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About

The Innate Immunity Unit comprises 18 members (4 permanent scientists, 4 engineers/technicians, 5 postdoctoral fellows, 5 PhD students) with complementary interests and expertise in immunology, developmental biology, virology and animal models. Together with the Lymphocytes and Immunity Unit (Ana Cumano), Dynamics of Immune Response Unit (Philippe Bousso) and Genome Integrity, Immunity and Cancer Unit (Ludovic Deriano), we form the Inserm Unit 1223 (Pathophysiology of the Immune System) that pursues collaborative projects involving lymphocyte development, differentiation and functional dynamics in mouse and man.

Members

James Di Santo
Head of Structure
Head
Hélène Strick-Marchand
Group Leader
Christian Vosshenrich
Group Leader
Nicolas Serafini
Permanent Researcher
Jean-Marc Doisne
Research Engineer
Pedro Goncalves
Post-doc
Guillemette Masse-Ranson
Post-doc
Laura Surace
Post-doc
Dylan Cherrier
PhD Student
Marie Solenne
Research Engineer
Angèle Schiavo
Technician
Danièle Sinnaya
Administrative Staff
Angélique Jarade
PhD Student
Carys Croft
PhD Student
Magali Dupont
PhD Student
Toshiki Eri
Post-doc
Giulia Girelli-Zubani
Post-doc
Anna Thaller
PhD Student
Lucy DE GUILHEM DE LATAILLADE
Research Engineer

Former Members

2000
2000
Name
Position
2015
2019
Erwan Corcuff
Research Engineer
2015
2019
Georges Azar
Post-doc
2015
2019
Abdessalem Rekiki
2015
2019
Milena Hasan
Head of Structure
2015
2019
Wei Xu
Post-doc
2015
2019
Sylvie Darche
Research Engineer
2015
2019
Naoko Satoh-Takayama
Permanent Researcher
2015
2019
Jean-Jacques Mention
2015
2019
Thomas Verrier
PhD Student
2015
2019
Mathilde Dusséaux
Post-doc
2015
2019
Cécile Pham
Administrative Staff
2015
2019
Silvia Lopez Lastra
PhD Student
2015
2019
Ai Ing Lim
PhD Student
2015
2019
Yan Li
Post-doc
2015
2019
Armanda Casrouge
Research Engineer
2015
2019
Wenjuan Jiao
PhD Student
Show all

Courses

09:00
02
Dec 2018
Course

10th HKU-Pasteur Immunology Course: December 2-15, 2018

  ‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
Innate Immunity
Cytometry and Biomarkers (UTechS CB)
LabEx Milieu Intérieur
Hong Kong University-Pasteur Research Pole
Immunology
Center for Translational Science
James Di Santo
Milena Hasan
Darragh Duffy
Tineke Cantaert
2018-12-02 09:00:00 2018-12-15 18:00:00 Europe/Paris 10th HKU-Pasteur Immunology Course: December 2-15, 2018   ‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […] HKU-Pasteur Research Centre, Hong Kong

Projects

Project
Ongoing
5 Members

Modeling SARS-CoV-2 infection and immune responses in humanized mouse models

Hélène Strick-Marchand (PI)
Project
Ongoing
13 Members

Deciphering the causes of Hidradenitis Suppurativa

Caroline Demangel (PI)

Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
Project
Ongoing
7 Members

ERC-2015-AdG ILC_REACTIVITY

James Di Santo (PI)

Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]
Project
Ongoing
6 Members

Think tank: Mucosal Immunology

Gérard Eberl (PI)

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Project
Ongoing
8 Members

Mouse Model to Understand Innate Lymphoid Cell Biology

James Di Santo (PI)

Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]
Project
Ongoing
3 Members

Pathogen co-infection : HIV, TB, Malaria and HCV

James Di Santo (PI)

Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]
Project
Ongoing
5 Members

Host responses to microbial intestinal invasion, impact on microbial dissemination

Marc Lecuit (PI)

We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Project
ongoing
1 Member

A novel mouse model for conditional gene targeting

James Di Santo (PI)

Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]

Transversal Project

Vaccinology and Immunotherapy initiative

Vaccines have had a major positive impact on public health world-wide through disease prevention that can be measured in millions of lives saved. Despite the successes, we still face major challenges in vaccine and […]

Cancer Initiative

With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]

Emerging Infectious Diseases

Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]

INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations

IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]

The Healthy Human Global Project

Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]

LabEx Milieu Intérieur

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. https://www.youtube.com/watch?v=IXlKElDJMc8 The Milieu Intérieur Project While the […]

LabEx Revive – Regenerative biology & medicine

Rationale and Objectives of Revive Consortium Major advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. The […]

Fundings

Publications

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Contact

Phone: 014568209 Email: james.di-santo@pasteur.fr Address 25-28 Rue du Docteur Roux