With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]
Study of DNA double-strand break repair regulation in B cells – implication for cancer therapy
Cancer cells frequently harbor somatic mutations leading to altered DNA repair pathways. In some cases, these defects can be therapeutically exploited as these tumor cells, but not healthy cells, rely on compensatory DNA repair […]
Mechanisms and consequences of chromosomal translocations
Chromosomal translocations can promote cancer development by disrupting tumor suppressors, activating oncogenes, or generating aberrant fusion proteins. Fusion genes are frequent in cancers and are used as diagnostic and prognostic tools to classify and […]
Think tank: Cancer
The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers
FROM PHYSIOLOGICAL DNA REARRANGEMENTS TO LYMPHOID CANCERS
B and T cell lymphoid cancers are among the most common human malignancies. Many factors, endogenous and exogenous, are implicated in the etiology of these disorders, but key oncogenic lesions often arise through […]
MECHANISMS OF DNA RECOMBINATION
DNA double-strand breaks (DSBs), although common, are extremely dangerous (Deriano and Roth, Annual Review of Genetics, 2013). Unlike most other DNA lesions, DSBs directly threaten genomic integrity by disrupting the physical continuity of […]
2022SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination., Nat Commun 2022 Jun; 13(1): 3707.
2022The Sec61 translocon is a therapeutic vulnerability in multiple myeloma., EMBO Mol Med 2022 03; 14(3): e14740.
2022The (Lack of) DNA Double-Strand Break Repair Pathway Choice During V(D)J Recombination, Frontiers in Genetics.
2021Fam72a enforces error-prone DNA repair during antibody diversification, Nature . 2021 Dec;600(7888):329-333. .
2021MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair., Nat Commun 2021 09; 12(1): 5421.
2020Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ., Nat Commun 2020 10; 11(1): 5239.
2019Breakage-fusion-bridge events trigger complex genome rearrangements and amplifications in developmentally arrested T cell lymphomas, Cell Rep. 2019 Jun 4;27(10):2847-2858.e4. .
2019Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function, Cell Death Differ. 2019 Apr 17. .
2018The immune system profoundly restricts intratumor genetic heterogeneity, Sci Immunol. 2018 Nov 23;3(29). pii: eaat1435. doi: 10.1126/sciimmunol.aat1435..
2018Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells., Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18..
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