Bioorganic chemistry of nucleic acids

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program_project
nrc
whocc
project
software
tool
patent

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Administrative Staff
Assistant Professor
Associate Professor
Clinical Research Assistant
Full Professor
Graduate Student
Lab assistant
Non-permanent Researcher
Permanent Researcher
Pharmacist
PhD Student
Physician
Post-doc
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

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Deputy Director of Center
Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

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Group : Salah Mecheri

Chromatin and Infection

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About

The research interests of the laboratory for Bioorganic Chemistry of Nucleic acids reside in the synthesis of activated building blocks of chemically modified nucleoside analogs for their use in selection experiments for the crafting of functional nucleic acids with enhanced activities. Particularly, we strive to generate modified aptamers to be used as tools for medical imaging applications and the detection of specific targets such as enzymes, peptides, cancer cells, and small molecules. In addition, we are developing catalytic nucleic acids for the detection of DNA lesions as well as for their use as synthetic tools in molecular biology.

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Undergraduate Student

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Jobs

Post-doc

Postdoctoral position in aptamer-labeling methods of macromolecular assemblies

Aptamer-labeling as a strategy to determine the structure of macromolecular assemblies A postdoc position for a talented postdoctoral researcher is available in the Structural Bioinformatics and Bioorganic Chemistry of Nucleic Acids units of the […]

Projects

project

Ongoing

4 Members

Expansion of the genetic alphabet with metal base pairs

Marcel Hollenstein (PI)

Expanding the genetic code beyond the A-T/G-C Watson-Crick canonical base pairs and 20 amino acids of natural organisms is a long standing goal in synthetic biology. Reprogrammation of the genetic code can lead to […]

project

Ongoing

5 Members

Therapeutic tools based on nucleic acids

Marcel Hollenstein (PI)

An important research axis of the laboratory is to modify nucleic acids with chemical groups in order to improve their therapeutic usefulness. Particularly, modified aptamers (i.e. oligonucleotides capable of binding to targets with high […]

project

Ongoing

4 Members

Synthesis of chemically modified nucleoside triphosphates

Marcel Hollenstein (PI)

Functional nucleic acids (aptamers, DNAzymes, ribozymes, and aptazymes) are generated by in vitro Darwinian evolution methods (SELEX and related methods of in vitro selection). We are interested to expand the capacity of these functional […]

Equipments

NMR spectrometer • Bruker • Avance 400 MHZ

Equipped with an ATM-BBO probe and a BACS-60 auto sampler.

Mass spectrometer • Waters • Q-ToF micro

Equipped with an ElectroSpray ionisation probe and an Alliance HPLC system.

DNA synthesizer • K&A Laborgeräte • H-8 DNA synthesizer

The H-8 DNA synthesizer is a robust DNA synthesizer that allows for the parallel synthesis of up to 8 DNA, RNA, and modified nucleic acids. In addition, the synthesizer has a low consumption of […]

Akta HPLC • GE Healthcare • Akta Pure

Our HPLC system is dedicated to the purification of modified oligonucleotides and nucleoside triphosphates. The purifications are usually carried out by anion exchange chromatography (analytical column from GE Healthcare) and reversed-phase HPLC (analytical and […]

Bioanalyzer • Agilent • Bioanalyzer 2100

Our bioanalyzer is dedicated to the quantification of PCR products stemming from in vitro selection pools for aptamers and DNA enzymes (DNAzymes) using natural and modified nucleic acids. For more information, see www.agilent.com