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© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.

About

Mission

Our core facility provides support in developing and characterizing VHH/nanobodies against the desired antigens. The main goal of this collaboration is to provide the right nanobodies that suit to the need of the user. We try not only to provide nanobodies but we can modify them: for example, according to the need, the nanobodies can be engineered to add a fluorochrome, to perform imaging; in this way, bispecific molecules can be created.

Nanobodies combine the advantages of binding activities of antibodies with properties of small molecules

Their features are

  • small size : 15kDa (1/10th of the size of a conventional antibody)
  • highly soluble
  • high affinity for the antigen
  • low immunogenicity (85-90% identity to human germline)
  • highly stable
  • well produced
  • diffuse in tissues
  • cross the Blood Brain Barrier
  • Bind intracellular targets

Our expertise includes

  • Phage display of phage VHH libraries
  • Expression and characterization of nanobodies
  • Site specific labeling with fluorochromes
  • Automatization of the processes
  • Rapid dipstick diagnostic tests

 

Sans titre

 

Certifications and Networks

We are IBiSA labeled.

We are part of the EuroMabnet Network, CFL (Core For Life) and CTLS (Core technologies for life sciences).

Services

Form

What we do Phage display technology enables the selection from repertoires of VHH displayed on the surface of filamentous bacteriophage. Llamas or Alpacas are immunized with antigens provided by the users; once the serum […]

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Pictures & Media

https://www.youtube.com/watch?v=hg2x8P9p7hU

Contact

Pierre Lafaye
Head of Antibody Engineering Platform
Phone: 01 40 61 39 20
25-28 Rue du Docteur Roux 75015, Paris – France