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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).

About

Members of the Unit “Chemistry of Biomolecules” contribute to multidisciplinary programs aimed at

  1. Validating biological targets of medical interest,
  2. Developing novel strategies towards chemically designed therapeutics, markers, diagnostic tools and vaccines,
  3. Investigating the role that some proteins, polysaccharides, and glycoconjugates play in disease progression and microbial pathogenesis in humans.

Major focus is on the development of efficient synthetic routes to novel oligosaccharides, glycopeptides, lipopeptides, peptides, and protein conjugates thereof. Two synthetic carbohydrate-based vaccine candidates developed in the unit are being evaluated in phase 1 and phase 2 clinical trial, respectively.

 

Former Members

2000
2000
Name
Position
2016
2019
Barel Louis-Antoine
PhD Student
2012
2015
Le Guen Yann
PhD Student
2014
2017
Le Heiget Guillaume
PhD Student
2011
2014
Pfister Hélène
PhD Student
2020
2021
Hinry Laetitia
Research Engineer
2014
2016
Julie Paoletti
Research Engineer
2016
2020
Cornil Johan
Post-doc
2020
2021
Cornil Johan
Post-doc
2015
2016
Zhaoyu Hu
Post-doc
2014
2016
Ligeour Caroline
Post-doc
2018
2020
Pitirollo Olimpia
Post-doc
2012
2016
Vandersquille Matthias
Post-doc
Show all

Projects

Transversal Project

Publications

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Contact

Phone: + 33 (0) 1 40 61 38 20
Email: laurence.mulard@pasteur.fr

Address

Unité de Chimie des Biomolécules

Institut Pasteur
25-28 Rue du Docteur Roux
75015, Paris
France