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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
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Applications
Technique

About

We are a multi-disciplinary team working on the interface between physical sciences, engineering, mathematical modeling, and applications of these fields to biological sciences.

Microfluidics: In recent years we have developed a large set of microfluidic tools to culture and observe cells (bacteria, mammalian cells, protists, …) under well-controlled conditions of a confined microchannel. These tools are based on  easy to use droplet manipulations, coupled with some robust chemical and biological protocols. The engineering of these tools has been coupled with a strong physical modelling aspect that allows us to understand the limits and capacities of the droplet manipulation, while also pointing us to new innovations.

Biological focus: Our current work is more focused on using these tools to gain new understanding of biological processes, by addressing biological questions through quantitative measurements and  mathematical modelling, in a quantitative biology approach. This combination now allows us to obtain new types of information on the cells under normal or stressed conditions.

Example projects: We are applying this approach to bacterial cells, namely to understand the emergence of antibiotic resistance in small populations of cells. We are also studying three-dimensional cultures of mammalian cells, which are thought to represent in vivo conditions much better than traditional 2D cell culture. Here, we are questioning the link between distribution of mechanical forces within a 3D culture and the biological function of the individual cells.

Technology transfer: In addition to the fundamental scientific research that we perform, we are also interested in transfering our technologies to companies. This transfer allows the innovations that emerge from our lab to become useful to a large number of other researchers, in a way that cannot be achieved by academic groups. The technology transfer can take place either by the spinning-off of startup companies or by licensing agreements.

Group: Our group is made up of several bright scientists wishing to work across scientific boundaries. As part of our recent installation on the Pasteur campus, we are looking to recruit several brilliant post-docs wishing to work along areas combining physics and engineering with biology.

This web page is still in the process of being created. Visit us again soon for more information.

Former Members

Three former PhD students of the group won the Ecole Polytechnique thesis prize.

Three startup companies have been founded by ex-students and post-docs of the team.

Several group members have gotten faculty positions in France, the USA, and Chile.

2000
2000
Name
Position
2019
2022
Charles Paul Moore
PhD student
2018
2022
Gustave Ronteix
PhD student
2019
2022
Shreyansh Jain
Postdoc
2017
2020
Raphael Tomasi
Postdoc
2018
2020
Salome Guttierez Ramos
Postdoc
2017
2019
Antoine Barizien
PhD Student
2017
2019
Aude Durand
Research Engineer
2016
2019
Adrien Saint-Sardos
Postdoc
2020
2023
Lena Le Quellec
PhD Student

Transversal Project

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Contact

Phone: Email: Address 25-28 Rue du Docteur Roux 75015, Paris France