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© Research
Publication : Cell reports

Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell reports - 26 May 2020

Tomasi RF, Sart S, Champetier T, Baroud CN,

Link to Pubmed [PMID] – 32460010

Link to DOI [DOI] – S2211-1247(20)30623-910.1016/j.celrep.2020.107670

Cell Rep 2020 May; 31(8): 107670

As three-dimensional cell culture formats gain in popularity, there emerges a need for tools that produce vast amounts of data on individual cells within the spheroids or organoids. Here, we present a microfluidic platform that provides access to such data by parallelizing the manipulation of individual spheroids within anchored droplets. Different conditions can be applied in a single device by triggering the merging of new droplets with the spheroid-containing drops. This allows cell-cell interactions to be initiated for building microtissues, studying stem cells’ self-organization, or observing antagonistic interactions. It also allows the spheroids’ physical or chemical environment to be modulated, as we show by applying a drug over a large range of concentrations in a single parallelized experiment. This convergence of microfluidics and image acquisition leads to a data-driven approach that allows the heterogeneity of 3D culture behavior to be addressed across the scales, bridging single-cell measurements with population measurements.

https://pubmed.ncbi.nlm.nih.gov/32460010