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About

Correlative FIB-SEM of intracellular bacteria

Our unit “Dynamics of host pathogen-interactions” develops novel approaches to investigate the interactions between pathogens and their hosts in single cells in real time.

In particular, we are interested in deciphering the molecular and cellular basis of how a number of bacterial pathogens, such as Shigella or Salmonella enter host cells during the infection process. To achieve this, we film these invasion events using innovative fluorescence microscopy. More specifically, we focus on the establishment of novel assays that allow us to monitor pathogen invasion; simultaneously tracking a large number of parameters involved in the invasion processes. In doing this we are able to correlate the pathogen behavior, its intracellular localization and the host responses it induces in single cells in real time. We are convinced that deciphering the molecular and cellular details of the invasion strategies used by the bacterial pathogens will identify novel drug targets and will provide new insight into fundamental cell biological processes.

We have obtained generous funding for our research by the following agencies and institutions during recent years and for the coming years: the Institut Pasteur, the Agence Nationale pour la Recherche (ANR), the European Union (ERC program and Marie Curie program), the Fondation Schlumberger pour l’Education et la Recherche, the Fundação para a Ciência e Tecnologia (FCT), the French Foreign Ministry and the Fondation pour la Recherche Medicale (FRM). We would like to thank them for their support.

Scanning EM of entring bacteria
Scanning EM of entring bacteria
Confocal analysis of Shigella invasion
Confocal analysis of Shigella invasion

Former Members

2000
2000
Name
Position
2015
2020
Célia Souque
Undergraduate Student
2015
2020
Jennifer Fredlund
Post-doc
2015
2020
Allon Weiner
Post-doc
2015
2020
José Vieira Dos Santos
Post-doc
2015
2020
Camille Rey
PhD Student
2015
2020
Jakub Voznica
PhD Student
2015
2020
Marion Bichet
Graduate Student
2015
2020
John Rohde
Visiting Scientist
2015
2020
Virginie Stevenin
Post-doc
2015
2020
Laura Barrio Cano
Post-doc
2015
2020
Noelia Lopez-Montero
Post-doc
2015
2020
John Bergqvist
Undergraduate Student
2015
2020
Arthur Bienvenu
Undergraduate Student
2016
2020
Yuen Yan Chang
Post-doc
2016
2020
Sonja Kühn
Post-doc
2016
2020
Chak Hon Luk
PhD student
2020
2021
Thomas Mazza
Undergraduate Student
2020
2021
Elise Paulin
Undergraduate Student
2020
2021
Arthur Lensen
Undergraduate Student
2016
2021
Magdalena Gil-Taran
Post-Doc
2022
2023
Margaux Bilay
Undergraduate Student
2019
2023
Lisa SANCHEZ
PhD student - Post-doc
2022
2023
Lola MARTINEZ
Undergraduate Student
2020
2023
Nora MELLOUK
Post-Doc
Show all

Courses

Microscopy – Principles and Applications of Fluorescence Microscopy

Fluorescence microscopy has revolutionized researchers’ ability to monitor cellular structures and dynamics. Over the last decades, the spectrum of applications of fluorescence microscopy has been constantly broadened by novel combinations of optics principles supported […]

2023-03-06 08:00:00 2023-03-17 19:00:00 Europe/Paris Microscopy – Principles and Applications of Fluorescence Microscopy Fluorescence microscopy has revolutionized researchers’ ability to monitor cellular structures and dynamics. Over the last decades, the spectrum of applications of fluorescence microscopy has been constantly broadened by novel combinations of optics principles supported […] 25-28 Rue du Dr Roux, 75015 Paris, France

Projects

Transversal Project

Fundings

Publications

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Pictures & Media

DIHP team in 2023

Contact

Phone: +33144389413 Jost Enninga Email: jost.enninga@pasteur.fr or Phone: +33145688446 Email: laurence.langlais@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France