Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.

About

Mission

Our core facility provides support in developing and characterizing VHH/nanobodies against the desired antigens. The main goal of this collaboration is to provide the right nanobodies that suit to the need of the user. We try not only to provide nanobodies but we can modify them: for example, according to the need, the nanobodies can be engineered to add a fluorochrome, to perform imaging; in this way, bispecific molecules can be created.

Nanobodies combine the advantages of binding activities of antibodies with properties of small molecules

Their features are

  • small size : 15kDa (1/10th of the size of a conventional antibody)
  • highly soluble
  • high affinity for the antigen
  • low immunogenicity (85-90% identity to human germline)
  • highly stable
  • well produced
  • diffuse in tissues
  • cross the Blood Brain Barrier
  • Bind intracellular targets

Our expertise includes

  • Phage display of phage VHH libraries
  • Expression and characterization of nanobodies
  • Site specific labeling with fluorochromes
  • Automatization of the processes

 

Sans titre

 

Certifications and Networks

We are IBiSA labeled.

We are part of the EuroMabnet Network, CFL (Core For Life) and CTLS (Core technologies for life sciences).
To find out more about the Technology Department, see here.

Services

Form

What we do Phage display technology enables the selection from repertoires of VHH displayed on the surface of filamentous bacteriophage. Llamas or Alpacas are immunized with antigens provided by the users; once the serum […]

Former Members

2000
2000
Name
Position
2015
2020
Farida Nato
Research Engineer
2015
2020
Tengfei Li
PhD Student
2015
2020
Pascal Lenormand
Technician
2015
2020
François Traincard
Research Engineer
2015
2020
Matthias Vandesquille
Post-doc
2015
2020
Sylvie Dartevelle
Technician
2015
2020
Françoise Marchand
Technician
2015
2020
Yannis Rahou
Technician
2015
2020
maria-chiara marinozzi
Post-doc
2015
2020
Margarida Esteves d’Almeida Gomes
Post-doc
2017
2020
elodie pothin
PhD Student
----
2023
Muriel Esnard
Administrative staff
2020
2023
Raphaëlle Drean
PhD Student
Show all

Projects

Transversal Project

Fundings

Publications

Download

Pictures & Media

https://www.youtube.com/watch?v=hg2x8P9p7hU

Contact

Pierre Lafaye
Head of Antibody Engineering Platform
Phone: 01 40 61 39 20
25-28 Rue du Docteur Roux 75015, Paris – France