Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Institut Pasteur/Antoinette Ryter
Coupe de Mycobacterium bovis ou bacille de Calmette et Guérin (BCG). Souche atténuée de bacille vivant, à l'origine du vaccin antituberculeux délivré par voie intradermique ou scarifications (Grossissement X 70000). Image colorisée.

About

Studying infections to discover new bioactive compounds and therapeutic targets

In the Pasteurian tradition, we are passionate about host-microbe interactions and their role in genesis of human diseases. Through the study of successfull pathogens, we aim to identifiy new means to manipulate the immune system and tackle cancer and infectious diseases. We have a particular knowledge of the immunosuppressive mechanisms evolved by mycobacteria. We also developed expertise in the immunometabolism of Hidradenitis Suppurativa, a chronic inflammatory skin disease associated with microbiome alterations. Our research is conducted at the molecular, cellular and whole organism levels in models of human disease, and it combines fundamental and translational studies.

Projects

Project
Completed
5 Members

Host fatty acids and immunity to Mycobacterium tuberculosis

Caroline Demangel (PI)

While the special relationship between Mycobacterium tuberculosis (Mtb) and host lipids has long been known, it remains a challenging enigma. It was clearly established that Mtb requires host fatty acids (FAs) and cholesterol to […]
Project
Ongoing
13 Members

Deciphering the causes of Hidradenitis Suppurativa

Caroline Demangel (PI)

Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
Project
Ongoing
8 Members

Therapeutic potential of mycolactone and synthetic surrogates

Caroline Demangel (PI)

Whether released by bacteria infecting the skin or injected via the subcutaneous route, mycolactone was found to diffuse into the leukocytes of peripheral blood and lymphoid organs. With this distribution profile, the unique effects […]
Project
Ongoing
5 Members

Immunity against Mycobacterium ulcerans : the subversive role of mycolactone

Caroline Demangel (PI)

Mycobacterium ulcerans causes Buruli ulcer, a neglected tropical skin disease manifesting as chronic wounds that can leave victims with major, life-long deformity and disability. Differently from other mycobacteria, including the related M. tuberculosis and […]
Project
Ongoing
5 Members

Biomarkers of Buruli ulcer disease

Caroline Demangel (PI)

Buruli ulcer is the third most common mycobacterial disease after Tuberculosis and Leprosy. It is a chronic, necrotizing disease of the skin and soft tissues that is reported in over thirty tropical and subtropical […]
Project
Completed
3 Members

Mycobacterial phenolic glycolipids and innate host defenses

Caroline Demangel (PI)

Across different species of mycobacteria, phenolic glycolipids (PGL) share a common lipid core and phenol ring that are embedded in the cell envelope, and differ in the saccharidic portion that is exposed on the […]
Project
Completed
4 Members

Mycolactone of Mycobacterium ulcerans and the actin cytoskeleton

Caroline Demangel (PI)

A distinctive feature of the human pathogen Mycobacterium ulcerans is the production of mycolactone. This original polyketide-derived macrolide is essential for bacterial virulence and sufficient to induce ulcerative lesions in the skin that are […]

Transversal Project

Drug Discovery & Screening at Institut Pasteur

The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]

Cancer Initiative

With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]

Emerging Infectious Diseases

Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]

Antimicrobial resistance

Antimicrobial resistance is dramatically increasing worldwide and is becoming one of the most urgent public health threats. There is an urgent need for actions to reverse the curve of antimicrobial resistance dissemination and to […]

The institut Carnot Pasteur MS

Carnot, label of excellence Founded in 2006, the Carnot Label, granted by the French government, was designed to develop partnership-based research, meaning research conducted by public laboratories in partnership with socio-economic players, primarily industry […]

LabEx Milieu Intérieur

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. https://www.youtube.com/watch?v=IXlKElDJMc8 The Milieu Intérieur Project While the […]

Fundings

Publications

Download

Contact

Administrative assistant: Marie-Luce Kop Phone: +33 (0)1 40 61 33 96 Email: marie-luce.kop@pasteur.fr 25-28 Rue du Docteur Roux 75015, Paris France