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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).

About

Members of the Unit “Chemistry of Biomolecules” contribute to multidisciplinary programs aimed at

  1. Validating biological targets of medical interest,
  2. Developing novel strategies towards chemically designed therapeutics, markers, diagnostic tools and vaccines,
  3. Investigating the role that some proteins, polysaccharides, and glycoconjugates play in disease progression and microbial pathogenesis in humans.

Major focus is on the development of efficient synthetic routes to novel oligosaccharides, glycopeptides, lipopeptides, peptides, and protein conjugates thereof. Two synthetic carbohydrate-based vaccine candidates developed in the unit are on their way to a phase one clinical trial. One of the two GMP batches has been obtained.

Former Members

Projects

Project
Ongoing
5 Members

GlycoShig1

Laurence Mulard (PI)

Synthetic carbohydrate-based conjugates as Shigella vaccine components: design, synthesis, selection and process validation
Project
Completed
6 Members

A synthetic carbohydrate-based conjugate vaccine ready for a clinical trial

Laurence Mulard (PI)
Project
Ongoing
6 Members

Protein conjugates for the diagnosis of Alzheimer’s disease

Pierre Lafaye (PI)

Development of specific imaging nanoprobes against intracerebral targets is a challenging field of research, particularly for the diagnosis of neurodegenerative diseases. Probes based on camelid single-domain antibody-fragments (VHHs or nanobodies) are promising tools due […]
Project
Ongoing
3 Members

CarbUniVax

Laurence Mulard (PI)

At the forefront of the rising fields of Chemical and Synthetic Biology, CarbUniVax is a multidisciplinary project sitting at the frontier between Glycosciences and Vaccinology. A multidisciplinary strategy is proposed that challenges ambitious goals […]
Project
ongoing
1 Member

Synthesis of peptide and protein conjugates towards novel therapeutics and/or diagnostic tools

Laurence Mulard (PI)

Synthetic peptides and conjugates thereof as potential antivirals (col. H. Lortat-Jacob (CEA, Grenoble), D. Bonnaffé (ICMMO, Orsay) A bi-substrate synthetic glycopeptide resulting from the covalent linkage between a CD4 peptide mimetic and a heparan […]
Project
Ongoing
3 Members

Carbohydrates as targets of immunity: their synthesis, antibody recognition and use as key vaccine components

Laurence Mulard (PI)

  Synthetic oligosaccharides are designed and used to identify immunodominant epitopes of bacterial polysaccharide antigens. Conjugates of the most promising oligosaccharides are developed as potential  vaccines. Focus is on diarrheal diseases. Shigellosis – bacillary […]
Project
Ongoing
4 Members

Use of nanobodies for imaging plaques and tangles in Alzheimer’s disease

Pierre Lafaye (PI)

Homodimeric VHHs offer new perspectives for in vivo immunodiagnosis. Because of their small size of about 12-14 kDa, VHHs rapidly pass the renal filter, which has a cutoff of about 60 kDa, resulting in […]

Transversal Project

Vaccinology and Immunotherapy initiative

Vaccines have had a major positive impact on public health world-wide through disease prevention that can be measured in millions of lives saved. Despite the successes, we still face major challenges in vaccine and […]

Cancer Initiative

With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]

Emerging Infectious Diseases

Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]

Antimicrobial resistance

Antimicrobial resistance is dramatically increasing worldwide and is becoming one of the most urgent public health threats. There is an urgent need for actions to reverse the curve of antimicrobial resistance dissemination and to […]

Publications

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Contact

Phone: + 33 (0) 1 40 61 38 20
Email: laurence.mulard@pasteur.fr

Address

Unité de Chimie des Biomolécules

Institut Pasteur
25-28 Rue du Docteur Roux
75015, Paris
France