Structure Content

Recipient: Gerald Spaeth, coordinator Agency: Campus France, MEAE, Type: Bi-national program France/Israel, 04/2018 – 03/2020  Leishmaniasis is among the five most serious parasitic diseases worldwide. The cutaneous form of the disease is prevalent in […]

Désolé, cet article est seulement disponible en EN.

Le contrôle de l’émergence de la COVID-19 en Europe, y compris en France, a été obtenu en combinant une réduction initiale de la transmission par des politiques de confinement, de rigueur variable et, un […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Host-associated microbes, collectively known as the host microbiota, have manifold effects on host biology. Like other animals, insects establish various symbiotic associations with their microbial communities that shape their individual phenotype and fitness. In […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Methanogenic archaea are phylogenetically diverse, ancient and environmentally widespread. They are common inhabitants of the gastrointestinal tract of humans and other animals, and produce methane, a potent green-house gas, as a metabolic by-product. Despite […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Extracellular vesicles (EVs), produced by eukaryotes, bacteria and archaea are increasingly recognized as important mediators of intercellular communication via transfer of a wide variety of molecular cargoes. Recently EVs of several intracellular pathogens have […]

Early steps of infection We have observed that chlamydia invasion of a host cell triggers a transient ubiquitination at the entry sites. Deubiquitination follows very rapidly (20 min post infection). We have identified a […]

Mycobacterium ulcerans causes Buruli ulcer, a neglected tropical skin disease manifesting as chronic wounds that can leave victims with major, life-long deformity and disability. Differently from other mycobacteria, including the related M. tuberculosis and […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

The RepliChroms project aims at decrypting plasmid adaptation mechanisms in their bacterial host. Bacterial genomes are composed of two types of replicons: chromosomes and plasmids. Bacteria commonly have a unique circular chromosome, and current […]

Désolé, cet article est seulement disponible en EN.

Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

L’étude DEV-SHP vise à documenter la perception des vaccinations, de la prescription ou la recommandation des vaccins aux patients d’une part ; du climat de discussion de la vaccination entre pairs, patients ou proches d’autre […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Les bactéries à Gram négatif sont entourées d’une enveloppe composée de deux membranes (les membranes dites externe et interne) séparées par l’espace périplasmique. Cette enveloppe contient des machines macromoléculaires qui assurent et régulent les […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

  NEUTROPat est une demande d’utilisation à des fins scientifiques de données et d’échantillons de participants de la cohorte COSIPOP. Quel est l’objectif ? L’objectif de cette recherche est de caractériser l’interaction entre les […]

BPV est une demande d’utilisation à des fins scientifiques d’échantillons biologiques collectés chez des participants de la cohorte COSIPOP Quel est l’objectif de la demande ?  L’objectif est d’étudier l’effet de molécules déjà utilisées […]

Désolé, cet article est seulement disponible en EN.

Ce projet vise à évaluer la campagne de vaccination contre les infections à papillomavirus humains (HPV) menée en 2023–2024 et 2024-2025 dans les collèges franciliens. Il comporte quatre volets complémentaires : Ce projet, mené […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

  Herpesviruses envelop glycoproteins     Herpesviridae are a large family of double-stranded DNA viruses, counting more than 200 members that infect humans and a wide range of invertebrates and vertebrates. Herpesviruses carry a […]

Présentation du projet Pour parvenir à l’élimination mondiale du virus de l’hépatite B (VHB), il est impératif d’éliminer la transmission mère-enfant (TME) en assurant une bonne couverture vaccinale de la dose à la naissance […]

Désolé, cet article est seulement disponible en EN.

Rare infected individuals who initiated antiretroviral therapy (ART) very early during primary infection can enter in remission after its interruption, a phenomenon known as post-treatment control. Interestingly, early treatment has been associated with the […]

PHAGESAFETY est une recherche scientifique impliquant l’utilisation de données et d’échantillons collectés dans le cadre de la cohorte COSIPOP. Quel est l’objectif de PHAGESAFETY ? L’objectif est d’identifier des marqueurs sanguins permettant d’évaluer la […]

Study objective The objective of the study is to investigate the effect of CSF changes on nerve cells. Analysing the response of nerve cells to CSF from uninfected donors, asymptomatic donors or people with […]

Bacteria exchange and recombine DNA to accelerate their evolution and adapt to new stress. Their evolvability is illustrated by the rapid emergence of multi resistant bacteria after the introduction of antibiotics. The most powerful […]

Désolé, cet article est seulement disponible en EN.

   NASOBACT est une recherche scientifique menée grâce à l’utilisation de données et d’échantillons biologiques collectés dans le cadre de la cohorte COSIPOP. Quel est l’objectif de NASOBACT. L’objectif est de caractériser les modifications […]

VAX-Action : lutter efficacement contre la réticence à la vaccination en Europe est un large programme européen coordonné par Université NOVA de Lisbonne au Portugal. Le programme inclus 5 pays européens : Portugal, Italie, […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Le sepsis est un problème de santé important et serait responsable de millions de décès dans le monde selon l’OMS. En France, une récente étude montre qu’entre 2015 et 2019, l’incidence du sepsis bactérien […]

La triple élimination de la transmission mère-enfant (TME) du VIH, du virus de l’hépatite B (VHB) et de la syphilis constitue l’une des principales priorités de l’agenda mondial en santé. Ces infections continuent de […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

VICTOR est une demande d’utilisation d’échantillons collectés dans le cadre de la cohorte COSIPOP. Quel est l’objectif ? L’objectif de cette recherche est de mettre au point une méthode de culture in vitro de […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

La coqueluche est une maladie respiratoire causée par une bactérie (Bordetella Pertussis) qui peut, dans certains cas et notamment chez les nourrissons, être sévère voire mortelle (on parle alors de coqueluche maligne). L’objectif de […]

Désolé, cet article est seulement disponible en EN.

Quel est objectif de la recherche POPCORN ? L’étude longitudinale POPCORN a pour objectif de comprendre l’évolution des attitudes et des comportements à l’égard des mesures préventives en situation d’épidémie en France (hexagonale et […]

Contexte de l’étude PoxVac22 La variole du singe est une maladie infectieuse apparentée à la variole (éradiquée en 1980), causée par un virus. Ce virus a été décrit pour la première fois chez l’homme […]

Désolé, cet article est seulement disponible en EN.

Présentation La maladie de Verneuil, est une maladie inflammatoire chronique de la peau très douloureuse et invalidante. A ce jour il n’existe aucun traitement permettant de la guérir. Les causes de la maladie sont […]

Désolé, cet article est seulement disponible en EN.

Priming mosquito immunity with fungus: A novel strategy to reduce malaria transmission

Cette étude en cours utilise les données des études ComCor et Cognitiv pour identifier les profils d’attitudes des adultes français vis-à-vis des vaccins contre la COVID-19, sur la base du modèle des 7C de […]

Désolé, cet article est seulement disponible en EN.

Dans PROTECT-B, nous visons à évaluer la performance en situation réelle du HBcrAg-TDR pour identifier les femmes enceintes positives au VHB avec des charges virales élevées (≥200 000 UI/mL) en Gambie et au Burkina […]

Désolé, cet article est seulement disponible en EN.

Plasmodium vivax est le parasite du paludisme humain le plus difficile à éliminer, car les méthodes de diagnostic conventionnelles ne parviennent pas à détecter les individus porteurs des formes dormantes hépatiques qui entretiennent la […]

L’élimination du paludisme passe par l’élimination de tous les types de paludisme. Malgré les progrès importants réalisés dans le développement de nouvelles interventions contre le paludisme à P. falciparum, l’objectif d’élimination du paludisme ne peut […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

TELOBUV est une demande d’utilisation à des fins scientifiques d’échantillons collectés auprès des participants de la cohorte COSIPOP. Quel est l’objectif ? L’objectif est de mettre au point une méthode de mesure de la […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Homodimeric VHHs offer new perspectives for in vivo immunodiagnosis. Because of their small size of about 12-14 kDa, VHHs rapidly pass the renal filter, which has a cutoff of about 60 kDa, resulting in […]

SBAcom est une demande de réutilisation de données et d’échantillons déjà collectés auprès de participants de la cohorte COSIPOP.                                                    Quel est l’objectif de SBAcom ? L’objectif de cette recherche est d’utiliser du plasma ou […]

Le projet Vax-Action MINT & SMART est centré sur le développement et l’évaluation d’outils à destination des professionnels de santé, pour les aider à aborder l’acceptation vaccinale avec leurs patients, dans le cadre de […]

En 2022 puis en 2024, l’Organisation Mondiale de la Santé (OMS) a déclaré le mpox “Urgence de Santé Publique de Portée Internationale” (USPPI) en raison de l’émergence de sous-clades du virus de la variole […]

This project intends to share expertise, developments, equipement and bioinformatics tools to apply Oxford Nanopore Technology sequencing to the detection, diagnostic and characterization of pathogens of public health importance. It corresponds to a collaboration […]

PVINVASION est une demande d’utilisation à visée scientifique de données et d’échantillons biologiques collectés chez des participants de la cohorte COSIPOP     Quel est l’objectif de cette demande ?                                             L’objectif est d’identifier les récepteurs cellulaires, autres que […]

METABACT est une demande d’utilisation d’échantillons collectés dans le cadre du projet de recherche COSIPOP. Quel est l’objectif de cette utilisation ? L’objectif est de décrire les modifications du métabolisme des macrophages induites par […]

