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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.

Projects

project
Ongoing
7 Members

CNF1 and Rho GTPases ubiquitylation in cellular invasion by uropathogenic E. coli

Emmanuel Lemichez (PI)

CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]
project
Ongoing
2 Members

Reorganization of cytoskeletal elements and cell migration – Perturbation of the regulation of cytoskeletal networks in glioblastoma cells

Sandrine Etienne-Manneville (PI)

How are cytoskeletal elements reorganized to promote cell migration? Is the regulation of the cytoskeletal networks perturbed in glioblastoma cells? We have shown that the three main cytoskeletal networks, microfilaments, microtubules and intermediate filaments […]
project
ongoing
1 Member

Determining the central components of polarity pathways and their affection during gliomagenesis

Sandrine Etienne-Manneville (PI)

What are the central components of polarity pathways ? Are they affected during gliomagenesis? Using astrocyte directed migration as a model system, we have identified evolutionary conserved polarity signals that control cell polarity and […]
project
ongoing
1 Member

Role and dynamics of cell-cell interactions during cell polarization and collective directed migration

Sandrine Etienne-Manneville (PI)

What are the role and the dynamics of cell-cell interactions during cell polarization and collective directed migration? How loss of cellular interactions affects the migratory behavior of glioblastoma cells? We have shown that the […]

Publications

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