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© Deriano Lab / Institut Pasteur
Chromosomes métaphasiques d’une cellule lymphoïde cancéreuse présentant une amplification des gènes Igh et c-myc

About

CANCER FROM WITHIN: immune cells reveal insights into mechanisms of DNA recombination and tumorigenesis. Lymphocytes are unique cell types of our adaptive immune system that require multiple rounds of cell divisions during their development and, most strikingly, multiple rounds of gene rearrangements during the formation of their antigen receptors. Our research major goal is to understand the mechanisms by which a lymphoid cell maintains the integrity of its DNA and prevents genomic instability and transformation. We study the DNA recombination processes – V(D)J recombination and class switch recombination – that are part of B- and T-cell development and the general DNA double-strand break response and repair mechanisms and pathways that lead to genetic instability and cancer.

Former Members

2000
2000
Name
Position
2015
2019
Tiama El Chaar
Postdoctoral Fellow
2015
2019
Christophe Clouin
Postdoctoral Fellow
2015
2019
Nicole Clarke
PhD Student
2015
2019
Valentine Murigneux
Research Engineer - Bioinformatics - Computational biology
2015
2019
Joy Bianchi
PhD Student
2015
2018
helene Lenden-Hasse
Research Engineer
2015
2020
Wei Yu
Postdoctoral Fellow
2017
2020
Wenming Wei
PhD Student

Projects

Transversal Project

Fundings

Publications

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Pictures & Media

 

DERIANO lab June 2021 – from left to right : Timea Marton, Ludovic Deriano, Danièle Sinnaya, Chloé Lescale, Estelle Vincendeau, Billie Libri, Tristan Estie–Caullet, Eva Guerin, François Dossin, (Marie Bedora-Faure, not on the picture).

238A6135

DERIANO lab July 2016 – from left to right : Jean Eudes Fahrner, Marie Bedora-Faure, Chloé Lescale, Valentine Murigneux, Wei Yu, Ludovic Deriano, Joy Bianchi, Léa Bacoccina, Hélène Lenden-Hasse, (Danièle Sinnaya – not on the picture).

Contact

Phone: +33 (0)1 44 38 93 55 Email: ludovic.deriano@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France