THERAPEPTICS est une demande d’utilisation d’échantillons et des données collectés dans le cadre de la cohorte COSIPOP. Quel est l’objectif ? L’objectif de cette recherche est de vérifier l’absence de toxicité sur des globules […]

LEPTBLOOD est une demande d’utilisation à des fins scientifiques de données et d’échantillons collectés auprès de participants de la cohorte COSIPOP Quel est l’objectif de cette demande ? L’objectif est de décrire la réponse […]

Ivory 1 est une demande d’utilisation à des fins scientifiques d’échantillons collectés auprès des participants de la cohorte COSIPOP. Quel est l’objectif ? L’objectif est la mise au point de techniques d’analyse des cellules immunitaires, […]

NICE est un projet de recherche réutilisant à des fins scientifiques des échantillons et des données collectés auprès des participants à de différentes cohortes de l’ANRS-MIE : ANRS CO5 (HIV-2), CO6 (PRIMO) et CO21 […]

LIPOARBOIVI est une demande d’utilisation à des fins scientifiques de données et d’échantillons de participants de la cohorte COSIPOP. Quel est l’objectif ? L’objectif est d’identifier les facteurs qui influant la capacité d’un moustique […]

ENVIMIC est une demande d’utilisation à des fins scientifiques d’échantillons collectés auprès des participants de la cohorte COSIPOP. Quel est l’objectif ? L’objectif de cette recherche est de cartographier les interactions entre les facteurs […]

The FURTHEST proposal concerns a multidisciplinary study that focuses on simian foamy viruses (SFVs) which are the most ancient retroviruses. SFVs are prevalent in non-human primates and are transmitted to humans via contact with […]

PANDORA est une demande d’utilisation à des fins scientifiques de données et d’échantillons collectés auprès des participants de la cohorte COSIPOP. Quel est l’objectif scientifique ? L’objectif est de décrire l’ensemble des formes parasitaires […]

DENDIAPRO-ICAReB est une demande de réutilisation de données et d’échantillons déjà collectés auprès de participants de la cohorte DiagmiColl Quel est l’objectif de DENDIAPRO-ICAReB ? L’objectif de cette recherche est d’identifier les protéines qui […]

AZIASP est une demande d’utilisation à des fins scientifiques de données et d’échantillons de participants de la cohorte COSIPOP. Quel est l’objectif ? L’objectif de la demande est valider expérimentalement les observations cliniques préliminaires, […]

Vous participez à l’étude BREASTMILKVIR, cette page vous est destinée. Vous y trouverez : Date de dernière actualisation : 10/09/2025 Quel est l’objectif de l’étude ? La recherche BREASTMILKVIR s’intéresse au lait maternel et […]

Présentation Le microbiote intestinal est un facteur potentiellement impliqué dans l’apparition de troubles tels que l’obésité. Des études menées chez la souris et chez l’homme mettent en évidence la présence de la bactérie Akkermansia […]

The ANRS 12225 – PEDIACAM III study involves a cohort of young adolescents infected with HIV placed early (median: 4 months) on antiretroviral therapy (ART) and not infected with HIV monitored in Cameroon. This […]

PERTSEVERE II- SIMOA SETUP est une demande d’utilisation à des fins scientifiques de données et d’échantillons de participants de la cohorte COSIPOP. Quel est l’objectif ? L’objectif de la demande de développer une technique […]

L’objectif de cette demande est de décrire les modifications observées des cellules NK lors du processus d’éducation.   Quelles données personnelles et quels échantillons collectés auprès des participants sont utilisés, et quelles analyses sont […]

PVMOC est une demande d’utilisation à des fins scientifiques de données et d’échantillons collectés auprès des participants de la cohorte COSIPOP. Quel est l’objectif ? L’objectif de la demande est d’étudier l’implication des différents […]

2016 – 2019         European Commission H2020 A global alliance for Zika virus control and prevention (ZIKALLIANCE) PI: Xavier de Lamballerie (Univ. Aix Marseille) A.-B. Failloux: WP6 Leader (18 partners)

Chronic immune activation during HIV infection is considered as the driving force of CD4+ T cell depletion and AIDS. In cART-treated patients, a residual systemic immune activation persists. It is this chronic low level […]

This multi-disciplinary study examines the changing nature and contexts of human contact with great apes and monkeys in equatorial Africa and the health consequences of that contact. Biomedical researchers have scrutinized the nature of […]

Cassandre is a project of personal database system, integrating a “user-friendly” interface to manage and explore multiple sets of large-scale experimental results in biology. Large-scale experiments that generate quantitative data, such as changes in […]

Dengue virus genotype replacements: investigating viral fitness differences driving the evolution of dengue epidemics Phylogenetic analyses have revealed that dengue virus (DENV) evolutionary dynamics are often characterized by the replacement of a DENV genotype […]

Current research investigations  Antibiotic use and Staphylococcus aureus resistant to antibiotics, ASAR This study is a prospective pharmacoepidemiological investigation involving the establishment of a cohort of hospitalized individuals not initially colonized with S. aureus. […]

AdipoTryp Trypanosoma brucei is a unicellular and extracellular parasite transmitted by the tsetse fly (Glossina genus) and causing Human African Trypanosomiasis (HAT) in Sub-Saharan Africa. If untreated, this neglected tropical disease has a case […]

AEGIS is a Marie Skłodowska -Curie Innovative Training Network (ITN) for early stage researchers (ESR) funded by the European Commission under the H2020 Programme the EU framework programme for research and innovation. The principal […]

Le monkeypox est un Orthopoxvirus émergent responsable de la variole du singe, une maladie cliniquement similaire à la variole avec une létalité autour de 1 à 10 %. Cette maladie est une zoonose initialement […]

A thousand fold improvement of an antiviral activity The starting point of this project was the modest activity displayed by compounds 1 and 2, on the phenotypic Measles-based antiviral assay designed by Pierre-Olivier Vidalain […]

The Mathematical Modelling of Infectious Diseases Unit works closely with public health agencies in France and abroad to provide modelling support during epidemics so that our assessments can contribute to evidence-based decision making and […]

The molecular basis of the meningococcal pathogenesis is under active exploration by several groups in the world. Full genome sequencing failed to reveal specific determinants that could discriminate between transmissibility and non offending colonisation […]

“Large-scale genomic re-encoding of RNA viruses for producing live-attenuated vaccine candidates” (RNA Vacci-Code)  

Understanding the molecular basis of host-pathogen interactions is critical for the discovery of new therapeutic approaches to treat infectious diseases, which in the face of increasing antibiotic resistance and emerging pathogens, is a major […]

Bacterial genomes are mainly composed of two types of replicons: chromosomes and plasmids. Plasmids are accessory mobile genetic elements acquired by horizontal transfer between strains or species. Their domestication by new hosts is of […]

The interaction between two eukaryotic genomes provides a fascinating example of co-evolution of host-parasite interactions. Two genomes, two epigenomes, two cellular systems living together. Our proposal focuses on the fascinating features of the interaction […]

Towards the design of new nitrogen fixing symbionts Elucidate how the capacity to establish a nitrogen fixing symbiosis with legumes has been acquired by new bacterial taxons via a lab-evolution experiment should allow developping […]

Intracellular parasitism is a major hallmark of the most successful and deadly human pathogens. This microbial survival strategy is especially devastating if immune cells are exploited as hosts. Here we propose to use the […]

The protozoan parasite Leishmania donovani causes fatal visceral leishmaniasis, one of the most neglected tropical diseases. In the absence of economic incentive, serious Research and Development (R&D) investments into anti-leishmanial drug development lack from […]

Infectious diseases are a major public health problem, and identification of novel potential therapeutic candidates is mandatory in a context of growing antibiotic resistance. As classical infection biology approaches are nearly exhausted in their […]

The Archaea represent an understudied but important fraction of microbial diversity present in a wide variety of environments and ecosystems, including the human body. They have key ecological roles and a unique place in […]

Methanogenesis is an archaeal-specific metabolism that could have been active as early as 3.5 Gy ago with a direct impact on the evolution of the Earth’s climate system, as well as on current global […]

Background: Clinical trials are performed under optimal conditions where patients are highly selected without co-morbidities, clinical supervision is provided by specialists, and strict protocols are used to enhance patient compliance. Due to this, results […]

The ANRS 12225-Pediacam study is coordinated by Mr. Tejiokem at the Center Pasteur in Cameroon. Since 2007, the project has included children exposed or infected with HIV-1 and a group of unexposed and uninfected […]

Chikungunya is a mosquito-transmitted disease of sub-tropical areas caused by an alphavirus, the Chikungunya virus (CHIKV). CHIKV infection has re-emerged after several decades causing large outbreaks, making it an important public health concern. The […]

Design of Antiviral drugs for Bronchiolitis Virus using a novel therapeutic target.

