The immune system comprises a collection of specialized cells and organs that fight infections and can survey cancer cells. Immune responses to pathogens and tumors are highly coordinated events that take place in complex and specialized tissue microenvironments. An integrated view of innate and adaptive immune responses to infections and cancer requires a better understanding of how immune cells communicate and fulfill their task in vivo. In addition, it is essential to unravel how pathogens and tumor microenvironment subvert their functions. Recent progresses in intravital two-photon imaging offer a novel perspective to address some of these critical issues in physiological settings. By further developping functional in vivo imaging, we aim at identifying critical aspects of T cell and NK cell activation and function during tumor growth, during infection by an intracellular parasite and during transplantation. Elucidating the fundamental mechanisms underlying the regulation of innate and adaptive immune responses in vivo will delineate basic principles to develop or improve immunotherapeutical strategies to treat cancer and infectious diseases.
ERC 2017-Advanced Grant ENLIGTHEN
To fight cancer or infections, a variety of immune cells are engaged in a tremendously complex, yet highly coordinated sequence of cellular processes. This coordination is enforced by distinct mechanisms of cellular communication allowing […]
The immune system is made up of specialized cells and tissues that act together to fight microbial infections and survey the body for malignant transformation. Immune responses are highly orchestrated and dynamic events that […]
Lymphocyte activation in lymphoid organs
Adaptive immune responses are initiated in secondary lymphoid organs through cellular interactions between antigen-specific T cells and antigen-presenting dendritic cells. One of the aim of our lab is to better understand how T cells […]
Immune responses during infections
Intracellular pathogens have developed strategies to survive in infected cells and reduce their recognition by the innate and adaptive immune systems. Our lab wishes to define the mechanisms influencing the recognition of infected cells […]
Immune responses following transplantation
Transplant rejection involves a coordinated attack of donor cells by the innate and the adaptive immune system of the host. To gain insight into this dynamic process, we have developed an ear skin graft […]
Immune responses against tumors
Cytotoxic T cells and NK cells (CTLs) are key players of anti-tumor immune responses. Despite our fundamental knowledge on the interplay between the immune system and tumor microenvironments, we have a poor understanding on […]
Dynamic In Situ Cytometry
The Dynamic In Situ Cytometry (DISC) is a new approach that combines advantages of both intravital imaging and flow cytometry analysis. With the help of the custom designed DISCit software, the DISC provides the opportunity […]
2020Optogenetic manipulation of calcium signals in single T cells in vivo, Nat Commun 2020 Mar;11(1):1143.
2019Tumor Immunosurveillance and Immunotherapies: A Fresh Look from Intravital Imaging, Trends Immunol. 2019 Nov;40(11):1022-1034.
2019Quorum Sensing by Monocyte-Derived Populations, Front Immunol 2019;10:2140.
2019Macropinocytosis Overcomes Directional Bias in Dendritic Cells Due to Hydraulic Resistance and Facilitates Space Exploration, Dev. Cell 2019 04;49(2):171-188.e5.
2019Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity, J. Exp. Med. 2019 May;216(5):1038-1049.
2018The immune system profoundly restricts intratumor genetic heterogeneity, Sci Immunol 2018 Nov;3(29).
2018A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses, Immunity 2018 Sep;.
2018A human immune system mouse model with robust lymph node development, Nat. Methods 2018 Aug;15(8):623-630.
2018Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division, J. Exp. Med. 2018 May;215(5):1481-1492.
2017CXCR3/CXCL10 Axis Shapes Tissue Distribution of Memory Phenotype CD8 T Cells in Nonimmunized Mice, J. Immunol. 2018 01;200(1):139-146.
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Phone: +33 1 40 61 35 12 Email: email@example.com Address: Institut Pasteur, Dynamics of Immune Responses Lab, 25 Rue du Docteur Roux 75015, Paris France How to come to the lab: We are based at the INSTITUT PASTEUR in PARIS, France. The nearest underground stations are “Pasteur” (Metro 6 & 12) and “Volontaires” (Metro 12). Our lab is located on the 4th floor of the Metchnikoff building (building n°67 on the map below), room n°4012.