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  • Director of Center
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© Institut Pasteur/Antoinette Ryter
Coupe de Mycobacterium bovis ou bacille de Calmette et Guérin (BCG). Souche atténuée de bacille vivant, à l'origine du vaccin antituberculeux délivré par voie intradermique ou scarifications (Grossissement X 70000). Image colorisée.

About

Studying microbes to discover new immune intervention strategies

In the Pasteurian tradition, we are passionate about host-microbe interactions and their role in genesis of human diseases. Through the study of chronic infections, we are looking for new ways to manipulate the immune system. We are particularly interested in the immunosuppressive strategies evolved by mycobacterial pathogens and the metabolic regulations of antimicrobial immunity. We work at the molecular, cellular and whole organism levels, to translate our knowledge into innovative treatments and vaccines.

Projects

Project
Ongoing
5 Members

TRANSLOCK-ER – Sec61 inhibitors for Oncology

Caroline Demangel (PI)

Multiple Myeloma (MM) is an incurable malignancy characterized by the uncontrolled expansion of plasma cells in the bone marrow. While proteasome inhibitors like bortezomib efficiently halt MM progression drug resistance inevitably develop, and novel […]
Project
Ongoing
2 Members

BAXERNA – Next generation Bacterial mRNA vaccines

Caroline Demangel (PI)

BAXERNA (www.baxerna.eu) is an EU-funded project that will develop next-generation mRNA vaccines against devastating bacterial infections like tuberculosis. The project consortium is led by researchers from VIB and UGent and includes multiple prominent European […]
Project
Ongoing
3 Members

ERC-Syg-2023 DRIMMS

Caroline Demangel (PI)

Lipid droplets as innate immunity hubs Successful defence against invaders is critical for survival of eukaryotic cells. Microbes have developed many strategies to subvert host organisms which, in turn, evolved several innate immune responses […]
Project
Ongoing
9 Members

Deci VERNEUIL – Etiology of Hidradenitis Suppurativa

Caroline Demangel (PI)

Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
Project
Ongoing
8 Members

BURULI Path: the subversive role of mycolactone

Caroline Demangel (PI)

Mycobacterium ulcerans causes Buruli ulcer, a neglected tropical skin disease manifesting as chronic wounds that can leave victims with major, life-long deformity and disability. Differently from other mycobacteria, including the related M. tuberculosis and […]

Transversal Project

Drug Discovery & Screening at Institut Pasteur

The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]

Cancer Initiative

With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]

Emerging Infectious Diseases

Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]

Antimicrobial resistance

Antimicrobial resistance is dramatically increasing worldwide and is becoming one of the most urgent public health threats. There is an urgent need for actions to reverse the curve of antimicrobial resistance dissemination and to […]

The institut Carnot Pasteur MS

Carnot, label of excellence Founded in 2006, the Carnot Label, granted by the French government, was designed to develop partnership-based research, meaning research conducted by public laboratories in partnership with socio-economic players, primarily industry […]

LabEx Milieu Intérieur

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]

Fundings

Publications

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Contact

Administrative assistant: Marie-Luce Kop Phone: +33 (0)1 40 61 33 96 Email: marie-luce.kop@pasteur.fr 25-28 Rue du Docteur Roux 75015, Paris France