In addition to a direct effect on the individual, the consumption of antiinfective drugs may have an indirect ecological benefit only visible at the population level. Moreover indirect ecological adverse effects may also exist […]

Broadly neutralizing HIV-1 antibodies (bNAbs) can develop in rare infected individuals several years after co-evolution with diversifying viruses. In animal models, passive immunotherapy with potent HIV-1 bNAbs has been shown to protect from infection […]

Lymphocytic choriomeningitis virus GP2 envelop protein Arenaviruses are important agents of zoonotic disease worldwide. The virions expose a tripartite envelope glycoprotein complex (GPC) at their surface, formed by the glycoprotein subunits GP1, GP2 and […]

Protein structure determination is crucial for understanding protein function, as it paves the way to the discovery of new drugs and of new approaches to control pathological biological processes. The recent advances in structural […]

Zoonotic viruses are viruses that have an animal reservoir but may also infect humans. The 2009 A(H1N1)pdm09 influenza pandemic, the SARS epidemic in 2003, the recent emergence of a novel coronavirus in the Middle […]

Achievement of malaria elimination requires development of novel strategies targeting the parasite sexual stages (gametocytes) to interfer with parasite transmission. The formation of Plasmodium falciparum gametocytes in the human host takes several days in which immature gametocyte-infected […]

Organic synthesis, still the limiting factor of Medicinal Chemistry? This ongoing project is based on our reviews (1-3) on the inhibitors of the ATPase functions of human heat shock protein 90 (HSP90) or bacterial […]

Bacteria display several mechanisms to adapt to their host-environment and successfully colonise it. One important mechanism of adaptation concerns the regulation of gene expression in response to external signals such as the presence of […]

Antibiotic resistance rates are increasing worldwide, especially for Gram-negative bacteria, potentially responsible for difficult-to-treat infections and therapeutic failures. While the high prevalence of resistance in hospitals is a long-lived concern, resistance is now spreading […]

The ERVB project aims to eliminate dog rabies in Bangui, capital of the Central African Republic, in 3 years (including canine vaccination campaigns). It is supported for 3 years (2019-2021) by the Coordination Organization […]

Recent experience with SARS and MERS-CoV reveals the hurdles of surveying pandemic risk of emerging infectious diseases. Initially, both diseases showed low transmissibility, insufficient to start pandemics. However, concerns were that, after a short […]

New therapeutic strategies are needed to combat the pandemics and the spread of multidrug resistant form of tuberculosis. This collaborative project between our group and Institut Pasteur of Korea aims to decipher the molecular […]

Commensal and pathogenic bacteria such as Escherichia coli produce various surface structures promoting their interaction with living or inert surfaces. We study the structure and regulation of E. coli adhesins and extracellular matrix polysaccharides contributing to biofilm […]

  Specific metabolic changes occurring during biofilm formation were hypothesized to lead to the production of biofilm-associated molecules and biofilm-specific functions. The  identification of biofilm-specific metabolites could reveal new aspects of biofilm biology, and lead to novel strategies […]

 One of the  of the hallmarks of biofilm physiology is its tolerance to a high level of antimicrobials. We are currently investigating the molecular mechanisms that lead to this transient ability to withstand antimicrobial treatments. […]

   Bacteria produce and release into their headspace a wide variety of volatile secondary metabolites. However, While detection and quantification of these volatiles as attractive or repellent odors and aromas are of great interest in food and cosmetic […]

Although  many clinically and ecologically relevant processes are known to be  performed by biofilm communities composed of strict or facultative anaerobic bacteria, biofilms were often studied in  aerobic conditions.  We use in vitro anaerobic culture systems […]

The Institut Pasteur has voluminous activities of microbial strain characterisation, in the context of epidemiological surveillance, biological resource centres collections management, and research. These activities involve National Reference Centers, WHO-collaborative centers, biological resources centers […]

  Our research unit aims at studying peptidoglycan (PGN) metabolism to better understand how bacteria assemble a mature and essential PGN that confers rigidity and shape to the cell despite a highly dynamic process […]

Biofilms are universal traits of bacteria defined as mixed species communities characterized by high cell density, reduced diffusion and heterogeneous structures. These characteristics induce behaviors and phenotype that are not observed in planktonic microorganisms […]

The main goals of our research activity aim at elucidating new pathways/mechanisms involved in the pathogenesis of low GC % Gram-positive bacteria that constitute a major burden for public health. We believe that in-depth […]

This project aims to describe the hydrodynamic and thermodynamic properties of the CyaA toxin and the conformational changes it undergoes during its translocation process across the lipid membranes of Bordetella pertussis (secretion) and of […]

Biofilm formation relies as much on bacterial adhesion properties than on surface chemistry, and many questions remain regarding biophysics of surface adhesion. In collaboration with physico-chemists and biophysicists, we used multidisciplinary approaches to investigate bacterial […]

About Bip:Bip The project Bip:Bip promotes an integrated use of known and modelled three-dimensional structures of proteins as an aid in complete genome annotation. The architectural organization of biological macromolecules is essential for the […]

Our research on Bordetella covers the population biology and epidemiology of various Bordetella species, including B. pertussis, the major agent of whooping cough; vaccine improvements; and the impact of vaccination on population evolution. Current […]

Several emerging arthropod-borne viruses (arboviruses) such as dengue, yellow fever, chikungunya and Zika viruses originate from sylvatic transmission cycles where they are transmitted among non-human primates by arboreal mosquitoes. Initial virus spillover from the […]

  Cell-cell fusion proteins are essential in development. We show that the C. elegans cell-cell fusion protein EFF-1 is structurally homologous to viral class II fusion proteins. The 2.6 Ang. crystal structure of the […]

Centre for the Analysis of Complex Systems in Complex Environments About CACSICE Cells function through transient interactions of macromolecular complexes. Understanding fully the dynamic processes of life at the molecular level requies understanding the […]

Biofilms formed by C. albicans on indwelling devices play a major role in the persistence of nosocomial infections, largely because of their elevated tolerance to antifungals. The Fungal Biology and Pathogenicity Unit at Institut […]

Following our introduction of Multi-Locus Sequence Typing (MLST) as the state-of-the-art methodology for molecular epidemiology studies of C. albicans, the Fungal Biology and Pathogenicity Unit at Institut Pasteur is now progressing into population genomics […]

Candida albicans and Candida glabrata are the two major yeast species responsible for invasive fungal infections in humans. Systemic infections due to C. albicans and C. glabrata are associated with high mortality rates despite […]

  Synthetic oligosaccharides are designed and used to identify immunodominant epitopes of bacterial polysaccharide antigens. Conjugates of the most promising oligosaccharides are developed as potential  vaccines. Focus is on diarrheal diseases. Shigellosis – bacillary […]

At the forefront of the rising fields of Chemical and Synthetic Biology, CarbUniVax is a multidisciplinary project sitting at the frontier between Glycosciences and Vaccinology. A multidisciplinary strategy is proposed that challenges ambitious goals […]

Clostridium difficile (CD), recently reclassified as Clostridioides difficile, a Gram-positive spore-forming anaerobic bacterium, has rapidly emerged as the leading cause of antibiotic-associated diarrheal disease in hospitals worldwide. The incidence and severity of CD infections […]

Leptospira spp. are thin, highly motile, slow-growing spirochetes that can be distinguished from other bacteria on the basis of their unique helical shape and the presence of periplasmic flagella. We showed that peptidoglycan sacculi […]

We propose to focus on deciphering the mechanistic underpinnings of intracellular replication, as a prominent source of pathogenesis. In particular, given its fundamental role in orchestrating central events to apicomplexan cell division, and flagellar […]

Concerted effort to address rational drug design against Chagas disease Through a multidisciplinary approach that combine medicinal chemistry, structural bioinformatics, molecular docking and immunobiology of the infectious process, we identified two new inhibitors of […]

Children’s Antibiotic Resistance colonization and Route of Transmission. The aim of this program is to assess the transmission of enterobacteria resistant to 3rd generation cephalosporines (EBRCIIIG) in hospitalized neonates in two low income countries […]

  An unprecedented epidemic of Chikungunya virus (CHIKV) infection recently occurred in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash, polyarthritis, and lethal cases […]

Chikungunya virus p62-E1 envelope glycoproteins The Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has caused widespread outbreaks of a debilitating human disease in the last 5 years. CHIKV invasion of susceptible cells […]

Structural and functional studies of Chikungunya virus entry into host cells Deciphering Chikungunya virus cell biology by high-throughput / high-content screening Chikungunya virus infection of fibroblasts Chikungunya virus and the central nervous system infection  

The ChinEBatRhab project aims to unravel the diversity and the circulation of rhabdoviruses in European and Chinese bats. It focused on an extensive surveillance in Chinese and European bats to investigate the prevalence and […]

The idea that Chlamydiae have been important in the evolutionary history of Archaeplastida (Plants) was first hinted at by the discovery that a surprisingly large number of genes in the Chlamydia genomes have closely-related […]

The asyptomatic infection by Chlamydia leads to severe complications such as infertility and ectopic pregnancy. We will attempt to understand how chlamydia infection induces either functional or organic infertility in female genital tract and […]

CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]

Hepatitis C virus (HCV) infection can trigger the development of autoimmune disorders among which, cryobulininemic vasculatitis is the most prevalent. HCV-associated cryobulininemic vasculatitis is mediated by mono-/oligo-clonal IgM cryoglobulins with rheumatoid factor activity, thought […]

CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]

The ComCor study is a nationwide case-control study which aims first to describe the locations and circumstances of recent SARS-CoV-2 infection, and second, to assess the role of different settings and activities in the […]

The aim of this study is to develop and evaluate a community-based home visit intervention in sub-Saharan Africa to improve the coverage of a timely birth dose of HBV vaccine and neonatal care practices […]

During the last decades, structural biology allowed to incredibly improve the information on the biological objects, from single biomolecules to molecular assemblies, and to get a better description  of the physics underlying the interactions […]

