We are looking for postdoc candidates to study addiction-like processes in rat models
Our lab Integrative Neurobiology of Cholinergic System investigates, through combined approaches from molecular and cellular biology to behavioral and cognitive neuroscience, the role of nicotinic acetylcholine receptors (nAChRs) in a set of neurobiological functions, […]
Role of human polymorphisms in nicotinic receptors in lung cancer and COPD
Lung diseases are also a major public health problem. Chronic obstructive pulmonary disease (COPD) will be the third cause of mortality worldwide in 2020 and lung cancer is the leading cause of cancer-related mortality […]
Role of the nicotinic receptor in Alzheimer’s disease pathology
There is experimental and biomedical evidence that the nicotinic acetylcholine receptor (nAChR) is implicated in Alzheimer’s Disease (AD) pathology. The only reasonably efficient FDA approved treatment for early stage AD, blockers of acetylcholine esterase […]
When Gut Bacteria Changes Brain Functions
We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
A Project of Integrative Neurobiology
Understanding mechanisms underlying normal complex behaviours and the abnormalities that accompany most neuropathologies is a primary challenge in fundamental and biomedical research. However, optimal use of the large body of genetic, molecular, electrophysiological, behavioural […]
Inception – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
Inception Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues. Inception program uses Integrative Biology, Social Science […]
2017GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons, Mol. Psychiatry 2017 Jul;.
2017Transcriptome of melanoma cells from two mouse models, Tyr:NRas(Q61K) and Tyr:Rack1-HA, Tyr:NRas(Q61K), Data Brief 2017 Oct;14:32-34.
2017RACK1 cooperates with NRAS(Q61K) to promote melanoma in vivo, Cell. Signal. 2017 Aug;36:255-266.
2017Nicotine reverses hypofrontality in animal models of addiction and schizophrenia, Nat. Med. 2017 Mar;23(3):347-354.
2016Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex, 2016 Dec 20;8(12):3430-3449. .
2016Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing., 2016 Dec 20;113(51):14823-14828..
2016Human polymorphisms in nicotinic receptors: a functional analysis in iPS-derived dopaminergic neurons, FASEB J. 2016 Nov;.
2016Cognitive Dysfunction, Affective States, and Vulnerability to Nicotine Addiction: A Multifactorial Perspective, Front Psychiatry 2016;7:160.
2016Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments, Psychopharmacology (Berl.) 2016 Jul;.
2016A role for β2* nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus, Neurobiol. Aging 2016 Jun;46:221-234.
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