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© Research
Publication : HPB : the official journal of the International Hepato Pancreato Biliary Association

A preoperative nomogram for predicting long-term survival after resection of large hepatocellular carcinoma (>10 cm).

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in HPB : the official journal of the International Hepato Pancreato Biliary Association - 19 Jun 2021

Ruiz E, Pineau P, Flores C, Fernández R, Cano L, Cerapio JP, Casavilca-Zambrano S, Berrospi F, Chávez I, Roche B, Bertani S,

Link to Pubmed [PMID] – 34226129

Link to DOI – S1365-182X(21)00177-510.1016/j.hpb.2021.06.006

HPB (Oxford) 2021 Jun; ():

It has previously been demonstrated that a fraction of patients with hepatocellular carcinoma (HCC) > 10 cm can benefit from liver resection. However, there is still a lack of effective decision-making tools to inform intervention in these patients.We analysed a comprehensive set of clinical data from 234 patients who underwent liver resection for HCC >10 cm at the National Cancer Institute of Peru between 1990 and 2015, monitored their survival, and constructed a nomogram to predict the surgical outcome based on preoperative variables.We identified cirrhosis, multifocality, macroscopic vascular invasion, and spontaneous tumour rupture as independent predictors of survival and integrated them into a nomogram model. The nomogram’s ability to forecast survival at 1, 3, and 5 years was subsequently confirmed with high concordance using an internal validation. Through applying this nomogram, we stratified three groups of patients with different survival probabilities.We constructed a preoperative nomogram to predict long-term survival in patients with HCC >10 cm. This nomogram is useful in determining whether a patient with large HCC might truly benefit from liver resection, which is paramount in low- and middle-income countries where HCC is often diagnosed at advanced stages.

https://pubmed.ncbi.nlm.nih.gov/34226129