  We recently demonstrated the existence of a phosphorylation-dependent control of glutamate metabolism in mycobacteria, in collaboration with H. O’Hare’s group in Leicester (O’Hare et al., 2008). Our results were supported by similar observations […]

The variable spectrum of diseases caused by C. difficile (CD) is correlated for the severe forms to the level of toxins produced during host infection. This strengthened the idea that regulation of toxin synthesis […]

2018 – 2023 “COST Action Aedes Invasive Mosquitoes (AIM)” (European Commission H2020) PI: Alessandra della TORRE (Universitat di Roma Sapienza)

Cryptococcus neoformans and C. gattii are encapsulated yeasts that can cause life-threatening disease; mainly in immune-suppressed patients, but also in immune-competent individuals. Cryptococcosis affects the lung and may spread to the brain, manifesting itself […]

  Challenges in understanding the determinants of anti-infection agent escape New antibiotic components are being developed and, provided the necessary investments are made, new antibiotics may therefore become available within the next few years. […]

CyaA, a 1706 residue-long protein, is one of the major virulence factors produced by B. pertussis and plays an important role in the early stages of respiratory tract colonization. This toxin uses an original […]

The goal of this project, funded by the Labex GrEX, is to decipher the interactions of Plasmodium falciparum gametocytes with erythroblastic islands, and to analyze the role of P. falciparum adhesins and of erythroblastic […]

In collaboration with the Institute of Vertebrate Biology in Brno, Czech Republic (Dr. Natalia Martinkova and Markéta Harazim), the aim of this project is to study the mechanisms of lyssavirus infection in bats based […]

Mycobacterium abscessus (M. abs) is an emerging pathogen causing lung infections in cystic fibrosis patients. Although the environmental reservoir of M. abs is currently unknown, M. abs possesses a gene pool dedicated to a […]

Deep learning methods use artificial neural networks to learn complex mappings between raw numeric input data and higher order semantic outputs. These computational techniques are at the heart of recent advances in artificial intelligence, with breakthrough […]

The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]

  Dengue virus E envelop glycoprotein The dengue virus (DENV) is a mosquito-borne member of the flavivirus genus responsible for roughly 50 million human infections each year. DENV is composed of four distinct but […]

Bacterial protein toxins are molecular nanodevices endowed with the capacity of inducing host specific unparalleled pathophysiological effects. Therefore, major challenges in toxinology include the development of countermeasures other than vaccination against bacterial protein toxins […]

  Nipah virus (NiV) is a bat-borne paramyxovirus found throughout South and South East Asia. With a case fatality ratio of >70% and no available treatment or vaccines, NiV has been identified by the […]

EpiK- The Cytosine code as potent target to kill pathogens and fight human diseases Today it is a major health need to find alternatives for increasing antibiotic resistance. Currently there is a large interest […]

Our research on Corynebacterium diphtheriae and related bacterial pathogenic species, including Corynebacterium ulcerans,  aims at defining the diversity, evolution and epidemiology of the agents of diphtheria and related infections. We study human and animal clinical isolates […]

Maintenance of genome integrity is crucial for bacteria to survive under stressful conditions, such as host immune defenses and antibiotics. Exposure to DNA damage might enhance cell-to-cell heterogeneity, eventually leading to states of protracted […]

The evolutionary roles of repeats Stress is often faced in nature, whether from lack of nutrients, arrival of competitors or predators, or the presence of toxic substances. The survival of stressed organisms can be […]

Le projet Vax-Action DRIVE vise à développer, mettre en œuvre et évaluer une intervention pour favoriser l’acceptation vaccinale vis-à-vis de la grippe chez les personnes âgées de 65 ans et plus. L’intervention repose sur […]

Context. Immature gametocytes are sequestered in the deep vasculature while mature gametocytes circulate in the peripheral blood. Mature gametocytes are thus exposed to the fine mechanical sensing displayed by the human spleen, which constantly […]

Acquisition of antibiotic resistant bacteria and development of the gut microbiome in neonates in low-income countries. Antibiotic resistance represents a major health issue worldwide. The situation is particularly acute in low-income countries (LIC), due […]

Le projet EBO-SURSY est financé par l’Union Européenne (UE) à hauteur de 8 millions d’euros. Il a été lancé le 15 janvier 2017 dans 10 pays prioritaires pour une période de 5 ans.   […]

The purpose of this study is to conduct a “history of the present” of the West African Ebola Outbreak by investigating the personal experiences and recollections of people involved in the humanitarian response. In […]

Tick-borne encephalitis virus (TBEV) is a growing health concern in Europe and Asia. It causes severe disease that can lead to permanent neurological complications or death. Recently, the incidence of TBEV infections in endemic […]

The emergence of Neisseria meningitidis serogroup X (NmX) in the African meningitis belt has urged understanding of this emergence as well as the development of diagnostic tools and vaccines for this serogroup, especially following […]

Crossing of the epithelium and endothelium barriers by pathogens and their toxins represents essential steps in pejorative evolution of infections. We have discovered that several exotoxins from S. aureus and C. botulinum disrupt epithelium and endothelium barriers by targeting […]

This project aims to study the pathogenesis of EV71-associated encephalitis. It combines in vitro and in vivo approaches.

Dynamics of the early steps of mammalian host infection by African trypanosomes Human African Trypanosomiasis or sleeping sickness is a neglected tropical disease caused by the flagellated protist Trypanosoma brucei. Nagana is a similar […]

2018 – 2020 “ENVironmental changes and mosquito-borne diseases: the example of West Nile (ENVIRON-MOS)” (IPIN) PI: Anna-Bella FAILLOUX (IP Paris)

Rearranged Mixed Lineage lLukaemia (MLLr) is a form of leukaemia representing approximately 75% of paediatric acute leukaemia and 10% of adult leukaemia (AML and ALL), with a very poor prognosis of survival at 5 […]

  Funding: ANR, Fondation Raoul Follereau, Fondation SANOFI Espoir. In this new research program, we will conduct for the first time the simultaneous collection of environmental (plants and insects) and human samples in two […]

Malaria remains a major global health problem due to the increasing spread of drug resistance and more than 400,000 deaths per year. New drugs that target multidrug resistant parasites are of highest priority. The […]

Malaria parasite infection in humans has been called “the strongest known force for evolutionary selection in the recent history of the human genome”, and we hypothesize that a similar statement may apply to the […]

CRISPR-Cas loci are the adaptive immune system of archaea and bacteria. They can capture pieces of invading DNA and use this information to degrade target DNA through the action of RNA-guided nucleases. The consequences […]

Microbes have played fundamental roles throughout our evolution and history. These roles were not only played by pathogens, but also by the trillions of microorganisms inhabiting our body –the microbiome–, which are essential for […]

The role of peptidoglycan in bacterial cell physiology: from bacterial shape to host-microbe interactions Peptidoglycan (PGN) is a major essential and unique component of the cell wall of both of Gram-negative and Gram-positive bacteria. […]

Ce projet vise à comprendre les interactions fonctionnelles et mécaniques entre chromosomes, périphérie nucléaire et cytosquelette, ainsi que leur influence sur la stabilité génomique, à travers des approches in vivo et in vitro chez […]

A Bayesian Framework for Cellular Structural Biology Objective : “The functioning of a single cell or organism is governed by the laws of chemistry and physics. The bridge from biology to chemistry and physics […]

Prokaryotes evolve rapidly new functionalities by horizontal gene transfer delivered by mobile genetic elements (MGE). MGE increase relatedness between individuals and thereby might also promote the establishment of microbial social networks. Many studies have […]

One of our important discoveries was the identification of a bacterial protein translocated into the host nucleus upon infection (Pennini et al, 2010). This protein, which we called NUE (NUclear Effector), shows histone methyl […]

One of the major challenges in bacterial infectious disease relates to infections taking place in the bloodstream (septicemia). Despite availability of antibiotics these types of infections lead to extremely severe conditions such as septic […]

Cell-Cell fusion in fertilization and developmental biology: a structural biology approach. My group has made seminal contributions in the past toward understanding the mechanism of membrane fusion used by enveloped viruses to infect a […]

Human Antibody Responses to Viruses Adaptive immune responses naturally occurring upon infection or induced by vaccination generate high affinity antibodies, and memory B-cell subsets to respond to further antigenic challenges, providing protection against (re-)infections. […]

DMP of the project : https://doi.org/10.5281/zenodo.7074306 A common strategy of bacterial pathogens is active or passive uptake into host cells. There, they can localize within a bacterial containing vacuole (BCV) or access the host […]

The folding of eukaryotic and prokaryotic chromosomes consists of an assortment of intertwined structural features. The resulting complex networks of contacts is highly dynamic and interacts functionally with, or regulates metabolic processes ranging from […]

Antimicrobial resistance (AMR) is one of the most pressing global health problems of our times. To counteract AMR, we urgently need new antibiotics, particularly with novel modes of action (MoA). However, while typical antibiotic […]

An infection is defined by the deleterious consequences of the interactions between a pathogen and a host. Thus, studying the biology of infection reveals critical properties of hosts and pathogens, and is a way […]

The success of organ transplantation depends on the lifelong use of immunosuppressive drugs to prevent rejection of the donor cells by the recipient’s immune system. These immunosuppressive drugs have several limitations, most notably major […]

