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  • department
  • center
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  • whocc
  • project
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  • tool
  • patent
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  • Assistant Professor
  • Associate Professor
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  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
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About

Bacterial protein toxins are remarkable protein nanodevices endowed with the capacity of inducing host specific unparalleled pathophysiological effects. Toxins offer a study subject of major interest for basic and medical research, as well as a critical topic for National security. Bacterial toxins under study in our laboratory include C. botulinum neurotoxins, that are among the most potent poisons in the world, while other toxins under study are associated with microbes responsible for highly frequent infectious diseases, such as C. difficileS. aureus and uropathogenic E. coli (UPEC). UPEC and S. aureus represent a raising concern in term of acquisition of extended profiles of antibiotic resistance.

Our main research axes are linked to the characterization of the mechanism of action of protein toxins at the molecular level, defining how these toxins are delivered by bacteria and their route in cells/tissues, the prediction of virulence potential of existing and emerging pathogens by studying the distribution of these toxins in bacterial genomes, as well as the study of host cell intrinsic reactions to proteome and cellular architecture alterations triggered by these toxins.

Our work will address health issues related to the impact of asymptomatic carriage in the gut of toxin-producing bacteria on the development of age-related diseases and identify infection susceptibility genes. Moreover, we are conducting applied researches aiming at developing harmonized neurotoxin detection methods within the frame of a European consortium and develop antitoxin countermeasures.

Former Members

2000
2000
Name
Position
2017
2020
Michel-Robert Popoff
Head of Structure
2017
2020
Georges Haustant
Technician
2019
2020
Mélanie Dos Santo
Engineer
2019
2021
Daniel Guerin
Technician
2019
2021
Yu Wu
Post Doctoral Fellow
2018
2021
Camille Morel
PhD student
2018
2022
Landry Tsoumtsa Meda
Post Doctoral Fellow
2019
2023
Elea Paillares
PhD student
2017
2023
Serena Petracchini
Post Doctoral Fellow

Projects

Transversal Project

Fundings

Publications

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Contact

Téléphone: 01 40 61 30 44 Email: emmanuel.lemichez@pasteur.fr Adresse: 25-28 Rue du Docteur Roux 75015, Paris France