Study of DNA double-strand break repair regulation in B cells – implication for cancer therapy
Cancer cells frequently harbor somatic mutations leading to altered DNA repair pathways. In some cases, these defects can be therapeutically exploited as these tumor cells, but not healthy cells, rely on compensatory DNA repair […]
Mechanisms and consequences of chromosomal translocations
Chromosomal translocations can promote cancer development by disrupting tumor suppressors, activating oncogenes, or generating aberrant fusion proteins. Fusion genes are frequent in cancers and are used as diagnostic and prognostic tools to classify and […]
Think tank: Cancer
The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers
FROM PHYSIOLOGICAL DNA REARRANGEMENTS TO LYMPHOID CANCERS
B and T cell lymphoid cancers are among the most common human malignancies. Many factors, endogenous and exogenous, are implicated in the etiology of these disorders, but key oncogenic lesions often arise through […]
MECHANISMS OF DNA RECOMBINATION
DNA double-strand breaks (DSBs), although common, are extremely dangerous (Deriano and Roth, Annual Review of Genetics, 2013). Unlike most other DNA lesions, DSBs directly threaten genomic integrity by disrupting the physical continuity of […]
2020Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ., Nat Commun 2020 10; 11(1): 5239.
2019Breakage-fusion-bridge events trigger complex genome rearrangements and amplifications in developmentally arrested T cell lymphomas, Cell Rep. 2019 Jun 4;27(10):2847-2858.e4. .
2019Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function, Cell Death Differ. 2019 Apr 17. .
2018The immune system profoundly restricts intratumor genetic heterogeneity, Sci Immunol. 2018 Nov 23;3(29). pii: eaat1435. doi: 10.1126/sciimmunol.aat1435..
2018Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells., Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18..
2018Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells, iScience. 2018 Jul 27;5:19-29. .
2017Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination, J. Immunol. Methods 2017 12;451:71-77.
2016The RAG Recombinase: Beyond Breaking, Mech Ageing Dev. 2016 Nov 15. pii: S0047-6374(16)30263-9. doi: 10.1016/j.mad.2016.11.003. [Epub ahead of print].
2016Synthetic lethality between PAXX and XLF in mammalian development, Genes Dev. 2016 Oct 1;30(19):2152-2157..
2016V(D)J Recombination: Orchestrating Diversity without Damage., Lescale C., and Deriano L., V(D)J Recombination: Orchestrating Diversity without Damage. In: Ralph A Bradshaw and Philip D Stahl (Editors-in-Chief), Encyclopedia of Cell Biology, Vol 3, Waltham, MA: Academic Press, 2016, pp. 550-566..
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