Infections remain a major cause of mortality in humans. New infections are emerging, and resistance to antimicrobial drugs is widespread and expanding. There is thus an urgent need to develop novel therapeutic strategies based on rationally-designed drugs […]

The Unit includes two National Reference Centers (CNR) and a WHO Collaborating Center. Our interests are the population dynamics of bacterial enteric pathogens such Salmonella, Shigella/Escherichia coli and Vibrio, with a special focus on […]

A  collaborative study with members of Pasteur Institute (A. Saez-Cirion, D. Scott-Algara), french perinatal cohort (ANRS CO10; J. Warszawsky) and 10 hospitals from Paris Area (Principal investigator, P. Frange). The study has included 76 […]

In cancer, infection and inflammation, the immune system’s function can be dysregulated, contributing to disease pathology. As part of this process, instead of fighting disease, immune cells may suppress beneficial immune responses and increase […]

The classical biotype of Vibrio cholerae O1 was responsible for the first six cholera pandemics, but is relatively unknown, with only 20 genome sequences (50% of which come from the same geographic area) for […]

Arthropod-borne viruses (arboviruses) pose a major threat to public health worldwide and are continuously (re-)emerging or spreading to uninfected areas. Recent examples notably include dengue, Chikungunya, yellow fever, and Zika virus disease. In addition […]

In comparison to other bacterial species, genetics and molecular basis of the pathogenesis of leptospires are in their infancy. An improved understanding of leptospiral pathogenesis requires reliable genetic tools for functional genetic analysis of […]

Expanding the genetic code beyond the A-T/G-C Watson-Crick canonical base pairs and 20 amino acids of natural organisms is a long standing goal in synthetic biology. Reprogrammation of the genetic code can lead to […]

Evolutionary processes largely rely on the production of diversity. Genetic robustness, by allowing the accumulation of neutral diversity within a population, has been associated with increase in evolutionary potential (evolvability). We have already shown […]

Type IV pili and pseudopili: structure, dynamics, assembly and molecular function Type IV pili and pseudopili assembled by type 2 secretion systems (T2SS) are thin dynamic fibers that perform diverse functions, from  adherence, motility, […]

The FiTeRaD (Field Tests for Rabies Diagnostic) project aims to develop and validate, in laboratory and in the field, the first point of care tests (POCT) for the rapid detection of the etiological agent […]

 Biofilm formation on medical devices is associated with hospital-acquired (nosocomial) infections. Due to biofilms’ high tolerance to antibiotics, classical treatments lack efficacy, and removal of the biofilm-contaminated device is often the only therapeutic option. […]

We will employ a target-based strategy for the development of novel drug leads against epigenetic targets in schistosomiasis, leishmaniasis, Chagas disease and malariafocusing on key histone modifying enzymes (HME), in particular those involved in […]

Visceral leishmaniasis is caused by the protozoan parasites Leishmania donovani and Leishmania infantum and is a potentially fatal disease in endemic areas around the world. During the infectious cycle, Leishmania alternate between the insect […]

FunComPath is a network within the Infect-ERA programme (www.infect-era.eu). Infect-ERA is an ERA-Net on human infectious diseases funded under the EU 7th Research Framework Programme (2013 – 2016). It is a continuation of the […]

Dengue is the most rapidly expanding, globally dominant arthropod-borne (arbo) viral disease. It affects close to 400 million people each year in more than 125 countries. Recent reports of autochtonous cases in Southern France […]

FunHoMic is a Marie Curie Innovative Training Network that will train 13 Early Stage Researchers and decipher the fungus-host-microbiota interplay to improve the management of fungal infections. FunHoMIc is coordinated by Christophe d’Enfert at […]

Detailed objectives of the research program 1) How lyssavirus infection moves in both space and in time and the role played by ecological factors in the dispersal of lyssaviruses in bats and dogs. The […]

Non-segmented negative strand RNA viruses are characterized by an intrinsic genome instability, the result of an error-prone RNA dependant RNA polymerase. To date, most viral populations have been characterized by their consensus genome sequences. […]

Cholera is thought by many to be a disease of the Victorian era. However, Yemen has recently experienced one of the largest ever cholera epidemics. The first cases were declared in September 2016, and […]

High-throughput sequencing has revolutionized our abilities to track and characterize novel bacterial strains as they emerge and disseminate globally. Genome-based epidemiological typing systems provide ultimate resolution for strain discrimination. Genome sequences may also be […]

Meningococcal components (pathogen associated molecular patterns, PAMPs) such as the LOS, peptidoglycan and membrane proteins are responsible for the induction of systemic inflammatory response. Recent and previous works from our group contributed in the […]

Non-glycolytic pathways in glycosomes: novel functions for trypanosome development and virulence Trypanosomes and Leishmania spp. are parasitic protozoans responsible for major human diseases, which account for ~24 million persons infected worldwide, with over 600 […]

Synthetic carbohydrate-based conjugates as Shigella vaccine components: design, synthesis, selection and process validation

The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes  bimonthly meetings and seminars around an HIV / AIDS research topic. Meetings and seminars are open to all. Meetings are usually held on […]

LeiSHield-MATI forms an international, inter- and multidisciplinary consortium that aims to gain scientific knowledge on parasite-vector-host interaction to allow future development of new therapeutic and preventive measures through research and innovation staff exchange and […]

Funding: ANRS & EC. The main research objectives of this multidisciplinary network funded by the ANRS and the EC are the assessment of the burden of HCV infection and disease in Egypt, the study […]

As a follow-up to ANRS funding for a feasibility study (ANRS 12232), I received in 2011 funding from ANRS for an in-depth anthropological study of hepatitis B and vaccination in Bobo Dioulasso and the […]

  Hepatitis C virus E2 envelop glycoprotein     The hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide, leading to cirrhosis and hepatocellular carcinoma. In spite of being the focus […]

Project with the following partners: -INSERM UMR1092, Université de Limoges (Marie-Cécile Ploy) -Anses, Unité Antibiorésistance et virulence bactériennes (Jean-Yves Madec) -INRAE, UMR-1282, Université de Tours (Sébastien Leclercq)

Little is known about the emergence and spread of the first antibiotic-resistant populations. It is believed, for example, that the very common penicillinase gene, blaTEM-1, discovered for the first time in E. coli in Greece […]

Mechanisms of HIV-1 replication and interaction with the immune system. More than 35 years after its appearance, the HIV/AIDS epidemic represents more than ever a public health threat worldwide. About 37 million people are […]

The pathogenesis of HIV infection, and in particular the development of immunodeficiency, remains incompletely understood. During HIV infection both innate and adaptive immune responses are raised, but they appear to be insufficient or too […]

Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]

We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]

Neurolisteriosis is a common and frequently fatal complication of Listeria monocytogenes infection in human and ruminants. It has a high impact on human and animal health, but only little is known about its pathogenesis. […]

Human infections caused by hepatitis B virus (HBV) are major healthcare issues. Despite available effective vaccines, more than 250 million individuals worldwide are chronically infected by HBV, which accounts for approximately 1 million deaths […]

The objective of this research project is to understand the molecular and functional basis of the memory B-cell antibody response to the SARS-CoV-2 Spike protein. One of the key goals of this research program […]

The i-Bird program was devoted to explore the ability of MRSA and ER3GC to disseminate within hospital clinical departments. This program involved tracing the clonal dissemination of MRSA and ER3GC among hospitalized patients and […]

i-Predict is a multicentric controlled randomized trial on genital infection with Chlamydia trachomatis (Ct), which is the most common bacterial sexually transmitted infection (STI), especially among young women. Mostly asymptomatic, this infection can be […]

I-Share is an Internet-based Students HeAlth Research Enterprise. It is an entirely new, prospective cohort of 30,000 students registered in the first years of study at the Universities of Bordeaux and Versailles-Saint-Quentin during five years and followed […]

ICISTEM is a collaborative project to guide and investigate the potential for HIV cure in HIV-infected patients requiring allogeneic stem cell transplantation for hematological disorders. The ICIISTEM consortium is composed of an expert European […]

Although PfEMP1/var is studied in many laboratories in the world, a number of key questions remain unknown. By analysing a mutant parasite (D10) with a chromosome 9 deletion and loss of adhesion, we linked […]

Dengue causes significant morbidity and mortality worldwide, with millions of symptomatic cases occurring throughout the central band of the world each year. Large increases in cases are often associated with a shift in predominant […]

A deeper understanding of mycobacterial individuality entails looking at this phenomenon in the fluctuating host environment. Micro-fabrication of host-mimicking platforms (either cell- or tissue-based) by standard photolithography or 3D-printing techniques could allow us to […]

  A second main line of research of the team is focused on the characterization of protein-protein interactions by exploiting a bacterial two-hybrid screening technology (BACTH) that we have previously developed (Karimova et al., […]

The vast majority of the studies evaluate effects of the above-minimal inhibitory concentration (above-MIC) of antibiotics on bacteria. However, bacteria frequently encounter low concentrations of antibiotics in their environments. Our goal is to elucidate […]

The peptidoglycan (PGN) is an essential macromolecule of bacteria composed of a glycan moiety cross-linked by small stem peptides. The assembly of this macromolecule is achieved by protein complexes that involve synthetases, scaffolding proteins […]

Chlamydia trachomatis  is the most common bacterial cause of sexually transmitted infection and is particularly prevalent in the young population. C. trachomatis  is an obligate intracellular bacterium infecting primarily epithelial cells of the genital […]

