Mechanisms and consequences of chromosomal translocations
Chromosomal translocations can promote cancer development by disrupting tumor suppressors, activating oncogenes, or generating aberrant fusion proteins. Fusion genes are frequent in cancers and are used as diagnostic and prognostic tools to classify and […]
Think tank: Cancer
The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
Think tank: B cells
The B-cell Interest Group (BIG) is a think-tank of immunologists focusing their research activities on diverse aspects of B lymphocytes and their effector molecules, antibodies. It gathers experts from the Institut Pasteur, the INEM […]
Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers
FROM PHYSIOLOGICAL DNA REARRANGEMENTS TO LYMPHOID CANCERS
B and T cell lymphoid cancers are among the most common human malignancies. Many factors, endogenous and exogenous, are implicated in the etiology of these disorders, but key oncogenic lesions often arise through […]
MECHANISMS OF DNA RECOMBINATION
DNA double-strand breaks (DSBs), although common, are extremely dangerous (Deriano and Roth, Annual Review of Genetics, 2013). Unlike most other DNA lesions, DSBs directly threaten genomic integrity by disrupting the physical continuity of […]
2016The RAG Recombinase: Beyond Breaking, Mech Ageing Dev. 2016 Nov 15. pii: S0047-6374(16)30263-9. doi: 10.1016/j.mad.2016.11.003. [Epub ahead of print].
2016Synthetic lethality between PAXX and XLF in mammalian development, Genes Dev. 2016 Oct 1;30(19):2152-2157..
2016V(D)J Recombination: Orchestrating Diversity without Damage., Lescale C., and Deriano L., V(D)J Recombination: Orchestrating Diversity without Damage. In: Ralph A Bradshaw and Philip D Stahl (Editors-in-Chief), Encyclopedia of Cell Biology, Vol 3, Waltham, MA: Academic Press, 2016, pp. 550-566..
2016Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination, Cell Rep. 2016 Sep 13;16(11):2967-79. doi: 10.1016/j.celrep.2016.08.069. Epub 2016 Sep 2..
2016RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair, Nat Commun 2016;7:10529.
2014Listeria monocytogenes dampens the DNA damage response, PLoS Pathog. 2014 Oct;10(10):e1004470.
2014RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of ‘alternative NHEJ’, Nucleic Acids Res. 2014 Jun;42(10):6352-64.
2013Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage, Annu. Rev. Genet. 2013;47:433-55.
2013RAG2’s acidic hinge restricts repair-pathway choice and promotes genomic stability, Cell Rep 2013 Sep;4(5):870-8.
2013Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers, Cell Rep 2013 Feb;3(2):359-70.
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