The research interests of the laboratory for Bioorganic Chemistry of Nucleic acids reside in the synthesis of activated building blocks of chemically modified nucleoside analogs for their use in selection experiments for the crafting of functional nucleic acids with enhanced activities. Particularly, we strive to generate modified aptamers to be used as tools for medical imaging applications and the detection of specific targets such as enzymes, peptides, cancer cells, and small molecules. In addition, we are developing catalytic nucleic acids for the detection of DNA lesions as well as for their use as synthetic tools in molecular biology.
About
Members
Projects
Transversal Project
Equipments
UV-VIS CARY 3500 COMPACT PELTIER • Agilent Technologies • UV-VIS CARY 3500 COMPACT PELTIER
Spectrophotometer for recording UV-melting curves for the determination of Tm values of DNA/RNA duplexes
NMR spectrometer • Bruker • Avance 400 MHZ
Equipped with an ATM-BBO probe and a BACS-60 auto sampler.
DNA synthesizer • K&A Laborgeräte • H-8 DNA synthesizer
The H-8 DNA synthesizer is a robust DNA synthesizer that allows for the parallel synthesis of up to 8 DNA, RNA, and modified nucleic acids. In addition, the synthesizer has a low consumption of […]
Akta HPLC • GE Healthcare • Akta Pure
Our HPLC system is dedicated to the purification of modified oligonucleotides and nucleoside triphosphates. The purifications are usually carried out by anion exchange chromatography (analytical column from GE Healthcare) and reversed-phase HPLC (analytical and […]
Fundings
Publications
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2022Evaluation of 3′-phosphate as a transient protecting group for controlled enzymatic synthesis of DNA and XNA oligonucleotides, Commun. Chem. 2022, 5, 68.
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2022Towards polymerase-mediated synthesis of artificial RNA–DNA metal base pairs, New J. Chem., 2022, 46, 4871-4876.
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2022A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, RSC Chem. Biol., 2022, 3, 85-95.
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2021Polymerase-mediated synthesis of artificial RNA-DNA metal base pairs, ChemRxiv 2021, 10.26434/chemrxiv-2021-2d0h6.
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2021A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, RSC Chemical Biology.
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2021A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, ChemRxiv 2021, 10.33774/chemrxiv-2021-5n9xv.
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2021Towards the enzymatic synthesis of phosphorothioate containing LNA oligonucleotides, Bioorg. Med. Chem. Lett. 48 (2021) 128242.
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2021A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes., Science 2021 04; 372(6541): 516-520.
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2021Enzymatic construction of metal-mediated nucleic acid base pairs, Metallomics, 2021, 13, mfab016.
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2021Recent progress in non-native nucleic acid modifications, Chem. Soc. Rev. 2021, 50, 5126–5164.
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Contact
Address 25-28 Rue du Docteur Roux 75015, Paris France