The immune system is composed of two arms: the innate and adaptive immunity. Until recently, the adaptive immune system was considered the only mediator of immune memory. However, we and others demonstrated that innate […]

Cryo-EM has greatly expanded our understanding of the structure and function of many important biological systems. The next challenges now concern the responses to the following questions. When advanced classification techniques of single-particle images […]

Collaborative project with UMR Virologie (INRA, ANSES, ENVA), Maisons-Alfort, France. Flaviviruses, which are principally transmitted by mosquitoes and ticks, cause devastating human diseases such as Dengue fever in the tropics and subtropics and are […]

Our main research projects focus on structural and functional studies of M. tuberculosis DNA gyrase and aim to understand the structural dynamics of DNA recognition by DNA gyrase and the quinolone resistance mechanisms in the treatment […]

We are studying different aspects of this gene capture system: their distribution, their contribution to the adaptive capacity of their host and their recombination processes. This natural genetic system is composed of two basic […]

Human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of a slowly progressive neurodegenerative disease, HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). This disease develops upon infiltration of HTLV-1-infected lymphocytes into the central nervous system, […]

Recipient: Gerald Spaeth, PI Agency: Pasteur Institute, Type: Collaborative grant, 01/2016 – 12/2019 Based on ongoing collaborative actions we propose the creation of an IMU between three teams at IP Paris (G. Spaeth), IP […]

  The InterVax project on practices and opinions of travellers with regard to vaccination is a comparative analysis of travellers’ general perception of vaccination on the one hand and their specific perception of travel […]

Mucosal transmission of HIV-1 can induce a local production of IgG and IgA antibodies predominantly targeting the gp41 subunit of the viral envelope glycoprotein gp160. However, whether they limit viral dissemination upon HIV-1 exposure […]

Most Cryptococccus neoformans genes are interrupted by introns, and alternative splicing occurs very often. In order to gain deeper insights into the distribution of introns in the C. neoformans genome, we have used RNA-Seq […]

Although the risk of HCV acquisition during certain medical procedures, such as dialysis or blood transfusion, has been previously estimated for patients from high-income countries, the overall risk of HCV acquisition associated with hospital […]

Join us on Google groups! KlebNET e-mail distribution list on Google groups. Please ask for registration, by explaining your interest in Klebsiella research or surveillance and providing your institution, so that the moderators can […]

CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]

Protozoan parasites of the genus Leishmania generate severe human diseases termed Leishmaniases. Due to their frequency and the severity of certain clinical forms, these diseases represent a major public health problem and limit the […]

We study the host and bacterial factors involved in Listeria monocytogenes invasion of the central nervous system. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, […]

We study the host and bacterial factors involved in Listeria monocytogenes invasion of the placenta. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, cell biology, […]

The LISTERIAGEN project aims to identify host genetic factors associated with susceptibility to listeriosis.

During the last decade, advances in the sequencing technologies have revealed a large set of new eukaryotic RNA molecules. For instance, whereas 75% of the human genome was recently reported to be transcribed only […]

(Last update: 10/10/2023) Context In early 2020, the first French death attributed to the SARS-CoV-2 virus was a teacher from Crépy-en-Valois, a city north of Paris. The intense circulation of the novel coronavirus in […]

(Collaborators: Alexandre Manirakiza, Sandrine Moussa, Aude Boulay, Olga Sakanga, Sébastien Breurec, Mirdad Kazanji(IP Bangui), Lenaig Le-Fouler, Muriel Vray (IP Paris)). Funding : Fondation de France. Accounting for HIV serological status in patients is critically […]

  Determinants of the spread and competitiveness of multiresistant bacteria  In 2000, we investigated whether pneumococcal resistance to penicillin G in a child population could be controlled by modifying the use of antibiotics in […]

(Collaborators : Tamara Giles-Vernick, Abdoulaye Traoré, Sodiomon B. Sirima). Funded by the World Health Organization, 2010-11. The primary aim was to test the acceptability and feasibility of an intervention package for the community management […]

Several enveloped RNA viruses of the Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae families are associated with a syndrome known as viral hemorrhagic fever (VHF). VHF is characterized by fever, vascular leakage, coagulation defects and multi-organ […]

The use of new technological approaches including microfluidics and organ-on-chip strategies has permitted the design of advanced in vitro assays to address a variety of questions including in the study of human infections.  These […]

Despite the conservation of central metabolism, an increasing amount of evidence indicates that there are unique features in Actinobacteria, one of the largest bacterial phyla that includes important human pathogens like Mycobacterium tuberculosis and […]

Since 2002 a centralized storage of therapeutic or preventive medications of bacterial infections in the community (MIBAC) has been initiated. Reimbursements for all systemic antibiotics (class J01 of the Anatomical Therapeutic classification), as well […]

We use intestinal organoids, live imaging and molecular/cell biology approaches to study Listeria monocytogenes translocation across the intestinal epithelium.

Although competitive interactions between bacteria (bacterial interference), are likely to represent a key aspect of many infectious processes, the nature of these interactions within mixed biofilm communities is poorly understood. We use in vitro biofilm models […]

Tuberculosis still remains a major threat for public health, with one-third of the world population latently infected, and more than one million deaths per year according to the WHO. Among the factors that have […]

Project MOD-COV (Modelling of the hOspital Dissemination of SARS-CoV-2) In the context of SARS-CoV-2 pandemic, healthcare institutions are confronted to major challenges. First the community spread is leading to a large demand in available […]

Cilia and flagella are found at the surface of most cells of the human body. Their malfunctioning results in ciliopathies, genetic diseases that affect 1 individual out of 400. Their construction relies on intraflagellar […]

Despite advances in modern biology and medicine, antibiotic-resistant bacteria (ARB) have spread in the community and in hospitals over the last decades, becoming a major public health problem. Mathematical modeling and computer simulations are […]

The interferon (IFN) response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs). Only a handful of these ISGs have been well characterized, mainly by artificial gain-of-function screening […]

The cilium is an important organelle for motility and cellular signaling found on most mammalian cells and on single celled organisms such as the parasite Trypanosoma brucei. Cilia formation requires the process of Intraflagellar […]

  We use in vitro and in vivo models of polymicrobial communities in order to better understand the molecular events underlying colonization resistance and pathogen exclusion by commensal bacteria   Articles on this topic David Pérez-Pascual, Sol Vendrell-Fernandez, […]

Bacteriophages infecting pathogenic bacteria, which have been studied for their in vivo activities and defined as valuable for therapeutic application, are in this project, subject to molecular studies ranging from bacterial receptor identification to […]

Fluorescent live cell imaging and single-cell analysis provide a clear glimpse into bacterial individuality. Discrete subpopulations can be separated either by conventional FACS or droplet sorting, and enriched subsets can be subjected to global […]

In the frame of a collaboration with Stephen Cusack (EMBL Grenoble) we showed that the direct interaction of the influenza virus polymerase (FluPol) PA subunit to the phosphorylated C-terminal domain of the cellular RNA […]

Our Unit investigates and characterises the molecular, genetic and cellular basis of the infection by Legionella. Legionella are environmental bacteria but some species like Legionella pneumophila or Legionella longbeachae are also opportunistic pathogens that […]

Cette page est destinée aux participants à l’étude MONALISA, afin d’y retrouver : les informations relatives à la recherche en cours la synthèse des résultats des études auxquelles ils ont participé dernière actualisation : […]

This project investigates the entomological genetic determinants of human DENV infectiousness to mosquitoes. Specifically, we are testing the hypothesis that mosquitoes are genetically variable in their dose-response to a DENV-infectious blood meal. We recently […]

2019 – 2023 “Mosquito host barriers driving vector specificity for arbovirus transmission (ArboVEC)” (ANR) PI: Kenneth VERNICK (IP Paris)

Specific interactions between host and pathogen genotypes are commonly found in invertebrate systems, but their genetic basis has not been elucidated. Such insect-virus genetic specificity plays a critical role in the emergence and evolution […]

Le projet MoustiKAP-P vise à relever le défi croissant des maladies vectorielles à moustiques autochtones en France métropolitaine en développant des stratégies de contrôle des maladies et de communication qui soient acceptables et réalisables. Il […]

HIV-controllers (HIC) (also called “elite controllers” or “elite suppressors”) are rare (less than 1%) HIV-infected patients who control viral replication to undetectable levels in the absence of antiretroviral treatment. In the context of the […]

Neonatal acquisition of ESBL-PE in the community of a Low-Income Country  Severe bacterial infections are a leading cause of neonatal deaths, with low income countries (LICs) bearing the highest burden. In LICs, neonatal bacterial […]

Chronic infection with hepatitis B virus (HBV) is an important cause of premature adult deaths in sub-Saharan Africa (SSA), due to liver cancer or cirrhosis. To reduce the disease burden, it is critical to […]

http://www.anrs.fr/fr/actualites/412/3-questions-michaela-muller-trutwin

The one-dimensional sequence of the genome is carried by long polymers (chromosomes), which fold in the three dimensional volume of the nucleus. How this folding occurs and what it implies for genome function remains […]

When individuals get infected by a pathogens, they will develop antibodies against that pathogen that will continue to circulate in their blood. By using assays that can detect these antibodies, we can develop an […]

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]

During the past year, using a murine model for experimental cerebral malaria (ECM), we pursued our investigation regarding the contribution of the allergic inflammatory response in the pathogenesis of malaria disease. Following the demonstration […]

