The immune system comprises a collection of specialized cells and organs that fight infections and can survey cancer cells. Immune responses to pathogens and tumors are highly coordinated events that take place in complex and specialized tissue microenvironments. An integrated view of innate and adaptive immune responses to infections and cancer requires a better understanding of how immune cells communicate and fulfill their task in vivo. In addition, it is essential to unravel how pathogens and tumor microenvironment subvert their functions. Recent progresses in intravital two-photon imaging offer a novel perspective to address some of these critical issues in physiological settings. By further developping functional in vivo imaging, we aim at identifying critical aspects of T cell and NK cell activation and function during tumor growth, during infection by an intracellular parasite and during transplantation. Elucidating the fundamental mechanisms underlying the regulation of innate and adaptive immune responses in vivo will delineate basic principles to develop or improve immunotherapeutical strategies to treat cancer and infectious diseases.
ERC 2017-Advanced Grant ENLIGTHEN
To fight cancer or infections, a variety of immune cells are engaged in a tremendously complex, yet highly coordinated sequence of cellular processes. This coordination is enforced by distinct mechanisms of cellular communication allowing […]
The immune system is made up of specialized cells and tissues that act together to fight microbial infections and survey the body for malignant transformation. Immune responses are highly orchestrated and dynamic events that […]
Lymphocyte activation in lymphoid organs
Adaptive immune responses are initiated in secondary lymphoid organs through cellular interactions between antigen-specific T cells and antigen-presenting dendritic cells. One of the aim of our lab is to better understand how T cells […]
Immune responses during infections
Intracellular pathogens have developed strategies to survive in infected cells and reduce their recognition by the innate and adaptive immune systems. Our lab wishes to define the mechanisms influencing the recognition of infected cells […]
Immune responses following transplantation
Transplant rejection involves a coordinated attack of donor cells by the innate and the adaptive immune system of the host. To gain insight into this dynamic process, we have developed an ear skin graft […]
Immune responses against tumors
Cytotoxic T cells and NK cells (CTLs) are key players of anti-tumor immune responses. Despite our fundamental knowledge on the interplay between the immune system and tumor microenvironments, we have a poor understanding on […]
Dynamic In Situ Cytometry
The Dynamic In Situ Cytometry (DISC) is a new approach that combines advantages of both intravital imaging and flow cytometry analysis. With the help of the custom designed DISCit software, the DISC provides the opportunity […]
2018The immune system profoundly restricts intratumor genetic heterogeneity, Sci Immunol 2018 Nov;3(29).
2018A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses, Immunity 2018 Sep;.
2018A human immune system mouse model with robust lymph node development, Nat. Methods 2018 Aug;15(8):623-630.
2018Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division, J. Exp. Med. 2018 May;215(5):1481-1492.
2018CXCR3/CXCL10 Axis Shapes Tissue Distribution of Memory Phenotype CD8+ T Cells in Nonimmunized Mice, J. Immunol. 2018 Jan;200(1):139-146.
2017Microchannels for the Study of T Cell Immunological Synapses and Kinapses, Methods Mol. Biol. 2017;1584:347-354.
2017In Vivo Imaging of T Cell Immunological Synapses and Kinapses in Lymph Nodes, Methods Mol. Biol. 2017;1584:559-568.
2016Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies, Sci Rep 2016 10;6:34382.
2016The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation, Immunity 2016 Jan;44(1):143-154.
2015In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity, Nat. Med. 2016 Jan;22(1):64-71.
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Phone: +33 1 40 61 35 12
Dynamics of Immune Responses Lab,
25 Rue du Docteur Roux
How to come to the lab:
We are based at the INSTITUT PASTEUR in PARIS, France.
The nearest underground stations are “Pasteur” (Metro 6 & 12) and “Volontaires” (Metro 12).
Our lab is located on the 4th floor of the Metchnikoff building (building n°67 on the map below), room n°4012.