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About

Web4Web3Web1

The aim of our research group is to decipher the rich and promising interface between membrane trafficking, lipid domain remodelling, cytoskeleton polarization and cell division in eukaryotic cells.

Cell division and thus cell proliferation ultimately relies on cytokinesis, which leads to the physical separation of the two daughter cells at the end of mitosis. Defects in properly orienting the mitotic spindle and the cytokinesis plane, as well as failure in completing cytokinesis have been shown to promote tumorigenesis in vivo. In the past, we and others demonstrated through RNAi-based screens that membrane traffic is essential for the late steps of cytokinesis. This was at the time a surprise, since these two fields were considered as independent areas of cell biology. Using live-cell imaging and advanced fluorescent microscopy, microfabrication techniques, genome-editing, high-content RNAi-based screens, analysis in human cells from patients and in mice in vivo, our lab is interested in the role of membrane trafficking in lipid and cytoskeleton remodeling at each step of animal cell division. Our current work thus addresses how membrane traffic polarizes cell lipids and associated cytoskeletons to control cytokinesis and successful cell division in normal and pathological situations. We predict that our results are likely to be relevant beyond the fields of cell division and cancer, such as in cell migration or phagocytosis of pathogens. citron2.smallBIS

Former Members

2000
2000
Name
Position
2003
2007
Ilektra Kouranti
PhD Student
2007
2011
Laurent Chesneau
Post-doc
2007
2077
Daphné Dambournet
PhD Student
2009
2013
Mickael Machicoane
PhD Student
2010
2018
Murielle Rocancourt
Technician
2010
2011
Pierre Larraufie
Undergraduate Student
2010
2013
Elizabeth Crowell
Post-doc
2012
2015
Clothilde Cauvin
PhD Student
2012
2016
Kerstin Klinkert
PhD Student
2013
2014
Anne-Lise Gaffuri
Post-doc
2014
2017
Alexandra Kumichel
Post-doc
2015
2016
Clément Boyer
Undergraduate Student
2015
2019
Jian Bai
PhD Student
2016
2017
Quentin Verdon
Post-doc
2016
2019
Cyril Addi
PhD Student
2016
2020
Adrien Presle
PhD Student
2017
2018
Maxime Cailleaux
Technician
2018
2019
Andrea Avila Avila
Undergraduate Student
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Projects

Transversal Project

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Contact

Membrane Traffic and Cell Division Lab Institut Pasteur 25-28 rue du Docteur Roux 75015 PARIS FRANCE

phone: 01 44 38 9409 (A. Echard) phone: 01 45 68 8403 (secretary) fax: 01 45 68 8954