Rift Valley fever (RVF) is a an arthropod-borne emerging viral disease that primarily affects domesticated animals (such as cattle, sheep and goats) and humans, with recent outbreaks in sub-Saharan Africa, Madagascar, and the Arabian […]

The genus Yersinia belongs to the Enterobacteriaceae family and is composed of 17 species, three of which are pathogenic for humans: Y. enterocolitica, Y. pseudotuberculosis and Y. pestis. Enteropathogenic species Y. enterocolitica and Y. […]

 Bovine Viral Diarrhea virus envelop protein E(rns) Pestiviruses, which belong to the Flaviviridae family of RNA viruses, are important agents of veterinary diseases causing substantial economical losses in animal farming worldwide. Pestivirus particles display […]

Bacterial resistance to antibiotics has become a major public health issue. A recent report, delivered to the Minister of Health in September 2015, pointed out 158,000 cases of infections by antibiotic-resistant bacteria annually in […]

In 1970, ten years after the beginning of the 7th pandemic (Indonesia, 1961), cholera hit Africa, where it has remained entrenched. Three decades later, the reported incidence of indigenous cholera in sub-Saharan Africa was […]

The agent of epidemic dysentery, the bacterium Shigella dysenteriae type 1, was isolated in Japan in 1897 by Dr Kyoshi Shiga during a massive epidemic of bloody diarrhea that caused 20,000 deaths over a […]

  Double-stranded (ds) RNA virus particles are organized around a central icosahedral core capsid made of 120 identical subunits. This core capsid is unable to invade cells from outside, and animal dsRNA viruses have […]

  The genes pknA and pknB are located near the origin of replication in M. tuberculosis and are part of a conserved operon that also includes pstP (coding the only known Ser/Thr protein phosphatase […]

Erythrocyte invasion is a complex process involving multiple interactions between Plasmodium merozoites and host erythrocytes. Unlike P. falciparum, which can use multiple erythrocyte receptors for invasion and has merozoite proteins with overlapping and redundant […]

This third project is to investigate other factors involved in genome plasticity of the complex genome of Vibrio species. The Vibrio group includes a large number of pathogenic species whose hosts range from human […]

Fluorescence microscopy is a defining technology in cellular biology but the diffraction of light limits the resolution of standard microscopes to ~200 nm, thus preventing detailed analyses of molecular structures. We are actively interested […]

Klebsiella pneumoniae is one of the most urgent threats to public health given its increasing resistance to antimicrobial agents including carbapenems, considered as last-resort antibiotics.  In this project we aim to understand the ecological, epidemiological and […]

2016 – 2020         European Research Council “Population genomics of co-evolution between non-retroviral RNA viruses and their hosts”; PI: Mariangela Bonizzoni (University of Pavia, Italy)

Protein-Protein Interactions (PPIs) are involved in most biological process and diseases. With a recently estimated number of 370,000 PPIs in humans, they constitute a large ‘reservoir’ for therapeutic development compared to ‘conventional’ drug targets. […]

Dog constitutes one of the major reservoirs of the rabies virus (RABV), and the main vector of rabies in humans (nearly 60,000 deaths per year worldwide), in particular in the endemic areas in Asia […]

Our unit participates in the PreDiCT-TB consortium, whose main goal it is to find the most rapid and reliable ways of identifying the most potent combinations of new drugs. Please find more information on […]

2018 – 2022 “PREventing EMerging Pathogenic Threats (PREEMPT)” (DARPA) PI: Carla SALEH (IP Paris)

“High-throughput screening of arboviruses in mosquitoes and ticks” (CHIPARBO)

We aim to study the adjuvant effects of Enterococcus hirae in antitumoral response. In particular, we want to identify how E. hirae translocates the intestinal barrier and the cells that mediate the antitumor effect.

The capacity to rapidly and accurately identify virulent strains of C. difficile in order to prevent severe and fatal infections remains a major chal- lenge for clinicians and investigators. Also, the evolution of an […]

Development of specific imaging nanoprobes against intracerebral targets is a challenging field of research, particularly for the diagnosis of neurodegenerative diseases. Probes based on camelid single-domain antibody-fragments (VHHs or nanobodies) are promising tools due […]

PDB Crystal Structures Resolution (A) Year NON-VIRAL proteins Eukariotyc cell-cell fusion 4OJC Wild-type full-length trimeric ectodomain of C. elegans fusion protein EFF-1  2.93 2014 4OJD C-ter truncated trimeric ectodomain of C. elegans fusion protein […]

Pathogenic protozoans of the trypanosomatid group still remain a major world health problem. Cycling between insect vectors and mammalian hosts, Trypanosoma cruzi is the causative agent of Chagas disease, while over 20 Leishmania species […]

This PTR aims to gain novel insight into the nature, the expression, and the regulation of Leishmania virulence factors through the investigation of genetics, transcriptomics, and proteomics differences between (i) virulent and avirulent L. […]

Our proposal aims to decipher novel subversion strategies used by Leishmania (i) to withstand, circumvent or inhibit anti-microbial activities of host macrophages and (ii) to interfere with the induction of Leishmania-specific immune responses. We […]

Our PTR project investigates at the complex interface between the intracellular pathogen Leishmania and its macrophage host cell. We will apply systems-wide analyses to elucidate the molecular mechanisms underlying the reciprocal metabolic relationship between […]

The Negativicutes are a poorly studied lineage of bacteria that include common inhabitants of the human oral and gut microbiome such as the anaerobe Veillonella, and which can also develop into opportunistic pathogens. Despite […]

Current knowledge of dengue virus (DENV) transmission provides, at best, only a partial understanding of a complicated and dynamic system with a public health track record that has more failures than successes. An important […]

Previously considered to cause limited human infection and mild disease, Zika virus (ZIKV) caused several large outbreaks in Yap Island in 2007, in French Polynesia in 2013-2014 and the 2015-2016 epidemic across the Americas […]

  From an applied perspective, we have shown in collaboration with the team of C. Leclerc, (Immune Regulation and Vaccinology, Institut Pasteur) that CyaA can be engineered to serve as a potent non-replicating vector […]

The public health relevance of retroviruses of zoonotic origin is illustrated by the human immunodeficiency virus (HIV) epidemic, the worldwide distribution of human T-lymphotropic viruses (HTLVs), and the morbidity and mortality associated with both […]

The Fungal Biology and Pathogenicity Unit at Institut Pasteur is interested in the regulation of the yeast-to-hypha transition in C. albicans because of its role in biofilm formation and, more generally, in virulence. While […]

  Other research projects are aimed at exploring the regulatory role of different nucleotides such ppGpp and pppGpp that are both thought to act as second messengers in many complex cellular responses to nutritional […]

2017 – 2022         European Commission H2020 Research capacity for the implementation of genetic control of mosquitoes -2 (Infravec 2) PI: Kenneth VERNICK (Institut Pasteur); A.-B. Failloux: co-leader of WP1 (14 partners)

The polysaccharide-encapsulated bacteria Neisseria meningitidis, Haemophilus influenzae (Hi) and Streptococcus pneumoniae are leading causes of serious bacterial infections. Beta lactams are the first line antibiotics in the treatment. These bacteria share the same ecological […]

  The ResiVax project, entitled SoVax for the French context study, addresses a crucial health issue, vaccine coverage and its social determinants, at a specific stage of life, student life. It relies on the […]

Invasive pneumococcal diseases (IPDs) are a major cause of morbidity and mortality worldwide. The mechanisms responsible for the epidemiological patterns of susceptible- and resistant- IPDs which include a yearly winter peak are still poorly […]

  Respiratory Syncytial Virus Nucleoprotein-RNA complex     Human respiratory syncytial virus (RSV) is the most important viral agent of pediatric respiratory tract disease worldwide, causing pneumonia and bronchiolitis in infants. No vaccine is currently […]

Knowledge concerning the interaction of SARS-CoV-2 with human and bat cells is sparse. We will use state-of-the-art RNA-sequencing analysis, original bioinformatics tools, loss-of-function approaches and mechanistic studies to identify and characterize coding and non-coding […]

2016 – 2018         Programmes Transversaux de Recherche Risk of reemergence of urban yellow fever in Brazil: role of the invasive mosquito Aedes albopictus PI: Ricardo Lourenço-de-Oliveira (Instituto de Oswaldo Cruz, Rio de Janeiro, Brazil)

The number of persons living with HIV-1 is around 35 million while roughly one million persons are living with HIV-2, with a decreasing prevalence. Both HIV-1 and HIV-2 are associated with AIDS, however most HIV-2 […]

Rabies is an untreatable disease of humans due to lyssaviruses and Rabies virus (RABV) in particular. RABV is a highly neurotropic virus which prevent inflammation during the early phase of infection. In the brain, […]

Cilia and flagella are essential eukaryotic organelles composed of an evolutionary conserved structure of 9 doublet microtubules that are similar but not equivalent. We propose that a tubulin post-translational modification called glutamylation could act […]

  Little is known about the three-dimensional organization of rubella virus, which causes a relatively mild measles-like disease in children but leads to serious congenital health problems when contracted in utero. Although rubella virus […]

The main objective of the SARAH project is to study the determinants of antibiotic resistant bacteria dissemination at the animal-human interface. We develop a methodological research based on mathematical modelling and the analysis of […]

