Cytoskeleton and Mechanobiology projects
Until now, the role of actin in cell migration has been extensively studied, but much less is known about the role of microtubules and Intermediate Filaments(IFs) (Dutour-Provenzano and Etienne-Manneville, 2021, 34033784; Etienne-Manneville, 2018, 30059630). […]
Covid19 related project
Role of the E-protein in intracellular viral behavior (Batiste Boëda, INSERM) The coronavius genome encodes four major structural proteins: the spike (S) protein, nucleocapsid (N) protein, membrane (M) protein, and the envelope (E) protein. […]
Cell Polarity projects
What are the central components of polarity pathways ? Are they affected during gliomagenesis? Using astrocyte directed migration as a model system, we have identified evolutionary conserved polarity signals that control cell polarity […]
Reorganization of cytoskeletal elements and cell migration – Perturbation of the regulation of cytoskeletal networks in glioblastoma cells
How are cytoskeletal elements reorganized to promote cell migration? Is the regulation of the cytoskeletal networks perturbed in glioblastoma cells? We have shown that the three main cytoskeletal networks, microfilaments, microtubules and intermediate filaments […]
Determining the central components of polarity pathways and their affection during gliomagenesis
What are the central components of polarity pathways ? Are they affected during gliomagenesis? Using astrocyte directed migration as a model system, we have identified evolutionary conserved polarity signals that control cell polarity and […]
Role and dynamics of cell-cell interactions during cell polarization and collective directed migration
What are the role and the dynamics of cell-cell interactions during cell polarization and collective directed migration? How loss of cellular interactions affects the migratory behavior of glioblastoma cells? We have shown that the […]
2023The diverse actions of cytoskeletal vimentin in bacterial infection and host defense., J Cell Sci 2023 Jan; 136(1): .
2022Non-catalytic allostery in α-TAT1 by a phospho-switch drives dynamic microtubule acetylation., J Cell Biol 2022 11; 221(11): .
2022PDE-Constrained Optimization for Nuclear Mechanics, 2022 IEEE International Conference on Image Processing (ICIP).
2022Using Fluorescence Recovery After Photobleaching data to uncover filament dynamics., PLoS Comput Biol 2022 Sep; 18(9): e1010573.
2022Impact of noise on the regulation of intracellular transport of intermediate filaments., J Theor Biol 2022 08; 547(): 111183.
2022PTEN inhibits AMPK to control collective migration., Nat Commun 2022 08; 13(1): 4528.
2022Live Imaging of Microtubule Dynamics in Glioblastoma Cells Invading the Zebrafish Brain, JoVE, 2022 Jul;185:e64093.
2022Live Imaging of Microtubule Dynamics in Glioblastoma Cells Invading the Zebrafish Brain., J Vis Exp 2022 07; (185): .
2022Microtubules tune mechanosensitive cell responses., Nat Mater 2022 03; 21(3): 366-377.
2022Molecular organization and mechanics of single vimentin filaments revealed by super-resolution imaging., Sci Adv 2022 Feb; 8(8): eabm2696.
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