Members of the Unit “Chemistry of Biomolecules” contribute to multidisciplinary programs aimed at
- Validating biological targets of medical interest,
- Developing novel strategies towards chemically designed therapeutics, markers, diagnostic tools and vaccines,
- Investigating the role that some proteins, polysaccharides, and glycoconjugates play in disease progression and microbial pathogenesis in humans.
Major focus is on the development of efficient synthetic routes to novel oligosaccharides, glycopeptides, lipopeptides, peptides, and protein conjugates thereof. Two synthetic carbohydrate-based vaccine candidates developed in the unit are being evaluated in phase 1 and phase 2 clinical trial, respectively.