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© Research

About

The research interests of the laboratory for Bioorganic Chemistry of Nucleic acids reside in the synthesis of activated building blocks of chemically modified nucleoside analogs for their use in selection experiments for the crafting of functional nucleic acids with enhanced activities. Particularly, we strive to generate modified aptamers to be used as tools for medical imaging applications and the detection of specific targets such as enzymes, peptides, cancer cells, and small molecules. In addition, we are developing catalytic nucleic acids for the detection of DNA lesions as well as for their use as synthetic tools in molecular biology.

Projects

project
Ongoing
4 Members

Expansion of the genetic alphabet with metal base pairs

Marcel Hollenstein (PI)

Expanding the genetic code beyond the A-T/G-C Watson-Crick canonical base pairs and 20 amino acids of natural organisms is a long standing goal in synthetic biology. Reprogrammation of the genetic code can lead to […]
project
Ongoing
5 Members

Therapeutic tools based on nucleic acids

Marcel Hollenstein (PI)

An important research axis of the laboratory is to modify nucleic acids with chemical groups in order to improve their therapeutic usefulness. Particularly, modified aptamers (i.e. oligonucleotides capable of binding to targets with high […]
project
Ongoing
4 Members

Synthesis of chemically modified nucleoside triphosphates

Marcel Hollenstein (PI)

Functional nucleic acids (aptamers, DNAzymes, ribozymes, and aptazymes) are generated by in vitro Darwinian evolution methods (SELEX and related methods of in vitro selection). We are interested to expand the capacity of these functional […]

Equipments

NMR spectrometer • Bruker • Avance 400 MHZ

Equipped with an ATM-BBO probe and a BACS-60 auto sampler.

Mass spectrometer • Waters • Q-ToF micro

Equipped with an ElectroSpray ionisation probe and an Alliance HPLC system.

DNA synthesizer • K&A Laborgeräte • H-8 DNA synthesizer

The H-8 DNA synthesizer is a robust DNA synthesizer that allows for the parallel synthesis of up to 8 DNA, RNA, and modified nucleic acids. In addition, the synthesizer has a low consumption of […]

Akta HPLC • GE Healthcare • Akta Pure

Our HPLC system is dedicated to the purification of modified oligonucleotides and nucleoside triphosphates. The purifications are usually carried out by anion exchange chromatography (analytical column from GE Healthcare) and reversed-phase HPLC (analytical and […]

Bioanalyzer • Agilent • Bioanalyzer 2100

Our bioanalyzer is dedicated to the quantification of PCR products stemming from in vitro selection pools for aptamers and DNA enzymes (DNAzymes) using natural and modified nucleic acids. For more information, see www.agilent.com

Fundings

Publications

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Contact

25-28 Rue du Docteur Roux 75015,
Paris France

email: marcel.hollenstein@pasteur.fr

Phone: +33 (0)1 44 38 94 66