The research interests of the laboratory for Bioorganic Chemistry of Nucleic acids reside in the synthesis of activated building blocks of chemically modified nucleoside analogs for their use in selection experiments for the crafting of functional nucleic acids with enhanced activities. Particularly, we strive to generate modified aptamers to be used as tools for medical imaging applications and the detection of specific targets such as enzymes, peptides, cancer cells, and small molecules. In addition, we are developing catalytic nucleic acids for the detection of DNA lesions as well as for their use as synthetic tools in molecular biology.
Energir: Energy dependent iron import by Gram-negative bacteria
Gram-negative bacteria are delimited by an envelope composed of two membranes (the outer and the inner-membranes) separated by the periplasmic space. This envelope includes macromolecular machines that ensure and regulate exchanges between the bacterium […]
Field Test for Rabies Diagnostic (FiTeRaD)
The FiTeRaD (Field Tests for Rabies Diagnostic) project aims to develop and validate, in laboratory and in the field, the first point of care tests (POCT) for the rapid detection of the etiological agent […]
Expansion of the genetic alphabet with metal base pairs
Expanding the genetic code beyond the A-T/G-C Watson-Crick canonical base pairs and 20 amino acids of natural organisms is a long standing goal in synthetic biology. Reprogrammation of the genetic code can lead to […]
Therapeutic tools based on nucleic acids
An important research axis of the laboratory is to modify nucleic acids with chemical groups in order to improve their therapeutic usefulness. Particularly, modified aptamers (i.e. oligonucleotides capable of binding to targets with high […]
Synthesis of chemically modified nucleoside triphosphates
Functional nucleic acids (aptamers, DNAzymes, ribozymes, and aptazymes) are generated by in vitro Darwinian evolution methods (SELEX and related methods of in vitro selection). We are interested to expand the capacity of these functional […]
Drug Discovery & Screening at Institut Pasteur
The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]
With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]
Spectrophotometer for recording UV-melting curves for the determination of Tm values of DNA/RNA duplexes
Equipped with an ATM-BBO probe and a BACS-60 auto sampler.
The H-8 DNA synthesizer is a robust DNA synthesizer that allows for the parallel synthesis of up to 8 DNA, RNA, and modified nucleic acids. In addition, the synthesizer has a low consumption of […]
Our HPLC system is dedicated to the purification of modified oligonucleotides and nucleoside triphosphates. The purifications are usually carried out by anion exchange chromatography (analytical column from GE Healthcare) and reversed-phase HPLC (analytical and […]
2022Ferrocene as a potential electrochemical reporting surrogate of abasic sites in DNA, Org. Biomol. Chem., 2022, 20, 8125 - 8135.
2022Chemical Modifications for a Next Generation of Nucleic Acid Aptamers, ChemBioChem 2022, 23, e202200006.
2022Benzoyl and pivaloyl as efficient protecting groups for controlled enzymatic synthesis of DNA and XNA oligonucleotides, Asian J. Org. Chem. 2022, e202200384.
2022Evaluation of 3′-phosphate as a transient protecting group for controlled enzymatic synthesis of DNA and XNA oligonucleotides, Commun. Chem. 2022, 5, 68.
2022Unbiased C3-Electrophilic Indoles: Triflic Acid Mediated C3-Regioselective Hydroarylation of N-H Indoles, Angew. Chem. Int. Ed. 2022, 61, e2022044.
2022Enantioselective Au(I)-Catalyzed Multicomponent Annulation via Tethered Counterion-Directed Catalysis, ACS Catal. 2022, 12, 4046 - 4053.
2022Synthesis, antiviral and antitumor activities investigations of a series of Ribavirin C-nucleoside analogue prodrugs, Bioorg. Chem. 2022, 122, 105723.
2022Towards polymerase-mediated synthesis of artificial RNA–DNA metal base pairs, New J. Chem., 2022, 46, 4871-4876.
2022Biochemical and XAS investigation of TsrM, a B12-dependent Radical SAM Enzyme Catalyzing Non-radical reaction, Chem. Eur. J. 2022, 28, e2022006.
2022A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, RSC Chem. Biol., 2022, 3, 85-95.
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