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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.
Publication : Current opinion in cell biology

Intermediate filaments against actomyosin: the david and goliath of cell migration.

Team: Cell Polarity, Migration And Cancer
Member: Sandrine Etienne-Manneville
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in cell biology - 02 Jul 2020

van Bodegraven EJ, Etienne-Manneville S,

Link to Pubmed [PMID] – 32623234

Link to DOI – S0955-0674(20)30069-710.1016/j.ceb.2020.05.006

Curr. Opin. Cell Biol. 2020 Jul; 66(): 79-88

Intermediate filaments (IFs), together with actin and microtubules, constitute the cytoskeleton and regulate essential biological processes including cell migration. Despite the well-described changes in the composition of IFs in migrating cells, the mechanism by which these changes may contribute to cell migration remains elusive. Recent studies show that IFs control cell migration by impacting the actomyosin machinery. This review discusses how the unique physical properties of IFs, the interplay between IFs and the actomyosin network, and the connection of IFs with cell adhesive structures participate in cell migration. We highlight the biochemical and mechanical mechanisms by which IFs control actomyosin-generated forces to influence migration speed and contribute to nuclear integrity and cell resilience to compressive forces in 2D, as well as in confined 3D migration.