- We use biophysical experimental techniques such as crystallography and cryo-EM to visualize at the atomic level the structure of molecules essential to life, such as DNA polymerases involved in DNA Repair and Cancer and ion channels involved in electric nerve signalling (cell-cell communications).
- We complement them with molecular and normal modes dynamics, so as to go beyond the essentially static pictures given by these methods.
- We also try to better understand the electrostatics of macromolecules and their interaction with the solvent and ligands, in order to be able to predict their binding properties.
- Our main goal is to design structure-inspired drugs (pharmacology) and re-design active site(s) to make them accept other substrates (synthetic biology).
- More details can be found at http://lorentz.dynstr.pasteur.fr or at http://www.dynstr.pasteur.fr
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About
Members
Groups
Laboratory

Architecture and Dynamics of Biological Macromolecules

Marc Delarue
Former Members
2000
2000
Name
Position
2005
2006
Erik Lindahl
Post-doc
2005
2010
Félix Romain
Ingénieur
2005
2008
Jérémie Piton
PhD Student
2005
2008
Cyril Azuara
PhD Student
2008
2014
Jerome Gouge
PhD Student
2008
2012
Hugues Nury
Post-doc
2009
2010
Claudine Mayer
Prof. Paris Cité
2010
2010
Dennis Ptchelkine
Post-doc
2012
2016
Frederic Poitevin
PhD Student
2014
2018
Zaineb Fourati-Kammoun
Post-doc
2015
2020
Frédéric Poitevin
Post-doc
2015
2020
Filippo Romoli
Post-doc
2015
2020
Danièle Sinnaya
Administrative Staff
2015
2020
Irina Volahasina Randrianjatovo-Gbalou
Post-doc
2015
2020
Pierre Raia
PhD Student
2015
2020
Jérôme Loc’h
Post-doc
2015
2020
Haidai Hu
PhD Student
2015
2020
Victoire Prat
Undergraduate Student
2016
2020
Thomas Ybert
Post-doc
2018
2021
Dariusz Czernecki
PhD Student
2018
2022
Clement Madru
Post-doc
2018
2021
Camille Samson
Post-doc