- We use biophysical experimental techniques such as crystallography and cryo-EM to visualize at the atomic level the structure of molecules essential to life, such as DNA polymerases involved in DNA Repair and Cancer and ion channels involved in electric nerve signalling (cell-cell communications).
- We complement them with molecular and normal modes dynamics, so as to go beyond the essentially static pictures given by these methods.
- We also try to better understand the electrostatics of macromolecules and their interaction with the solvent and ligands, in order to be able to predict their binding properties.
- Our main goal is to design structure-inspired drugs (pharmacology) and re-design active site(s) to make them accept other substrates (synthetic biology).
- More details can be found at http://lorentz.dynstr.pasteur.fr or at http://www.dynstr.pasteur.fr
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About
Members
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Group

DNA replication group

Ludovic Sauguet
Former Members
2000
2000
Name
Position
2015
2020
Zeineb Fourati-Kammoun
Post-doc
2015
2020
Frédéric Poitevin
Post-doc
2015
2020
Filippo Romoli
Post-doc
2015
2020
Danièle Sinnaya
Administrative Staff
2015
2020
Irina Volahasina Randrianjatovo-Gbalou
Post-doc
2015
2020
Pierre Raia
PhD Student
2015
2020
Thomas Ybert
Post-doc
2015
2020
Jérôme Loc’h
Post-doc
2015
2020
Haidai Hu
PhD Student
2015
2020
Victoire PRAT
Undergraduate Student
2017
2010
Dariusz Czernecki
PhD Student
2018
2021
Camille Samson
Post-doc