© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Laboratory

Chemistry of Biomolecules

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Head

Laurence Mulard

CNRS Paris 5 UMR3523
Department of Structural Biology & Chemistry
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About

Members of the Unit “Chemistry of Biomolecules” contribute to multidisciplinary programs aimed at

  1. Validating biological targets of medical interest,
  2. Developing novel strategies towards chemically designed therapeutics, markers, diagnostic tools and vaccines,
  3. Investigating the role that some proteins, polysaccharides, and glycoconjugates play in disease progression and microbial pathogenesis in humans.

Major focus is on the development of efficient synthetic routes to novel oligosaccharides, glycopeptides, lipopeptides, peptides, and protein conjugates thereof. Two synthetic carbohydrate-based vaccine candidates developed in the unit are on their way to a phase one clinical trial. One of the two GMP batches has been obtained.

 

Projects

Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).

A synthetic carbohydrate-based conjugate vaccine ready for a clinical trial
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).

Protein conjugates for the diagnosis of Alzheimer’s disease

Development of specific imaging nanoprobes against intracerebral targets is a challenging field of research, particularly for the diagnosis of neurodegenerative diseases. Probes based on camelid single-domain antibody-fragments (VHHs or nanobodies) are promising tools due […]
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).

Clinical development of cancer vaccines

CyaA-based therapeutic cancer vaccinesBased on our discovery that a bacterial protein, the adenylate cyclase (CyaA), binds to dendritic cells (DCs), we have developed a highly efficient vector capable of targeting a wide range of […]
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).

CarbUniVax

At the forefront of the rising fields of Chemical and Synthetic Biology, CarbUniVax is a multidisciplinary project sitting at the frontier between Glycosciences and Vaccinology. A multidisciplinary strategy is proposed that challenges ambitious goals […]
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).

Synthesis of peptide and protein conjugates towards novel therapeutics and/or diagnostic tools

Synthetic peptides and conjugates thereof as potential antivirals (col. H. Lortat-Jacob (CEA, Grenoble), D. Bonnaffé (ICMMO, Orsay) A bi-substrate synthetic glycopeptide resulting from the covalent linkage between a CD4 peptide mimetic and a heparan […]
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).

Carbohydrates as targets of immunity: their synthesis, antibody recognition and use as key vaccine components

  Synthetic oligosaccharides to identify immunodominant epitopes of bacterial polysaccharide antigens and conjugates thereof as potential enteric vaccines: focus on Shigella (col. A. Phalipon, P. Sansonetti, H. Lafolly, M.L. Gougeon (IP), J. Westdijk, C. […]

Publications

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