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About

The central nervous system of vertebrates is a complex assembly of neurons and glial cells, set-up in specific locations and numbers, and generated throughout life from progenitor cells in a process called neurogenesis. We aim to gain insight into the mechanisms controlling neurogenesis, and in particular defining the neural progenitor (NP)/ neural stem cell (NSC) state in the vertebrate brain.

A precise control of NP maintenance and recruitment operates during development, but the maintenance of NSCs until adulthood is also crucial as adult neurogenesis can be involved in later adaptation, growth or repair events. We are using the model system zebrafish, with unprecedented advantages for manipulating gene function both during development and in adulthood, and where adult NSCs are abundant. We especially focus on Notch signaling, which controls the maintenance of NP pools in the embryo but that we also recently identified as a major component of the homeostasis of adult NSC pools through its positive regulation of NSC quiescence. Overall, we are combining large scale profiling approaches, genetic invalidations, lineage tracing and live imaging in the embryo and adult to identify the cellular hierarchies and the Notch-interacting cascades that control NP/NSC « stemness », proliferation and recruitment.

Members

Former Members

2000
2000
Name
Position
Valentina Cuccioli
Post-doc
Marie-Elise Schwartz
Research Engineer
Rosaria Esposito
Post-doc
Bastian Rochette
Graduate Student
Delphine Cussigh
Research Engineer
Luz Yvette Lopez Diaz
Research Engineer
Emmanuel Than-Trong
Post-doc
Sylvie Laganier
Administrative Staff
Marion Coolen
Permanent Researcher
Alessandro Alunni
Permanent Researcher
Laure Mancini
PhD Student
Nicolas Tcheng
M2 Student
Louis Degroux
Technicien
Nicolas Chanthapathet
Technicien
Udi Binshtok
Post-doc
Miriam Labusch
Post-doc
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Courses

Advances in Stem Cell Biology (ASCB)

This course is intended for research scientists and PhD students who already have laboratory experience and a good knowledge (equivalent to a Master level) in developmental and cell biology. It provides a wide scope […]

2024-06-24 08:30:00 2024-07-05 18:00:00 Europe/Paris Advances in Stem Cell Biology (ASCB) This course is intended for research scientists and PhD students who already have laboratory experience and a good knowledge (equivalent to a Master level) in developmental and cell biology. It provides a wide scope […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Projects

Transversal Project

Services

Zebrafish Projects Hub

The Zebrafish Projects Hub (Zorgl’hub) aims to provide Pasteur research groups with the possibility to conduct short term zebrafish trial projects, as a functional complement to existing projects using other models/cells or to obtain […]

Featured publications

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Contact

Phone: Email: Address 25-28 Rue du Docteur Roux 75015, Paris France