SHERLOCK4HAT African trypanosomes are transmitted by the bite of the tsetse fly and cause the debilitating, and often fatal, neglected tropical disease sleeping sickness, or Human African Trypanosomiasis (HAT). Trypanosoma brucei gambiense, the parasites […]

One of the significant drivers of phenotypic heterogeneity is noise in gene expression, which in turn is greatly influenced by fluctuations in the number of RNA molecules. Subcellular visualization of RNA turnover and quality […]

Bacteria produce hundreds of volatile compounds, important for the crafting of microbe-based foods like wine, beer, or cheese. Although  the odorant chemicals emitted by bacteria were rarely characterized in the context of bacteria-bacteria or bacteria-host […]

Cliquer ici pour aller à l’enquête Confinement, mesures barrières, limitation des rassemblements etc. Les mesures de prévention actuellement mises en place sont inédites. Elles ont fondamentalement modifié les contacts que nous avons au quotidien. […]

Healthcare-associated infections (HAI) have been occurring with increased incidence and severity over the last decades, becoming a major public health issue. A wide range of control strategies is already available, including hygiene measures, barrier […]

To design effective ways to mitigate the spread of a pathogen in a population, it is important to first have a good understanding of the transmission characteristics of the pathogen as well as the […]

Targeting antimicrobial resistance through bacterial adhesin research Strains, Diagnostics, and Variants StraDiVarious is a European doctoral network studying strain variants of ESKAPE pathogens to develop rapid diagnostics and identify therapeutic targets. Our research hypothesis […]

2018 – 2022 “Strengthening Omics Data Analysis Capacities in Pathogen-Host Interaction – PHINDaccess” (European Commission H2020) PI: Helmi Merdassi (Institut Pasteur of Tunis)  

Our project proposes to address, in vitro and in cells infected with Flaviviruses and Coronaviruses, the mechanisms by which enzymes forming the replication transcription complexes i) replicate and transcribe faithfully the RNA genome, ii) […]

  The CyaA toxin is a 1706 residues-long bifunctional protein (Figure 1): the calmodulin-activated, catalytic domain is located in the 400 amino-proximal residues, whereas the carboxy-terminal 1306 residues are responsible for the binding of […]

Our overall goal is to understand the cellular and molecular aspects of immune response to SARS-CoV-2 virus in terms of activation of over-reactive immunity and induction of immune protection. COVIMUNE is designed to target […]

CRISPR loci and the associated Cas genes are the adaptive immune system of archeae and bacteria. They have the ability to capture pieces of DNA from viruses and other invading genetic elements [1], and […]

Listeriosis is a leading cause of death from food-transmitted bacterial pathogens. It can cause infections in the blood stream and brain, and lead to abortion, neonatal infection and fetal death. The causative organism, Listeria […]

The symbiotic microbiota plays an essential role at many levels of host physiology, and germfree mice develop a large number of defects. In the intestine, the microbiota metabolises nutrients and toxins to generate an […]

An exciting symposium will be organised at the Institut Pasteur on 23rd and 24th November 2015. Web site

Protein secretion in bacteria is highly specific. Substrates secreted via the Type II secretion nanomachines are fully folded prior to secretion and are specifically recognized in their native state. In some cases, they even […]

Functional nucleic acids (aptamers, DNAzymes, ribozymes, and aptazymes) are generated by in vitro Darwinian evolution methods (SELEX and related methods of in vitro selection). We are interested to expand the capacity of these functional […]

Synthetic peptides and conjugates thereof as potential antivirals (col. H. Lortat-Jacob (CEA, Grenoble), D. Bonnaffé (ICMMO, Orsay) A bi-substrate synthetic glycopeptide resulting from the covalent linkage between a CD4 peptide mimetic and a heparan […]

New TARGETs for osteoporosis: from mesenchymal stem cells to the regulation of osteogenesis and BONE mass.

  Our basic research on virulence gene control revealed that epigenetic factors such as histone methylation control antigenic variation but also the developmental progression of malaria parasites during the complex life cycle in the […]

Malaria is a tropical disease due to a parasite named Plasmodium. It is a global health problem, still causing more than 450.000 deaths each year (mostly African children) and over 200 million infections (http://www.who.int/malaria/en/). […]

Our unit is partner in the TBVAC 2020 consortium and participates actively in the research of improved whole cell vaccines against tuberculosis. More information on the consortium and its main goals is available via […]

The aim of this project is to develop a more grounded, robust historical context for the emergence of HIV. While some hypotheses for the emergence of HIV have been suggested, they have been offered […]

EVA-GLOBAL objective is to generate the largest accessible collection of human, animal and plant viruses in the world and move beyond the current state-of-the-art to provide an increasingly valuable resource and service to the […]

Replication-associated gene dosage effects Maximal growth rates are central to microbial life-history strategies because there is a trade-off between fast growth in copiotrophs and scavenging potential in slow-growing oligotrophs. When E. coli’s generation time […]

  This is a lattice-like structure that is unique to Euglena and Kinetoplastida protozoa (see picture above). It is tightly attached to the axoneme as only trypsin treatment can separate the two structures. It […]

Clostridium difficile, a Gram-positive, anaerobic, spore-forming bacterium, is a major cause of nosocomial infections such as antibiotic-associated diarrhea. Spores are the vector of its transmission and persistence in the environment. Despite the importance of […]

An important research axis of the laboratory is to modify nucleic acids with chemical groups in order to improve their therapeutic usefulness. Particularly, modified aptamers (i.e. oligonucleotides capable of binding to targets with high […]

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]

(Collaborators: Sébastien Breurec, Ionela Gouandjika,Thierry Frank, Caroline Martin (IP Bangui), Petulla bata, Jean Gody (Complexe pédiatrique Bangui), Tamara Giles-Vernick, Loic chartier, Muriel Vray (IP Paris)). Funding : The fondation Total. Diarrhea ranks as the […]

A collaboration with the electron microscopy expert Cristina Risco (CSIC, Madrid) led us to propose a model in which the endoplasmic reticulum (ER) plays an essential role in the trafficking of newly synthesized viral […]

Pulmonary infections are a leading cause of death worldwide and infections caused by antibiotic-resistant bacteria are steadily increasing. We study how virulent bacteriophages can be used to treat bacterial lung infections. We develop infectious […]

Trypanosoma brucei gambiense causes chronic Human African Trypanosomiasis. These extra-cellular protist parasites are transmitted by tsetse flies and proliferate in the host blood. We have recently demonstrated that the skin was a major yet […]

  The trypanosome cell African trypanosomes are protozoa (unicellular organisms) belonging to the Kinetoplastida order. They are elongated cells (20-25 µm long, 3-5 µm wide), although certain variations are observed during the life cycle. […]

Dengue is caused by dengue virus (DENV), a virus which can be transmitted by Aedes mosquitos. Half of the world’s population live in areas where the mosquito and the virus are circulating. Infection by […]

Vaccination is one of the greatest successes of modern medicine. The first generation of viral vaccines relied on empiric attenuation by repeated passage in animals and/or cultured cells. A successful attenuation process eliminates virulence […]

In order to understand the spread of infectious diseases, we are often interested in the transmission relationship between pairs of cases. The use of pathogen sequences has revolutionized our ability to characterize the relationship […]

Deciphering the impact of Plasmodium/Trypanosoma co-infections on the vectorial capacity of Anopheles mosquitoes. Malaria and African trypanosomiasis (AT), also known as sleeping sickness in humans and Nagana in cattle, are two parasitic diseases prevalent […]

The Innovative Training Network ViBrANT (Viral and Bacterial Adhesin Network Training) brings together world-leading European scientists to train 15 graduate students (early stage researchers) in interdisciplinary research into viral and bacterial adhesins. ViBrANT is […]

The Viral Host Range database (VHRdb) represents a unique resource for the community to rapidly find, document analyze and disseminate data related to the range of hosts that a virus can infect. Over the […]

Digestive tract of mammals is one of the most complex microbial ecosystems subject to both external and internal factors, through food consumption and interactions with intestinal cells. We are developing and using several experimental […]

The major goal of the vaccine research institute (VRI) consists in boosting the development of a vaccine against HIV.  The VRI is a laboratory of excellence (Labex) created as part of the first PIA […]

We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]

Project in collaborations with the following partners; – InBio Unit, Inria (Grégory Batt) -CNRS, Laboratoire de Recherche en Informatique, Université Paris-Saclay (Flora Jay) -INSERM, Délégation régionale Paris 11, U1184 RESIST Team (Thierry Naas) -CNRS, […]

The genus Leptospira includes >60 Leptospira species  and more than 300 serovars have been described. Little is known about the circulating etiological agents of leptospirosis in most of the regions of the world. Detailed […]

Zika virus multiplication and cytopathic effects The Zika virus (ZIKV) epidemics in South East Asia, French Polynesia, the Caribbean islands and the Americas, and its association with neurological disorders including Guillain-Barré syndrome and microcephaly […]

25 leading research and public health organizations from Latin America, North America, Africa, Asia and Europe united to fight Zika virus today and build long-term outbreak response capacity in Latin America. ZikaPLAN takes a […]

The enhanced responsiveness observed in human monocytes and mediated by β‑glucan priming is directed towards several other pathogens that are not obligatory fungal-related. This enhanced responsiveness coined training is translated by increased pro-inflammatory cytokines […]

β-glucan, the most abundant fungal cell wall polysaccharide in C. albicans, has gained much attention from the scientific community in the last few decades for its fascinating but not yet fully understood immunobiology. Study […]