CANCER FROM WITHIN: immune cells reveal insights into mechanisms of DNA recombination and tumorigenesis. Lymphocytes are unique cell types of our adaptive immune system that require multiple rounds of cell divisions during their development and, most strikingly, multiple rounds of gene rearrangements during the formation of their antigen receptors. Our research major goal is to understand the mechanisms by which a lymphoid cell maintains the integrity of its DNA and prevents genomic instability and transformation. We study the DNA recombination processes – V(D)J recombination and class switch recombination – that are part of B- and T-cell development and the general DNA double-strand break response and repair mechanisms and pathways that lead to genetic instability and cancer.
Study of DNA double-strand break repair regulation in B cells – implication for cancer therapy
Cancer cells frequently harbor somatic mutations leading to altered DNA repair pathways. In some cases, these defects can be therapeutically exploited as these tumor cells, but not healthy cells, rely on compensatory DNA repair […]
Mechanisms and consequences of chromosomal translocations
Chromosomal translocations can promote cancer development by disrupting tumor suppressors, activating oncogenes, or generating aberrant fusion proteins. Fusion genes are frequent in cancers and are used as diagnostic and prognostic tools to classify and […]
Think tank: Cancer
The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers
FROM PHYSIOLOGICAL DNA REARRANGEMENTS TO LYMPHOID CANCERS
B and T cell lymphoid cancers are among the most common human malignancies. Many factors, endogenous and exogenous, are implicated in the etiology of these disorders, but key oncogenic lesions often arise through […]
MECHANISMS OF DNA RECOMBINATION
DNA double-strand breaks (DSBs), although common, are extremely dangerous (Deriano and Roth, Annual Review of Genetics, 2013). Unlike most other DNA lesions, DSBs directly threaten genomic integrity by disrupting the physical continuity of […]
With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]
2022The Sec61 translocon is a therapeutic vulnerability in multiple myeloma., EMBO Mol Med 2022 Jan; (): e14740.
2022The (Lack of) DNA Double-Strand Break Repair Pathway Choice During V(D)J Recombination, Frontiers in Genetics.
2021Xist nucleates local protein gradients to propagate silencing across the X chromosome., Cell 2021 Dec; 184(25): 6174-6192.e32.
2021SPEN is required for Xist upregulation during initiation of X chromosome inactivation., Nat Commun 2021 Dec; 12(1): 7000.
2021Fam72a enforces error-prone DNA repair during antibody diversification, Nature . 2021 Dec;600(7888):329-333. .
2021MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair., Nat Commun 2021 09; 12(1): 5421.
2021m6A RNA methylation regulates the fate of endogenous retroviruses., Nature 2021 03; 591(7849): 312-316.
2020Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ., Nat Commun 2020 10; 11(1): 5239.
2020SPEN integrates transcriptional and epigenetic control of X-inactivation., Nature 2020 02; 578(7795): 455-460.
2019Breakage-fusion-bridge events trigger complex genome rearrangements and amplifications in developmentally arrested T cell lymphomas, Cell Rep. 2019 Jun 4;27(10):2847-2858.e4. .
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Pictures & Media
DERIANO lab June 2021 – from left to right : Timea Marton, Ludovic Deriano, Danièle Sinnaya, Chloé Lescale, Estelle Vincendeau, Billie Libri, Tristan Estie–Caullet, Eva Guerin, François Dossin, (Marie Bedora-Faure, not on the picture).
DERIANO lab July 2016 – from left to right : Jean Eudes Fahrner, Marie Bedora-Faure, Chloé Lescale, Valentine Murigneux, Wei Yu, Ludovic Deriano, Joy Bianchi, Léa Bacoccina, Hélène Lenden-Hasse, (Danièle Sinnaya – not on the picture).
Phone: +33 (0)1 44 38 93 55 Email: firstname.lastname@example.org Address 25-28 Rue du Docteur Roux 75015, Paris France