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© Jacob SEELER & Anne DEJEAN, Institut Pasteur
Immunostaining of PML nuclear bodies involved in acute promyelocytic leukemia

About

Our laboratory is interested in studying the epigenetic and cellular mechanisms underlying normal and pathological cell fate decisions with a particular emphasis on early embryo development and cancer.

How the identity of mature cells is maintained in multicellular organisms and how it is subverted in disease, particularly in cancer, are essential questions in biology and medicine. Cellular identity is dictated by transcriptional programs mediated by specific chromatin configurations, yet the mechanisms by which lineage choice decisions are choreographed to generate the adult organism or are corrupted in tumors remain poorly understood. Notably, the role of post-translational modifications of proteins by other proteins in this process is still enigmatic. We have shown recently that modification of chromatin proteins by the small SUMO protein acts as a general mechanism that safeguards cell identity. Lowering the SUMO epigenetic barriers facilitates cell fate change and is able to generate embryo-like structures from embryonic stem cells in a dish.

We are investigating the importance of SUMO modification in chromatin biology and gene expression and understanding how this modification regulates the establishment of the specific gene expression programs underlying cellular plasticity. We are using approaches including single cell -omics, chromatin biology, genome editing, protein biochemistry, live imaging as well as synthetic embryoid and organoid model systems. Beyond extending the mechanistic understanding of cellular diversification, we are probing the highly druggable SUMO pathway in the generation of faithful in vitro models of mammalian embryos and in malignancy reversion. In another approach, we are developing an integrated genome-wide profiling approach to dissect the molecular bases of hepatocellular carcinoma development in adolescents and young adults. Our research should bring new contributions in the mechanistic understanding of cellular diversity in normal and injured states, with a view toward therapeutic strategies seeking to manipulate sumoylation in regenerative medicine and cancer treatment.

Former Members

2000
2000
Name
Position
2015
2019
Ilan Theurillat
PhD Student
2017
2019
Luis Ignacio Lopez Ferreira
Post-doc
2015
2019
Juan Pablo Cerapio Arroyo
PhD Student
2003
2019
Oliver Bischof
Permanent Researcher
2015
2019
Ying Cao
Post-doc
2008
2014
Helene Neyret Khan
2011
2014
Pierre Lapaquette
2015
2020
Adrien Decque
Non-permanent Researcher
2015
2020
Umut Sahin
2015
2020
Maud Demarque
Post-doc
2009
2012
Sabrina Fritah
2015
2020
Moussa Benhamed
2005
2009
Müge Ogrunc
Non-permanent Researcher
2015
2020
Nadine Martin
Non-permanent Researcher
1998
2004
Olivier Kirsh
Permanent Researcher
2015
2020
Andreas Werner
Project Manager
2015
2020
Klaus Schwamborn
Permanent Researcher
2015
2020
Catherine Lavau
Permanent Researcher
2015
2020
Joop Jansen
Permanent Researcher
2015
2020
Grégory David
Permanent Researcher
2015
2020
Stefan Müller
Permanent Researcher
2015
2020
François Lehembre
Permanent Researcher
2015
2020
Karim Nacerddine
Project Manager
2015
2020
Pavan-kumar Puvvula
Permanent Researcher
2015
2020
Dieter Pullirsch
Permanent Researcher
2015
2020
Yoon Ra Her
Post-doc
2015
2020
Thibaut Snollaerts
Post-doc
2015
2020
Eleftheria (Elma) Chalatsi
PhD Student
2015
2020
Pablo Garcia Gutierrez
Post-doc
2019
2019
Coraline Méheux
Administrative Staff
Show all

Projects

Transversal Project

Fundings

  • The Sjoberg Foundation

Publications

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Contact

Phone: 01 45 68 88 23 Email: anne.dejean@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France