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About

The Innate Immunity Unit comprises 16 members (4 permanent scientists, 4 engineers/technicians, 5 postdoctoral fellows, 3 PhD students) with complementary interests and expertise in immunology, developmental biology, virology and animal models.

Together with the Lymphopoiesis Unit (Ana Cumano) and Dynamics of Immune Response Unit (Philippe Bousso), we form the Inserm Unit 668 (Pathophysiology of the Immune System) that pursues collaborative projects involving lymphocyte development, differentiation and functional dynamics.

 

News
News

‘ILC-poiesis’: A new model of human ILC differentiation

19
Mar 2017
Innate Immunity
Center for Translational Science
Ai Ing Lim
Yan Li
Silvia Lopez Lastra
Armanda Casrouge
Nicolas Serafini
Laura Surace
Guillemette Masse-Ranson
Hélène Strick-Marchand
Lars Rogge
James Di Santo

Ai Ing’s paper on human ILC precursors was recently published in Cell.  Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation. Cell. 2017 Mar 9;168(6):1086-1100.e10. doi: 10.1016/j.cell.2017.02.021. Ai Ing Lim,1,2,3 Yan Li,1,2 […]

Projects

project
Ongoing
7 Members

ERC-2015-AdG ILC_REACTIVITY

James Di Santo (PI)

Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]
project
Ongoing
15 Members

Adult neurogenesis and brain plasticity

Pierre-Marie Lledo (PI)

The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]
project
Ongoing
6 Members

Think tank: Mucosal Immunology

Gérard Eberl (PI)

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
project
Ongoing
8 Members

Mouse Model to Understand Innate Lymphoid Cell Biology

James Di Santo (PI)

Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]
project
Ongoing
3 Members

Pathogen co-infection : HIV, TB, Malaria and HCV

James Di Santo (PI)

Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]
project
Ongoing
5 Members

Host responses to microbial intestinal invasion, impact on microbial dissemination

Marc Lecuit (PI)

We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
project
ongoing
1 Member

A novel mouse model for conditional gene targeting

James Di Santo (PI)

Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]

Transversal Project

Inception – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations

Inception Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues. Inception program uses Integrative Biology, Social Science […]

LabEx Milieu Intérieur

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]

LabEx Revive – Regenerative biology & medicine

  Rationale and Objectives of Revive Consortium Major advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. […]

Fundings

Publications