Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Jacob SEELER & Anne DEJEAN, Institut Pasteur
Immunostaining of PML nuclear bodies involved in acute promyelocytic leukemia

About

Cancer is a disease of gene expression that leads to the progressive transformation of normal cells into malignant and metastatic tumor cells. Aberrant gene expression can result from genetic alterations activating oncogenes or inactivating tumor suppressor genes. In addition to the instructions contained in the DNA, a second level of information, the so-called epigenetic information, has recently emerged as another potent mechanism regulating gene expression that do not involve changes in the genotype. Recent studies provide compelling evidence that incorrect establishment and/or mis-interpretation of this epigenetic information, including DNA methylation, chromatin modifications and noncoding RNA expression,  can also play an important role in cancer, thus informing novel approaches for chromatin therapies aimed at restoring a normal transcriptional program.

Our laboratory is interested in studying the cellular and molecular mechanisms underlying normal and pathological cell fates with a particular emphasis on cancer and tissue regeneration. We are investigating the importance of the post-translational modification by the small SUMO protein in chromatin biology and gene expression in response to stress, and understanding how this modification regulates, at the chromatin level, the establishment of the specific gene expression programs underlying cell identity. Notably, we are identifying the proteins modified by SUMO and exploring the functional dynamics of sumoylation during cell fate changes, such as reperogramming to stem cells, trandifferentiation and differentiation in early embryogenesis. We are also developping an integrated genome-wide profiling approach to dissect the molecular bases of hepatocellular carcinoma development in adolescents and young adults. Ultimately, we hope that our research will bring new contributions in understanding the mechanisms that underlie normal and pathological cell plasticity, with a view toward therapeutic strategies seeking to manipulate sumoylation levels in regenerative medicine and cancer treatment.

Former Members

2000
2000
Name
Position
2015
2020
Pierre Lapaquette
2015
2020
Helene Neyret Khan
2015
2020
Adrien Decque
Non-permanent Researcher
2015
2020
Omar Vivar
2015
2020
Umut Sahin
2015
2020
Maud Demarque
Post-doc
2015
2020
Sabrina Fritah
2015
2020
Moussa Benhamed
2015
2020
Müge Ogrunc
Non-permanent Researcher
2015
2020
Nadine Martin
Non-permanent Researcher
2015
2020
Olivier Kirsh
Permanent Researcher
2015
2020
Andreas Werner
Project Manager
2015
2020
Klaus Schwamborn
Permanent Researcher
2015
2020
Catherine Lavau
Permanent Researcher
2015
2020
Joop Jansen
Permanent Researcher
2015
2020
Grégory David
Permanent Researcher
2015
2020
Stefan Müller
Permanent Researcher
2015
2020
François Lehembre
Permanent Researcher
2015
2020
Karim Nacerddine
Project Manager
2015
2020
Pavan-kumar Puvvula
Permanent Researcher
2015
2020
Dieter Pullirsch
Permanent Researcher
2015
2020
Sophie Guinoiseau
Research Engineer
2015
2020
Yoon Ra Her
Post-doc
2015
2020
Louise Marie Da
Administrative Staff
2015
2020
Ricardo Iván Martínez-Zamudio
Post-doc
2015
2020
Thibaut Snollaerts
Post-doc
2015
2020
Florence Geay
Administrative Staff
2015
2020
Eleftheria (Elma) Chalatsi
PhD Student
2015
2020
Pablo Garcia Gutierrez
Post-doc
2015
2020
Ying Cao
Post-doc
2015
2020
Pierre-François Roux
Post-doc
2015
2020
Juan Pablo Cerapio Arroyo
PhD Student
Show all

Jobs

Projects

Transversal Project

Fundings

Publications

Download

Contact

Phone: 01 45 68 88 23 Email: anne.dejean@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France