Marc Delarue

We use biophysical experimental techniques such as crystallography and cryo-EM to visualize at the atomic level the structure of molecules essential to life, such as DNA polymerases involved in DNA Repair and Cancer and ion channels involved in electric nerve signalling (cell-cell communications).
We complement them with molecular and normal modes dynamics, so as to go beyond the essentially static pictures given by these methods.
We also try to better understand the electrostatics of macromolecules and their interaction with the solvent and ligands, in order to be able to predict their binding properties.
Our main goal is to design structure-inspired drugs (pharmacology) and re-design active site(s) to make them accept other substrates (synthetic biology).
More details can be found at http://lorentz.dynstr.pasteur.fr or at http://www.dynstr.pasteur.fr