrication, photo- and soft-lithography, advanced 3D cell culture systems, organoids and Organ-on-Chip  technology especially targeted for the better understanding of complex cell-microenvironment interactions.

Working with us

The facility operates on a project basis. To submit a project application or ask your questions, you can email us. We will then organise a one-to-one meeting in order outline a viable project of the following type:

  • Do-It-Yourself : Projects in this category can benefit from the full set of bookable equipment at the facility. the users have to be to work as autonomous users. Training sessions can be organised to reach this status.
  • Proof-of-Concept: These projects aims at investigating whether the envisioned bioengineering approach helps with the biological question at hand. A first round of investigation is directly performed by the facility personnel (chip design and fabrication, cell encapsulation assay…). In a later stage, users will be requested to take over the data generation process after the first proof-of-concept.
  • Co-Development: Here the involvement of the Biomaterials and Microfluidics core facility will be larger and will span over a longer period of time. We typically propose leading a technological work package (Chip design, Organoid production….) within a larger consortium. Our contribution can then be transferred to the different partners.
  • Organ-on-Chip: The Organ-on-Chip center hosted by the Biomaterials & Microfluidics core facility is geared towards the production fully matured Emulate recapitulating different types of organs. We provide dedicated personnel and chip actuation machines in a BSL2 and BSL3 environment.

You still have a question ? Please do not hesitate to contact us at bmcf@pasteur.fr

 

Join the community of users on Microsoft Teams

Where to find us (and the other facilities) click here to obtain the map

Guidelines for users and core facility teams: click here to obtain the guide

Services

Booking site

Production of Custom Micropatterns for Cell Culture

We provide an integrated solution for the design and fabrication of micropatterns. This service based on the local functionalization of cell culture substrates with extracellular matrix components or other proteins.

Organ-on-Chip Technology – Emulate

Organ-on-Chip center The center is equipped with Emulate technology (multiple Zoé and Orbs) Multiple Organ mimics are available (Intestine, Liver, kidney, Lung…). Experiments can be performed in BSL2 and BSL3 conditions. The center is […]

Design and Production of Microfluidic Devices

The Biomaterials and Microfluidics core facility is fully geared for the design, production and testing of  microfluidic devices. The team will provide expertise, protocols and equipment to allow users to produce “homemade” chips.

Advanced 3D Cell Culture Systems

We provide a library of 3D cell culture scaffolds with tunable biophysical and biochemical properties.

Equipments

Booking site

UV/Ozone cleaner • Jelight • UVO Cleaner

This machine is used for sterilizing microfluidic chips, creating micropatterns on glass coverslips or as a source of UV for photopolymerization

Rheometer • Malvern • Kinexus Ultra+

This machine is dedicated to the measurement of the mechanical properties of different materials. 20 and 4 mm geometries are available.

PDMS • Station • Thinky

This station is equipped with a automated mixer, degassing bottles, a balance a  couple of ovens

Stylus Profiler • Bruker • DektakXT

A machine for measuring the height and the roughness of microfabricated structures. Range: 0.1 to 500 micron.

Computational fluid dynamics simulation • Software • COMSOL Multiphysics

A software dedicated to finite element simulation of the all the physical parameters that can occur in a microfluidic chip (flow, shear stress, diffusion, gradient formation….)

Photomask layout • Software • Clewin 5

Vectorial drawing of photolithography masks

Spincoater • SCS • 6800

Programmable spincoater dedicated to the production of thin layers of PDMS

2 • Microfluidic syringe pumps • Cetoni • neMESYS

Computer controlled (programmable) syringe pump system dedicated to microfluidic chip perfusion. One controller plus two low pressure modules and a pressure sensor.

Inverted microscope for live cell imaging • Zeiss • Axiovert

Inverted microscope for live cell imaging capabilities. The microscope is built for speed in order to reduce the interval between time points when acquiring a timelapse experiment. Standard LED fluorescence is available (Colibri system). […]

Oxygen Plasma cleaner • Femto Science • Cute

Oxygen plasma cleaner. Applications: surface activation, PDMS bonding, cleaning. Controllable vacuum, gas injection, power, treatment time.

Mask aligner • Süss Microtec • MJB4

Manual mask aligner equipped with a topside microscope and dual objectives. Micrometric screws allow a precise mask-substrate alignment.   

Former Members

2000
2000
Name
Position
2015
2015
Raphaël Gayet
Master Student
2016
2020
Yasemin Atiyas
Undergraduate Student
2016
2020
Camille Berthault
2016
2020
Igor Molybog
Undergraduate Student
2016
2020
Stefan Rouach
Undergraduate Student
2016
2020
Charlotte Bouquerel
Graduate Student
2016
2020
Anette Funfak
Post-doc

Projects

Fundings

Publications

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Contact

Phone: +33 1 44 38 92 75 Email: bmcf@pasteur.fr; samy.gobaa@pasteur.fr Address: 25-28 Rue du Docteur Roux 75015, Paris France