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  • PhD Student
  • Physician
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  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
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  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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About

The research interests of the laboratory for Bioorganic Chemistry of Nucleic acids reside in the synthesis of activated building blocks of chemically modified nucleoside analogs for their use in selection experiments for the crafting of functional nucleic acids with enhanced activities. Particularly, we strive to generate modified aptamers to be used as tools for medical imaging applications and the detection of specific targets such as enzymes, peptides, cancer cells, and small molecules. In addition, we are developing catalytic nucleic acids for the detection of DNA lesions as well as for their use as synthetic tools in molecular biology.

Former Members

Jobs

Post-doc

Postdoc position for chemoenzymatic synthesis of RNA oligonucleotides

Synthesis of long RNA sequences using a chemoenzymatic strategy   A postdoc position for a talented postdoctoral researcher is available in the Bioorganic Chemistry of Nucleic Acids unit of the Pasteur Institute, Paris, France. […]
Post-doc

Postdoc position for the synthesis of carbohydrate-siRNA therapeutic oligonucleotides

Design, synthesis and evaluation of carbohydrate-siRNA chimeras as novel therapeutic agents A postdoc position for a talented postdoctoral researcher is available in the Chemistry of Biomolecules and Bioorganic Chemistry of Nucleic Acids units at […]

Projects

Project
Ongoing
3 Members

Field Test for Rabies Diagnostic (FiTeRaD)

Laurent Dacheux (PI)

The FiTeRaD (Field Tests for Rabies Diagnostic) project aims to develop and validate, in laboratory and in the field, the first point of care tests (POCT) for the rapid detection of the etiological agent […]
Project
Ongoing
4 Members

Expansion of the genetic alphabet with metal base pairs

Marcel Hollenstein (PI)

Expanding the genetic code beyond the A-T/G-C Watson-Crick canonical base pairs and 20 amino acids of natural organisms is a long standing goal in synthetic biology. Reprogrammation of the genetic code can lead to […]
Project
Ongoing
5 Members

Therapeutic tools based on nucleic acids

Marcel Hollenstein (PI)

An important research axis of the laboratory is to modify nucleic acids with chemical groups in order to improve their therapeutic usefulness. Particularly, modified aptamers (i.e. oligonucleotides capable of binding to targets with high […]
Project
Ongoing
4 Members

Synthesis of chemically modified nucleoside triphosphates

Marcel Hollenstein (PI)

Functional nucleic acids (aptamers, DNAzymes, ribozymes, and aptazymes) are generated by in vitro Darwinian evolution methods (SELEX and related methods of in vitro selection). We are interested to expand the capacity of these functional […]

Equipments

UV-VIS CARY 3500 COMPACT PELTIER • Agilent Technologies • UV-VIS CARY 3500 COMPACT PELTIER

Spectrophotometer for recording UV-melting curves for the determination of Tm values of DNA/RNA duplexes

NMR spectrometer • Bruker • Avance 400 MHZ

Equipped with an ATM-BBO probe and a BACS-60 auto sampler.

DNA synthesizer • K&A Laborgeräte • H-8 DNA synthesizer

The H-8 DNA synthesizer is a robust DNA synthesizer that allows for the parallel synthesis of up to 8 DNA, RNA, and modified nucleic acids. In addition, the synthesizer has a low consumption of […]

Akta HPLC • GE Healthcare • Akta Pure

Our HPLC system is dedicated to the purification of modified oligonucleotides and nucleoside triphosphates. The purifications are usually carried out by anion exchange chromatography (analytical column from GE Healthcare) and reversed-phase HPLC (analytical and […]

Bioanalyzer • Agilent • Bioanalyzer 2100

Our bioanalyzer is dedicated to the quantification of PCR products stemming from in vitro selection pools for aptamers and DNA enzymes (DNAzymes) using natural and modified nucleic acids. For more information, see www.agilent.com

Fundings

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Contact

Address 25-28 Rue du Docteur Roux 75015, Paris France